Neuroprotective effect of ginsenoside-Rg1 on cerebral ischemia/reperfusion injury in rats by downregulating protease-activated receptor-1 expression.

abstract：AIMS:microRNA-96 (miR-96) is considered as a tumor suppressor in multiple malignancies. Some studies have indicated that EZRIN could be regulated by the miR-96 in several kinds of cancer cells. However, the function of miR-96 in human osteosarcoma has not been investigated intensively so far. In this study, we mainly e...

journal_title：Life sciences

authors： Yao Q,Pei Y,Zhang X,Xie B

更新日期：2018-06-15 00:00:00

abstract：:14-Hydroxy-retro-retinol was previously described as an in vivo and in vitro metabolite of retinol. Furthermore, the retinoid 4-hydroxy-retinol was identified as an endogenous occurring retinoid in the amphibian organism and an in vitro metabolite of retinol. We describe in the present study that 14-hydroxy-retro-reti...

journal_title：Life sciences

authors： Rühl R,Hamscher G,Garcia AL,Nau H,Schweigert FJ

更新日期：2005-02-18 00:00:00

abstract：:Chronic voluntary running of mice is known to increase the circadian peak of plasma corticosterone without change in the level of adrenocorticotropic hormone (ACTH). In order to investigate how chronic exercise modulates the circadian HPA axis, we used two weeks of voluntary wheel running of mice and confirmed the sig...

journal_title：Life sciences

authors： Otawa M,Arai H,Atomi Y

更新日期：2007-01-30 00:00:00

abstract：:Formation of etretinate, ethyl ester of acitretin, can be confirmed in vitro and in vivo using acitretin as the substrate. Etretinate was identified by LC/MS. The in vitro incubation was performed using rat and human liver 12,000 g supernatant, and the in vivo experiment was conducted in rats after oral dosing of acit...

journal_title：Life sciences

authors： Chou RC,Wyss R,Huselton CA,Wiegand UW

更新日期：1991-01-01 00:00:00

abstract：AIMS:Rg1 is the most active component of traditional Chinese medicine ginseng, having anti-aging and anti-oxidative stress features in multiple organs. Cellular senescence of hepatocytes is involved in the progression of a wide spectrum of chronic liver diseases. In this study, we investigated the potential benefits an...

journal_title：Life sciences

authors： Qi R,Jiang R,Xiao H,Wang Z,He S,Wang L,Wang Y

更新日期：2020-08-01 00:00:00

abstract：AIMS:3-Nitropropionic acid (3-NPA) is a naturally occurring fungal toxin that leads to ATP-depletion by inhibiting mitochondrial succinate dehydrogenase and produces chemical anoxia. The present study was conducted to identify the involvement of inhibitory system in 3-NPA-induced depression of spinal reflexes. METHODS...

journal_title：Life sciences

authors： Gupta R,Deshpande SB

更新日期：2008-11-21 00:00:00

abstract：:Although exogenous cannabinoid ligands such as delta9-tetrahydrocannabinol (THC) have been implicated in reward-related learning and aversion, the hedonic effects of the endogenous cannabinoid agonist anandamide (arachidonylethanolamide) have never been assessed. Thus, the effects of anandamide were tested in a place ...

journal_title：Life sciences

authors： Mallet PE,Beninger RJ

更新日期：1998-01-01 00:00:00

abstract：:Since somatostatin inhibits basal and stimulated gastric acid secretion and gastrin release, it is conceivable that decreased gastric somatostatin concentration may be one of the factors responsible for gastric hypersecretion found in patients who have undergone long-term pylorotomy for hypertrophic pyloric stenosis. ...

journal_title：Life sciences

authors： Barrios V,Urrutia MJ,Hernández M,Lama R,García-Novo MD,Hernanz A,Arilla E

更新日期：1994-01-01 00:00:00

abstract：AIMS:Aristolochic acid (AA) nephrotoxicity is related to accumulation of methylglyoxal (MGO) and N(ε)-(carboxymethyl)lysine (CML) in the mouse kidney. We studied the activity of renal semicarbazide-sensitive amine oxidase (SSAO), a key enzyme involved in MGO generation, in AA-treated mice, and investigated nephroprotec...

journal_title：Life sciences

authors： Huang TC,Chen SM,Li YC,Lee JA

更新日期：2014-09-26 00:00:00

abstract：:Estrogen can enhance or reduce lymphocyte functions in vitro depending on dose and exposure duration. The purpose of this study was to determine the effect of in vivo 17 beta-estradiol (E2) on apoptosis and necrosis in lymphoid tissue of female C567BL/6 mice. Animals were ovariectomized (OVX), ovariectomized and 17 be...

