Cryopreservation of rat precision-cut liver slices by ultrarapid freezing: influence on phase I and II metabolism and on cell viability upon incubation for 24 hours.

abstract：:Previous studies demonstrated a direct action of interleukin-1 (IL-1) on release of hormones from rat anterior pituitary cells in monolayer culture. To rule out any possibility of a paracrine effect from the elevated hormones in the static monolayer system, and to examine further the dynamics of hormone release elicit...

journal_title：Life sciences

authors： Beach JE,Smallridge RC,Kinzer CA,Bernton EW,Holaday JW,Fein HG

更新日期：1989-01-01 00:00:00

abstract：:The expression of the corticotropin-releasing hormone (CRH) gene and the arginine vasopressin (AVP) gene in the hypothalamus examined in bilateral nephrectomized rats by in situ hybridization histochemistry. The expression of the CRH gene was significantly increased in the parvocellular part of the paraventricular nuc...

journal_title：Life sciences

authors： Nomura M,Serino R,Yamamoto Y,Ozaki Y,Saito J,Matsumoto T,Yamashita H,Ueta Y

更新日期：2002-12-20 00:00:00

abstract：:It has been shown that some cytochrome P450-dependent enzyme activities could present daily fluctuations, particularly CYP3A isoenzymes which are enhanced during the dark period. The aim of this study was to investigate whether age and photoperiodic conditions at different circadian stages could influence these fluctu...

journal_title：Life sciences

authors： Martin C,Dutertre-Catella H,Radionoff M,Debray M,Benstaali C,Rat P,Thevenin M,Touitou Y,Warnet JM

更新日期：2003-06-06 00:00:00

abstract：:Triiodothyronine (T3) and estrogen (E2) play important roles in the bone remodeling process and signaling of receptor activator of the nuclear factor-kappa β (RANKL) and osteoprotegerin (OPG) expressed by osteoblasts. However, little is known of the molecular action of these hormones in conditions of hyperthyroidism a...

journal_title：Life sciences

authors： Olímpio RMC,Moretto FCF,De Sibio MT,de Oliveira M,Mathias LS,Gonçalves BM,Deprá IC,Tilli HP,Rodrigues BM,Saraiva PP,Maria DA,Nogueira CR

更新日期：2019-08-15 00:00:00

abstract：:Mutations that increase constitutive activity and alter ligand binding have been used to investigate the structure and mechanism of activation of muscarinic receptors. These data are reviewed with reference to the recently published three-dimensional structure of rhodopsin. Residues in TM3 and TM6 where amino acid sub...

journal_title：Life sciences

authors： Spalding TA,Burstein ES

更新日期：2001-04-27 00:00:00

abstract：:Extracts of Hypericum perforatum (St. John's wort) have antidepressant properties in depressed patients and exert antidepressant-like action in laboratory animals. The phloroglucinol derivative hyperforin has become a topic of interest, as this Hypericum component is a potent inhibitor of monoamines reuptake. The mole...

journal_title：Life sciences

authors： Roz N,Rehavi M

更新日期：2003-06-13 00:00:00

abstract：:The role of p44/42 mitogen-activated protein kinase (MAPK) in the expression of intercellular adhesion molecule-1 (ICAM-1) in NCI-H292 cells, a human bronchial epithelial cell line, was analyzed. Treatment with the protein kinase C (PKC) activator 12-O-tetradecanoylphorbol 13-acetate (TPA) (16.2 nM) or interferon-gamm...

journal_title：Life sciences

authors： Shibuya Y,Hirasawa N,Sakai T,Togashi Y,Muramatsu R,Ishii K,Yamashita M,Takayanagi M,Ohuchi K

更新日期：2004-06-11 00:00:00

abstract：AIMS:Active immunization with human vascular endothelial growth factor (hVEGF) vaccines provides a therapeutic option instead of bevacizumab therapy. However, the immunity to self-molecule is difficult to elicit due to immune tolerance. A bioactive peptide of two tandem repeats of mHSP70407-426 (M2) has exhibited poten...

journal_title：Life sciences

authors： Xu M,Zhang Y,Dong W,Jiang L,Zhang J,Yu P,Xie S,Zhou L

更新日期：2018-05-15 00:00:00

abstract：:A phase 1, randomized, double-blind, placebo-controlled, dose escalation study of the purine derivative, AIT-082 (Neotrofin, NeoTherapeutics) was conducted in mild Alzheimer's disease (AD) patients to evaluate multiple-dose safety, tolerability, and pharmacokinetics. Possible short-term effects of AIT-082 on cognition...

journal_title：Life sciences

authors： Grundman M,Capparelli E,Kim HT,Morris JC,Farlow M,Rubin EH,Heidebrink J,Hake A,Ho G,Schultz AN,Schafer K,Houston W,Thomas R,Thal LJ,Alzheimer's Disease Cooperative Study.

