当前位置： SCI文献检索 > LIFE SCIENCES期刊下所有文献 > Long-term co-administration of sodium nitrite and sodium hydrosulfide inhibits hepatic gluconeogenesis in male type 2 diabetic rats: Role of PI3K-Akt-eNOS pathway.

Long-term co-administration of sodium nitrite and sodium hydrosulfide inhibits hepatic gluconeogenesis in male type 2 diabetic rats: Role of PI3K-Akt-eNOS pathway.

Abstract：

OBJECTIVE:A deficiency in hydrogen sulfide (H2S) and nitric oxide (NO) contributes to the development of type 2 diabetes (T2D). An inhibitory effect on liver gluconeogenesis has been reported in rats with T2D with co-administration of sodium nitrite and sodium hydrosulfide (NaSH); the underlying mechanisms have however not yet been elucidated. The aim of this study is to determine the long-term effects of co-administering sodium nitrite and NaSH on expression of genes involved in liver gluconeogenesis in rats with T2D. METHODS:T2D was induced using a high fat diet combined with low-dose of streptozotocin (30 mg/kg). Rats were divided into 5 groups (n = 7/group): Control, T2D, T2D + nitrite, T2D + NaSH, and T2D + nitrite+NaSH. Nitrite (50 mg/L) and NaSH (0.28 mg/kg) were administered for 9 weeks. Intraperitoneal pyruvate tolerance test (PTT) was performed at the end of the ninth week and mRNA expressions of PI3K, Akt, eNOS, PEPCK, G6Pase, and FBPase were measured in the liver. RESULTS:Co-administration of nitrite and NaSH decreased elevated serum glucose concentrations during PTT. Compared to T2D + nitrite, co-administration of nitrite and NaSH resulted in significant increases in mRNA expression of PI3K, Akt, and eNOS and significant decreases in mRNA expression of G6Pase and FBPase but had no effect on PEPCK expression. CONCLUSION:Long-term NaSH administration at low-dose, potentiated the inhibitory effects of nitrite on mRNA expression of key liver gluconeogenic enzymes in rats with T2D. This inhibitory effect of nitrite and NaSH co-administration on gluconeogenesis were associated with increased gene expression of PI3K, Akt, and eNOS in the liver.

journal_name

Life Sci

journal_title

Life sciences

authors

Jeddi S,Gheibi S,Carlström M,Kashfi K,Ghasemi A

doi

10.1016/j.lfs.2020.118770

subject

Has Abstract

pub_date

2021-01-15 00:00:00

pages

118770

eissn

0024-3205

issn

1879-0631

pii

S0024-3205(20)31523-X

journal_volume

265

pub_type

杂志文章

相关文献

LIFE SCIENCES文献大全
  • Acid secretagogue mechanisms of a GABA-mimetic (PCPGABA) in the anesthetized rat: effects of hypothermia.

    abstract：:The secretagogue action of lipophilic, GABA-mimetic, beta-(p-chlorophenyl)-gamma-aminobutyric acid (PCPGABA) was studied in the rat in relation to body temperature. PCPGABA (2 to 8 mg/kg s.c.) stimulated acid output in the urethane-anesthetized rat whose core temperature ranged between 28 to 30 degrees C. However, thi...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(90)90144-g

    authors： Hara N,Hara Y,Goto Y

    更新日期：1990-01-01 00:00:00

  • Characterization of human, dog and rabbit corpus cavernosum type 5 phosphodiesterases.

    abstract：:Human, dog and rabbit corpus cavernosum type 5 phosphodiesterases (PDE5) were isolated and their characteristics were compared. The three enzymes showed Km values of 0.8, 2.1 and 2.3 uM, respectively. They exhibited similar pH-dependence with optimal pH being 7.5. They required Mg++ for activity and the activity was s...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/s0024-3205(01)00989-4

    authors： Wang P,Wu P,Myers JG,Stamford A,Egan RW,Billah MM

    更新日期：2001-03-16 00:00:00

  • High-dose pentazocine antagonizes the antinociception induced by high-dose morphine.

