当前位置： SCI文献检索 > LIFE SCIENCES期刊下所有文献 > Acute creatine ingestion in human: consequences on serum creatine and creatinine concentrations.

Acute creatine ingestion in human: consequences on serum creatine and creatinine concentrations.

Abstract：

:The aim of the study was to explore the effect of an acute dose of creatine (Cr) ingestion on serum Cr and serum creatinine (Crn) concentrations. Sixteen healthy subjects ingested a single dose of Cr (20 g) followed by the measurement of serum Cr and Crn concentration for 3 h up to a maximum of 6 h (n=6). In response to Cr ingestion a large rise in serum Cr concentration was observed (by 50 folds) occurring approximately 2 1/2h after the ingestion (peak value of 2.17 +/- 0.66 mmol x l(-1)). We also found a moderate but significant rise in serum Crn concentration averaging 13 % after 3 h (peak value at 99.5 +/- 10.5 micromol x l(-1)). A dose response curve obtained in two case studies, in whom different doses of Cr were ingested (0, 2.5, 5, 10, 15, 20 g and 0, 10, 20, 30 g), showed that serum Cr concentration as well as the peak time increased linearly with Cr ingestion. In addition, acute Crn ingestion (5 g) resulted in a substantial increase in serum Crn concentration (by 10 folds) but led to a minor rise in serum Cr concentration (by 2 folds). These results suggest that when acute doses of Cr are ingested in humans, the degree of conversion of exogenous Cr to Crn in the stomach and the gut can be considered as negligible following the first 6 h of ingestion. However, further studies are required to explore the prolonged effect of Cr on Crn metabolism.

journal_name

Life Sci

journal_title

Life sciences

authors

Schedel JM,Tanaka H,Kiyonaga A,Shindo M,Schutz Y

doi

10.1016/s0024-3205(99)00512-3

subject

Has Abstract

pub_date

1999-10-29 00:00:00

pages

2463-70

issue

23

eissn

0024-3205

issn

1879-0631

pii

S0024320599005123

journal_volume

65

pub_type

杂志文章

相关文献

LIFE SCIENCES文献大全
  • Characterization of type 2 opiate receptors.

    abstract：:Recent evidence suggests that the Type 1 opiate receptor (in rat striatal patches) is a mobile receptor which is able to adopt a mu, delta, or kappa opiate receptor ligand selectivity pattern under appropriate conditions. In this paper, we have investigated such a possibility for Type 2 opiate receptors which are visu...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(82)90183-7

    authors： Olgiati V,Quirion R,Bowen WD,Pert CB

    更新日期：1982-10-18 00:00:00

  • Enhanced sensitivity to naltrexone is associated with an up-regulation in GABA receptor function.

    abstract：:Rats were made sensitive to the effects of the opioid antagonist naltrexone by treating them once weekly with cumulative doses of the drug (1, 3, 10, 30 and 100 mg/kg). Sensitization was monitored by measuring salivation following naltrexone administration. During the first week of treatment, no salivation was noted f...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(92)90341-l

    authors： Schindler CW,Marley RJ,Goldberg SR

    更新日期：1992-01-01 00:00:00

  • Evidence that diclofenac and celecoxib are thyroid hormone receptor beta antagonists.

    abstract：UNLABELLED:Long term use of NSAIDs is linked to side effects such as gastric bleeding and myocardial infarction. AIMS:Use of in silico methods and pharmacology to investigate the potential for NSAIDs diclofenac, celecoxib and naproxen to bind to nuclear receptors. MATERIALS AND METHODS:In silico screening predicted t...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2016.01.013

    authors： Zloh M,Perez-Diaz N,Tang L,Patel P,Mackenzie LS

    更新日期：2016-02-01 00:00:00

  • Role of nitric oxide and endothelium-derived hyperpolarizing factor (EDHF) in the regulation of blood pressure by leptin in lean and obese rats.

