Abstract:
:Matrikines, peptides originating from the fragmentation of extracellular matrix proteins are identified to play important role in both health and disease. They possess biological activities, much different from their parent protein. Identification of such bioactive cryptic regions in the extracellular matrix proteins has attracted the researchers all over the world in the recent decade. These bioactive peptides could find use in preparation of biomaterials and tissue engineering applications. Matrikines identified in major extracellular matrix (ECM) proteins like collagen, elastin, fibronectin, and laminin are being extensively studied for use in tissue engineering and regenerative medicine. They are identified to modulate cellular activity like cell growth, proliferation, migration and may induce apoptosis. RGD, a well-known peptide identified in fibronectin with cell adhesive property is being investigated in designing biomaterials. Collagen hexapeptide GFOGER was found to promote cell adhesion and differentiation. Laminin also possesses regions with strong cell adhesion property. Recently, cell-penetrating peptides from elastin are used as a targeted delivery system for therapeutic drugs. The continued search for cryptic sequences in the extracellular matrix proteins along with advanced peptide coupling chemistries would lead to biomaterials with improved surface properties. This review article outlines the peptides derived from extracellular matrix and some of the possible applications of these peptides in therapeutics and tissue engineering applications.
journal_name
Life Scijournal_title
Life sciencesauthors
Sivaraman K,Shanthi Cdoi
10.1016/j.lfs.2018.10.056subject
Has Abstractpub_date
2018-12-01 00:00:00pages
22-33eissn
0024-3205issn
1879-0631pii
S0024-3205(18)30682-9journal_volume
214pub_type
杂志文章,评审相关文献
LIFE SCIENCES文献大全abstract:AIMS:Toll-like receptor (TLR)9 ligand CpG-oligodeoxynucleotide (CpG-ODN) exerts preconditioning in myocardial ischemia/reperfusion. We hypothesized a postconditioning effect of CpG-ODN in a murine closed-chest model of myocardial infarction. MATERIALS AND METHODS:C57BL/6 (12 weeks, male, WT) mice were instrumented at ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2014.09.029
更新日期:2014-12-05 00:00:00
abstract::Hemi-pituitary glands of ovariectomized rats were superfused for 4 h with either LHRH or the analog buserelin (HOE 766) at several concentrations, and thereafter with medium only for another 1.5 h. In a further experiment glands were exposed for 2.5 h to LHRH or buserelin at a single concentration (5 ng/ml) and subseq...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(86)90524-2
更新日期:1986-08-04 00:00:00
abstract:AIM:Cadmium is a persistent ubiquitous environmental toxicant that elicits several biological defects on delicate body organs. Growing evidence suggests that cadmium (Cd) may perturb signaling pathways to induce oxidative pancreatitis. Thus, we explored whether hesperidin, a flavonone, could mitigate Cd-induced oxidati...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2020.118268
更新日期:2020-10-15 00:00:00
abstract::The effects of the tricyclic antidepressant imipramine (20 mg/kg) and the beta-adrenoceptor agonist clenbuterol (0.5 mg/kg) on the serum concentrations of tyrosine, tryptophan, glucose and insulin were compared 30 min after intraperitoneal injection. The drugs had nearly identical effects on serum tyrosine, which was ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(90)90621-w
更新日期:1990-01-01 00:00:00
abstract::XY99-5038 is a preparation from a specific formula provided by Dr. Yan Xin, a renowned Traditional Chinese Medicine specialist. This formulation has proven to be effective without side effects but has not been studied under rigorous laboratory conditions. In order to investigate the role of XY99-5038 in protecting neu...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(01)01122-5
更新日期:2001-06-08 00:00:00
abstract:AIMS:The study aimed to investigate the protective effect of chronic intermittent hypobaric hypoxia (CIHH) on endothelium function and relaxation of mesenteric artery in metabolism syndrome (MS) rats. MAIN METHODS:Male adult Sprague-Dawley rats were randomly divided into control (CON), CIHH (treated with 28-days hypob...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2018.05.008
更新日期:2018-07-15 00:00:00
abstract:BACKGROUND:Gastric cancer is a severe disease with a high occurrence rate worldwide. And lncRNAs are demonstrated to be responsible for cancer growth and metastasis. So, it is of great importance to explore the lncRNAs involved mechanism of gastric cancer occurrence and development deeply. METHODS:Transfection was con...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2020.117478
更新日期:2020-05-15 00:00:00
abstract:AIMS:The aims of this study were to evaluate the effects of p62/SQSTM1 expression levels on lipopolysaccharide (LPS)-induced mucus secretion in BEAS-2B bronchial epithelial cells by measuring expression levels of the MUC5AC gene and the Mucin-5AC (MUC5AC) protein. MATERIALS AND METHODS:Bronchial epithelial cells, BEAS...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2018.09.030
更新日期:2018-10-15 00:00:00
abstract::Inositol hexaphosphate (InsP6 or IP6) is ubiquitous. At 10 microM to 1 mM concentrations, IP6 and its lower phosphorylated forms (IP(1-5)) as well as inositol (Ins) are contained in most mammalian cells, wherein they are important in regulating vital cellular functions such as signal transduction, cell proliferation a...
