听力与言语-语言病理学

行为科学

医学伦理学

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  • Poly (ADP-ribose) polymerase-1 as a promising drug target for neurodegenerative diseases.

    abstract:AIMS:Poly (ADP-ribose) polymerase- (PARP)-1 is predominantly triggered by DNA damage. Overexpression of PARP-1 is known for its association with the pathogenesis of several CNS disorders, such as Stroke, Parkinson's disease (PD), Alzheimer's disease (AD), Huntington (HD) and Amyotrophic lateral sclerosis (ALS). NAD+ de...

    journal_title:Life sciences

    pub_type: 杂志文章,评审

    doi:10.1016/j.lfs.2020.118975

    authors: Thapa K,Khan H,Sharma U,Grewal AK,Singh TG

    更新日期:2021-02-15 00:00:00

  • CRISPR-cas9 genome editing delivery systems for targeted cancer therapy.

    abstract::The prokaryotic CRISPR-Cas systems could be applied as revolutionized genome editing tool in live cells of various species to modify, visualize and identify definite sequences of DNA and RNA. CRISPR-Cas could edit the genome by homology-directed repair and non-homologous end joining mechanisms. Furthermore, DNA-target...

    journal_title:Life sciences

    pub_type: 杂志文章,评审

    doi:10.1016/j.lfs.2020.118969

    authors: Ghaemi A,Bagheri E,Abnous K,Taghdisi SM,Ramezani M,Alibolandi M

    更新日期:2021-02-15 00:00:00

  • Mechanisms involved in the possible protective effect of chrysin against sodium arsenite-induced liver toxicity in rats.

    abstract::Arsenic as a one of the most important toxic metals could induce hepatotoxicity. Previous reports revealed the significance of oxidative stress in promoting of arsenic-induced liver toxicity. The aim of the present investigation is to evaluate the effect of chrysin (CHR), a natural flavonoid with potent antioxidant ac...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/j.lfs.2020.118965

    authors: Fatemi I,Khalili H,Mehrzadi S,Basir Z,Malayeri A,Goudarzi M

    更新日期:2021-02-15 00:00:00

  • The "irisin system": From biological roles to pharmacological and nutraceutical perspectives.

    abstract::The scientific interest in irisin, a myokine discovered in 2012, has grown exponentially in recent years. Irisin, which is mainly produced in skeletal muscle, influences the browning process of adipose tissue and lipid and energy metabolism. Recent discoveries highlight that the potential of this hormone may have been...

    journal_title:Life sciences

    pub_type: 杂志文章,评审

    doi:10.1016/j.lfs.2020.118954

    authors: Flori L,Testai L,Calderone V

    更新日期:2021-02-15 00:00:00

  • Modulatory mechanisms of NLRP3: Potential roles in inflammasome activation.

    abstract::The NLRP3 inflammasome regulates innate immune and inflammatory responses by promoting pro-inflammatory cytokines such as IL-18 and IL-1β. NLRP3 is one of the main factors restricting the activation of the inflammasome, which is closely related to the abundance and localization of NLRP3. A substantial number of studie...

    journal_title:Life sciences

    pub_type: 杂志文章,评审

    doi:10.1016/j.lfs.2020.118918

    authors: Ge Q,Chen X,Zhao Y,Mu H,Zhang J

    更新日期:2021-02-15 00:00:00

  • Downregulation of redox imbalance and iNOS/NF-ĸB/caspase-3 signalling with zinc supplementation prevents urotoxicity of cyclophosphamide-induced hemorrhagic cystitis in rats.

    abstract:AIM:Cyclophosphamide (CYP) chemotherapy induces bladder toxicity and hemorrhagic cystitis in cancer patients constituting a current clinical concern. Oxidative inflammatory cascades have been implicated as the mechanism contributing to CYP bladder urotoxicity. We thus assayed to explore whether zinc (Zn) supplementatio...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/j.lfs.2020.118913

    authors: Famurewa AC,Edeogu CO,Offor FI,Besong EE,Akunna GG,Maduagwuna EK

    更新日期:2021-02-01 00:00:00

  • Vildagliptin, a dipeptidyl peptidase-4 inhibitor, reduces betel-nut induced carcinogenesis in female mice.