    abstract：:We investigated the role of nitric oxide (NO) and endothelium-derived hyperpolarizing factor (EDHF) in hemodynamic action of leptin. The effect of leptin (1 mg/kg i.p.) on systolic blood pressure (SBP) was examined in lean rats and in rats made obese by feeding highly palatable diet for either 1 or 3 months. Separate ...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2005.12.041

    authors： Bełtowski J,Wójcicka G,Jamroz-Wiśniewska A

    更新日期：2006-05-30 00:00:00

  • Regulation of fatty acid synthesis and Delta9-desaturation in senescence of human fibroblasts.

    abstract：AIMS:Normal human cells in culture progressively lose their capacity for replication, ending in an irreversible arrested state known as replicative senescence. Senescence has been functionally associated to the process of organismal ageing and is also considered a major tumor-suppressing mechanism. Although a great dea...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2008.11.009

    authors： Maeda M,Scaglia N,Igal RA

    更新日期：2009-01-16 00:00:00

  • The nonspecific nature of the vanadate inhibition of rat ileal (NA,K)-ATPase.

    abstract：:Vanadate has been suggested as an intracellular regulator of (Na+ + K+)-ATPase. To test this hypothesis we examined the stimulatory and inhibitory effects of vanadate on 86--Rb efflux and influx (measurements of the activity of the Na-pump) in rat ileum under conditions of normal, reduced and increased (Na+ + K+)-ATPa...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(88)90486-9

    authors： Hajjar JJ,Rowe WA,Tomicic TK

    更新日期：1988-01-01 00:00:00

  • Metformin promotes autophagy in ischemia/reperfusion myocardium via cytoplasmic AMPKα1 and nuclear AMPKα2 pathways.

    abstract：AIMS:In myocardial ischemia-reperfusion (MI/R) injury, impaired autophagy function worsens cardiomyocyte death. AMP-activated protein kinase (AMPK) is a heterotrimeric protein that plays an important role in cardioprotection and myocardial autophagic function. AMPKα1 and α2 are localized primarily in the cytoplasm and ...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2019.04.002

    authors： Wang Y,Yang Z,Zheng G,Yu L,Yin Y,Mu N,Ma H

    更新日期：2019-05-15 00:00:00

  • Brain TRH and Cyclo (His-Pro) and brain protein in the newborn rat are altered by maternal liquid protein feeding.

    abstract：:Liquid protein diet (LPD) has been shown previously to produce maternal and fetal weight loss and fetal congenital anomalies, including cataracts and craniofacial malformations. Therefore, to examine the effects of LPD in pregnancy upon the central nervous system of pups, pregnant dams were fed either a 20% casein die...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(83)90867-6

    authors： Mori M,Wilber JF,Nakamoto T

    更新日期：1983-04-04 00:00:00

  • Structural derivatives of pindolol: relationship between in vivo and in vitro potencies for their interaction with central beta-adrenergic receptors.

    abstract：:Although (-)-125I-iodopindolol (IPIN) can be used to label beta-adrenergic receptors in the central nervous system (CNS) in vivo, use of this ligand for receptor imaging studies in humans may be limited due to its relatively poor penetration into the CNS. A series of derivatives related to pindolol was therefore studi...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(87)90688-6

    authors： Tejani-Butt SM,Brunswick DJ

    更新日期：1987-08-24 00:00:00

  • MiR-216b-5p inhibits cell proliferation in human breast cancer by down-regulating HDAC8 expression.

    abstract：AIM:Over-expression of histone deacetylase 8 (HDAC8) has been demonstrated in breast cancer. But the underlying molecular mechanism of HDAC8 on the progression of breast cancer remains unknown. MicroRNAs (miRs) are proposed as important molecules in cancer progression by targeting specific oncogenes or tumor-suppressor...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2019.116945

    authors： Menbari MN,Rahimi K,Ahmadi A,Elyasi A,Darvishi N,Hosseini V,Mohammadi-Yeganeh S,Abdi M

    更新日期：2019-11-15 00:00:00

  • Oral resveratrol supplementation improves Metabolic Syndrome features in obese patients submitted to a lifestyle-changing program.

    abstract：AIMS:The aim of the present study was to evaluate the oral resveratrol effects associated with diet and physical training changes on anthropometric and biochemical parameters. MAIN METHODS:25 individuals aged from 30 to 60 years old; with Body Mass Index (BMI) ≥ 30 kg/m2 were included in the study. Following the prima...

