Identification of 14-hydroxy-retro-retinol and 4-hydroxy-retinol as endogenous retinoids in rats throughout neonatal development.

abstract：AIMS:We previously found that paeoniflorin, a major constituent of Paeonia lactiflora Pall, could induce heat shock proteins (HSPs) in cultured mammalian cells without apparent toxicity (Yan et al. 2004). We here investigated the induction of HSPs by paeoniflorin in mouse stomach and the effect of paeoniflorin on the H...

journal_title：Life sciences

authors： Asai M,Kawashima D,Katagiri K,Takeuchi R,Tohnai G,Ohtsuka K

更新日期：2011-02-14 00:00:00

abstract：:3-methylglutaconic (MGT), 3-methylglutaric (MGA) and occasionally 3-hydroxyisovaleric (OHIVA) acids accumulate in a group of diseases known as 3-methylglutaconic aciduria (MGTA). Although the clinical presentation of MGTA is mainly characterized by neurological symptoms, the mechanisms of brain damage in this disease ...

journal_title：Life sciences

authors： Leipnitz G,Seminotti B,Amaral AU,de Bortoli G,Solano A,Schuck PF,Wyse AT,Wannmacher CM,Latini A,Wajner M

更新日期：2008-03-12 00:00:00

abstract：:Neurodegenerative diseases need the drugs to be delivered right inside the brain to maximizing the therapeutic effects. This can be achieved by use of novel targeted delivery systems such as nanoemulsions. Nanoemulsions (NE) are nano-sized emulsions that are manufactured for enhancing the delivery of drugs to the targ...

journal_title：Life sciences

authors： Nirale P,Paul A,Yadav KS

更新日期：2020-03-15 00:00:00

abstract：OBJECTIVE:The aim of this study was to investigate the role of HLA-DR, HLA-G and CD99 during cervical carcinogenesis and to examine the prognostic significance of these protein expressions in invasive squamous cell carcinoma (SCC). METHODS:Using specific antibodies for HLA-DR, HLA-G and CD99, we examined protein expre...

journal_title：Life sciences

authors： Zhou JH,Ye F,Chen HZ,Zhou CY,Lu WG,Xie X

更新日期：2006-04-25 00:00:00

abstract：:The present study was carried out in order to identify the changes in expression of multidrug resistance-associated protein (Mrp) 2 and P-glycoprotein (P-gp) in the intestine and remote organs after intestinal ischemia-reperfusion (I/R). Mrp2 expression in the jejunum and liver was decreased at 6 h after I/R. This dec...

journal_title：Life sciences

authors： Ogura J,Kobayashi M,Itagaki S,Hirano T,Iseki K

更新日期：2008-06-20 00:00:00

abstract：:The effect of gonadal steroids on the response to analgesia testing was determined in castrated male and female rats and castrated male and female rats treated with testosterone propionate (TP) and estradiol benzoate (EB), respectively. The time to respond to a noxious somatic stimulus in the form of heat was assessed...

journal_title：Life sciences

authors： Forman LJ,Tingle V,Estilow S,Cater J

更新日期：1989-01-01 00:00:00

abstract：:In the present study the possibility of provoking an irreversible blockade of P2-receptors in vivo by photolyzing ANAPP3 was investigated. ANAPP3 administered as an intraarterial infusion produced a short-lived blockade of P2-receptor mediated contractions of cat urinary bladders in situ. However, irradiation of the b...

journal_title：Life sciences

authors： Theobald RJ Jr,Hoffman V

更新日期：1986-04-28 00:00:00

abstract：:The aim of the present study was to determine the role of adrenals in gonadal activity in the male toad during the breeding season. Exogenous administration of corticosterone or metapyrone for 6 days inhibited adrenal delta5-3beta(delta 5-3 beta) hydroxysteroid (delta5-3beta-HSD) and testicular 17beta (17 beta) hydrox...

journal_title：Life sciences

authors： Biswas NM,Chaudhuri GR,Sarkar M,Sengupta R

更新日期：2000-02-18 00:00:00

abstract：:Interleukin-1 (IL-1) is a monokine which has been demonstrated to produce a variety of seemingly diverse metabolic events including fever, neutrophilia, anorexia, altered mineral metabolism, muscle catabolism, and fibroblast proliferation. Because many of the clinical features of alcoholic hepatitis are metabolic abno...

journal_title：Life sciences

authors： McClain CJ,Cohen DA,Dinarello CA,Cannon JG,Shedlofsky SI,Kaplan AM

更新日期：1986-10-20 00:00:00

abstract：:Cultured adult skin fibroblasts were studied for binding and functional evidence of muscarinic receptors in order to assess their utility as a model of cholinergic function in affective illness. Saturable, specific, high affinity binding could be demonstrated in intact cells from some cell lines with [3H]-NMS, but not...