    abstract:AIM:Betel-nut, a popular masticatory among Southeast Asian populations is a class I carcinogen, previously associated with dyslipidemia and aberrant lipid metabolism, and is reported to be used more frequently by females, than males. This study investigates the potential of repurposing the anti-diabetic drug, vildaglip...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/j.lfs.2020.118870

    authors: Nath M,Bhattacharjee K,Choudhury Y

    更新日期:2021-02-01 00:00:00

  • Renal ischemia-reperfusion leads to hypertension and changes in proximal tubule Na+ transport and renin-angiotensin-aldosterone system: Role of NADPH oxidase.

    abstract::Acute renal injury (AKI) is a risk factor for the development of hypertension, which involves oxidative stress, changes in Na+ handling, and the intrarenal renin-angiotensin-aldosterone system (RAAS) as underlying mechanisms. We investigated in rats whether renal ischemia-reperfusion (IR) leads to changes in the proxi...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/j.lfs.2020.118879

    authors: Lima NKS,Farias WRA,Cirilo MAS,Oliveira AG,Farias JS,Aires RS,Muzi-Filho H,Paixão ADO,Vieira LD

    更新日期:2021-02-01 00:00:00

  • Codelivery of STAT3 and PD-L1 siRNA by hyaluronate-TAT trimethyl/thiolated chitosan nanoparticles suppresses cancer progression in tumor-bearing mice.

    abstract::Immunotherapy methods using potential tumor microenvironment modulators have elicited durable therapeutic responses in cancer treatment. Immune checkpoint molecule programmed cell death-ligand 1 (PD-L1) and oncogenic transcription factor STAT3 (signal transducer and activator of transcription-3) assigned as inhibitory...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/j.lfs.2020.118847

    authors: Bastaki S,Aravindhan S,Ahmadpour Saheb N,Afsari Kashani M,Evgenievich Dorofeev A,Karoon Kiani F,Jahandideh H,Beigi Dargani F,Aksoun M,Nikkhoo A,Masjedi A,Mahmoodpoor A,Ahmadi M,Dolati S,Namvar Aghdash S,Jadidi-Niaragh F

    更新日期:2021-02-01 00:00:00

  • Intra-platelet serotonin and YAP contributed to poor prognosis of hepatocellular carcinoma.

    abstract:AIMS:Intra-platelet 5-HT (IP 5-HT) and YAP exhibit an important role in hepatocellular carcinoma (HCC). The aim of the study was to investigate whether IP 5-HT and YAP could affect the progression and prognosis of HCC. METHODS:5-HT level and YAP expression were measured and were compared between HCC patients and contr...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/j.lfs.2021.119140

    authors: Liu S,Zhai M,Xiao W,Zhou Q,Zhang D,Gong Y,Deng C,Liu C,Li L,He C

    更新日期:2021-01-29 00:00:00

  • OIP5-AS1 facilitates Th17 differentiation and EAE severity by targeting miR-140-5p to regulate RhoA/ROCK2 signaling pathway.

    abstract:AIMS:Multiple sclerosis (MS) is one of the commonest neurologic disorders globally. LncRNA OIP5-AS1 has been found to be implicated in the etiology of MS. This study was to explore the roles and molecular mechanisms of OIP5-AS1 in the development of MS. MATERIALS AND METHODS:RT-qPCR assay was used to measure expressio...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/j.lfs.2021.119108

    authors: Liu R,Li Y,Zhou H,Wang H,Liu D,Wang H,Wang Z

    更新日期:2021-01-27 00:00:00

  • Design and screening of a novel neuropilin-1 targeted penetrating peptide for anti-angiogenic therapy in glioma.

    abstract:AIMS:This study aimed to design and screen a dual functional fusion peptide that could penetrate the blood-brain barrier and target neuropilin 1 (NRP1) overexpressed in vascular endothelial cells for the anti-angiogenesis of glioma treatment. MAIN METHODS:At the cellular level, the in vitro anti-angiogenic activity of...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/j.lfs.2021.119113

    authors: Zhao L,Chen H,Lu L,Zhao C,Malichewe CV,Wang L,Guo X,Zhang X

    更新日期:2021-01-27 00:00:00

  • Cardiovascular protective properties of oxytocin against COVID-19.

    abstract::SARS-CoV-2 infection or COVID-19 has become a worldwide pandemic; however, effective treatment for COVID-19 remains to be established. Along with acute respiratory distress syndrome (ARDS), new and old cardiovascular injuries are important causes of significant morbidity and mortality in COVID-19. Exploring new approa...

