Activation of CFTR Cl(-) channel by tyrphostins via a protein tyrosine kinase-independent pathway in forskolin-stimulated renal epithelial A6 cells.

abstract：:Indomethacin (0.14-.5 mM concentration) inhibits nitric oxide production in murine peritoneal macrophages. This was evidenced by measuring both nitrite production or 14C-L-citrulline formation. The inhibition was caused by the diminution of de novo inducible nitric oxide synthase production as demonstrated by Western ...

journal_title：Life sciences

authors： Hrabák A,Vercruysse V,Kahán IL,Vray B

更新日期：2001-03-09 00:00:00

abstract：AIMS:Ginsenoside-Rg1 (G-Rg1), a saponin that is a primary component of ginseng, is very useful and important in traditional Chinese medicine for stroke. The objective of this study was to explore the mechanisms underlying the neuroprotective effect of G-Rg1 on focal cerebral ischemia/reperfusion. MAIN METHODS:Focal ce...

journal_title：Life sciences

authors： Xie CL,Li JH,Wang WW,Zheng GQ,Wang LX

更新日期：2015-01-15 00:00:00

abstract：:To evaluate possible deleterious effects of commonly used herbicides on leukocytes, cytokine production was selected as a sensitive indicator. After in vitro exposure of human peripheral blood mononuclear cells from normal donors, the production of all 3 cytokines tested--interferon-gamma (a type 1 cytokine), interleu...

journal_title：Life sciences

authors： Hooghe RJ,Devos S,Hooghe-Peters EL

更新日期：2000-05-19 00:00:00

abstract：:Arsenic as a one of the most important toxic metals could induce hepatotoxicity. Previous reports revealed the significance of oxidative stress in promoting of arsenic-induced liver toxicity. The aim of the present investigation is to evaluate the effect of chrysin (CHR), a natural flavonoid with potent antioxidant ac...

journal_title：Life sciences

authors： Fatemi I,Khalili H,Mehrzadi S,Basir Z,Malayeri A,Goudarzi M

更新日期：2021-02-15 00:00:00

abstract：:Multidrug resistance-associated proteins (Mrps) are ATP-dependent transporters which transport a wide variety of anionic and cationic compounds. The purpose of this study was to determine the tissue distribution of Mrp5 and 6 in male and female Sprague-Dawley rats in various tissues, and to investigate whether the exp...

journal_title：Life sciences

authors： Maher JM,Cherrington NJ,Slitt AL,Klaassen CD

更新日期：2006-04-04 00:00:00

abstract：:To study the source of immunoreactive epidermal growth factor (ir-EGF) released by thrombin formation we removed 99.9% of the leukocytes normally present in platelet-rich plasma and induced coagulation with 30 mM of Ca2+. The absence of leukocytes did not reduce the amount of ir-EGF released; thus platelets are most l...

journal_title：Life sciences

authors： Kiuru J,Viinikka L,Myllylä G,Pesonen K,Perheentupa J

更新日期：1991-01-01 00:00:00

abstract：:As the relationship between emotional behavior and electrocardiographic (ECG) change induced by hypothalamic stimulation is poorly understood, eighty-four points in various areas within the hypothalamus in conscious cats were stimulated electrically through chronically implanted electrodes, the objective being to clar...

journal_title：Life sciences

authors： Tashiro N,Tanaka T,Fukumoto T,Hirata K,Nakao H

更新日期：1985-03-18 00:00:00

abstract：:Histamine is a biogenic amine that plays an essential role in controlling many physiological functions, both in the central nervous system (CNS) and the peripheral nervous system (PNS). Most of these physiological effects are mediated through interactions with four histamine receptor subtypes, all of which are members...

journal_title：Life sciences

authors： Micallef S,Stark H,Sasse A

更新日期：2013-10-10 00:00:00

abstract：:The aim of this study is to investigate the effect of three cucurbitacins (Cuc) E, D and I on the bilirubin-albumin binding, both in human serum albumin (HSA) and in plasma. Bilirubin-HSA solution and plasma free of cucurbitacins were prepared as well as others containing serial concentrations of cucurbitacins. The co...

journal_title：Life sciences

authors： Greige-Gerges H,Abou Khalil R,Chahine R,Haddad C,Harb W,Ouaini N

更新日期：2007-01-16 00:00:00

abstract：:Ancylostoma ceylanicum, the human hookworm parasite, exhibited significant secretion of cholinesterase when maintained in vitro in RPMI-1640 medium. Secretion of the enzyme was linear up-to 4 hours of incubation. About 40 percent of the total cholinesterase activity was localized in the soluble fraction, while remaini...

journal_title：Life sciences

authors： Tekwani BL

更新日期：1992-01-01 00:00:00

abstract：:Patients with neurogenic orthostatic hypotension due to multiple system atrophy (MSA) or pure autonomic failure (PAF) excrete lower amounts of homovanillic acid (HVA) than do normal subjects. There is a highly significant correlation between the rates of excretion of HVA and norepinephrine metabolites. The regression ...

