Delta9-tetrahydrocannabinol, but not the endogenous cannabinoid receptor ligand anandamide, produces conditioned place avoidance.


:Although exogenous cannabinoid ligands such as delta9-tetrahydrocannabinol (THC) have been implicated in reward-related learning and aversion, the hedonic effects of the endogenous cannabinoid agonist anandamide (arachidonylethanolamide) have never been assessed. Thus, the effects of anandamide were tested in a place conditioning task. Male Wistar rats received THC (0.0-8.0 mg/kg) or anandamide (0.0-16.0 mg/kg) during conditioning sessions. The half-life of anandamide was increased by pretreatment with the protease inhibitor phenylmethylsulfonyl fluoride (2.0 mg/kg). A significant place aversion was found at the 1.0 and 1.5 mg/kg doses of THC. No significant place conditioning effects were found with anandamide. Locomotor activity during conditioning was significantly decreased by the 1.0, 1.5, 2.0 and 4.0 mg/kg doses of THC as well as the 8.0 and 16.0 mg/kg doses of anandamide. These results fail to implicate the endogenous cannabinoid anandamide in reward-related learning or aversion.


Life Sci


Life sciences


Mallet PE,Beninger RJ




Has Abstract


1998-01-01 00:00:00














  • Shock-induced modulation of lymphocyte reactivity: suppression, habituation, and recovery.

    abstract::The present study was designed to evaluate the suppressive effect of different frequencies of signaled-shock presentations on mitogenic reactivity of lymphocytes in Lewis rats, and to assess the recovery of that reactivity at varying times after the shocks. The results showed that the magnitude of decreased reactivity...

    journal_title:Life sciences

    pub_type: 杂志文章


    authors: Lysle DT,Lyte M,Fowler H,Rabin BS

    更新日期:1987-10-12 00:00:00

  • A gene-based anti-angiogenesis therapy as a novel strategy for cancer treatment.

    abstract::Angiogenesis-targeted therapy of cancer is considered a promising strategy for therapeutic management of cancer progression. Over the last two decades, a few anti-angiogenesis monoclonal antibodies (mAbs) blocking VEGF signaling have been developed and approved by the FDA. The most widely used anti-angiogenesis drug i...

    journal_title:Life sciences

    pub_type: 杂志文章


    authors: Fallah A,Heidari HR,Bradaran B,Sisakht MM,Zeinali S,Molavi O

    更新日期:2019-12-15 00:00:00

  • Differential uptake of liposomes varying in size and lipid composition by parenchymal and kupffer cells of mouse liver.

    abstract::Using liposomes differing in size and lipid composition, we have studied the uptake characteristics of the liver parenchymal and Kupffer cells. Desferal labeled with iron-59 was chosen as a radiomarker for the liposomal content, because Desferal in its free form does not cross cellular membranes. At various time inter...

    journal_title:Life sciences

    pub_type: 杂志文章


    authors: Rahman YE,Cerny EA,Patel KR,Lau EH,Wright BJ

    更新日期:1982-11-08 00:00:00

  • Chromatin organization and transcriptional activity in human embryonic lung fibroblasts aged in vitro.

    abstract::Chromatin organization was examined in confluent cultures of embryonic lung fibroblasts in the middle and at the end of their replicative lifespan. Age-related modifications resulted in an unusually wide spacing of the chromatin threads induced by a mild loosening treatment and an increased sensitivity of the nucleoso...

    journal_title:Life sciences

    pub_type: 杂志文章


    authors: Puvion-Dutilleul F,Puvion E,Macieira-Coelho A

    更新日期:1983-06-13 00:00:00

  • Effects of ethanol on locomotor and anxiety-like behaviors and the acquisition of ethanol intake in Lewis and spontaneously hypertensive rats.

    abstract::The purpose of the present study was to investigate whether Lewis (LEW) and spontaneously hypertensive rats (SHR), characterized in numerous behavioral tests as strains with high-anxiety and low-anxiety, respectively, could differ in their sensitivity to the effects of ethanol in the elevated plus maze (EPM) and the o...

    journal_title:Life sciences

    pub_type: 杂志文章


    authors: Da Silva GE,Vendruscolo LF,Takahashi RN

    更新日期:2005-06-24 00:00:00

  • Studies on in vitro effect of free fatty acids on water content and osmotic fragility of rabbit (Lepus cuniculus) erythrocytes.