    journal_title:Life sciences

    pub_type: 杂志文章,评审

    doi:10.1016/j.lfs.2021.119130

    authors: Wang SC,Wang YF

    更新日期:2021-01-26 00:00:00

  • Harmine inhibits the proliferation and migration of glioblastoma cells via the FAK/AKT pathway.

    abstract:AIMS:Glioblastoma is one of the most invasive tumors of the central nervous system, and has a high degree of malignancy and poor prognosis. Harmine, an active ingredient extracted from perennial herbs, has been reported to have obvious antitumor effects on various tumors. However, the effects of harmine on glioblastoma...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/j.lfs.2021.119112

    authors: Zhu YG,Lv YX,Guo CY,Xiao ZM,Jiang QG,Kuang H,Zhang WH,Hu P

    更新日期:2021-01-26 00:00:00

  • Aerobic exercise attenuates ectopic renal sinus adipose tissue accumulation-related renal hypoxia injury in obese mice.

    abstract:AIMS:We explored the effect of aerobic exercise on renal sinus adipose (RSA) accumulation and RSA accumulation-related renal injury in obese mice. MAIN METHODS:C57BL/6J male mice (n = 30) were evenly divided into three groups: control group (CON, n = 10), obese group (OB, n = 10; given high-fat diet) and obese + aerob...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/j.lfs.2021.119106

    authors: Wang SS,Gu Q,Liu N,Li J,Liu X

    更新日期:2021-01-23 00:00:00

  • The MIR155 host gene/microRNA-627/HMGB1/NF-κB loop modulates fibroblast proliferation and extracellular matrix deposition.

    abstract::Pulmonary fibrosis (PF), which is characterized by excessive matrix formation, may ultimately lead to irreversible lung damage and thus death. Fibroblast activation has been regarded as a central event during PF pathogenesis. In our previous study, we confirmed that the miR-627/high-mobility group box protein 1 (HMGB1...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/j.lfs.2021.119085

    authors: Li J,Zhang X,Wang T,Li J,Su Q,Zhong C,Chen Z,Liang Y

    更新日期:2021-01-20 00:00:00

  • Statistical analysis of COVID-19 infection caused by environmental factors: Evidence from Pakistan.

    abstract:BACKGROUND:Coronavirus disease 2019 (COVID-19) has become a severe public health problem around the globe. Various epidemiological, statistical, and laboratory-based studies have shown that the role of temperature and other environmental factors has important influence in the transmission of coronaviruses. Scientific r...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/j.lfs.2021.119093

    authors: Fawad M,Mubarik S,Malik SS,Ren J

    更新日期:2021-01-18 00:00:00

  • Design and characterization of a recombinant immunotoxin for targeted therapy of breast cancer cells: In vitro and in silico analyses.

    abstract:AIMS:GnRH-DFF40 (gonadotropin releasing hormone-DNA fragmentation factor 40) humanized recombinant immunotoxin serves as a prospective candidate for targeted therapy of malignancies with over-expressed gonadotropin releasing hormone receptor (GnRHR). In this study, we attempted to generate a GnRH-based chimeric protein...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/j.lfs.2020.118866

    authors: Barazesh M,Mohammadi S,Jalili S,Kavousipour S,Faraji SN,Mokarram P,Pirhadi S

    更新日期:2021-01-15 00:00:00

  • Dynamic of plasma IL-22 level is an indicator of thymic output after allogeneic hematopoietic cell transplantation.

    abstract:AIMS:Interleukin-22 (IL-22) promotes thymus recovery and improves T-cell recovery in preclinical allogeneic hematopoietic cell transplant models. However, the correlation between IL-22 and thymus recovery is unknown in human transplant. MATERIALS AND METHODS:In this study, plasma IL-22 levels of transplanted humans we...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/j.lfs.2020.118849

    authors: Shang L,Duah M,Xu Y,Liang Y,Wang D,Xia F,Li L,Sun Z,Yan Z,Xu K,Pan B

    更新日期:2021-01-15 00:00:00

  • Autophagy alleviates mitochondrial DAMP-induced acute lung injury by inhibiting NLRP3 inflammasome.

    abstract:AIM:Acute lung injury (ALI) is characterized by alveolar macrophage overactivation and uncontrolled pulmonary inflammation. Mitochondrial damage-associated molecular patterns (MTDs), one type of damage-associated molecular patterns (DAMPs) released from ruptured mitochondrial, can induce inflammation which participates...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/j.lfs.2020.118833

    authors: Peng W,Peng F,Lou Y,Li Y,Zhao N,Shao Q,Chen J,Qian K,Zeng Z,Zhan Y,Jiang R,Liu F

