Abstract：
:The conversion of lyso-platelet activating factor (lyso-PAF) to PAF in cultured paranasal sinus mucosa obtained from normal human subjects was studied. The PAF concentration in the medium was determined after addition of lyso-PAF. PAF became detectable at 10 minutes after the addition of 10(-8)M lyso-PAF, and reached a maximum concentration (3.25 x 10(-9)M) at 20 minutes. The PAF level then gradually declined to become undetectable at 60 minutes after addition of lyso-PAF. Thus PAF is very unstable having a half-life calculated to be 12.8 minutes with an elimination constant of k = 0.05377 minutes-1. In contrast, lyso-PAF is known to be a stable metabolite of PAF as well as a precursor of PAF. The results obtained from this study suggest that the turnover of lyso-PAF to PAF may play a role in evoking prolonged inflammation in target organs or tissues.
journal_name
Life Scijournal_title
Life sciencesauthors
Inoue H,Ganbo T,Hisamatsu K,Ishida Hdoi
10.1016/0024-3205(93)90483-jsubject
Has Abstractpub_date
1993-01-01 00:00:00pages
PL227-32issue
21eissn
0024-3205issn
1879-0631pii
0024-3205(93)90483-Jjournal_volume
52pub_type
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