journal_title:Life sciences
pub_type: 杂志文章,评审
doi:10.1016/s0024-3205(97)00092-1
更新日期:1997-01-01 00:00:00
abstract::The discovery and development of new drugs targeting voltage-gated ion channels are important for treating a variety of medical conditions and diseases. Ion channels are molecular nanostructures expressed ubiquitously throughout the whole body, and are involved in many basic physiological processes. Over the years, na...
journal_title:Life sciences
pub_type: 杂志文章,评审
doi:10.1016/j.lfs.2011.04.020
更新日期:2011-10-10 00:00:00
abstract::There is evidence that senescence affects neurotransmission at different levels. In particular, this review summarizes the studies on age-dependent modifications in protein phosphorylation, which represents the final pathway in the action of transmitters and hormones at neuronal level. Cyclic AMP-dependent protein kin...
journal_title:Life sciences
pub_type: 杂志文章,评审
doi:10.1016/0024-3205(91)90492-t
更新日期:1991-01-01 00:00:00
abstract::The behavioral response induced by the intravesical instillation of capsaicin has been investigated in catheter-implanted, freely moving, conscious male and female rats. Intravesical instillation of capsaicin (25 nmol/rat in 0.5 ml) evoked an intense licking directed toward the lower abdominal and perineal skin which ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(94)90054-x
更新日期:1994-01-01 00:00:00
abstract::Daily s.c. injection of (-)deprenyl (2.0 mg/kg/day) for three weeks in young male rats caused a threefold increase in superoxide dismutase (SOD) activity in the striatum of the brain compared with the value in saline-injected control rats. Furthermore, the activity of catalase (but not of glutathione peroxidase) was a...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(91)90466-o
更新日期:1991-01-01 00:00:00
abstract::Using a ligation method, rat rectal epithelium was exposed to 2% sodium salicylate, and light and electron microscopic methods were used to assay for: 1) permeability of the epithelium to a marker dye, trypan blue, and 2) damage expressed in terms of disruption of the epithelial surface. Rectal mucosa was exposed to s...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(83)90656-2
更新日期:1983-09-12 00:00:00
abstract::Extracts of Hypericum perforatum (St. John's wort) have antidepressant properties in depressed patients and exert antidepressant-like action in laboratory animals. The phloroglucinol derivative hyperforin has become a topic of interest, as this Hypericum component is a potent inhibitor of monoamines reuptake. The mole...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(03)00295-9
更新日期:2003-06-13 00:00:00
abstract::To determine how protein kinase C (PKC) activity influences properties of the tetrodotoxin-resistant sodium current (TTX-R I(Na)) in neonatal rat nodose ganglion (NG) neurons, we assessed the effects of phorbol,-12-myristate,13-acetate (PMA), one of the PKC activators, and staurosporine, one of the PKC inhibitors, on ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2005.04.053
更新日期:2005-11-19 00:00:00
abstract:AIMS:Sepsis is a major cause of morbidity and mortality in the elderly population. In prior studies, we have shown that in vivo, the inflammatory response in aged animals is exaggerated as compared to young animals and that this response likely accounts for the increased morbidity and mortality. Part of this uncontroll...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2010.03.009
更新日期:2010-05-08 00:00:00
abstract::Aberrant methylation of promoter CpG islands (CGIs) can inactivate the expression of many tumor suppressor genes and play an important role in the carcinogenesis of gastric cancer. The tumor suppressor gene RB1, which encodes a cell cycle regulator, is hypermethylated and downregulated in multiple kinds of cancer. Act...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2020.118580
更新日期:2020-12-15 00:00:00
abstract:AIMS:Transient ischemia of osteoporotic bones during elective orthopedic surgery or fracture repair carries risks for serious complications, and estrogen loss or replacement has a potential to influence ischemia-reperfusion-induced inflammatory activation. To clarify this, we investigated the periosteal inflammatory ch...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2010.11.004
更新日期:2011-01-17 00:00:00