journal_title：Life sciences

authors： Kelsoe JR Jr,Gillin JC,Janowsky DS,Brown JH,Risch SC,Lumkin B

更新日期：1986-04-14 00:00:00

abstract：:The aim of this study is to investigate the effect of three cucurbitacins (Cuc) E, D and I on the bilirubin-albumin binding, both in human serum albumin (HSA) and in plasma. Bilirubin-HSA solution and plasma free of cucurbitacins were prepared as well as others containing serial concentrations of cucurbitacins. The co...

journal_title：Life sciences

authors： Greige-Gerges H,Abou Khalil R,Chahine R,Haddad C,Harb W,Ouaini N

更新日期：2007-01-16 00:00:00

abstract：AIMS:This study aims to explore factors that influence glucocorticoid (GC)-related genes and receptors/regulatory enzyme expression in intrauterine growth restriction (IUGR) filial rats. MAIN METHODS:An IUGR animal model was established by starvation, and brain tissue was removed after birth. Affymetrix Rat Gene 2.0 S...

journal_title：Life sciences

authors： Ding YX,Shi Y,Han WJ,Cui H

更新日期：2016-04-01 00:00:00

abstract：AIMS:Interleukin-22 (IL-22) promotes thymus recovery and improves T-cell recovery in preclinical allogeneic hematopoietic cell transplant models. However, the correlation between IL-22 and thymus recovery is unknown in human transplant. MATERIALS AND METHODS:In this study, plasma IL-22 levels of transplanted humans we...

journal_title：Life sciences

authors： Shang L,Duah M,Xu Y,Liang Y,Wang D,Xia F,Li L,Sun Z,Yan Z,Xu K,Pan B

更新日期：2021-01-15 00:00:00

abstract：AIMS:Perinatal hypoxic-ischemic insult has acute and long term deleterious effects on many organs including heart. Although tumor necrosis factor alpha (TNF-α) has been reported to increase soon after hypoxia, the inhibition of this mediator has not been documented. The aim of this study was to investigate the effects ...

journal_title：Life sciences

authors： Büyükakilli B,Atici A,Özkan A,Balli E,Güneş S,Turhan AH,Hallioglu O,Kanik A

更新日期：2012-06-06 00:00:00

abstract：:The additive effects of combined valsartan and spironolactone on plasma and cardiac aldosterone escape were evaluated in spontaneously hypertensive rats (SHRs). Twenty-four SHRs were treated with valsartan (30 mg/kg body weight per day), spironolactone (20 mg/kg body weight per day) and a combination of both for 4 mon...

journal_title：Life sciences

authors： Liang YH,Wang JM,Zhou Y,Jiang XJ,Jiang H,Huang CX

更新日期：2004-08-27 00:00:00

abstract：:The putative anxiolytic activity of succinic acid was examined in male mice by using a number of experimental paradigms of anxiety and compared with that of the known anxiolytic compound diazepam. Use of the elevated plus-maze test revealed that diazepam (1.0, 2.0 and 4.0 mg/kg, PO) or succinic acid (3.0 or 6.0 mg/kg,...

journal_title：Life sciences

authors： Chen SW,Xin Q,Kong WX,Min L,Li JF

更新日期：2003-11-07 00:00:00

abstract：AIMS:Ginsenoside-Rg1 (G-Rg1), a saponin that is a primary component of ginseng, is very useful and important in traditional Chinese medicine for stroke. The objective of this study was to explore the mechanisms underlying the neuroprotective effect of G-Rg1 on focal cerebral ischemia/reperfusion. MAIN METHODS:Focal ce...

journal_title：Life sciences

authors： Xie CL,Li JH,Wang WW,Zheng GQ,Wang LX

更新日期：2015-01-15 00:00:00

abstract：:We found that platelet-activating factor (PAF) stimulated the production of prostaglandin (PG) E2 in MC3T3-E1 cells in a time- and dose-dependent manner. 1.0 microM PAF gave a maximal stimulation of PGE2 production by MC3T3-E1 cells after a 4 hr PAF-treatment. Furthermore, the PAF-induced PGE2 production was abolished...

journal_title：Life sciences

authors： Shibata Y,Ogura N,Moriya Y,Abiko Y,Izumi H,Takiguchi H

更新日期：1991-01-01 00:00:00

abstract：:The conversion of lyso-platelet activating factor (lyso-PAF) to PAF in cultured paranasal sinus mucosa obtained from normal human subjects was studied. The PAF concentration in the medium was determined after addition of lyso-PAF. PAF became detectable at 10 minutes after the addition of 10(-8)M lyso-PAF, and reached ...

journal_title：Life sciences

authors： Inoue H,Ganbo T,Hisamatsu K,Ishida H

更新日期：1993-01-01 00:00:00

abstract：:Mitochondria are known to develop a series of abnormalities as a result of ischemia. The inability of mitochondria to resume normal function following reperfusion has been implicated as an important factor in irreversible cell damage. However, the mechanism of mitochondrial injury after ischemic brain insult is poorly...