    abstract：AIMS:To investigate the effects of high doses of pentazocine on antinociception induced by a high dose of morphine and the role of the kappa-opioid receptors (KORs) in these effects in mice. MAIN METHODS:Sixty-six C57BL/6J mice were pretreated with a KOR antagonist, nor-binaltorphimine (nor-BNI) (10mg·kg(-1)), or a no...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2015.02.023

    authors： Shu H,Wang Z,Ye F,Li Q,Dou Y,Lin Y,Huang W,Xiao X

    更新日期：2015-06-01 00:00:00

  • Pharmacologically evoked apnoeas. Receptors and nervous pathways involved.

    abstract：:This review analyses the knowledge about the incidence of transient apnoeic spells, induced by substances which activate vagal chemically sensitive afferents. It considers the specificity and expression of appropriate receptors, and relevant research on pontomedullary circuits contributing to a cessation of respiratio...

    journal_title：Life sciences

    pub_type： 杂志文章,评审

    doi：10.1016/j.lfs.2018.12.021

    authors： Szereda-Przestaszewska M,Kaczyńska K

    更新日期：2019-01-15 00:00:00

  • Serum gastrin level and gastric somatostatin content and binding in long-term pyloromyotomized children.

    abstract：:Since somatostatin inhibits basal and stimulated gastric acid secretion and gastrin release, it is conceivable that decreased gastric somatostatin concentration may be one of the factors responsible for gastric hypersecretion found in patients who have undergone long-term pylorotomy for hypertrophic pyloric stenosis. ...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(94)00734-9

    authors： Barrios V,Urrutia MJ,Hernández M,Lama R,García-Novo MD,Hernanz A,Arilla E

    更新日期：1994-01-01 00:00:00

  • Study on the metabolism of lyso-platelet activating factor (lyso-PAF) in human paranasal sinus mucosa. The cultured ciliated epithelium can convert lyso-PAF to PAF.

    abstract：:The conversion of lyso-platelet activating factor (lyso-PAF) to PAF in cultured paranasal sinus mucosa obtained from normal human subjects was studied. The PAF concentration in the medium was determined after addition of lyso-PAF. PAF became detectable at 10 minutes after the addition of 10(-8)M lyso-PAF, and reached ...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(93)90483-j

    authors： Inoue H,Ganbo T,Hisamatsu K,Ishida H

    更新日期：1993-01-01 00:00:00

  • Acute effects of oral olanzapine treatment on the expression of fatty acid and cholesterol metabolism-related gene in rats.

    abstract：AIMS:Second-generation antipsychotic drugs (SGAs) have a high risk for serious metabolic side-effects including dyslipidemia. This study aimed to investigate the acute effects of oral olanzapine treatment on the expression of genes for fatty acid and cholesterol biosynthesis in rats. MAIN METHODS:Female Sprague-Dawley...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2015.01.033

    authors： Liu X,Deng C,Cao S,Gong J,Wang BC,Hu CH

    更新日期：2015-05-01 00:00:00

  • Effect of KW-3902, a novel adenosine A1 receptor antagonist, on sodium-dependent phosphate and glucose transport by the rat renal proximal tubular cell.

    abstract：:KW-3902, 1,3-dipropyl-8-(3-noradamantanyl)xanthine, is a novel potent and selective adenosine A1-receptor antagonist. KW-3902 has been found to cause significant diuresis and natriuresis. To investigate the action of this adenosine A1-receptor antagonist on phosphate transport in renal proximal tubular cells, we studi...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(94)00567-2

    authors： Cai H,Batuman V,Puschett DB,Puschett JB

    更新日期：1994-01-01 00:00:00

  • Androgen/androgen receptor affects gentamicin-induced nephrotoxicity through regulation of megalin expression.

    abstract：AIM:Investigation whether androgen/androgen receptor (AR) might regulate megalin expression and/or functionality and thus affecting Gentamicin-induced nephrotoxicity (GIN). MAIN METHODS:Male Wistar rats were treated with gentamicin with/out AR ligands (testosterone as agonist and flutamide as antagonist). Megalin expr...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2020.117628

    authors： Elsakka EGE,Elsisi AM,Mansour OAA,Elsadek BEM,Abd Elaziz AI,Salama SA,Allam S

    更新日期：2020-06-15 00:00:00

  • Reduction of stress-induced analgesia following ethanol exposure in mice.

