Proteomic analysis of honokiol-induced cytotoxicity in thyroid cancer cells.

abstract：:Static sense organs composed of a hollow statocyst surrounded by sensory hairs and containing aggregate bodies (statoliths) have been detected in various species of Vespinae. On the frons in the groove traversing its center (the frontal groove) there is a deep pit and around it a membrane enclosing a cyst-like sac. In...

journal_title：Life sciences

authors： Ishay JS,Shimony T,Arcan L

更新日期：1983-04-11 00:00:00

abstract：AIMS:Vitamin D is a well-known endocrine regulator of calcium/phosphate homeostasis and has been reported as having a wide range of activities that are potentially beneficial for human health. This study aimed to investigate the effects of pretreatment of vitamin D3 (100, 1000, and 10,000 IU/kg) against lipopolysacchar...

journal_title：Life sciences

authors： Mokhtari-Zaer A,Hosseini M,Salmani H,Arab Z,Zareian P

更新日期：2020-07-15 00:00:00

abstract：:The mechanism of spontaneous coronary contractions was investigated in the rabbit. Arteries with intact endothelium did not spontaneously contract. However, spontaneous coronary contractions were generated after the removal of the endothelium. NG-nitro-L-arginine methyl ester and methylene blue, the inhibitors of the ...

journal_title：Life sciences

authors： Omote M,Mizusawa H

更新日期：1994-01-01 00:00:00

abstract：AIM:Despite recent advances in therapeutic strategies, cancer is still a leading cause of mortality worldwide. Mitochondrial dysfunction is implicated in cancer initiation and metastasis, and even in chemo- and radio-resistance. However, the precise role of mitochondria in cancer is crosstalk and controversial. This st...

journal_title：Life sciences

authors： Kheirandish-Rostami M,Roudkenar MH,Jahanian-Najafabadi A,Tomita K,Kuwahara Y,Sato T,Roushandeh AM

更新日期：2020-03-01 00:00:00

abstract：:As the relationship between emotional behavior and electrocardiographic (ECG) change induced by hypothalamic stimulation is poorly understood, eighty-four points in various areas within the hypothalamus in conscious cats were stimulated electrically through chronically implanted electrodes, the objective being to clar...

journal_title：Life sciences

authors： Tashiro N,Tanaka T,Fukumoto T,Hirata K,Nakao H

更新日期：1985-03-18 00:00:00

abstract：:Obesity leads to various changes in the body. Among them, the existing inflammatory process may lead to an increase in the production of reactive oxygen species (ROS) and cause oxidative stress. Oxidative stress, in turn, can trigger mitochondrial changes, which is called mitochondrial dysfunction. Moreover, excess nu...

journal_title：Life sciences

authors： de Mello AH,Costa AB,Engel JDG,Rezin GT

更新日期：2018-01-01 00:00:00

abstract：:Efficacy of chemotherapy may be maximized and its toxicity can be minimized if drugs would be administered at specified daily times. The present study was aimed to examine if the protection of amifostine against cisplatin toxicity is time dependent. Amifostine is an organic thiophosphate that protects selectively norm...

journal_title：Life sciences

authors： Asna N,Lewy H,Ashkenazi IE,Deutsch V,Peretz H,Inbar M,Ron IG

更新日期：2005-03-04 00:00:00

abstract：AIMS:Septic shock, the severe form of sepsis, is associated with development of progressive damage in multiple organs. Kidney can be injured and its functions altered by activation of coagulation, vasoactive-peptide and inflammatory processes in sepsis. Endothelin (ET)-1, a potent vasoconstrictor, is implicated in the ...

journal_title：Life sciences

authors： Jesmin S,Shimojo N,Yamaguchi N,Mowa CN,Oki M,Zaedi S,Sultana SN,Rahman A,Islam M,Sawamura A,Gando S,Kawano S,Miyauchi T,Mizutani T

更新日期：2014-05-02 00:00:00

abstract：:Indomethacin (0.14-.5 mM concentration) inhibits nitric oxide production in murine peritoneal macrophages. This was evidenced by measuring both nitrite production or 14C-L-citrulline formation. The inhibition was caused by the diminution of de novo inducible nitric oxide synthase production as demonstrated by Western ...

journal_title：Life sciences

authors： Hrabák A,Vercruysse V,Kahán IL,Vray B

更新日期：2001-03-09 00:00:00

abstract：:We studied the effect of interleukin-1 alpha (IL-1) on corticotropin-releasing hormone (CRH) secretion by explanted rat hypothalami in vitro. We also assessed possible mediation of arachidonic acid metabolites on IL-1-stimulated CRH secretion, by preincubating hypothalami with the cyclooxygenase inhibitor indomethacin...