    abstract::The effects of free fatty acids in the blood on osmotic fragility and water content of erythrocytes when combined with hyperthermia were investigated. The isotonic buffer, containing the fatty acid, was added to the erythrocyte suspension to a final concentration of 200 microM/L. The samples were kept for one hour in ...

    journal_title:Life sciences

    pub_type: 杂志文章


    authors: Kogawa H,Yabushita N,Nakajima T,Kageyama K

    更新日期:1998-01-01 00:00:00

  • Effect of exogenous ascorbic acid intake on biosynthesis of ascorbic acid in mice.

    abstract::The effect of exogenous ascorbic acid intake on biosynthesis of ascorbic acid in mice has been studied. After the mice were on diets containing added ascorbic acid for two months, the activities of ascorbic acid synthesizing enzymes in the mouse liver homogenates were measured using L-gulono-gamma-lactone as a substra...

    journal_title:Life sciences

    pub_type: 杂志文章


    authors: Tsao CS,Young M

    更新日期:1989-01-01 00:00:00

  • VIP-ellipticine derivatives inhibit the growth of breast cancer cells.

    abstract::The effects of vasoactive intestinal peptide (VIP)-ellipticine (E) derivatives were investigated on breast cancer cells. VIP-ALALA-E and VIP-LALA-E inhibited 125I-VIP binding to MCF-7 cells with an IC(50) values of 1 and 0.2 microM respectively. VIP-ALALA-E and VIP-LALA-E caused elevation of cAMP in MCF-7 cells with E...

    journal_title:Life sciences

    pub_type: 杂志文章


    authors: Moody TW,Czerwinski G,Tarasova NI,Michejda CJ

    更新日期:2002-07-19 00:00:00

  • The use of intermediate electron acceptors to enhance MTT bioreduction in a microculture tetrazolium assay for human growth hormone.

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    journal_title:Life sciences

    pub_type: 杂志文章


    authors: Goodwin CJ,Holt SJ,Downes S,Marshall NJ

    更新日期:1996-01-01 00:00:00

  • Mesenchymal stem cell administration at coronary artery reperfusion in the rat by two delivery routes: a quantitative assessment.

    abstract:AIMS:Ideally, mesenchymal stem cells (MSC) home to and/or remain at the site of damaged myocardium when administered after myocardial infarction. However, MSC may not remain in the heart, but instead relocate to other areas. We investigated quantitatively the distribution of labeled rat MSC, given by two routes after c...

    journal_title:Life sciences

    pub_type: 杂志文章


    authors: Hale SL,Dai W,Dow JS,Kloner RA

    更新日期:2008-09-26 00:00:00

  • Supraphysiological level of estrogen exposure in vivo increases lymphoid cell death in mice.

    abstract::Estrogen can enhance or reduce lymphocyte functions in vitro depending on dose and exposure duration. The purpose of this study was to determine the effect of in vivo 17 beta-estradiol (E2) on apoptosis and necrosis in lymphoid tissue of female C567BL/6 mice. Animals were ovariectomized (OVX), ovariectomized and 17 be...

    journal_title:Life sciences

    pub_type: 杂志文章


    authors: Zajchowski S,Hoffman-Goetz L

    更新日期:2000-03-03 00:00:00

  • Aortic coarctation induces oxidative stress in rat tissues.

    abstract::The purpose of this study was to evaluate the induction of oxidative stress in heart and erythrocytes from rats with abdominal aorta coarctation (Coa) compared with sham-operated normotensive controls (Sham). The group of Coa animals developed myocardial hypertrophy, showing heart homogenates markedly increased levels...

    journal_title:Life sciences

    pub_type: 杂志文章


    authors: Polizio AH,Gorzalczany S,Taira C,Peña C

    更新日期:2006-07-04 00:00:00

  • Stimulation of the secretion of dehydroepiandrosterone by melatonin in mouse adrenals in vitro.

    abstract::Adrenals of young adult male mice kept on a LD 12:12 lighting regimen for three weeks prior to study and harvested at four different circadian stages were incubated for 2 hours with 0.4 IU synthetic ACTH in 2 ml Krebs-Ringer buffer (KR), or with 50, 150, and 450 microM of melatonin in KR containing 0.4 IU ACTH. The ad...

    journal_title:Life sciences

    pub_type: 杂志文章


    authors: Haus E,Nicolau GY,Ghinea E,Dumitriu L,Petrescu E,Sackett-Lundeen L

    更新日期:1996-01-01 00:00:00

  • Heterogeneity in the performance of outbred Sprague-Dawley rats in an elevated-plus maze test: a possible animal model for anxiety disorder.