journal_title：Life sciences

authors： Kopin IJ,Oliver JA,Polinsky RJ

更新日期：1988-01-01 00:00:00

abstract：:Gastric ulceration associated with the use of NSAIDs is most frequently observed in elderly women, the same sector of society most likely to be receiving therapy for osteoporosis. As some anti-osteoporosis medications have been suggested to irritate the upper gastrointestinal mucosa, we evaluated the ability of one su...

journal_title：Life sciences

authors： Elliott SN,McKnight W,Davies NM,MacNaughton WK,Wallace JL

更新日期：1998-01-01 00:00:00

abstract：AIMS:To identify the target of an adipose specific aptamer adipo-8, predict the potential interaction between adipo-8 and its target, and investigate lipid-lowering effect of adipo-8 in vitro and in vivo. MAIN METHODS:Distinct membranous protein of 3T3-L1 adipocyte pulled-down by adipo-8 was mass-spectrometry analyzed...

journal_title：Life sciences

authors： Zhong W,Zhang Y,Tan W,Zhang J,Liu J,Wang G,Liao J,Liu B,Chen K,Yu B,Deng Y,Zou Y,Pu Y,Liu H

更新日期：2020-06-15 00:00:00

abstract：:Ozone is a highly efficient disinfectant which may have significant advantages in water treatment compared to chlorine. It has, however, been shown that mutagenic and possibly carcinogenic byproducts may be produced under certain conditions of ozonation. Light chlorination following ozonization may meet the highest st...

journal_title：Life sciences

authors： Carmichael NG,Winder C,Borges SH,Backhouse BL,Lewis PD

更新日期：1982-01-11 00:00:00

abstract：:To examine the direct effects of tributyltin acetate (TBTA) on osteoclasts and osteoblasts, teleost scale, which has both osteoclasts and osteoblasts and is similar to mammalian membrane bone, was used in the present study. The activities of tartrate-resistant acid phosphatase and alkaline-phosphatase, as respective i...

journal_title：Life sciences

authors： Suzuki N,Tabata MJ,Kambegawa A,Srivastav AK,Shimada A,Takeda H,Kobayashi M,Wada S,Katsumata T,Hattori A

更新日期：2006-04-18 00:00:00

abstract：:Effects of 1-methyl-4-phenylpyridine(MPP+), a putative neurotoxic metabolite of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine(MPTP), on the contents of dopamine were examined in the various regions of the rat brain. Under anesthesia with pentobarbital sodium and flunitrazepam, MPP+ 150 micrograms/rat was intracerebrove...

journal_title：Life sciences

authors： Okada M,Yokotani K,Yamashita M,Ikeda H,Osumi Y

更新日期：1989-01-01 00:00:00

abstract：:The cholinergic neurotransmission has been implicated in various forms of neural plasticity such as kindling and learning. The present study examined the effects of scopolamine, a muscarinic cholinergic antagonist, on the development of behavioral sensitization to methamphetamine (MA). Rats treated with MA (1 mg/kg, s...

journal_title：Life sciences

authors： Ohmori T,Abekawa T,Koyama T

更新日期：1995-01-01 00:00:00

abstract：:The effects of nicotine on normal physiological function are of increasing concern. Preliminary to studies on the effects of prenatal exposure to nicotine, we examined methods of administering nicotine to rats. Drinking water containing nicotine was not palatable to rats and was an unsatisfactory method in our hands, ...

journal_title：Life sciences

authors： Murrin LC,Ferrer JR,Zeng WY,Haley NJ

更新日期：1987-04-27 00:00:00

abstract：:Human uridinediphosphate-glucuronosyltransferase 1A1 (UGT1A1) was expressed in Salmonella typhimurium TA1535 cells by transfection of the cells with plasmids carrying the UGT1A1 cDNA. UGT1A1 cDNA was isolated by a polymerase chain reaction from human liver total RNA and was inserted into the pSE420 plasmid, linked to ...

journal_title：Life sciences

authors： Fujita K,Mogami A,Hayashi A,Kamataki T

更新日期：2000-04-07 00:00:00

abstract：:YM-09151-2(cis-N-(1-benzyl-2-methylpyrrolidin-3-yl) -5-chloro-2-methoxy-4-methylaminobenzamide) is a new benzamide which has been reported to be an antagonist of dopamine (DA) at D1-type DA receptors. In the present study, we have examined the extent of the interaction of YM-09151-2 with D2-type DA receptors in the an...

