Abstract：
:The optical isomers of apomorphine (APO) and N-propylnorapomorphine (NPA) were interacted with three biochemical indices of dopamine (DA) receptors in extrapyramidal and limbic preparations of rat brain tissue. There were consistent isomeric preferences for the R(-) configuration of both DA analogs in stimulating adenylate cyclase (D-1 sites) and in competing for high affinity binding of 3H-spiroperidol (D-2 sites) and of 3H-ADTN (DA agonist binding sites) in striatal tissue, with lesser isomeric differences in the limbic tissue. The S(+) apomorphines did not inhibit stimulation of adenylate cyclase by DA. The tendency for greater activity or higher apparent affinity of R(-) apomorphines in striatum may reflect the evidently greater abundance of receptor sites in that region. There were only small regional differences in interactions of the apomorphine isomers with all three receptor sites, except for a strong preference of (-)NPA for striatal D-2 sites. These results do not parallel our recent observations indicating potent and selective antidopaminergic actions of S(+) apomorphines in the rat limbic system. They suggest caution in assuming close parallels between current biochemical and functional, especially behavioral, methods of evaluating dopamine receptors of mammalian brain.
journal_name
Life Scijournal_title
Life sciencesauthors
Kula NS,Baldessarini RJ,Bromley S,Neumeyer JLdoi
10.1016/0024-3205(85)90596-xsubject
Has Abstractpub_date
1985-09-16 00:00:00pages
1051-7issue
11eissn
0024-3205issn
1879-0631pii
0024-3205(85)90596-Xjournal_volume
37pub_type
杂志文章相关文献
LIFE SCIENCES文献大全abstract：:NMDA receptors are involved in the modulation of neuropathic pain behavior and central sensitization. In vivo, this is mostly demonstrated by the use of specific antagonists such as MK801. Because studies evaluating the direct impact of spinal NMDA in neuropathic pain models are lacking, we performed a series of exper...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2004.10.068
更新日期：2005-06-10 00:00:00
abstract：AIMS:In this study, we conducted a meta-analysis to systematically compare the diagnostic accuracy of IGRAs performed for extrasanguinous body fluids with that performed for blood in the diagnosis of TB. MAIN METHODS:Multiple English and Chinese databases were searched up to November 2017. Studies that complied with t...
journal_title：Life sciences
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.lfs.2018.02.004
更新日期：2018-03-15 00:00:00
abstract：AIMS:Toxoplasma gondii (T. gondii) is an intracellular Apicomplexan parasite and a causative agent of toxoplasmosis in human. Its parasitic invasion leads to encephalitis, uveitis, chorioretinitis and congenital infection. Host invasion by T. gondii is mediated by Moving junction (MJ) complex formed by secretory protei...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2018.10.022
更新日期：2018-11-15 00:00:00
abstract：:Renal handling of the aminoglycoside antibiotics gentamicin and tobramycin were studied before and after one hour of constant intravenous infusions adjusted to maintain a concentration of 15 micrograms/mL. A solitary renal autotransplant model in four conscious volume replete 40 Kg sheep was used. This unique surgical...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(83)90032-2
更新日期：1983-01-17 00:00:00
abstract：:This work was designed to study neurogenic, atropine resistant contractions of the cat urinary bladder. Urinary bladder contractions were induced by pelvic nerve stimulation (PNS) and the administration of acetylcholine (Ach) and purine compounds. The results show that atropine (2 mg/kg) depresses the maintained porti...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(83)90374-0
更新日期：1983-05-23 00:00:00
abstract：AIMS:The aim of the study was to identify key miRNAs related to hepatocellular carcinoma (HCC) and then to explore their potential function and clinical significance. MATERIALS AND METHODS:The miRNA expression profiles of 387 HCC and 62 normal liver tissues were obtained from the Gene Expression Omnibus (GEO) and The ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2019.116596
更新日期：2019-09-01 00:00:00
abstract：:[3H] Dynorphin can be shown to bind to the brains of both rat and guinea pigs with approximately 50% specific binding. Characterization of the binding in terms of multiple opiate receptor types supports the kappa selectivity of dynorphin in guinea pig. However, in rat brain, a substantial proportion of the [3H] dynorp...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(83)90499-x
更新日期：1983-01-01 00:00:00