journal_title：Life sciences

authors： Zajchowski S,Hoffman-Goetz L

更新日期：2000-03-03 00:00:00

abstract：:This report documents studies on the spontaneous reactivation of human erythrocyte acetylcholinesterase and human serum butyrylcholinesterase following inhibition by organophosphinate esters. The spontaneous reactivation reactions were carried out at 26.0 degrees C in 0.10 M phosphate buffer of pH 7.6. Based upon resu...

journal_title：Life sciences

authors： Lawson MA,Lieske CN,Fox-Talbot MK,Meyer HG

更新日期：1985-05-06 00:00:00

abstract：:We report that both Na+ and Ca2+ currents are involved in the action potentials and in the hormone release from rat somatotrophs in primary culture. Single somatotrophs were identified by reverse hemolytic plaque assay (RHPA) and transmembrane voltage and currents were recorded using the whole-cell mode of the patch-c...

journal_title：Life sciences

authors： Chen C,Zhang J,Vincent JD,Israel JM

更新日期：1990-01-01 00:00:00

abstract：AIMS:Alzheimer's disease (AD) is characterized by vascular dysfunction, in addition to memory impairment. Previously we found that β-sheet breaker peptides (βSBPs) improved memory impairment induced by amyloid β-peptide Aβ40. In this study we investigated βSBP effects on vascular responses in a rat model of AD. MAIN M...

journal_title：Life sciences

authors： Bölükbaşı Hatip FF,Hatip-Al-Khatib I

更新日期：2013-02-27 00:00:00

abstract：:Dialyzed aqueous extracts of plant pollen are widely used in the clinical practice of allergy for diagnostic and therapeutic purposes. The present investigation shows that such allergenic extracts are capable of consuming complement in every human serum, independent of the clinical condition. Complement is engaged by ...

journal_title：Life sciences

authors： Berrens L,de la Cuadra B,Gallego MT

更新日期：1997-01-01 00:00:00

abstract：:The effects of opioids on human subjective olfactory function have rarely been investigated. This is despite the fact that opioid receptors are widely distributed throughout the olfactory systems. Using an established validated test of subjective olfactory function, olfactory threshold, odor discrimination and odor id...

journal_title：Life sciences

authors： Lötsch J,Darimont J,Skarke C,Zimmermann M,Hummel T,Geisslinger G

更新日期：2001-09-28 00:00:00

abstract：:The changes in hepatic energy state were assessed by 31P-nuclear magnetic resonance spectroscopy (31P-MRS) and arterial ketone body ratio (AKBR) in brain dead dogs. 31P-MRS and AKBR were measured before and at 3 hours after brain death. Wiggers' shock model was employed to compare the energy metabolism during hypotens...

journal_title：Life sciences

authors： Kitai T,Tanaka A,Terasaki M,Okamoto R,Ozawa K,Morikawa S,Inubushi T

更新日期：1991-01-01 00:00:00

abstract：:Previous in vitro evidence suggests that adrenaline causes K influx in skeletal muscle by stimulating a ouabain sensitive Na/K ATPase membrane pump. However in rabbits, adrenaline induced hypokalaemia was not significantly altered by pretreatment with digoxin (50 micrograms/kg). Rats were infused with adrenaline or sa...

journal_title：Life sciences

authors： Struthers AD,Davies DL,Harland D,Price JS,Brown RA,Quigley C,Brown MJ

更新日期：1987-01-05 00:00:00

abstract：:This study investigated the effect of berberine (BER) in the mouse forced swim test (FST) and in the tail suspension test (TST), two models predictive of antidepressant activity. We also investigated the antidepressant-like mechanism of BER by the combination of the desipramine [DES, an inhibitor of reuptake of noradr...

journal_title：Life sciences

authors： Peng WH,Lo KL,Lee YH,Hung TH,Lin YC

更新日期：2007-08-23 00:00:00

abstract：:Heterotrimeric G-protein signalling systems are primarily activated via cell surface receptors possessing the seven membrane span motif. Several observations suggest the existence of other modes of input to such signalling systems either downstream of effectors or at the level of G-proteins themselves. Using a functio...

journal_title：Life sciences

authors： Cismowski MJ,Takesono A,Bernard ML,Duzic E,Lanier SM

更新日期：2001-04-06 00:00:00

abstract：AIMS:Asymmetric dimethylarginine (ADMA) is an endogenous competitive inhibitor of nitric oxide (NO) synthase, an enzyme responsible for the generation of NO. Plasma concentrations of ADMA increase in the elderly and in postmenopausal women. In fact, an elevated ADMA level is a risk factor of cardiovascular disease. Aer...

journal_title：Life sciences

authors： Tanahashi K,Akazawa N,Miyaki A,Choi Y,Ra SG,Matsubara T,Kumagai H,Oikawa S,Miyauchi T,Maeda S