    abstract：:In the present study, we examined the effects of ethanol treatment on the subsequent expression of opioid and nonopioid forms of swim stress-induced analgesia (SSIA). In Experiment 1, mice were injected with ethanol (2.5 g/kg, i.p.) or an equal volume of saline once a day for two days. Animals received no treatment on...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/s0024-3205(98)00328-2

    authors： Bell RL,Soignier RD,Olson RD,Vaccarino AL

    更新日期：1998-01-01 00:00:00

  • Decreases in repetitive extrasystole threshold in the conscious pig with myocardial infarct were reversed by tyrosine.

    abstract：:Reports indicate that the administration of tyrosine, the precursor amino acid for catecholaminergic neurotransmitters, may be beneficial under conditions of physiologic stress. We studied the effects of tyrosine on vulnerability to ventricular arrhythmia in conscious pigs with healing myocardial infarcts, and sham op...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(91)90583-w

    authors： Pinto JM,Kirby DA,Maher TJ,Lown B

    更新日期：1991-01-01 00:00:00

  • Acute creatine ingestion in human: consequences on serum creatine and creatinine concentrations.

    abstract：:The aim of the study was to explore the effect of an acute dose of creatine (Cr) ingestion on serum Cr and serum creatinine (Crn) concentrations. Sixteen healthy subjects ingested a single dose of Cr (20 g) followed by the measurement of serum Cr and Crn concentration for 3 h up to a maximum of 6 h (n=6). In response ...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/s0024-3205(99)00512-3

    authors： Schedel JM,Tanaka H,Kiyonaga A,Shindo M,Schutz Y

    更新日期：1999-10-29 00:00:00

  • The kinin released from high molecular weight-kininogen is responsible for inflammatory exudation in rats: detection of kinin-free-kininogen in the exudate by immunoblot analysis.

    abstract：:Kinin release and its involvement in inflammatory exudation were assessed by immuno-blot analysis of the kinin-precursor protein, high molecular weight kininogen (HK). HK consists of heavy (H) chain, bradykinin and light (L) chain. After bradykinin was released by plasma kallikrein, HK remains two-chain-kinin-free for...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(93)90206-i

    authors： Fujie H,Hayashi I,Oh-ishi S

    更新日期：1993-01-01 00:00:00

  • Evidence for the presence of CB1 cannabinoid receptors on peripheral neurones and for the existence of neuronal non-CB1 cannabinoid receptors.

    abstract：:The discovery of CB1 and CB2 receptors and of endogenous agonists for these receptors has sparked renewed interest in the therapeutic potential of cannabinoids. This has led to a need for strategies that will provide a better separation of wanted from unwanted effects, particularly for CB1 receptor agonists. Possible ...

    journal_title：Life sciences

    pub_type： 杂志文章,评审

    doi：10.1016/s0024-3205(99)00282-9

    authors： Pertwee RG

    更新日期：1999-01-01 00:00:00

  • Ectopic TWEAKR expression in type I fiber of stroke-prone spontaneously hypertensive rats is related to slow muscle-specific hypotrophy.

    abstract：AIMS:Stroke-prone spontaneously hypertensive rats (SHRSP) show significantly lower body weight than normotensive Wistar-Kyoto rats (WKY). Our hypotheses are as follows: weight loss of the skeletal muscle is related to hypertension-related diseases, and muscle hypotrophy is useful as a therapeutic target for hypertensio...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2019.116919

    authors： Inoue T,Hagiyama M,Maenishi O,Kimura M,Mizuguchi N,Mine Y,Kimura R,Chikugo T,Itoh T,Satou T,Ito A

    更新日期：2019-11-15 00:00:00

  • Insulin secretion and protein phosphorylation in PKC-depleted islets of Langerhans.

    abstract：:Protein kinase C (PKC)-dependent phosphorylation of endogenous substrates was measured in electrically permeabilised rat islets of Langerhans. The PKC-activating phorbol ester, 4 beta-phorbol myristate acetate (PMA), caused a slow but prolonged increase in insulin secretion from permeabilised islets, which was accompa...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(92)90180-w

    authors： Jones PM,Persaud SJ,Howell SL

    更新日期：1992-01-01 00:00:00

  • Cardioprotective effects of baicalein on heart failure via modulation of Ca(2+) handling proteins in vivo and in vitro.

