The effect of PKC activity on the TTX-R sodium currents from rat nodose ganglion neurons.

abstract：:Defects in the mitochondrial genome have been associated with Parkinson's and Alzheimer's disease, and apoptosis can be triggered by the presence of energetically compromised mitochondria. Thus, in this study we have examined whether the divalent cations Cu2+ and Mn2+ could influence mitochondrial function in vitro. M...

journal_title：Life sciences

authors： Heron P,Cousins K,Boyd C,Daya S

更新日期：2001-02-23 00:00:00

abstract：:Several antihistamines were evaluated for their ability to interact with sigma, muscarinic and histaminic H1 binding sites in rat brain preparations. All of the antihistamines were able to interact with the sigma site, as well as the other two sites. In addition, tripelennamine was found to elicit sigma-like behaviors...

journal_title：Life sciences

authors： Gray NM,Contreras PC,Allen SE,Taylor DP

更新日期：1990-01-01 00:00:00

abstract：BACKGROUND:Cardiovascular disease (CVD) is the leading cause of mortality worldwide. Cardiac fibrosis is the scarring process occurs commonly with CVDs impairing the function and structure of heart. Herein, we investigated the role of circPAN3 in the pathogenesis of cardiac fibrosis. METHODS:A rat myocardial infarctio...

journal_title：Life sciences

authors： Li F,Long TY,Bi SS,Sheikh SA,Zhang CL

更新日期：2020-09-15 00:00:00

abstract：:By using multiple time-point constant-rate infusions of deuterium-labeled phosphorylcholine, appropriate kinetic parameters were obtained for use in the calculation of the turnover rate of acetylcholine (TRACh) in selected mouse brain regions. After obtaining these data, the relationship between the analgesic agent co...

journal_title：Life sciences

authors： Chen R,Robinson SE

更新日期：1992-01-01 00:00:00

abstract：AIMS:We previously found that paeoniflorin, a major constituent of Paeonia lactiflora Pall, could induce heat shock proteins (HSPs) in cultured mammalian cells without apparent toxicity (Yan et al. 2004). We here investigated the induction of HSPs by paeoniflorin in mouse stomach and the effect of paeoniflorin on the H...

journal_title：Life sciences

authors： Asai M,Kawashima D,Katagiri K,Takeuchi R,Tohnai G,Ohtsuka K

更新日期：2011-02-14 00:00:00

abstract：:XY99-5038 is a preparation from a specific formula provided by Dr. Yan Xin, a renowned Traditional Chinese Medicine specialist. This formulation has proven to be effective without side effects but has not been studied under rigorous laboratory conditions. In order to investigate the role of XY99-5038 in protecting neu...

journal_title：Life sciences

authors： Xin Y,Fong YT,Wolf G,Wolf D,Cao W

更新日期：2001-06-08 00:00:00

abstract：:Although several reports imply that anticoagulants and preservatives contain zinc, the quantity of zinc in heparin, if any, has not been documented. Zinc concentration was determined by flame atomic absorption spectroscopy in varying dilutions of multiple commercially obtained samples of purified sodium heparin N = 15...

journal_title：Life sciences

authors： Gervin CA,Gervin AS,Nichols W,Corrigan JJ Jr

更新日期：1983-12-26 00:00:00

abstract：:Following a report that nortriptyline was found useful in the control of enuresis in adults, presumably as an anticholinergic, its likely mechanism of action and apparent bladder specificity have now been investigated in vitro. The ratios of anticholinergic potencies (reciprocal of dissociation contents, Ki) for four ...

journal_title：Life sciences

authors： Rehavi M,Weiss H,Nissenkorn I,Rubinstein R,Cohen S

更新日期：1987-05-04 00:00:00

abstract：:The present study investigated the protective actions of the antioxidant scutellarin against the cytotoxicity produced by exposure to H2O2 in PC12 cells. This was done by assaying for MTT (3,(4,5-dimethylthiazole-2-yl)2,5-diphenyl-tetrazolium bromide) reduction and lactate dehydrogenase (LDH) release. Reactive oxygen ...

journal_title：Life sciences

authors： Hong H,Liu GQ

更新日期：2004-04-30 00:00:00

abstract：:The plasma concentration of the dopamine (DA) metabolite, homovanillic acid (HVA), is used as an indicator of central nervous system dopaminergic activity. Using percutaneously inserted catheters we were able to obtain blood samples simultaneously from the right and left internal jugular veins. Veno-arterial HVA plasm...

journal_title：Life sciences

authors： Lambert GW,Eisenhofer G,Cox HS,Horne M,Kalff V,Kelly M,Jennings GL,Esler MD

更新日期：1991-01-01 00:00:00

abstract：:The discovery and development of new drugs targeting voltage-gated ion channels are important for treating a variety of medical conditions and diseases. Ion channels are molecular nanostructures expressed ubiquitously throughout the whole body, and are involved in many basic physiological processes. Over the years, na...

journal_title：Life sciences

authors： de Araújo DA,Freitas C,Cruz JS

更新日期：2011-10-10 00:00:00

abstract：:Initial acute behavioral studies in mice indicated that phencyclidine (PCP) produced marked motor impairment as measured by the inverted screen technique with an ED50 value of 4.1 muMole/kg (i.v.). Phenylcyclohexene (PC) was considerably less active with an ED50 value of 325 muMole/kg (i.v.). PCP was also shown to be ...