更新日期：2003-06-20 00:00:00

abstract：:Comparison of neuronal and non-neuronal membrane transport of, and neuroexcitation by, the dicarboxylic amino acids bring out provocative similarities in structural selectivity, and hence in the strategies for studying them. Parallel anomalies in stereoselectivity show for both phenomena that the recognition sites are...

journal_title：Life sciences

authors： Christensen HN,Makowske M

更新日期：1983-12-05 00:00:00

abstract：:In the present study the effects of Granulocyte-Macrophage Colony Stimulating Factor (GM-CSF) on fibroblast growth and activity have been studied. In this regard the AA have evaluated in primary cultures of human gengival normal fibroblasts (PG1 cells): a)-the expression of GM-CSF receptor (GM-CSFR) (alfa unit) on the...

journal_title：Life sciences

authors： Postiglione L,Montagnani S,Riccio A,Ladogana P,Salzano S,Vallefuoco L,Rossi G

更新日期：1998-01-01 00:00:00

abstract：:Seasonal and diurnal variations in tonic pain reactions were examined in female and male CBA/J mice maintained in a 12/12 dark/light cycle, at controlled temperature and humidity conditions. Animals were injected into the dorsum of one hindpaw with a dilute (20 microl, 1%) formalin solution. Pain-related behaviors wer...

journal_title：Life sciences

authors： Perissin L,Facchin P,Porro CA

更新日期：2003-01-10 00:00:00

abstract：:The metabolism of benzene and toluene was investigated in preparations of human bone marrow incubated with S-adenosyl-L-methionine. Benzene undergoes a methyl-substitution reaction to yield toluene as a metabolite. Furthermore, toluene undergoes methyl-substitution in preparations of human bone marrow incubated with S...

journal_title：Life sciences

authors： Flesher JW,Myers SR

更新日期：1991-01-01 00:00:00

abstract：:Release of alpha-MSH from the pars intermedia melanotrope cells of Xenopus laevis is regulated by various classical neurotransmitters and neuropeptides. We have examined the effect of two of these regulatory substances, the neurotransmitter GABA and the CRF-related peptide sauvagine, on the adenylate cyclase system of...

journal_title：Life sciences

authors： Jenks BG,van Zoest ID,de Koning HP,Leenders HJ,Roubos EW

更新日期：1991-01-01 00:00:00

abstract：AIMS:The effects of chronic administration of Ferutinin (phytoestrogen found in the plants of genus Ferula), compared with those elicited by estradiol benzoate, were evaluated, following ovariectomy, on the uterus of ovariectomized rats as regard weight, size, structure and histomorphometry. MAIN METHODS:The experimen...

journal_title：Life sciences

authors： Ferretti M,Bertoni L,Cavani F,Benincasa M,Sena P,Carnevale G,Zavatti M,Viesti VD,Zanoli P,Palumbo C

更新日期：2012-01-16 00:00:00

abstract：:The concentration of epinephrine, norepinephrine, dopamine, met-enkephalin-, ACTH-, calcitonin- and somatostatin-like immunoreactivity (IR) were determined in the extracts of 9 adrenal pheochromocytomas from 7 patients. Six of these patients had Sipple's syndrome. There was a close correlation between the amounts of m...

journal_title：Life sciences

authors： Lamberts SW,Bons E,Oosterom R,Bruining H,de Greef WJ,Hackeng WH

更新日期：1984-07-23 00:00:00

abstract：:Rats were submitted to 110 dB white noise exposure for 1, and 6 hours and brain alpha 1, beta 1 and benzodiazepine receptor binding was evaluated with selective ligands. An increase in cerebral benzodiazepine receptor (CBR) concentration, without any significant change in affinity constant, occurred after the 6 h trea...

journal_title：Life sciences

authors： Breschi MC,Martini C,Scatizzi R,Cristofani R,Giannaccini G,Martinotti E,Lucacchini A

更新日期：1995-01-01 00:00:00

abstract：AIM:The present study aimed to understand the relationship between pharmacological activation of mGlu4 receptors and regulation of its gene in the hippocampus. MAIN METHODS:The expression level of the GRM4 gene, encoding mGluR4 receptors, was studied in the hippocampus and frontal cortex of rats after pharmacological ...

journal_title：Life sciences

authors： Pershina EV,Arkhipov VI

更新日期：2016-05-15 00:00:00

abstract：AIMS:Evidence has indicated U50,488H, a selective κ-opioid receptor (κ-OR) agonist, administered before ischemia attenuates apoptosis and infarction during ischemia and reperfusion (I/R). However, it remains unclear whether U50,488H postconditioning reduces apoptosis during I/R. This study was designed, therefore, to t...

journal_title：Life sciences

authors： Tong G,Sun Z,Wei X,Gu C,Kaye AD,Wang Y,Li J,Zhang Q,Guo H,Yu S,Yi D,Pei J

更新日期：2011-01-03 00:00:00

abstract：:The effects of free fatty acids in the blood on osmotic fragility and water content of erythrocytes when combined with hyperthermia were investigated. The isotonic buffer, containing the fatty acid, was added to the erythrocyte suspension to a final concentration of 200 microM/L. The samples were kept for one hour in ...