    abstract：AIMS:Baicalein is a widely used Chinese herbal medicine extracted from Labiatae plants Scutellaria baicalensis Georgi's dry root, which has multiple pharmacological activities. However, the precise mechanism of baicalein against myocardial remodeling remains poorly understood. The aim of our study was to investigate th...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2015.12.036

    authors： Zhao F,Fu L,Yang W,Dong Y,Yang J,Sun S,Hou Y

    更新日期：2016-01-15 00:00:00

  • Emotional behavior and arrhythmias induced in cats by hypothalamic stimulation.

    abstract：:As the relationship between emotional behavior and electrocardiographic (ECG) change induced by hypothalamic stimulation is poorly understood, eighty-four points in various areas within the hypothalamus in conscious cats were stimulated electrically through chronically implanted electrodes, the objective being to clar...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(85)90494-1

    authors： Tashiro N,Tanaka T,Fukumoto T,Hirata K,Nakao H

    更新日期：1985-03-18 00:00:00

  • Selective inhibition of human acetylcholinesterase by galanthamine in vitro and in vivo.

    abstract：:We investigated the inhibition of human cholinesterases by galanthamine, an alkaloid of the common snowdrop (galanthus nivalis). In vitro, the compound showed potent enzyme inhibition and 50-fold selectivity for acetylcholinesterase (EC 3.1.1.7) as opposed to butyrylcholinesterase (EC 3.1.1.8). There was no difference...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(90)90429-u

    authors： Thomsen T,Kewitz H

    更新日期：1990-01-01 00:00:00

  • Impacts of icodextrin on integrin-mediated wound healing of peritoneal mesothelial cells.

    abstract：AIMS:Exposure to glucose and its metabolites in peritoneal dialysis fluid (PDF) results in structural alterations of the peritoneal membrane. Icodextrin-containing PDF eliminates glucose and reduces deterioration of peritoneal membrane function, but direct effects of icodextrin molecules on peritoneal mesothelial cells...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2012.04.036

    authors： Matsumoto M,Tamura M,Miyamoto T,Furuno Y,Kabashima N,Serino R,Shibata T,Kanegae K,Takeuchi M,Abe H,Okazaki M,Otsuji Y

    更新日期：2012-06-14 00:00:00

  • Striatal dopamine release and biphasic pattern of locomotor and motor activity under gas narcosis.

    abstract：:Inert gas narcosis is a neurological syndrome appearing when humans or animals are exposed to hyperbaric inert gases (nitrogen, argon) composed by motor and cognitive impairments. Inert gas narcosis induces a decrease of the dopamine release at the striatum level, structure involved in the regulation of the extrapyram...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/s0024-3205(03)00183-8

    authors： Balon N,Risso JJ,Blanc F,Rostain JC,Weiss M

    更新日期：2003-05-02 00:00:00

  • Carbon-11 labelled cholecystokininB antagonists: radiosynthesis and evaluation in rats.

    abstract：:Three cholecystokinin type B (CCKB) receptor antagonists were labelled with 11C and evaluated ex vivo in rat biodistribution studies. The CCKB antagonists were YF 476 and two other compounds of the basic 3-ureido-1,4-benzodiazepine class. Following tail-vein administration of [11C]-YF 476 exceedingly low levels of rad...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/s0024-3205(00)01021-3

    authors： Wilson AA,Jin L,Garcia A,DaSilva JN,Houle S

    更新日期：2001-02-02 00:00:00

  • Stability of epidermal growth factor in the gastrointestinal lumen of suckling and weaned pigs.

    abstract：:The stability of epidermal growth factor (EGF) in the gastrointestinal humen of 3-day-old suckling and 45-day-old weaned pigs was examined by incubating iodine labeled recombinant human EGF (hEGF) in the gastrointestinal fluids at 37 degrees C and monitoring the generation of acid soluble radioactivity. Chromatographi...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(96)00285-8

    authors： Shen WH,Xu RJ

    更新日期：1996-01-01 00:00:00

  • Assessment of the cerebellar neurotoxic effects of nicotine in prenatal alcohol exposure in rats.