    journal_title：Life sciences

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.lfs.2020.117962

    authors： Batista-Jorge GC,Barcala-Jorge AS,Silveira MF,Lelis DF,Andrade JMO,de Paula AMB,Guimarães ALS,Santos SHS

    更新日期：2020-09-01 00:00:00

  • Bisphenol A: What lies beneath its induced diabetes and the epigenetic modulation?

    abstract：:Nowadays, endocrine disrupting chemical pollution has become one of the major concerns due to the potential role of these chemicals in provoking endocrine disorders especially type 2 diabetes. As a widespread endocrine disrupting chemical, Bisphenol A, with modest estrogenic activity can exert its detrimental effects ...

    journal_title：Life sciences

    pub_type： 杂志文章,评审

    doi：10.1016/j.lfs.2018.10.044

    authors： Rahmani S,Pour Khalili N,Khan F,Hassani S,Ghafour-Boroujerdi E,Abdollahi M

    更新日期：2018-12-01 00:00:00

  • Streptozotocin-induced diabetes provokes changes in serotonin concentration and on 5-HT1A and 5-HT2 receptors in the rat brain.

    abstract：:Since reduced levels of brain serotonin are known to cause behavioural abnormalities, to which diabetics are also prone, we investigated the effect, in rats, of chronic diabetes on brain serotonin concentration and on the numbers of 5-HT(1A) and 5-HT2 receptors in cerebral cortex and brainstem. Our data show that stre...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/s0024-3205(97)00084-2

    authors： Sandrini M,Vitale G,Vergoni AV,Ottani A,Bertolini A

    更新日期：1997-01-01 00:00:00

  • Serotonin uptake and imipramine binding in blood platelets and brain of Fawn-hooded and Sprague Dawley rats.

    abstract：:The kinetic parameters of serotonin (5-HT) uptake and imipramine binding of the synaptosomes and blood platelets of male Fawn-hooded rats, which have a 5-HT storage abnormality, and normal Sprague-Dawley rats were compared. The Vmax for 5-HT uptake of synaptosomes from Fawn-hooded rats was significantly greater than t...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(83)90792-0

    authors： Arora RC,Tong C,Jackman HL,Stoff D,Meltzer HY

    更新日期：1983-08-01 00:00:00

  • Fructose-induced inflammation, insulin resistance and oxidative stress: A liver pathological triad effectively disrupted by lipoic acid.

    abstract：AIMS:Fructose administration induces hepatic oxidative stress, insulin resistance, inflammatory and metabolic changes. We tested their potential pathogenic relationship and whether these alterations can be prevented by R/S-α-lipoic acid. MAIN METHODS:Wistar rats received during 21days a commercial diet or the same die...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2015.07.010

    authors： Castro MC,Massa ML,Arbeláez LG,Schinella G,Gagliardino JJ,Francini F

    更新日期：2015-09-15 00:00:00

  • The Chinese medicine Bu-Zhong-Yi-Qi-Tang inhibited proliferation of hepatoma cell lines by inducing apoptosis via G0/G1 arrest.

    abstract：:Bu-Zhong-Yi-Qi-Tang (BZYQT), a Chinese herbal medicine, inhibited the proliferation of human hepatoma cell lines (Hep3B, HepG2 and HA22T) dose-dependently. The IC50s of BZYQT on the proliferation of Hep3B, HepG2 and HA22T were 432.5+/-31.8 microg/ml, 455.4+/-24.2 microg/ml, and 2284.3+/-77.2 microg/ml respectively on ...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/s0024-3205(01)01226-7

    authors： Kao ST,Yeh CC,Hsieh CC,Yang MD,Lee MR,Liu HS,Lin JG

    更新日期：2001-08-17 00:00:00

  • Selective inhibition of human acetylcholinesterase by galanthamine in vitro and in vivo.

