The CRF-related peptide sauvagine stimulates and the GABAB receptor agonist baclofen inhibits cyclic-AMP production in melanotrope cells of Xenopus laevis.

abstract：:The melanocortins are a family of bioactive peptides derived from proopiomelanocortin. Those peptides, included among hormones and comprising ACTH, alpha-MSH, beta-MSH and gamma-MSH, are best known mainly for their physiological effects, such as the control of skin pigmentation by alpha-MSH, and ACTH effects on pigmen...

journal_title：Life sciences

authors： Starowicz K,Przewłocka B

更新日期：2003-07-04 00:00:00

abstract：:Tumor necrosis factor alpha (TNF-alpha) modulates various events through several different pathways. Many tumor cells are resistant to this cytokine. Pretreatment of these cells with actinomycin D enhances TNF-alpha-induced apoptosis. In the present study, we investigated the mechanism of this enhancement and whether ...

journal_title：Life sciences

authors： Nishida S,Yoshioka S,Kinoshita-Kimoto S,Kotani M,Tsubaki M,Fujii Y,Tomura TT,Irimajiri K

更新日期：2003-12-26 00:00:00

abstract：:In order to estimate the intestinal stability of ebiratide [H-Met(O2)-Glu-His-Phe-D-Lys-Phe-NH(CH2)8-NH2], a novel adrenocorticotropic hormone (ACTH) analogue, after oral administration, the hydrolytic properties of ebiratide were determined in the rat small intestinal fluid and mucosal homogenates. Ebiratide was extr...

journal_title：Life sciences

authors： Okagawa T,Fujita T,Murakami M,Yamamoto A,Shimura T,Tabata S,Kondo S,Muranishi S

更新日期：1994-01-01 00:00:00

abstract：:Previous studies showed that acute treatment with aminophylline (AMPY) significantly elevated maximum thermogenesis and improved cold tolerance in rats and man in severe cold. However, the exact mechanism by which AMPY enhances thermogenesis was unknown. Rats receiving enprofylline (ENPRO) (1.5 and 15 mg/kg, i.p.), a ...

journal_title：Life sciences

authors： Wang LC,Jourdan ML,Lee TF

更新日期：1989-01-01 00:00:00

abstract：:The recovery rate of striatal dopamine receptors following blockade by N-ethoxycarbonyl-2-ethoxy-1, 2-dihydroquinoline (EEDQ) in vivo is reduced by 25-35% in striata from senescent Wistar rats when compared to mature counterparts. No differences in binding affinity for [3H]-spiperone were observed for the different ag...

journal_title：Life sciences

authors： Henry JM,Roth GS

更新日期：1984-08-20 00:00:00

abstract：:Bromopride (BRO) and domperidone (DOMP) are dopamine D2 blocking agents used in gastroenterology clinics because of their anti emetic effect as well as their central and peripheral actions of increasing gastrointestinal motor activity. The rationale for these experiments was to compare BRO- and DOMP-effects on plasma,...

journal_title：Life sciences

authors： Nasello AG,Gidali D,de Sá-Rocha LC,Felicio LF

更新日期：1995-01-01 00:00:00

abstract：:Matrikines, peptides originating from the fragmentation of extracellular matrix proteins are identified to play important role in both health and disease. They possess biological activities, much different from their parent protein. Identification of such bioactive cryptic regions in the extracellular matrix proteins ...

journal_title：Life sciences

authors： Sivaraman K,Shanthi C

更新日期：2018-12-01 00:00:00

abstract：:This study was undertaken to compare the activity of muscarinic and beta adrenergic receptors in bovine peripheral lung to the corresponding receptor activity in tracheal smooth muscle. We used [3H] quinuclidinyl benzilate (QNB) and [3H]dihydroalprenolol (DHA) to measure muscarinic and beta receptor activity, respecti...

journal_title：Life sciences

authors： Cheng JB,Townley RG

更新日期：1982-06-14 00:00:00

abstract：:Danshen, a Chinese herbal medicine has been widely used for the treatment of cardiovascular diseases. Magnesium tanshinoate B (MTB) is an active compound purified from Danshen. The objective of this study was to investigate the effect of MTB on the susceptibility of low density lipoproteins (LDL) to oxidative modifica...

journal_title：Life sciences

authors： O K,Lynn EG,Vazhappilly R,Au-Yeung KK,Zhu DY,Siow YL

更新日期：2001-01-12 00:00:00

abstract：AIMS:Microvascular endothelial cell dysfunction is a leading cause of radiation-induced heart disease (RIHD). BRCA1 plays an important role in DNA damage repair. The study aims to explore the effect of BRCA1 in endothelial cells involved in RIHD. MATERIALS AND METHODS:BRCA1 and p21 expression were detected in human um...