    abstract：:The adverse effects of prenatal nicotine and alcohol exposure on human reproductive outcomes are a major scientific and public health concern. In the United States, substantial percentage of women (20-25%) of childbearing age currently smoke cigarettes and consume alcohol, and only a small percentage of these individu...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2017.12.010

    authors： Bhattacharya D,Majrashi M,Ramesh S,Govindarajulu M,Bloemer J,Fujihashi A,Crump BR,Hightower H,Bhattacharya S,Moore T,Suppiramaniam V,Dhanasekaran M

    更新日期：2018-02-01 00:00:00

  • A novel 2,3-benzodiazepine-4-one derivative AMPA antagonist inhibits G2/M transition and induces apoptosis in human leukemia Jurkat T cell line.

    abstract：:It has been shown that the antagonism of glutamate receptors activity was able inhibit proliferation and induce apoptosis in several neuronal and non-neuronal cancer cell lines. In addition, it has been shown that glutamate might facilitate the spread and growth of leukemia T cells through interactions with AMPA recep...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2016.03.051

    authors： Parenti S,Casagrande G,Montanari M,Espahbodinia M,Ettari R,Grande A,Corsi L

    更新日期：2016-05-01 00:00:00

  • Effect of single and repeated administration of amitriptyline on neuropathic pain model in rats: Focus on glutamatergic and upstream nitrergic systems.

    abstract：AIMS:Few studies have compared the interaction of single and repeated administration of amitriptyline (amit) with the nitrergic system and glutamatergic system in the experimental model of neuropathic pain. We aimed to evaluate the antinociceptive effect of single and repeated administration of amit and to assess wheth...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2019.116752

    authors： Farghaly HSM,Elbadr MM,Ahmed MA,Abdelhaffez AS

    更新日期：2019-09-15 00:00:00

  • 125I-beta-endorphin binding to neuroblastoma X glioma NG108-15 cells: distribution of delta opioid receptors.

    abstract：:The mouse neuroblastoma x rat glioma hybrid NG108-15 was previously shown to express delta opioid receptors. Because neuroblastoma cells display different phenotypes and cloned cell lines are heterogenous, we studied the characteristics and distribution of human 125I-beta-endorphin (125I-beta E) binding sites in cultu...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(92)90306-a

    authors： Cone RI,Rosenfeld S,Lameh J,Sadée W

    更新日期：1992-01-01 00:00:00

  • Cyotomedical therapy for insulinopenic diabetes using microencapsulated pancreatic beta cell lines.

    abstract：:Current therapy for type 1 diabetes mellitus involves a daily regimen of multiple subcutaneous or intramuscular injections of recombinant human insulin. To achieve long-term insulin delivery in vivo, we investigated the applicability of cytomedical therapy using beta TC6 cells or MIN6 cells, both of which are murine p...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/s0024-3205(02)01724-1

    authors： Suzuki R,Okada N,Miyamoto H,Yoshioka T,Sakamoto K,Oka H,Tsutsumi Y,Nakagawa S,Miyazaki J,Mayumi T

    更新日期：2002-08-30 00:00:00

  • The bovine peripheral-type benzodiazepine receptor: a receptor with low affinity for benzodiazepines.

    abstract：:The density of bovine peripheral-type benzodiazepine receptors (PBR) in four tissues was highest in adrenal cortex. The adrenal cortex PBR cofractionated with a mitochondrial membrane marker enzyme and could be solubilized with intact ligand binding properties using digitonin. The membrane bound and soluble mitochondr...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(91)90090-x

    authors： Parola AL,Laird HE 2nd

    更新日期：1991-01-01 00:00:00

  • Myocardial hypothermia induced after reperfusion does not prevent adverse left ventricular remodeling nor improve cardiac function.

    abstract：AIMS:The purpose of the study was to determine whether late therapeutic hypothermia (LTH), administered after reperfusion, could prevent adverse left ventricular (LV) remodeling and improve cardiac function in the rat myocardial ischemia/reperfusion model. MAIN METHODS:Rats were randomized to normothermia (n = 10) or ...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2019.04.026

    authors： Shi J,Dai W,Carreno J,Hale SL,Kloner RA,Kay GL

    更新日期：2019-07-15 00:00:00