journal_title：Life sciences

authors： Kogawa H,Yabushita N,Nakajima T,Kageyama K

更新日期：1998-01-01 00:00:00

abstract：AIMS:This study was aimed to investigate the effect of Lycium barbarum polysaccharides (LBP) on renal function and inflammatory reaction in rabbits with diabetic nephropathy. MAIN METHODS:Diabetes was induced by injecting alloxan (ALX). Japanese male white rabbits were randomly assigned into 5 groups: normal control g...

journal_title：Life sciences

authors： Zhao Q,Li J,Yan J,Liu S,Guo Y,Chen D,Luo Q

更新日期：2016-07-15 00:00:00

abstract：:The mechanism of the generation and the quantitative analysis of singlet oxygen (1O2) formed by the exposure of a hematoporphyrin derivative (HpD) to light was re-evaluated by electron spin resonance (ESR) combined with 2,2,6,6,-tetramethyl-4-piperidine (TMPD). The change from TMPD to 2,2,6,6,-tetramethyl-4-piperidine...

journal_title：Life sciences

authors： Ando T,Yoshikawa T,Tanigawa T,Kohno M,Yoshida N,Kondo M

更新日期：1997-01-01 00:00:00

abstract：AIMS:Sodium nitrite is used to inhibit the growth of microorganisms and is responsible for the desirable red color of meat; however, it can be toxic in high quantities for humans and other animals. Moreover, glycogen, a branched polysaccharide, efficiently stores and releases glucose monosaccharides to be accessible fo...

journal_title：Life sciences

authors： Al-Gayyar MM,Alyoussef A,Hamdan AM,Abbas A,Darweish MM,El-Hawwary AA

更新日期：2015-01-01 00:00:00

abstract：:Oxytocin (OT) and arginine-8-vasopressin (AVP) were measured by radioimmunoassay in micropunched hypothalamic neurosecretory nuclei of estrous cycling female Sprague-Dawley rats. In the paraventricular nucleus (PVN): the concentration (pg/microgram protein) of OT was significantly higher in rats in diestrus than durin...

journal_title：Life sciences

authors： Greer ER,Caldwell JD,Johnson MF,Prange AJ Jr,Pedersen CA

更新日期：1986-06-23 00:00:00

abstract：:Lewis rats were trained to self-stimulate the medial forebrain bundle (MFB) using a rate-frequency paradigm. They were then tested for the effects of the cannabinoid receptor agonist CP 55,940, the selective cannabinoid receptor antagonist SR 141716 and the dopamine D1 receptor antagonist SCH 23390. CP 55,940 (0, 10, ...

journal_title：Life sciences

authors： Arnold JC,Hunt GE,McGregor IS

更新日期：2001-11-21 00:00:00

abstract：AIMS:Previous investigations by our group have shown that prenatal treatment with lipopolysaccharide (LPS; 100 μg/kg, intraperitoneally) on gestation day (GD) 9.5 in rats, which mimics infections by Gram-negative bacteria, induces short- and long-term behavioral and neuroimmune changes in the offspring. Because LPS ind...

journal_title：Life sciences

authors： Galvão MC,Chaves-Kirsten GP,Queiroz-Hazarbassanov N,Carvalho VM,Bernardi MM,Kirsten TB

更新日期：2015-01-01 00:00:00

abstract：:Chromogranin A (CgA) is an acidic protein co-released with catecholamines during exocytosis from sympathetic nerve terminals and chromaffin cells. Previous work has demonstrated that large scale perturbations in sympathetic nervous system (SNS) functioning result in corresponding changes in CgA levels in plasma. Littl...

journal_title：Life sciences

authors： Dimsdale JE,O'Connor DT,Ziegler M,Mills P

更新日期：1992-01-01 00:00:00

abstract：:Formation of etretinate, ethyl ester of acitretin, can be confirmed in vitro and in vivo using acitretin as the substrate. Etretinate was identified by LC/MS. The in vitro incubation was performed using rat and human liver 12,000 g supernatant, and the in vivo experiment was conducted in rats after oral dosing of acit...

journal_title：Life sciences

authors： Chou RC,Wyss R,Huselton CA,Wiegand UW

更新日期：1991-01-01 00:00:00

abstract：AIMS:To investigate the effects of curcumin on alveolar epithelial injury in a rat model of chronic obstructive pulmonary disease (COPD) and its potential mechanism. MAIN METHODS:The rat COPD model was established by cigarette smoke exposure combined with intratracheal administration of lipopolysaccharide. Thirty-eigh...

journal_title：Life sciences

authors： Zhang M,Xie Y,Yan R,Shan H,Tang J,Cai Y,Yin J,Chen M,Zhang J,Yang X,Zhang Q,Li Y

更新日期：2016-11-01 00:00:00

abstract：:The available preclinical literature on the antihyperlipidemic properties of beta-pyridylcarbinol is reviewed. Similarities between the pharmacological profiles for beta-pyridylcarbinol and nicotinic acid, and evidence for the metabolic conversion of beta-pyridylcarbinol to nicotinic acid are discussed. Several review...

journal_title：Life sciences

authors： Cohen M

更新日期：1985-11-25 00:00:00