更新日期：2014-07-11 00:00:00

abstract：:Sphinganine (SP) pre-treatment potentiated the retinoic acid (RA)-induced (4-96h exposures) differentiation and increase of alkaline phosphatase (ALP) activity. A higher percentage of SP pre-treated cells in RA exposures resembled mature myelocytes or granulocytes; greater increase in ALP activity was observed. In cel...

journal_title：Life sciences

authors： Wei LL,Hui EK,Wei JS,Tzeng WF,Yung BY

更新日期：1993-01-01 00:00:00

abstract：:Fenfluramine, a drug that induces increased synaptic serotonin, was used to train Fawn-Hooded rats in a drug discrimination paradigm. This strain of rats is thought to possess a genetic serotonin storage abnormality. The intent of the study was to see if the Fawn-Hooded rat was similar or dissimilar to the more freque...

journal_title：Life sciences

authors： Schechter MD

更新日期：1997-01-01 00:00:00

abstract：:This study was designed to document possible changes in bupivacaine and its main metabolite, des-butyl-bupivacaine (PPX) kinetics in mice after a single 5 mg/kg injection of diltiazem. After a single 20 mg/kg i.p. dose of bupivacaine, kinetic parameters of bupivacaine were not statistically different but the ratio AUC...

journal_title：Life sciences

authors： Bruguerolle B,Lorec AM

更新日期：1994-01-01 00:00:00

abstract：:Since reduced levels of brain serotonin are known to cause behavioural abnormalities, to which diabetics are also prone, we investigated the effect, in rats, of chronic diabetes on brain serotonin concentration and on the numbers of 5-HT(1A) and 5-HT2 receptors in cerebral cortex and brainstem. Our data show that stre...

journal_title：Life sciences

authors： Sandrini M,Vitale G,Vergoni AV,Ottani A,Bertolini A

更新日期：1997-01-01 00:00:00

abstract：:Certain things have not changed since my colleague and I last reviewed the role of dietary salt in hypertension [Haddy, F.J., Pamnani, M.B., 1995. Role of dietary salt in hypertension. Journal of the American College of Nutrition 14, 428-438]. Over half of hypertensives are still salt sensitive, i.e., they respond to ...

journal_title：Life sciences

authors： Haddy FJ

更新日期：2006-09-20 00:00:00

abstract：AIMS:Previous study demonstrated that Ginsenoside Rd. (GS-Rd) could improve cognitive and memory function in animal model of Alzheimer's disease. This study was aimed to investigate whether GS-Rd could improve non-amyloidogenic pathway by activating estrogen receptor (ER). MAIN METHODS:10mg/kg GS-Rd in ovariectomy (OV...

journal_title：Life sciences

authors： Yan X,Hu G,Yan W,Chen T,Yang F,Zhang X,Zhao G,Liu J

更新日期：2017-01-01 00:00:00

abstract：:Sweat glands are innervated by sympathetic neurons which undergo a change in transmitter phenotype from noradrenergic to cholinergic during development. As soon as the glands begin to differentiate, M3 muscarinic receptor mRNA and binding sites are detectable. Receptor expression appears in the absence of innervation ...

journal_title：Life sciences

authors： Landis SC

更新日期：1999-01-01 00:00:00

abstract：:Pharmacokinetic and pharmacodynamic interactions between simvastatin, a 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor, and diltiazem, a calcium antagonist, were investigated in 7 male and 4 female patients with hypercholesterolemia and hypertension. The patients were given, for one in a three con...

journal_title：Life sciences

authors： Watanabe H,Kosuge K,Nishio S,Yamada H,Uchida S,Satoh H,Hayashi H,Ishizaki T,Ohashi K

更新日期：2004-12-03 00:00:00

abstract：AIMS:Thrombin is a serine proteinase that is not only involved in coagulation cascade, but also mediates a number of biological responses relevant to tissues repair, and induces bronchoconstriction. TGF-β plays a pivotal role in airway remodeling due to its effects on airway smooth muscle proliferation and extracellula...

journal_title：Life sciences

authors： Yao ZH,Xie HJ,Yuan YL,Huo YT,Cao J,Lai WY,Cai RJ,Cheng YX

更新日期：2018-03-15 00:00:00

abstract：AIMS:The effects of chronic administration of Ferutinin (phytoestrogen found in the plants of genus Ferula), compared with those elicited by estradiol benzoate, were evaluated, following ovariectomy, on the uterus of ovariectomized rats as regard weight, size, structure and histomorphometry. MAIN METHODS:The experimen...

journal_title：Life sciences

authors： Ferretti M,Bertoni L,Cavani F,Benincasa M,Sena P,Carnevale G,Zavatti M,Viesti VD,Zanoli P,Palumbo C

更新日期：2012-01-16 00:00:00