abstract：:Nucleotides, e.g. ATP and ADP, are important signaling molecules, which elicit several biological responses. The degradation of nucleotides is catalyzed by a family of enzymes called NTPDases (nucleoside triphosphate diphosphohydrolases). The present study reports the enzymatic properties of a NTPDase (CD39, apyrase, ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(03)00596-4
更新日期：2003-09-05 00:00:00
abstract：:Increased levels of particulate matter (PM) air pollutants in East Asia have resulted in detrimental health impacts increasing morbidity and mortality. Epidemiological studies suggest a possible relation between the cutaneous exposure of PM and increased oxidative stress and inflammation which lead to skin lesions. Th...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2019.116714
更新日期：2019-09-15 00:00:00
abstract：:In the present study we compared, in vivo in rats, the hepatobiliary transport of monovalent (silver:Ag) and divalent metals (zinc:Zn; cadmium:Cd) with that of copper (Cu). Cu can have two oxidation states in vivo, i.e. Cu(I) and Cu(II). Studies were performed in normal Wistar (NW) rats and mutant GY Wistar rats. The ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(96)00447-x
更新日期：1996-01-01 00:00:00
abstract：AIMS:Gender difference in cardiac ischemia-reperfusion (IR) induced injury has been reported in animal models. However, a large-scale clinical trial found an increase in cardiovascular incidents in women with hormone replacement therapy. The present study is aimed to explore possible mechanisms of gender difference in ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2013.06.019
更新日期：2013-08-28 00:00:00
abstract：AIMS:The aim of the present study was to evaluate the possible antioxidant role of oleic acid (OA) against Cd-induced injuries in the heart and liver tissues of male Wistar rats. MAIN METHODS:Rats were treated with either vehicle (control), or OA (10 mg/kg b.w., fed orally), or Cd (0.44 mg/kg b.w., s.c.), or both (OA ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2020.117324
更新日期：2020-03-01 00:00:00
abstract：AIM:Myocardial infarction (MI), an important cause of morbidity and mortality, can be followed by left ventricular dysfunction and cardiomyocyte loss. Cardiac repair mechanisms may subsequently improve left ventricular function. Exercise training has been suggested to have cardioprotective effects against MI damage, bu...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2019.02.045
更新日期：2019-03-15 00:00:00
abstract：AIMS:Poly (ADP-ribose) polymerase- (PARP)-1 is predominantly triggered by DNA damage. Overexpression of PARP-1 is known for its association with the pathogenesis of several CNS disorders, such as Stroke, Parkinson's disease (PD), Alzheimer's disease (AD), Huntington (HD) and Amyotrophic lateral sclerosis (ALS). NAD+ de...
journal_title：Life sciences
pub_type： 杂志文章,评审
doi：10.1016/j.lfs.2020.118975
更新日期：2021-02-15 00:00:00
abstract：:We investigated the involvement of alpha 1-adrenoceptor subtypes in the positive chronotropic response to norepinephrine (NE) in neonatal rat cardiac myocytes at day 3 of culture. The cardiac myocytes at day 3 of culture exhibited a dose-dependent positive chronotropic response to NE in the presence of propranolol, a ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(94)90155-4
更新日期：1994-01-01 00:00:00
abstract：:In order to better understand the mechanisms underlying the reduction in GH secretion in diabetic rats, we have characterized and measured SRIH receptors in the hypothalamus and anterior pituitary gland 5 and 9 days after induction of diabetes in the rat. Experimental diabetes was induced by an intraperitoneal injecti...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(94)90151-1
更新日期：1994-01-01 00:00:00
abstract：:We investigated the role of sensory nerves in glucose tolerance in conscious Wistar rats neonatally treated with neurotoxin capsaicin or vehicle. Intravenous glucose tolerance tests (IVGTT, 150, 300 and 450 mg in 30 min) were performed to measure glucose tolerance, and glucose, insulin and glucagon levels were measure...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2005.03.011
更新日期：2005-07-29 00:00:00
abstract：:Although the aging effect of dopamine D2 receptor in the striatum is well-documented, the effect of age on the extrastriatal dopamine D2 receptor has not been fully examined. Since the density of extrastriatal dopamine D2 receptor is very low, suitable ligands are limited. In this study, we used [11C]FLB 457 to quanti...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(01)01205-x
更新日期：2001-07-20 00:00:00
abstract：:To evaluate possible deleterious effects of commonly used herbicides on leukocytes, cytokine production was selected as a sensitive indicator. After in vitro exposure of human peripheral blood mononuclear cells from normal donors, the production of all 3 cytokines tested--interferon-gamma (a type 1 cytokine), interleu...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(00)00586-5
