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Reduction of stress-induced analgesia following ethanol exposure in mice.

Abstract：

:In the present study, we examined the effects of ethanol treatment on the subsequent expression of opioid and nonopioid forms of swim stress-induced analgesia (SSIA). In Experiment 1, mice were injected with ethanol (2.5 g/kg, i.p.) or an equal volume of saline once a day for two days. Animals received no treatment on day 3. On day 4, the animals were tested for opioid (3-min swim in water maintained at 32 degrees C) or nonopioid (3-min swim in water maintained at 20 degrees C) SSIA in the hotplate test (52 degrees C). Mice pretreated with ethanol injections showed a decrease in nonopioid SSIA, but not in opioid SSIA. In Experiment 2, mice were given an ethanol solution (10%) or tap water to drink for 15 days. On day 16, all animals were given tap water to drink. On day 17, the animals were tested for opioid or nonopioid SSIA. Neither form of SSIA was modified in mice that drank the ethanol solution. These results show that ethanol pretreatment can modify nonopioid endogenous analgesic responses in mice. Further, the route of administration influences the effects of ethanol pretreatment on SSIA.

journal_name

Life Sci

journal_title

Life sciences

authors

Bell RL,Soignier RD,Olson RD,Vaccarino AL

doi

10.1016/s0024-3205(98)00328-2

subject

Has Abstract

pub_date

1998-01-01 00:00:00

pages

731-6

issue

9

eissn

0024-3205

issn

1879-0631

pii

S0024320598003282

journal_volume

63

pub_type

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