Abstract：
:Antagonists of GABA(B) receptors are expected to have proconvulsant action also in developing brain. Two antagonists (CGP55845 and CGP46381) were tested in a model of cortical epileptic afterdischarges (ADs) in 12-, 18- and 25-day-old rat pups with implanted electrodes. CGP55845 was dissolved in dimethylsulfoxide and the results demonstrated marked proconvulsant action of this solvent which masked possible action of the antagonist. Water soluble antagonist CGP46381 led to marked potentiation of ADs in 12-day-old animals, its action decreased with age, it was negligible in 25-day-old rats. Our results demonstrated important inhibitory role of GABA(B) receptors at very early stages of maturation.
journal_name
Physiol Resjournal_title
Physiological researchauthors
Mareš Pdoi
10.33549/physiolres.932599subject
Has Abstractpub_date
2013-01-01 00:00:00pages
S109-14issue
Suppl 1eissn
0862-8408issn
1802-9973pii
932599journal_volume
62pub_type
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