    abstract：:We investigated the inhibition of human cholinesterases by galanthamine, an alkaloid of the common snowdrop (galanthus nivalis). In vitro, the compound showed potent enzyme inhibition and 50-fold selectivity for acetylcholinesterase (EC 3.1.1.7) as opposed to butyrylcholinesterase (EC 3.1.1.8). There was no difference...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(90)90429-u

    authors： Thomsen T,Kewitz H

    更新日期：1990-01-01 00:00:00

  • Heterogeneity in the performance of outbred Sprague-Dawley rats in an elevated-plus maze test: a possible animal model for anxiety disorder.

    abstract：:A wide variation in the performance of inbred rats measured in the evaluated plus maze test suggests a possible genetic basis for anxiety response (AR). To gain further insight into the role of genetics in AR, we have characterized AR in male outbred S-D rats. Rats were placed in the black compartment (BC) facing the ...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(96)00480-8

    authors： Prasad A,Henry M,Prasad C

    更新日期：1996-01-01 00:00:00

  • Ginsenoside Rd promotes non-amyloidogenic pathway of amyloid precursor protein processing by regulating phosphorylation of estrogen receptor alpha.

    abstract：AIMS:Previous study demonstrated that Ginsenoside Rd. (GS-Rd) could improve cognitive and memory function in animal model of Alzheimer's disease. This study was aimed to investigate whether GS-Rd could improve non-amyloidogenic pathway by activating estrogen receptor (ER). MAIN METHODS:10mg/kg GS-Rd in ovariectomy (OV...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2016.11.002

    authors： Yan X,Hu G,Yan W,Chen T,Yang F,Zhang X,Zhao G,Liu J

    更新日期：2017-01-01 00:00:00

  • In vitro synergy of azole antifungals and methotrexate against Candida albicans.

    abstract：OBJECTIVE:This study aims to evaluate the effective of azoles and MTX for patients with invasive candidiasis. METHODS:We used the disk diffusion assay and the checkerboard assay to evaluate the in vitro interactions between MTX and antifungals. In addition, we used the transmission electron microscopy to observe the u...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2019.116827

    authors： Yang J,Gao L,Yu P,Kosgey JC,Jia L,Fang Y,Xiong J,Zhang F

    更新日期：2019-10-15 00:00:00

  • Amygdalin delays cell cycle progression and blocks growth of prostate cancer cells in vitro.

    abstract：AIMS:Despite impressive survival benefits from new agents to treat metastasized prostate cancer (PCa), progressive drug resistance hinders long-term response and restricts the efficacy of subsequent therapy. Due to reported antitumor activity of amygdalin and growing popularity for complementary and alternative medicin...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2016.01.039

    authors： Makarević J,Tsaur I,Juengel E,Borgmann H,Nelson K,Thomas C,Bartsch G,Haferkamp A,Blaheta RA

    更新日期：2016-02-15 00:00:00

  • Rapid and opposite effects of cortisol and estradiol on human erythrocyte Na+,K+-ATPase activity: relationship to steroid intercalation into the cell membrane.

    abstract：:We determined whether two naturally occurring steroids, cortisol and 17beta-estradiol (E2), can rapidly modulate the activity of an important membrane protein, human erythrocyte (RBC) Na+,K+-ATPase, an enzyme that does not bind either hormone directly. We also determined the membrane binding locations for cortisol and...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/s0024-3205(99)00360-4

    authors： Golden GA,Mason RP,Tulenko TN,Zubenko GS,Rubin RT

    更新日期：1999-01-01 00:00:00

  • Effect of angiotensin II on a spinal nociceptive reflex in the rat: receptor and mechanism of action.

    abstract：:The effect on thermonociceptive threshold of intrathecally (i.t.) administered angiotensin II (Ang II) was assessed in the rat tail-flick test. Rats were pretreated, 15 min earlier, with i.t. naloxone (opiate antagonist), losartan (Ang II selective antagonist at AT1 receptor) or [Sar1, Leu8] Ang II (non selective Ang ...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/s0024-3205(97)00410-4

    authors： Toma N,Sgambato V,Couture R

    更新日期：1997-01-01 00:00:00

  • Unique modulation of central 5-HT2 receptor binding sites and 5-HT2 receptor-mediated behavior by continuous gepirone treatment.