journal_title：Life sciences

authors： Bernardini R,Calogero AE,Mauceri G,Chrousos GP

更新日期：1990-01-01 00:00:00

abstract：:Fluorescence spectroscopy was used to examine the biophysical characteristics of human platelet membranes as a function of subject age. The structural order of membrane lipid domains was determined with the use of 1,6-diphenyl-1,3,5-hexatriene (DPH), a fluorescent probe that preferentially localizes in the hydrocarbon...

journal_title：Life sciences

authors： Cohen BM,Zubenko GS

更新日期：1985-10-14 00:00:00

abstract：AIMS:Histone deacetylase inhibitors (HDACis) are promising anticancer drugs that open new areas of epigenetic drug discovery. Multiple myeloma (MM) is a malignant tumor of the blood system that is difficult to cure and often relapses. Here, we investigated the in vitro effects of a novel HDACi, LMK-235, on MM cells, an...

journal_title：Life sciences

authors： Li X,Guo Y,Kuang X,Zhao L,Li H,Cheng B,Wang W,Zhang Z,Liu P,Wang J

更新日期：2019-04-15 00:00:00

abstract：AIM:The purpose of this study was to investigate whether the flavonoid quercetin can prevent alterations in the behavioral tests and of cholinergic neurotransmission in rats submitted to the ethidium bromide (EB) experimental demyelination model during events of demyelination and remyelination. MAIN METHODS:Wistar rat...

journal_title：Life sciences

authors： Beckmann DV,Carvalho FB,Mazzanti CM,Dos Santos RP,Andrades AO,Aiello G,Rippilinger A,Graça DL,Abdalla FH,Oliveira LS,Gutierres JM,Schetinger MR,Mazzanti A

更新日期：2014-05-17 00:00:00

abstract：:We studied effects of tyrphostin A23 (an inhibitor of protein tyrosine kinase; PTK) and tyrphostin A63 (an inactive analog of tyrphostin A23) on forskolin-activated cystic fibrosis transmembrane conductance regulator (CFTR) Cl(-) channels and Cl(-) secretion in renal epithelial A6 cells. Tyrphostin A23 and A63 had no ...

journal_title：Life sciences

authors： Niisato N,Nishio K,Marunaka Y

更新日期：2002-07-26 00:00:00

abstract：:A review of the rapidly accumulating data in the literature continues to support the notion that catecholamines regulate ovarian function, and extends the complexity of catecholaminergic effects on the ovary via interactions with pituitary and adrenal hormones. It is clear that catecholamines affect growth and differe...

journal_title：Life sciences

authors： Spicer LJ

更新日期：1986-11-10 00:00:00

abstract：:In our previous studies, exposure of mice to millimeter waves (MW) increased the duration of anesthesia caused by either ketamine or chloral hydrate, and this effect was blocked by naloxone. To further characterize the biological effects of MW, we have chosen a new animal model of experimental itch. Male Swiss albino ...

journal_title：Life sciences

authors： Rojavin MA,Cowan A,Radzievsky AA,Ziskin MC

更新日期：1998-01-01 00:00:00

abstract：:Biliary excretion is the main route of disposal of bilirubin and impaired excretion results in jaundice, a well recognisable symptom of liver disease. Conjugation of bilirubin in the liver is essential for its clearance. The glucuronidation of bilirubin is catalysed by the microsomal UDP-glucuronosyltransferase UGT1A1...

journal_title：Life sciences

authors： Bustamante N,Cantarino MH,Arahuetes RM,Cubero FJ,Ortiz A

更新日期：2006-03-06 00:00:00

abstract：:Involvement of cyclic AMP-dependent protein kinase in the desensitization of GABAB receptor expressed in Xenopus oocytes was studied. GABA produced an outward current in the presence of bicuculline, under voltage-clamp conditions. Baclofen mimicked the effect of GABA, thereby indicating that the response to GABA in th...

journal_title：Life sciences

authors： Yoshimura M,Yoshida S,Taniyama K

更新日期：1995-11-17 00:00:00

abstract：:Stability and distribution of orally administered epidermal growth factor (EGF) were examined in newborn and 5-day-old pigs. Forty-five minutes after oral administration of iodine-125 labeled EGF, 60 and 50% of the radioactivity administered were recovered from the internal organs in newborn and 5-day-old pigs, respec...

journal_title：Life sciences

authors： Shen WH,Xu RJ

更新日期：1998-01-01 00:00:00

abstract：:Using hot plate method, analgesia induced by noncatecholic phenylethylamines, phenethylamine, phenylethanolamine and amphetamine, was inhibited by naloxone, reserpine, apomorphine and p-chlorophenylalanine, while potentiated by haloperidol. These results suggest that phenylethylamines induced analgesia involves centra...