    abstract::A wide variation in the performance of inbred rats measured in the evaluated plus maze test suggests a possible genetic basis for anxiety response (AR). To gain further insight into the role of genetics in AR, we have characterized AR in male outbred S-D rats. Rats were placed in the black compartment (BC) facing the ...

    journal_title:Life sciences

    pub_type: 杂志文章


    authors: Prasad A,Henry M,Prasad C

    更新日期:1996-01-01 00:00:00

  • Fas/CD95 is associated with glucocorticoid-induced osteocyte apoptosis.

    abstract::Prolonged use of glucocorticoids is associated with decreased bone formation, increased resorption and osteonecrosis, through direct and indirect effects on the activity and viability of bone effector cells, osteoblasts and osteoclasts, and osteocytes. This study has investigated molecular pathways implicated in Dexam...

    journal_title:Life sciences

    pub_type: 杂志文章


    authors: Kogianni G,Mann V,Ebetino F,Nuttall M,Nijweide P,Simpson H,Noble B

    更新日期:2004-10-29 00:00:00

  • Omega-3 and omega-6 polyunsaturated fatty acids: Dietary sources, metabolism, and significance - A review.

    abstract::Linoleic acid (LA) (n-6) and α-linolenic acid (ALA) (n-3) are essential fatty acids (EFAs) as they cannot be synthesized by humans or other higher animals. In the human body, these fatty acids (FAs) give rise to arachidonic acid (ARA, n-6), eicosapentaenoic acid (EPA, n-3), and docosahexaenoic acid (DHA, n-3) that pla...

    journal_title:Life sciences

    pub_type: 杂志文章,评审


    authors: Saini RK,Keum YS

    更新日期:2018-06-15 00:00:00

  • The failing human heart does not release nitrogen oxides.

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    journal_title:Life sciences

    pub_type: 临床试验,杂志文章


    authors: Kaye DM,Chin-Dusting J,Esler MD,Jennings GL

    更新日期:1998-01-01 00:00:00

  • The non-neuronal cholinergic system in peripheral blood cells: effects of nicotinic and muscarinic receptor antagonists on phagocytosis, respiratory burst and migration.

    abstract::Peripheral blood cells express the complete non-neuronal cholinergic system. For example synthesis of acetylcholine and nicotinic as well muscarinic receptors have been demonstrated in leucocytes isolated from human peripheral blood. In the present experiments mononuclear cells and granulocytes were isolated from the ...

    journal_title:Life sciences

    pub_type: 杂志文章


    authors: Neumann S,Razen M,Habermehl P,Meyer CU,Zepp F,Kirkpatrick CJ,Wessler I

    更新日期:2007-05-30 00:00:00

  • Arachidonic acid metabolism modulates vasopressin-induced renal vasoconstriction.

    abstract::Previous studies have shown that cytochrome P450-Arachidonic Acid (P450-AA) metabolites modify the vascular tone of several vessels and that vasopressin (AVP) stimulates P450-AA metabolism. Thus, in the present study, we decided to investigate if the vasoconstrictor effect of AVP is related to activation of P450-AA me...

    journal_title:Life sciences

    pub_type: 杂志文章


    authors: Vazquez B,Rios A,Escalante B

    更新日期:1995-01-01 00:00:00

  • Thiol group may be involved in the irreversible blockade of presynaptic alpha 2-adrenoreceptors by pyrextramine and benextramine in the isolated guinea pig ileum.

    abstract::This study, conducted on isolated guinea pig ileum, was designed to establish the mechanism of presynaptic alpha 2-adrenoreceptor blockade by the tetramine disulfides, benextramine and pyrextramine. At 1 microM these drugs irreversibly blocked norepinephrine (NE)-induced inhibition of the twitch response to electrical...

    journal_title:Life sciences

    pub_type: 杂志文章


    authors: Brasili L,Cassinelli A,Angeli P,Melchiorre C

    更新日期:1986-05-05 00:00:00

  • 2-(4-Carboxyphenyl)-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide potentiates nitrosation of a heterocyclic amine carcinogen by nitric oxide.

    abstract::Although nitrosation plays an important role in initiation of carcinogenesis, the reactive nitrogen oxygen species (RNOS) mediating this reaction by multiple pathways have not been determined. The heterocyclic amine carcinogen 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) was used as a target to investigate RNOS and pa...

    journal_title:Life sciences

    pub_type: 杂志文章


    authors: Lakshmi VM,Zenser TV

    更新日期:2007-01-23 00:00:00

  • Phorbol esters, but not the hormonal form of vitamin D, induce changes in protein kinase C during differentiation of human histiocytic lymphoma cell line (U-937).