    更新日期:2021-01-15 00:00:00

  • Spirulina inhibits hepatocellular carcinoma through activating p53 and apoptosis and suppressing oxidative stress and angiogenesis.

    abstract:BACKGROUND:Most hepatocellular carcinoma cases are diagnosed at late stages of the disease, which makes it the second cause of cancer mortality worldwide. For advanced-stage patients, chemotherapeutic drugs are the best treatment option; however, their adverse effects and high cost are still major obstacles for effecti...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/j.lfs.2020.118827

    authors: Mahmoud YI,Shehata AMM,Fares NH,Mahmoud AA

    更新日期:2021-01-15 00:00:00

  • Thermal inactivation of SARS COVID-2 virus: Are steam inhalations a potential treatment?

    abstract:BACKGROUND:The emergence of SARS-CoV-2 pandemic has upset health systems around the world and caused immeasurable losses and costs. Until a vaccine will become available, the recommended prevention measures remain physical distancing and enhanced hygiene. METHODS AND FINDINGS:The proteic structure external to the viru...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/j.lfs.2020.118801

    authors: la Marca G,Barp J,Frenos S,Mugelli A,Galli L,Calistri E,Biasucci G,De Masi S,Guerrini R

    更新日期:2021-01-15 00:00:00

  • Increased circulating CD31+/CD42b-EMPs in Perthes disease and inhibit HUVECs angiogenesis via endothelial dysfunction.

    abstract:AIMS:Endothelial microparticles (EMPs) are extracellular vesicles secreted by endothelial cells. The purpose of this research is to explore that the clinical significance and roles in angiogenesis and endothelial dysfunction of circulating microparticles in Perthes disease. MAIN METHODS:We collected platelet-poor plas...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/j.lfs.2020.118749

    authors: Li B,Huang Q,Lin C,Lu R,Wang T,Chen X,Liu Z,Liu Y,Wu J,Wu Y,Liao S,Ding X

    更新日期:2021-01-15 00:00:00

  • Long-term co-administration of sodium nitrite and sodium hydrosulfide inhibits hepatic gluconeogenesis in male type 2 diabetic rats: Role of PI3K-Akt-eNOS pathway.

    abstract:OBJECTIVE:A deficiency in hydrogen sulfide (H2S) and nitric oxide (NO) contributes to the development of type 2 diabetes (T2D). An inhibitory effect on liver gluconeogenesis has been reported in rats with T2D with co-administration of sodium nitrite and sodium hydrosulfide (NaSH); the underlying mechanisms have however...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/j.lfs.2020.118770

    authors: Jeddi S,Gheibi S,Carlström M,Kashfi K,Ghasemi A

    更新日期:2021-01-15 00:00:00

  • Dexamethasone programs lower fatty acid absorption and reduced PPAR-γ and fat/CD36 expression in the jejunum of the adult rat offspring.

    abstract::The progeny of rats born and breastfed by mothers receiving dexamethasone (DEX) during pregnancy exhibits permanent reduction in body weight and adiposity but the precise mechanisms related to this programming are not fully understood. In order to clarify this issue, the present study investigated key aspects of lipop...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/j.lfs.2020.118765

    authors: de Souza DN,Teixeira CJ,Veronesi VB,Murata GM,Santos-Silva JC,Hecht FB,Vicente JM,Bordin S,Anhê GF

    更新日期:2021-01-15 00:00:00

  • Multi-omics analysis of copy number variations of RNA regulatory genes in soft tissue sarcoma.

    abstract:AIMS:RNA regulatory genes were closely associated with tumorigenesis and prognosis in multiple tumors. Copy number variation (CNV) is a frequent characteristic in soft tissue sarcomas (STS). However, little is known regarding their possible roles in STS. MAIN METHODS:RNA sequence profiles and CNV data of 255 STS patie...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/j.lfs.2020.118734

    authors: Wang X,Han Y,Li J,Hong D,Xue Z,Huang H,Du Z,Hou Y,Li H,Li H,Liao H,Xie X,Ding C

    更新日期:2021-01-15 00:00:00

  • Azelnidipine treatment reduces the expression of Cav1.2 protein.