abstract::The ontogeny of endothelin (ET) system in rats was studied in preterm (18 days of gestation), term (21 days of gestation) and 1 week post term rats. Brains were dissected out and (1) processed for the estimation of endogenous ET-1 by RIA and (2) membranes were prepared for radioreceptor binding. Receptor characteristi...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(92)90300-e
更新日期:1992-01-01 00:00:00
abstract::The substituted glucopyranose ring structure 2-hydroxypropyl-beta-cyclodextrin (CDEX) increases the solubility of molecules by inclusion of the agent in the lipophilic interior of the ring. This property is of particular use for the administration of molecules by the intracerebral (ICV) or intrathecal (IT) routes. In ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(91)90537-l
更新日期:1991-01-01 00:00:00
abstract::Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by symptoms that include social communication impairments, interaction deficits, and repetitive and stereotyped behaviors. Recent studies have suggested that imbalanced cytokine levels are associated with impaired behavioral outcomes in ind...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2019.116930
更新日期:2019-11-15 00:00:00
abstract::Muscarinic agonists elicit contraction in the standard guinea pig ileum bioassay through activation of M3 muscarinic receptors that are also linked to phosphoinositide hydrolysis. Surprisingly, the most abundant muscarinic receptor in the ileum is the M2 which causes a specific inhibition of cyclic AMP accumulation el...
journal_title:Life sciences
pub_type: 杂志文章,评审
doi:10.1016/0024-3205(94)00035-q
更新日期:1995-01-01 00:00:00
abstract:AIMS:This study investigates the effect of a new combination of glucosamine hydrochloride, chondroitin sulfate, methylsulfonylmethane, Harpagophytum procumbens root extract (standardized to 3% harpagoside) and bromelain extract (GCMHB) on formalin-induced damage to cartilage tissue in the rat knee joint and evaluates t...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2015.03.012
更新日期:2015-06-01 00:00:00
abstract::We have investigated the antidiabetic activity of luteolin 5-rutinoside in streptozotocin(STZ)-induced diabetic rats. Treatment for 20 days with 2 mg/kg increased both pancreatic insulin and DNA content. When both luteolin 5-rutinoside (2 mg/kg) and glibenclamide (1 mg/kg) were administered concurrently to STZ-diabeti...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(96)00231-7
更新日期:1996-01-01 00:00:00
abstract::Single unit recordings were obtained from putative dopaminergic neurons in the substantia nigra of awake, freely moving rats. The cells exhibited waveforms, range of firing rates and types of firing patterns identical to those of identified DA neurons of anesthetized or paralyzed rats. Two firing patterns were observe...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(85)90448-5
更新日期:1985-05-20 00:00:00
abstract::The effects of vasoactive intestinal peptide (VIP)-ellipticine (E) derivatives were investigated on breast cancer cells. VIP-ALALA-E and VIP-LALA-E inhibited 125I-VIP binding to MCF-7 cells with an IC(50) values of 1 and 0.2 microM respectively. VIP-ALALA-E and VIP-LALA-E caused elevation of cAMP in MCF-7 cells with E...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(02)01741-1
更新日期:2002-07-19 00:00:00
abstract::Peroxisome proliferator-activated receptor (PPAR) and retinoid x receptor (RXR) play important roles in fatty acid metabolism. The present study examined the regulation of retinoic acid receptor (RAR alpha, beta, and gamma), RXR (alpha, beta, and gamma), PPAR, cytochrome P450 2E1 (CYP2E1), catalase, and beta-actin gen...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(94)00953-8
更新日期:1995-01-01 00:00:00
abstract::Several experiments were conducted to evaluate the effects of chronic amphetamine on the influenza A (PR-8/34) virus specific immune injury in CD-1 mice. Treatment with amphetamine resulted in a significant increase of lung virus titers and pulmonary vascular permeability. Amphetamine also increased the lethality of i...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(93)90520-d
更新日期:1993-01-01 00:00:00
abstract::Epinephrine (E) infusions raise blood pressure and there is an excess incidence of hypertension among males and blacks. However, reports of E levels by ethnicity, gender, and blood pressure status are inconsistent. Insensitive assays, variability in plasma E levels within individuals, and the small size of most studie...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(00)00568-3
更新日期:2000-05-05 00:00:00