journal_title：Life sciences

authors： Zeng ZM,Du HY,Xiong L,Zeng XL,Zhang P,Cai J,Huang L,Liu AW

更新日期：2020-03-01 00:00:00

abstract：AIMS:Right ventricular failure (RVF) varies significantly from the more common left ventricular failure (LVF). This study was undertaken to determine potential molecular pathways that are important in human right ventricular (RV) function and may mediate RVF. MATERIALS AND METHODS:We analyzed mRNA of human non-failing...

journal_title：Life sciences

authors： Williams JL,Cavus O,Loccoh EC,Adelman S,Daugherty JC,Smith SA,Canan B,Janssen PML,Koenig S,Kline CF,Mohler PJ,Bradley EA

更新日期：2018-03-01 00:00:00

abstract：:10(-4) M ouabain increases aldosterone production at 3.6 and 5.4 mM potassium concentrations, whereas at high potassium concentration (7 mM) even lower concentration of ouabain (10(-8) M) decreases it. As ouabain has been shown to be produced by the adrenal cortex, a local paracrine regulation of aldosterone productio...

journal_title：Life sciences

authors： Szalay KS

更新日期：1993-01-01 00:00:00

abstract：AIMS:Cortisol is a glucocorticoid in mammals, but has both gluco- and mineralocorticoid activities in teleost fish. Our previous in vivo studies on osmoregulatory esophagi of euryhaline fish showed that epithelial apoptosis for the simple epithelium in seawater and cell proliferation for the stratified epithelium in fr...

journal_title：Life sciences

authors： Takagi C,Takahashi H,Kudose H,Kato K,Sakamoto T

更新日期：2011-01-31 00:00:00

abstract：:The opiate antagonist naloxone was found to block nitrous oxide analgesia in a stereospecific fashion. Using a modified hotplate test in mice, the (-)-enantiomer of naloxone (which has a KD of approximately 1 nM for opiate receptors) antagonized the analgesic actions of nitrous oxide in a dose-dependent (2.5-20 mg/kg)...

journal_title：Life sciences

authors： Moody EJ,Mattson M,Newman AH,Rice KC,Skolnick P

更新日期：1989-01-01 00:00:00

abstract：:SARS-CoV-2 infection or COVID-19 has become a worldwide pandemic; however, effective treatment for COVID-19 remains to be established. Along with acute respiratory distress syndrome (ARDS), new and old cardiovascular injuries are important causes of significant morbidity and mortality in COVID-19. Exploring new approa...

journal_title：Life sciences

authors： Wang SC,Wang YF

更新日期：2021-01-26 00:00:00

abstract：AIMS:To investigate the effects of high doses of pentazocine on antinociception induced by a high dose of morphine and the role of the kappa-opioid receptors (KORs) in these effects in mice. MAIN METHODS:Sixty-six C57BL/6J mice were pretreated with a KOR antagonist, nor-binaltorphimine (nor-BNI) (10mg·kg(-1)), or a no...

journal_title：Life sciences

authors： Shu H,Wang Z,Ye F,Li Q,Dou Y,Lin Y,Huang W,Xiao X

更新日期：2015-06-01 00:00:00

abstract：:In this study, we determined the expression of protein kinase C (PKC) isoforms during pregnancy. At pregnant duration, PKC alpha was down-modulated in the deciduomata but not in the myometrium. Down-modulation was compatible with the increase in cell mitosis, which reached a maximum at 8-9 days. On the other hand, PKC...

journal_title：Life sciences

authors： Shyu JC,Hsieh YS,Chang CL,Tsai CC,Liu HC,Chang AC,Yang LC,Lin LY,Liu JY

更新日期：1999-01-01 00:00:00

abstract：:Three neurodegenerative diseases, Huntington's disease (HD), Kennedy's disease (hereditary spinobulbar muscular atrophy, SBMA), and type 1 spinocerebellar ataxia (SCA-1) have been found to share a common genetic defect: an unstable region of repeated CAG trinucleotides which are thought to be translated into a polyglu...

journal_title：Life sciences

authors： Cha JH,Dure LS 4th

更新日期：1994-01-01 00:00:00

abstract：:Insulin therapy remains the standard of care for achieving and maintaining adequate glycemic control, especially in hospitalized patients with critical and noncritical illnesses. Insulin therapy is more effective against elevated fasting glycaemia but less in the reduction of postprandial hyperglycaemia. It is associa...

journal_title：Life sciences

authors： Bavec A

更新日期：2014-03-18 00:00:00

abstract：:The present study investigated the effects of nitric oxide synthase (NOS) inhibitors on the seizure threshold of DMCM in mice. The seizure threshold of DMCM was evaluated using an intravenous infusion technique. The threshold of DMCM was significantly decreased by pretreatment with N-nitro-L-arginine (NOARG; 8 mg/kg) ...