journal_title：Life sciences

authors： Meltzer HY,Mikuni M,Simonovic M,Gudelsky GA

更新日期：1983-02-28 00:00:00

abstract：:Carbachol (CCH), serotonin (5HT), divalent ionophore A23187, cAMP, and certain neuropeptides, i.e. substance P (SP), inhibit the initial rate of uptake (influx) of 22Na into isolated chicken villus enterocytes. All these agents also increase cytosolic Ca. However, the increases stimulated by CCH, 5HT, and cAMP are not...

journal_title：Life sciences

authors： Chang EB,Musch MW

更新日期：1990-01-01 00:00:00

abstract：:Doxorubicin and daunorubicin, the anthracycline antitumor agents, were evaluated for their in vitro and in vivo effect on phosphodiesterase (PDE) activity in mouse tissues. Doxorubicin at a concentration of 10(-4)M inhibited cardiac c-AMP (adenosine 3',5', monophosphate) PDE activity 50% of the control whereas in lung...

journal_title：Life sciences

authors： Law J,Fumagalli A,Schein PS,Rahman A

更新日期：1985-02-11 00:00:00

abstract：:This study examined the protective role of metallothionein (MT) against pulmonary damage caused by acute exposure to metallic mercury (Hg0) vapor using MT-null and wild-type mice. Both strains of mice were exposed to Hg0 at 6.6 to 7.5 mg/m3 for 4 hr each day for 3 consecutive days. This dosing protocol was lethal to o...

journal_title：Life sciences

authors： Yoshida M,Satoh M,Shimada A,Yasutake A,Sumi Y,Tohyama C

更新日期：1999-01-01 00:00:00

abstract：:The α chain of interleukin 3 receptor (IL-3Rα or CD123), together with the common β (βc) subunit, forms a high-affinity IL-3R with biological function. In recent years, emerging research has found that CD123 is highly expressed on the surface of various cells (e.g., leukemia stem cells, LSCs), and it is associated wit...

journal_title：Life sciences

authors： Liu K,Zhu M,Huang Y,Wei S,Xie J,Xiao Y

更新日期：2015-02-01 00:00:00

abstract：:The pathogenesis of abdominal aortic aneurysm remains unclear. The aim of the present study was to establish whether isoleucyl-tRNA synthetase (Iars) regulates the differentiation and apoptosis of vascular smooth muscle cells (VSMCs) during the development of abdominal aortic aneurysm (AAA). In addition, the contribut...

journal_title：Life sciences

authors： Li B,Wang Z,Chen R,Hong J,Wu Q,Hu J,Hu Z,Zhang M

更新日期：2019-05-01 00:00:00

abstract：:We observed a significant increase in plasma atrial natriuretic factor (ANF) in antiorthostatic hypokinetic suspension (AOH) rats after 2 h of suspension when the experiment was made during day. Plasma ANF was investigated in relation to renal glomerular ANF receptors during AOH at night. The aim of this study was 1) ...

journal_title：Life sciences

authors： Gauquelin G,Schiffrin EL,Garcia R,Entresangles M,Cantin M,Gharib C

更新日期：1988-01-01 00:00:00

abstract：:Intravenous (IV) administration of 10 ug/kg of morphine sulfate increased the firing rate of Type A dopamine neurons but decreased the extracellular activity of Type B dopamine cells in the substantia nigra pars compacta and ventral tegmental area of anesthetized male rats. The morphine-produced increase in Type A cel...

journal_title：Life sciences

authors： Ostrowski NL,Hatfield CB,Caggiula AR

更新日期：1982-11-15 00:00:00

abstract：:The inhibitory effect of some isoxazolpyrimidine derivatives on iNOS and COX-2 endotoxin induction in mouse peritoneal macrophages has been studied. Three of these compounds inhibited nitrite and PGE2 accumulation in a concentration dependent-manner at microM range. None of these active compounds affected iNOS, COX-2,...

journal_title：Life sciences

authors： Vidal A,Ferrándiz ML,Ubeda A,Guillén I,Riguera R,Quintela JM,Peinador C,Moreira MJ,Alcaraz MJ

更新日期：2000-01-21 00:00:00

abstract：:Acute post-ischemic cardiac failure was studied in isolated rat hearts. Xylitol, glutamine, aspartic acid and glycine were added during reperfusion, resulting in no inotropic effect. Concanavalin A had a moderate inotropic effect. When concanavalin A added with xylitol, glutamine, aspartic acid and glycine, a rapid re...

journal_title：Life sciences

authors： Tan ZT,Tan L,Wang XW

更新日期：1993-01-01 00:00:00

abstract：:Recent studies on video game playing have uncovered a wide range of measurable physiological effects on the organism, such as increases in cardiovascular activity and breathing responses. However, the exact source of these effects remains unclear. Given the well-known effects of sound on physiological activity, especi...

journal_title：Life sciences

authors： Hébert S,Béland R,Dionne-Fournelle O,Crête M,Lupien SJ

更新日期：2005-04-01 00:00:00