    abstract：:The effect of continuous treatment with the selective 5-HT1A agonist gepirone upon 5-HT2-mediated behavior and cortical 5-HT2 receptor binding sites was examined in naive rats or rats receiving noradrenergic (DSP4) or serotonergic (5,7-DHT) lesions. Continuous administration of gepirone in non-lesioned rats for 3, 7, ...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(91)90478-t

    authors： Yocca FD,Eison AS,Hyslop DK,Ryan E,Taylor DP,Gianutsos G

    更新日期：1991-01-01 00:00:00

  • Effects of isomers of apomorphines on dopamine receptors in striatal and limbic tissue of rat brain.

    abstract：:The optical isomers of apomorphine (APO) and N-propylnorapomorphine (NPA) were interacted with three biochemical indices of dopamine (DA) receptors in extrapyramidal and limbic preparations of rat brain tissue. There were consistent isomeric preferences for the R(-) configuration of both DA analogs in stimulating aden...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(85)90596-x

    authors： Kula NS,Baldessarini RJ,Bromley S,Neumeyer JL

    更新日期：1985-09-16 00:00:00

  • Oxidized glucocorticoids counteract glucocorticoid-induced apoptosis in murine thymocytes in vitro.

    abstract：:11Beta-hydroxyglucocorticoids (HGCs) are known to induce apoptosis in immature T cells. Here we show that 11-oxoglucocorticoids (OGCs), which are oxidized metabolites of HGCs, counteract the apoptosis-inducing effects of HGC in murine thymocytes in vitro. Corticosterone at concentrations ranging from 0.1-100 microM in...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/s0024-3205(01)01069-4

    authors： Hirano T,Horigome H,Ishishita H,Uda S,Oka K

    更新日期：2001-05-18 00:00:00

  • Size heterogeneity of epidermal growth factor in human body fluids.

    abstract：:We measured the concentration of immunoreactive (IR) hEGF in various body fluids by radioimmunoassay (RIA) and evaluated its size heterogeneity by size exclusion high performance liquid chromatography combined with RIA or with time-resolved immunofluorometric assay (TR-IFMA). Mean concentration was 80 ng/ml in urine, ...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(87)90069-5

    authors： Pesonen K,Viinikka L,Koskimies A,Banks AR,Nicolson M,Perheentupa J

    更新日期：1987-06-29 00:00:00

  • Effects of transforming growth factor beta1 on cell growth and parathyroid hormone-related protein in Walker 256 tumor cells.

    abstract：:Hypercalcemic strains of the rat Walker 256 (W256) tumor synthesize parathyroid hormone-related protein (PTHrP) and at least one of them produces an ill-defined transforming growth factor activity. We tested the production of transforming growth factor (TGF) beta by a hypercalcemic W256 tumor strain, and assessed its ...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/s0024-3205(99)00437-3

    authors： Benítez-Verguizas J,Loarte D,de Miguel F,Esbrit P

    更新日期：1999-01-01 00:00:00

  • Involvement of the tuberomammillary nucleus of the hypothalamus in the modulation of nociception and joint edema in a model of monoarthritis.

    abstract：AIMS:Investigate the involvement of the histaminergic projections from tuberomammillary nucleus (TMN) to the spinal cord in the modulation of nociception and peripheral edema in a model of monoarthritis. MAIN METHODS:Subacute monoarthritis was induced by an intraarticular injection of carrageenan followed by LPS 72 h ...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2020.118521

    authors： Stein T,Tonussi CR

    更新日期：2020-12-01 00:00:00

  • Therapeutic effect of bifemelane on unilateral cerebral ischemia in gerbils.

    abstract：:To examine the therapeutic effect of 4-(o-benzylphenoxy)-N-methylbutylamine hydrochloride (bifemelane) on neuronal ischemia-reperfusion injury, we evaluated the neurological score in gerbils subjected to unilateral common carotid occlusion. Using the neurological score method, we selected animals which showed stroke s...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(95)00297-j

    authors： Hata R,Matsumoto M,Kitagawa K,Tagaya M,Matsuyama T,Sugita M,Kamada T

    更新日期：1995-01-01 00:00:00