journal_title：Life sciences

authors： Tsuda M,Suzuki T,Misawa M

更新日期：1997-01-01 00:00:00

abstract：:In recent years, natural products have increasingly attracted more attention because of their potential anticancer activity and low intrinsic toxicity. Hispidulin is a natural flavonoid with a wide range of biological activities, including anti-inflammatory, antifungal, antiplatelet, anticonvulsant, anti-osteoporotic,...

journal_title：Life sciences

authors： Liu K,Zhao F,Yan J,Xia Z,Jiang D,Ma P

更新日期：2020-10-15 00:00:00

abstract：AIMS:Resveratrol (Res) which is a polyphenolic phytoalexin, has various biological properties. In the present study, we investigated whether Res extracted from Polygonum cuspidatum can reduce oxidative damage and cognitive impairment in senescence-accelerated mouse (SAM). MAIN METHODS:Senescence-accelerated mice were ...

journal_title：Life sciences

authors： Liu GS,Zhang ZS,Yang B,He W

更新日期：2012-10-29 00:00:00

abstract：:To examine the therapeutic effect of 4-(o-benzylphenoxy)-N-methylbutylamine hydrochloride (bifemelane) on neuronal ischemia-reperfusion injury, we evaluated the neurological score in gerbils subjected to unilateral common carotid occlusion. Using the neurological score method, we selected animals which showed stroke s...

journal_title：Life sciences

authors： Hata R,Matsumoto M,Kitagawa K,Tagaya M,Matsuyama T,Sugita M,Kamada T

更新日期：1995-01-01 00:00:00

abstract：:We administered intravenous adenosine to 11 neonatal rabbits. Adenosine depressed respiration in 10 of 11 rabbits. For the group as a whole the adenosine-induced respiratory depression was highly significant (p less than 0.001). After aminophylline administration to the same animals the respiratory effect of intraveno...

journal_title：Life sciences

authors： Watt AH,Buss DC,Routledge PA

更新日期：1987-01-05 00:00:00

abstract：:Quinolinic acid (QUIN) levels are elevated in patients and animals suffering from chronic infectious diseases. In the present study, male Sprague-Dawley rats were used to test the anti-inflammatory effects of QUIN using the carrageenan (CGN)-induced paw edema assay and the CGN sponge assay. Results of these studies in...

journal_title：Life sciences

authors： Heyliger SO,Mazzio EA,Soliman KF

更新日期：1999-01-01 00:00:00

abstract：:This paper describes the use of complex liposomes as real membrane models to evaluate the potential benefits of several antioxidants in relation to lipid peroxidation. The xanthine oxidase/Fe(3+)-ADP-EDTA and the Fe(2+)/H2O2 systems have been used to generate hydroxyl radicals and the water soluble azo-compound 2,2'-a...

journal_title：Life sciences

authors： Gutiérrez ME,García AF,Africa de Madariaga M,Sagrista ML,Casadó FJ,Mora M

更新日期：2003-04-11 00:00:00

abstract：:The present study was to test whether the recently described endogenous ligand for the cannabinoid receptor; arachidonyl-ethanolamide (anandamide, ANA), may produce similar effects on pregnancy as the main psychoactive component of marihuana: delta9-tetrahydrocannabinol (THC) in rats. ANA, THC (0.02 mg/kg i.p./day, re...

journal_title：Life sciences

authors： Wenger T,Fragkakis G,Giannikou P,Probonas K,Yiannikakis N

更新日期：1997-01-01 00:00:00

abstract：:It has been reported that while bacteria and higher plants possess two different pathways for the biosynthesis of putrescine, via ornithine decarboxylase (ODC) and arginine decarboxylase (ADC); the fungi, like animals, only use the former pathway. We found that contrary to the earlier reports, two of the phytopathogen...

journal_title：Life sciences

authors： Khan AJ,Minocha SC

更新日期：1989-01-01 00:00:00

abstract：:The involvement of atriopeptin in hypertension was investigated in spontaneously hypertensive rats (SHR). It was found that intravenous injection of atriopeptin III (20-80 nmol/kg) markedly decreased the mean arterial pressure in anesthetized SHR in a dose dependent manner. The heart rate was not significantly affecte...

journal_title：Life sciences

authors： Xie CW,Song DL,Ding JF,Chang JK,Chang D,Tang J

更新日期：1986-03-17 00:00:00

abstract：:The effects of isolation and water scheduling on mitogen induced lymphocyte proliferation were investigated. Isolated rats were animals which had been raised in group-housed conditions and then transferred to individual cages with ad lib access to water for a 1 or 2 week period. Water scheduled rats were maintained in...

journal_title：Life sciences

authors： Jessop JJ,Gale K,Bayer BM

更新日期：1988-01-01 00:00:00