journal_title：Life sciences

authors： Kubota K,Matsuoka Y,Sakuma M,Satoh S,Uruno T,Sunagane N

更新日期：1982-09-20 00:00:00

abstract：AIMS:Diabetes increases oxidant stress and impairs endothelium-dependent relaxation. We investigated whether the antioxidant 3',4'-dihydroxyflavonol (DiOHF) reduces the release of superoxide (O(2)(-)) and preserves endothelial function in aortae from diabetic rats. MAIN METHODS:Type-1 diabetes was induced in Sprague-D...

journal_title：Life sciences

authors： Woodman OL,Malakul W

更新日期：2009-07-03 00:00:00

abstract：:The mammalian pineal gland synthesizes melatonin in a circadian manner, peaking during the dark phase. This synthesis is primarily regulated by sympathetic innervations via noradrenergic fibers, but is also modulated by many peptidergic and hormonal systems. A growing number of studies reveal a complex role for melato...

journal_title：Life sciences

authors： Garcia RA,Afeche SC,Scialfa JH,do Amaral FG,dos Santos SH,Lima FB,Young ME,Cipolla-Neto J

更新日期：2008-01-02 00:00:00

abstract：:Sexual interactions have multiple effects on oxytocin systems in the brain. In the present study we observed that allowing estrogen-progesterone treated ovariectomized rats to be mounted ten times by a male significantly decreased the density (beta max) of thymic oxytocin receptors. Animals were ovariectomized and aft...

journal_title：Life sciences

authors： Caldwell JD,Walker CH,Pedersen CA,Mason GA

更新日期：1993-01-01 00:00:00

abstract：:The anthropogenic chemicals nonylphenol, bisphenol A, phthalic acid benzyl n-butyl ester, phthalic acid di-n-butyl ester and phthalic acid di(2-ethylhexyl) ester have been shown to possess sex hormone-like activity. To explore the possible actions of these chemicals on the autacoid synthesis in the body, we investigat...

journal_title：Life sciences

authors： Fujimoto Y,Sakuma S,Inoue T,Uno E,Fujita T

更新日期：2002-03-29 00:00:00

abstract：:Glucocorticoids (GCs) are hormones with anti-inflammatory and immuno-suppressive effects. The use of hormonal medicine like GCs may cause systemic adverse effects. In the present study, the cellular response of murine pre-osteoclast cell line RAW264.7 to dexamethasone (DEX) was investigated and the result demonstrated...

journal_title：Life sciences

authors： Zhang Q,Fong CC,Zhang Y,Tzang CH,Fong WF,Yang M

更新日期：2008-01-16 00:00:00

abstract：:We have recently shown that the vasoconstrictor serotonin (5-HT) inhibits oxygen uptake in perfused hindlimb possibly due to vascular shunting. Thus in the present study the effect of 5-HT on insulin-mediated glucose uptake was assessed. Rat hindlimbs were perfused at constant flow with medium containing 8.3 mM glucos...

journal_title：Life sciences

authors： Rattigan S,Dora KA,Colquhoun EQ,Clark MG

更新日期：1993-01-01 00:00:00

abstract：AIMS:The long non-coding RNA (lncRNA) was reported to be involved in the progress of various cancers, however, its effect in colorectal cancer (CRC) remains unknown. The goal of the present study is to investigate the function role of lncRNA PCAT-1 in colorectal cancer. MAIN METHODS:The expression of lncRNA PCAT-1 in ...

journal_title：Life sciences

authors： Qiao L,Liu X,Tang Y,Zhao Z,Zhang J,Feng Y

更新日期：2017-11-01 00:00:00

abstract：:Significant elevation in plasma corticosterone of rats achieved by intraperitoneal (i.p.) administration of corticosterone (2.4 mg/kg) was associated with a rapid (2.5 min) and significant increase in hypothalamic histamine (HA) levels which persisted for 60 min. Midbrain and cortical HA concentrations were not affect...

journal_title：Life sciences

authors： Mazurkiewicz-Kwilecki IM

更新日期：1983-03-07 00:00:00

abstract：:gamma-Aminobutyric acid (GABA) receptor-mediated 36chloride (36Cl-) uptake was measured in synaptoneurosomes from rat brain. GABA and GABA agonists stimulated 36Cl- uptake in a concentration-dependent manner with the following order of potency: Muscimol greater than GABA greater than piperidine-4-sulfonic acid (P4S)gr...

journal_title：Life sciences

authors： Luu MD,Morrow AL,Paul SM,Schwartz RD

更新日期：1987-09-07 00:00:00

abstract：AIMS:Nicotine is a risk factor for various diseases, including osteoporosis, oral cancer, and periodontal disease. Numerous studies have elucidated the effects of nicotine on cell proliferation and differentiation. The purpose of this study was to determine the effects of nicotine on the proliferation and osteoblast di...

journal_title：Life sciences

authors： Kim BS,Kim SJ,Kim HJ,Lee SJ,Park YJ,Lee J,You HK

更新日期：2012-01-16 00:00:00