journal_title：Life sciences

authors： Kariman K

更新日期：1985-07-08 00:00:00

abstract：:Early induction of VEGF was studied in liver, kidney and lung of spontaneously diabetic rats. Western blot analysis, northern hybridization were applied to show the expression of VEGF in different organs. Radiolabelled hypoxia responsive element (HRE) and cAMP responsive element (CRE) oligonucleotides were assayed by ...

journal_title：Life sciences

authors： Braun L,Kardon T,Reisz-Porszasz ZS,Banhegyi G,Mandl J

更新日期：2001-10-12 00:00:00

abstract：:Several cryopreservation methods for precision-cut rat liver slices (PCLS) have been proposed, allowing a short-term (a few hours) maintainance of viability and functionality upon thawing. The aim of the present study was to test the metabolic capacity of PCLS cryopreserved by an ultrarapid method. The biotransformati...

journal_title：Life sciences

authors： Vanhulle VP,Martiat GA,Verbeeck RK,Horsmans Y,Calderon PB,Eeckhoudt SL,Taper HS,Delzenne N

更新日期：2001-04-13 00:00:00

abstract：:The present study was conducted to characterize the binding of neurotransmitter receptors (dopamine D(2), serotonin 5-HT(2), histamine H(1), adrenaline alpha(1) and muscarine M(l) receptors) in the rat's brain after the oral administration of haloperidol, risperidone, and olanzapine. Haloperidol at 1 and 3 mg/kg displ...

journal_title：Life sciences

authors： Uchida S,Kato Y,Hirano K,Kagawa Y,Yamada S

更新日期：2007-04-03 00:00:00

abstract：:The tumor promoter okadaic acid (OKA), is a marine toxin of algal origin, identified as a potent inhibitor of protein phosphatases 1 and 2A, and possibly enhancing calcium influx through voltage dependent calcium channels (VSSC). We now report that OKA at concentrations as low as 0.5 nM produced neurotoxicity, charact...

journal_title：Life sciences

authors： Fernández MT,Zitko V,Gascón S,Novelli A

更新日期：1991-01-01 00:00:00

abstract：:The injection of neostigmine into the hippocampus of anesthetized rats increased the mean arterial blood pressure (17% of baseline after 60 min injection) and decreased the heart rate (24% of baseline after 60 min injection). These changes were blocked by the co-administration of methylatropine into the hippocampus. I...

journal_title：Life sciences

authors： Haruta K,Iguchi A,Matsubara T,Itoh K,Chen CL,Yoshida S,Terada R,Kanashiro M,Suzuki O,Nishimura H

更新日期：1992-01-01 00:00:00

abstract：:Hypercalcemic strains of the rat Walker 256 (W256) tumor synthesize parathyroid hormone-related protein (PTHrP) and at least one of them produces an ill-defined transforming growth factor activity. We tested the production of transforming growth factor (TGF) beta by a hypercalcemic W256 tumor strain, and assessed its ...

journal_title：Life sciences

authors： Benítez-Verguizas J,Loarte D,de Miguel F,Esbrit P

更新日期：1999-01-01 00:00:00

abstract：:Previous studies have paid little attention to the anticonvulsant effect of anticholinergic drugs that act on both muscarinic (M) and nicotinic (N) receptors during soman-induced seizures. Therefore, with the establishment of a soman-induced seizures model in rats, this study evaluated the efficacy in preventing soman...

journal_title：Life sciences

authors： Wang YA,Zhou WX,Li JX,Liu YQ,Yue YJ,Zheng JQ,Liu KL,Ruan JX

更新日期：2005-11-26 00:00:00

abstract：:We examined the effects of estrogen, 12-O-tetradecanoylphorbol 13 acetate (TPA), and lipopolysaccharide (LPS) on the gene expression of platelet-derived growth factor (PDGF) by the monocyte/macrophage cell line, THP-1. THP-1 cells were exposed to TPA for 48 or 96 hours to induce differentiation. Some were treated with...

journal_title：Life sciences

authors： Shanker G,Sorci-Thomas M,Adams MR

更新日期：1995-01-01 00:00:00

abstract：:The effect of i.v. injection of various doses of naloxone (NAL) on plasma adrenocorticotropin (ACTH) and prolactin (Prl) in conscious animals bearing an indwelling intrajugular catheter was assessed. The effects were evaluated in animals which were left undisturbed and in others subjected to either restraint or ether ...

journal_title：Life sciences

authors： Xu RK,McCann SM

更新日期：1989-01-01 00:00:00

abstract：:Opiate addiction could involve a change in the binding of endogenous antiopiates. A candidate for such a role is Tyr-MIF-1 (Tyr-Pro-Leu-Gly-NH2), a brain peptide that can antagonize exogenous and endogenous opiates and bind to opiate receptors. Its primary action, however, may be through its own binding site in brain,...

journal_title：Life sciences

authors： Zadina JE,Kastin AJ,Ge LJ,Gulden H,Bungart KJ

更新日期：1989-01-01 00:00:00