    abstract:AIMS:Azelnidipine, a third-generation dihydropyridine calcium channel blocker (DHP CCB), has a characteristic hypotensive effect that persists even after it has disappeared from the plasma, which is thought to be due to its high hydrophobicity. However, because azelnidipine is unique, it might have other unknown effect...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/j.lfs.2021.119043

    authors: Nasu F,Obara Y,Okamoto Y,Yamaguchi H,Kurakami K,Norota I,Ishii K

    更新日期:2021-01-13 00:00:00

  • Carbonic anhydrase inhibition, antioxidant activity against alveolar epithelial cells and antibacterial effect against Klebsiella pneumoniae enabled by synthesized silica nanoparticles through laser ablation technique.

    abstract::Silica (SiO2) nanoparticles (NPs) were synthesized by laser ablation method and were characterized by TEM and DLS techniques. Afterwards, their inhibition activity against carbonic anhydrase (CA) isoforms (CA I and CA II) was explored by experimental and theoretical analysis. Also, the protective effect of SiO2 NPs ag...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/j.lfs.2021.119032

    authors: Xu N,Lu W,Meng L,Feng X,Xuan J,Liu F,Feng Z

    更新日期:2021-01-12 00:00:00

  • The effects of drug transporters on the efficacy of methotrexate in the treatment of rheumatoid arthritis.

    abstract::The ATP-binding cassette (ABC) and solute carrier (SLC) transporter families consist of common drug transporters that mediate the efflux and uptake of drugs, respectively, and play an important role in the absorption, distribution, metabolism and excretion of drugs in vivo. Rheumatoid arthritis (RA) is an autoimmune d...

    journal_title:Life sciences

    pub_type: 杂志文章,评审

    doi:10.1016/j.lfs.2020.118907

    authors: Gao J,Wang C,Wei W

    更新日期:2021-01-08 00:00:00

  • Exosomal miR-22-3p from human umbilical cord blood-derived mesenchymal stem cells protects against lipopolysaccharid-induced acute lung injury.

    abstract:BACKGROUND:Mesenchymal stem cells (MSCs) are widely applied in various clinical disorders, including acute lung injury (ALI). We aimed to investigate the effects of human umbilical cord blood-derived mesenchymal stem cells (UCB-MSCs)-derived exosomal microRNA-22-3p (miR-22-3p) on lipopolysaccharid (LPS)-induced ALI via...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/j.lfs.2020.119004

    authors: Zheng Y,Liu J,Chen P,Lin L,Luo Y,Ma X,Lin J,Shen Y,Zhang L

    更新日期:2021-01-06 00:00:00

  • Combination therapy with semaglutide and rosiglitazone as a synergistic treatment for diabetic retinopathy in rodent animals.

    abstract:OBJECTIVE:To investigate the protective efficacies and potent mechanisms of combination therapy with semaglutide and rosiglitazone (RSG) on the high-glucose incubated human ARPE-19 cells and diabetic retinopathy (DR) model rats. MAIN METHODS:The CCK-8 methods were used to evaluate the protective effects of semaglutide...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/j.lfs.2020.119013

    authors: Yang X,Wu S,Feng Z,Yi G,Zheng Y,Xia Z

    更新日期:2021-01-05 00:00:00

  • Long non-coding RNA and mRNA profile analysis in the parotid gland of mouse with type 2 diabetes.

    abstract:AIMS:Salivary gland dysfunction is a common complication of diabetes mellitus (DM). Long non-coding RNA (lncRNA) is evidenced to involve in the functional regulation of salivary gland, however, its role in DM-impaired gland is unknown. Therefore, this study aimed to investigate the expression profiles and functional ne...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/j.lfs.2020.119009

    authors: Huang Y,Liu HM,Wu LL,Yu GY,Xiang RL

    更新日期:2021-01-04 00:00:00

  • Lysine demethylase 5B suppresses CC chemokine ligand 14 to promote progression of colorectal cancer through the Wnt/β-catenin pathway.

    abstract:AIMS:Epigenetic and genetic alterations are crucial events in the onset and progression of human cancers including colorectal cancer (CRC). This work aims to probe the relevance of lysine demethylase 5B (KDM5B) to the progression of CRC and the possible molecules involved. MATERIALS AND METHODS:KDM5B expression in CRC...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/j.lfs.2020.118726

    authors: Yan G,Li S,Yue M,Li C,Kang Z

    更新日期:2021-01-01 00:00:00

  • Curcumol inhibits KLF5-dependent angiogenesis by blocking the ROS/ERK signaling in liver sinusoidal endothelial cells.