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    journal_title:Life sciences

    pub_type: 杂志文章


    authors: Mezzetti G,Bagnara GP,Monti MG,Pernecco Casolo L,Bonsi L,Brunelli MA

    更新日期:1987-05-25 00:00:00

  • Steroidogenic impairment due to reduced ovarian transcription of cytochrome P450 side-chain-cleavage (P450scc) and steroidogenic acute regulatory protein (StAR) during experimental nephrotic syndrome.

    abstract::The nephrotic syndrome is a renal disease characterized by proteinuria, hypoproteinemia, edema and hyperlipidemia. It has been reported that female nephrotic rats are characterized by loss of the oestrus cycle, follicle atresia, low gonadotropin and steroid concentrations; particularly, undetectable estradiol levels. ...

    journal_title:Life sciences

    pub_type: 杂志文章


    authors: Peña-Rico M,Guadalupe Ortiz-López M,Camacho-Castillo L,Cárdenas M,Pedraza-Chaverri J,Menjívar M

    更新日期:2006-07-10 00:00:00

  • Tetramethylpyrazine protects palmitate-induced oxidative damage and mitochondrial dysfunction in C2C12 myotubes.

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    journal_title:Life sciences

    pub_type: 杂志文章


    authors: Gao X,Zhao XL,Zhu YH,Li XM,Xu Q,Lin HD,Wang MW

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  • The proteins interacting with C-terminal of μ receptor are identified by bacterial two-hybrid system from brain cDNA library in morphine-dependent rats.

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    journal_title:Life sciences

    pub_type: 杂志文章


    authors: Zhou P,Jiang J,Dong Z,Yan H,You Z,Su R,Gong Z

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  • Ginsenoside Rd promotes non-amyloidogenic pathway of amyloid precursor protein processing by regulating phosphorylation of estrogen receptor alpha.

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    journal_title:Life sciences

    pub_type: 杂志文章


    authors: Yan X,Hu G,Yan W,Chen T,Yang F,Zhang X,Zhao G,Liu J

    更新日期:2017-01-01 00:00:00

  • Conversion of delta-, kappa- and mu-receptor selective opioid peptide agonists into delta-, kappa- and mu-selective antagonists.

    abstract::2',6'-Dimethyl substitution of the Tyr(1) residue of opioid agonist peptides and deletion of the positively charged N-terminal amino group or its replacement with a methyl group has recently been shown to represent a general structural modification to convert opioid peptide agonists into antagonists. This conversion r...

    journal_title:Life sciences

    pub_type: 杂志文章


    authors: Schiller PW,Weltrowska G,Nguyen TM,Lemieux C,Chung NN,Lu Y

    更新日期:2003-06-27 00:00:00

  • Separation of rabbit ileum mucus secretion from electrolyte and water secretion by cholera enterotoxin, verapamil and A23187.

    abstract::Net water, Na+, Cl- and HCO3- fluxes were measured in in vivo rabbit ileal loops, while mucus secretion was assessed by measuring the glycoprotein or total sialic acid secreted into the lumen, or by measuring the luminal fluid viscosity. Inoculating loops with cholera enterotoxin (CT) produced a sustained secretion of...

    journal_title:Life sciences

    pub_type: 杂志文章


    authors: George MH,Leitch GJ

    更新日期:1983-02-21 00:00:00

  • A novel methylthio metabolite of s-triazolo[3,4-a]phthalazine, a lead compound for the development of antianxiety drugs, in rats.

    abstract::When s-triazolo[3,4-a]phthalazine (Tri-P) was orally administered in rats, a more lipophilic metabolite M-1 than the parent compound was isolated from the urine. The metabolite M-1 was identified as 7-methylthio Tri-P by means of high resolution MS and two-dimensional NMR spectrometry. Furthermore, the 7-methylthio co...

    journal_title:Life sciences

    pub_type: 杂志文章


    authors: Imamura Y,Noda A,Imamura T,Ono Y,Okawara T,Noda H

    更新日期:2003-11-21 00:00:00

  • In vitro synergy of azole antifungals and methotrexate against Candida albicans.

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    journal_title:Life sciences

    pub_type: 杂志文章


    authors: Yang J,Gao L,Yu P,Kosgey JC,Jia L,Fang Y,Xiong J,Zhang F

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