更新日期：2000-05-19 00:00:00
abstract：AIMS:Honokiol is a natural product extracted from herbal plants such as the Magnolia species which have been shown to exhibit anti-tumor and anti-metastatic properties. However, the effects of honokiol on thyroid cancers are largely unknown. MATERIALS AND METHODS:To determine whether honokiol might be useful for the t...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2018.06.002
更新日期：2018-08-15 00:00:00
abstract：:The present study examined the discriminative stimulus and response rate-decreasing effects of kappa opioids in pigeons trained to discriminate a 0.017 mg/kg dose of bremazocine from saline. Bremazocine, spiradoline, CI977, U69,593 and U50,488 substituted completely for the bremazocine stimulus in a dose-dependent and...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(94)90115-5
更新日期：1994-01-01 00:00:00
abstract：:The compound (+)-MR200 [(+)-methyl (1R,2S)-2-{[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]methyl}-1-phenylcyclopropanecarboxylate] is a sigma ligand with increased affinity and selectivity compared to the structurally related ligand haloperidol. From the results of a previous study on the modulation of a systemically ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2005.10.005
更新日期：2006-04-18 00:00:00
abstract：:Current treatment of Alzheimer's Disease (AD) requires acetylcholinesterase inhibition to increase acetylcholine (ACh) concentrations in the synaptic cleft. Another mechanism by which ACh levels can be increased is blockade of presynaptic M2 muscarinic autoreceptors that regulate ACh release. An antagonist designed fo...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(01)01056-6
更新日期：2001-04-27 00:00:00
abstract：:Aromatase transforms irreversibly androgens into estrogens and is present in the endoplasmic reticulum of various tissues including the mammalian testis. In rat all testicular cells except peritubular cells express aromatase. Indeed in adult rat germ cells (pachytene spermatocytes and round spermatids) we have demonst...
journal_title：Life sciences
pub_type： 杂志文章,评审
doi：10.1016/j.lfs.2011.06.004
更新日期：2011-10-10 00:00:00
abstract：:P120-catenin (P120) was known to function in adhesion between cells and signal transduction in many types of cells. In this study, we investigated the expression and role of P120 in pulmonary fibrosis and transforming growth factor beta (TGF-β) mediated lung fibroblast-to-myofibroblast differentiation (fibroblast diff...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2019.05.052
更新日期：2019-08-01 00:00:00
abstract：AIMS AND METHODS:We previously reported that angiotensin II (AngII) restores the vascular reactivity diminished by hemorrhagic shock. In this study, we investigated whether the beneficial effects of AngII are related to regulation of gap junctions (GJs) and connexin43 (Cx43), and the implication of MAPK signaling and m...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2018.11.019
更新日期：2019-01-01 00:00:00
abstract：:Specific 125I-CCK receptor binding was significantly increased in brain tissue taken from guinea pig or mouse following chronic (2-3 week) daily administration of haloperidol (2-3 mg/kg/day). Scatchard analysis indicated the increase in CCK binding was due to an increased receptor number (B max) with no change in affi...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(83)90224-2
更新日期：1983-02-21 00:00:00
abstract：AIMS:To investigate the effects of high doses of pentazocine on antinociception induced by a high dose of morphine and the role of the kappa-opioid receptors (KORs) in these effects in mice. MAIN METHODS:Sixty-six C57BL/6J mice were pretreated with a KOR antagonist, nor-binaltorphimine (nor-BNI) (10mg·kg(-1)), or a no...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2015.02.023
更新日期：2015-06-01 00:00:00
abstract：:The purpose of this investigation was to determine the effects of experimental dicrocoeliosis on bile formation in the hamster. Studies were carried out at 120 days after infection with an oral dose of 40 metacercariae of Dicrocoelium dendriticum. A significant elevation in bile flow (+20%) and in the biliary output o...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(98)00474-3
更新日期：1998-01-01 00:00:00
abstract：:Specific binding sites for atrial natriuretic peptide (ANP) were identified and characterized in primary cultures of human thyroid cells. Saturation analysis using [125I] alpha rat ANP as the ligand showed a single class of high affinity binding (Kd = 0.2 nM) which was inhibited by atriopeptin I and the alpha -human f...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(89)90172-0
更新日期：1989-01-01 00:00:00