    abstract:AIMS:Liver fibrosis is a difficult problem in the medical field. We previously reported that curcumol, a bioactive substance, may inhibit the pathological angiogenesis of liver sinusoidal endothelial cells (LSECs) and play a good anti-hepatic fibrosis effect. However, the mechanism of curcumol inhibiting angiogenesis i...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/j.lfs.2020.118696

    authors: Gao L,Yang X,Li Y,Wang Z,Wang S,Tan S,Chen A,Cao P,Shao J,Zhang Z,Zhang F,Zheng S

    更新日期:2021-01-01 00:00:00

  • Comparison of IVF and IVM outcomes in the same patient treated with a modified IVM protocol along with an oocytes-maturing system containing melatonin: A pilot study.

    abstract:AIM:To compare embryonic developmental competence and clinical outcomes of oocytes matured in vivo (IVF oocytes) and those matured in vitro (IVM oocytes) from the same IVM/IVF cycles, and to analyze the clinical efficiency of a melatonin-supplemented in vitro maturation system combined with a modified IVM/IVF protocol....

    journal_title:Life sciences

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.lfs.2020.118706

    authors: Li X,Mu Y,Elshewy N,Ding D,Zou H,Chen B,Chen C,Wei Z,Cao Y,Zhou P,Zhang Z

    更新日期:2021-01-01 00:00:00

  • Recent advances in studies of molecular hydrogen in the treatment of pancreatitis.

    abstract::Pancreatitis is an inflammatory disease of the pancreas characterized by acinar cell injury and is associated with the abnormal release of trypsin, which results in high mortality due to systemic inflammatory response syndrome (SIRS) and multiple organ dysfunction syndrome (MODS). The inflammatory response, impaired a...

    journal_title:Life sciences

    pub_type: 杂志文章,评审

    doi:10.1016/j.lfs.2020.118641

    authors: Li Y,Li G,Suo L,Zhang J

    更新日期:2021-01-01 00:00:00

  • Effect of acetylsalicylic acid on inflamed adipose tissue. Insulin resistance and hepatic steatosis in a mouse model of diet-induced obesity.

    abstract:AIMS:Obesity represents a global health problem. Excessive caloric intake promotes the release of inflammatory mediators by hypertrophic adipocytes and obesity-induced inflammation is now recognized as a risk factor for the development of several diseases, such as cardiovascular diseases, insulin resistance, type-II di...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/j.lfs.2020.118618

    authors: Sardi C,Martini E,Mello T,Camelliti S,Sfondrini L,Marcucci F,Kallikourdis M,Sommariva M,Rumio C

    更新日期:2021-01-01 00:00:00

  • Aerobic exercise training attenuates doxorubicin-induced ultrastructural changes in rat ventricular myocytes.

    abstract:AIMS:To investigate the effects of aerobic exercise training on cardiomyocyte ultrastructure, oxidative stress, and activation of protein synthesis pathways in a model of cardiomyopathy induced by doxorubicin (Dox). MAIN METHODS:Male Sprague Dawley rats were randomly assigned to Control (saline, sedentary), Dox/sedent...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/j.lfs.2020.118698

    authors: Sequeira CM,Martins MA,Alves R,Nascimento ALR,Botti GCRM,Rocha VN,Matsuura C

    更新日期:2021-01-01 00:00:00

  • Cardioprotection of pharmacological postconditioning on myocardial ischemia/reperfusion injury.

    abstract::Acute myocardial infarction is associated with high rates of morbidity and mortality and can cause irreversible myocardial damage. Timely reperfusion is critical to limit infarct size and salvage the ischemic myocardium. However, reperfusion may exacerbate lethal tissue injury, a phenomenon known as myocardial ischemi...

    journal_title:Life sciences

    pub_type: 杂志文章,评审

    doi:10.1016/j.lfs.2020.118628

    authors: Wu Y,Liu H,Wang X

    更新日期:2021-01-01 00:00:00

  • Effects of oleuropein on tumor cell growth and bone remodelling: Potential clinical implications for the prevention and treatment of malignant bone diseases.

    abstract::Oleuropein (Ole) is the main bioactive phenolic compound present in olive leaves, fruits and olive oil. This molecule has been shown to exert beneficial effects on several human pathological conditions. In particular, recent preclinical and observational studies have provided evidence that Ole exhibits chemo-preventiv...

    journal_title:Life sciences

    pub_type: 杂志文章,评审

    doi:10.1016/j.lfs.2020.118694

    authors: Leto G,Flandina C,Crescimanno M,Giammanco M,Sepporta MV

    更新日期:2021-01-01 00:00:00

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