Abstract：
:Using non-cholesterol sterols investigation several authors postulated a hypothesis that in the metabolic syndrome cholesterol endogenous synthesis is increased and its absorption decreased. Our study is the first attempt to evaluate the direct relation of cholesterol metabolism to the principal pathogenetic phenomenon of the metabolic syndrome--namely to insulin resistance. We have measured insulin sensitivity by two methods--Quicki (Quantitative Sensitivity Check Index) and intravenous insulin tolerance test (Kitt) and 3 indirect markers--fasting insulin level, fasting C-peptide level and SHBG (sex hormone binding globulin). The investigation was performed in three groups of subjects with a different prevalence of insulin resistance: 72 non-diabetics with ischemic heart disease, 117 young blood donors and 63 type 2 diabetics on diet therapy only. Analyzing altogether 60 relationships--between four sterols (lathosterol, squalene, sitosterol and campesterol) and five markers of insulin resistance in three groups of subjects--we have found only six significant relations between cholesterol synthesis and absorption and insulin resistance in all groups of patients. Our results indicate that there exists a significant relationship between insulin sensitivity and indices of either increased cholesterol synthesis or decreased cholesterol absorption. Insulin resistance explains only a part of both abnormalities mentioned above.
journal_name
Physiol Resjournal_title
Physiological researchauthors
Smahelová A,Hyspler R,Haas Tsubject
Has Abstractpub_date
2007-01-01 00:00:00pages
749-55issue
6eissn
0862-8408issn
1802-9973pii
1065journal_volume
56pub_type
杂志文章abstract：:The review aims to summarize current knowledge on the effects of moderate alcohol consumption (1 standard drink a day for women; 2 drinks a day for men) on triglyceride concentration in circulation. Current evidence suggests that the relationship between alcohol consumption and triglyceridemia is J-shaped. Triglycerid...
journal_title：Physiological research
pub_type： 杂志文章,评审
doi：10.33549/physiolres.933178
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journal_title：Physiological research
pub_type： 杂志文章
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journal_title：Physiological research
pub_type： 杂志文章
doi：
更新日期：2009-01-01 00:00:00
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更新日期：2000-01-01 00:00:00
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pub_type： 临床试验,杂志文章
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更新日期：2005-01-01 00:00:00
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journal_title：Physiological research
pub_type： 杂志文章
doi：
更新日期：2002-01-01 00:00:00
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pub_type： 杂志文章
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pub_type： 杂志文章
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journal_title：Physiological research
pub_type： 杂志文章
doi：
更新日期：1998-01-01 00:00:00
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更新日期：2005-01-01 00:00:00
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pub_type： 杂志文章
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更新日期：2012-01-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2017-09-26 00:00:00
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journal_title：Physiological research
pub_type： 杂志文章,评审
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更新日期：2000-01-01 00:00:00
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journal_title：Physiological research
pub_type： 杂志文章,评审
doi：
更新日期：2000-01-01 00:00:00
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journal_title：Physiological research
pub_type： 杂志文章
doi：
更新日期：2001-01-01 00:00:00
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pub_type： 杂志文章
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journal_title：Physiological research
pub_type： 杂志文章
doi：
更新日期：1997-01-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2004-01-01 00:00:00
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更新日期：2003-01-01 00:00:00
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更新日期：2007-01-01 00:00:00
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