journal_title：Life sciences

authors： Holsapple MP,Munson AE,Freeman AS,Martin BR

更新日期：1982-08-23 00:00:00

abstract：:In rodents an action of estrogen is required for the initiation of implantation of the blastocyst into the endometrium of a progesterone-primed uterus. Thus removal of endogenous estrogen, either directly by ovariectomy or indirectly by hypophysectomy, prevents implantation in the pregnant rat. In the present study, d...

journal_title：Life sciences

authors： Johnson DC

更新日期：1996-01-01 00:00:00

abstract：:Osteoarthritis (OA) is a complex joint disorder with a number of underlying physical, biochemical, biomechanical and genetic causes. Obesity is considered to be one of the major risk factors for the development and progression of OA. It actively contributes to the inflammatory status and to cartilage degradation in th...

journal_title：Life sciences

authors： Scotece M,Mobasheri A

更新日期：2015-11-01 00:00:00

abstract：AIMS:Asymmetric dimethylarginine (ADMA), an endogenous nitric oxide synthase inhibitor, has been reported to be a novel marker for the progression of chronic kidney disease (CKD). We have recently found that accumulation of ADMA could trigger peritubular capillary loss, thus contributing to tubulointerstitial ischemia ...

journal_title：Life sciences

authors： Ueda S,Yamagishi S,Matsumoto Y,Kaida Y,Fujimi-Hayashida A,Koike K,Tanaka H,Fukami K,Okuda S

更新日期：2009-06-05 00:00:00

abstract：:A novel bioactive lipid, cyclic phosphatidic acid (cPA), was identified in lipids bound to human serum albumin. A cPA fraction was extracted and purified from human serum albumin by use of a combination of preparative TLC and HPLC. Electrospray ionization mass spectrometry of the purified fraction showed molecular ion...

journal_title：Life sciences

authors： Kobayashi T,Tanaka-Ishii R,Taguchi R,Ikezawa H,Murakami-Murofushi K

更新日期：1999-01-01 00:00:00

abstract：AIMS:Extensive evidence supports a role for voltage-gated calcium channels (VGCC) and TRPV1 receptors in pain transmission and modulation. We investigated the profile of analgesic interaction between Phα1β toxin (a VGCC blocker) and SB366791 (selective TRPV1 antagonist) in a model of acute pain induced by capsaicin. Ch...

journal_title：Life sciences

authors： Palhares MR,Silva JF,Rezende MJS,Santos DC,Silva-Junior CA,Borges MH,Ferreira J,Gomez MV,Castro-Junior CJ

更新日期：2017-08-01 00:00:00

abstract：:SGK1 is one of the protein-serine/threonine kinases that is activated by insulin in a PI3K-dependent manner. Although SGK1 mediates a variety of biological activities, the mechanisms regulating its activity remain unclear. In this study, we examined the potential roles of calcium signaling in the activation of SGK1. T...

journal_title：Life sciences

authors： Imai S,Okayama N,Shimizu M,Itoh M

更新日期：2003-04-04 00:00:00

abstract：:Four Rhesus monkeys were subjected to daily administration of 2.5 mg of tetrahydrocannabinol (THC)/kg body wt, after establishing the norms for complete blood count, T- and B-cell concentrations, and the dose response of thymidine incorporation after PHA stimulation. THC was administered daily for 3 weeks, the treatme...

journal_title：Life sciences

authors： Silverman AY,Darnell BJ,Montiel MM,Smith CG,Asch RH

更新日期：1982-01-04 00:00:00

abstract：:Because of the low selectivity of available ligands, pharmacological approaches to elucidate the functional difference among muscarinic acetylcholine receptor (mAChR) subtypes have been problematic. As an alternative approach, we have established a series of mutant mouse lines deficient in each mAChR subtype (mAChR KO...

journal_title：Life sciences

authors： Matsui M,Yamada S,Oki T,Manabe T,Taketo MM,Ehlert FJ

更新日期：2004-11-05 00:00:00

abstract：AIMS:Transplantation of bone marrow mononuclear cells (BMMCs) exerts neuroprotection against cerebral ischemia. We examined the therapeutic timepoint of allogeneic BMMC transplantation in a rat model of focal cerebral ischemia, and determined the effects of repeated transplantation outside the therapeutic window. MAIN...

journal_title：Life sciences

authors： Kamiya F,Ueda M,Nito C,Kamiya N,Inaba T,Suda S,Saito T,Muraga K,Katayama Y

更新日期：2014-01-24 00:00:00

abstract：:There is a significant need to evaluate the therapeutic potential of natural products and other compounds purported to be hepatoprotective. Acetaminophen-induced liver injury, especially in mice, is an attractive and widely used model for this purpose because it is both clinically relevant and experimentally convenien...

journal_title：Life sciences

authors： Jaeschke H,McGill MR,Williams CD,Ramachandran A

更新日期：2011-04-25 00:00:00

abstract：:Recent studies have shown that acyl-CoA:cholesterol acyltransferase (ACAT) plays an important role in the initiation of diabetes-associated hypercholesterolemia. To confirm this hypothesis, effects of a potent ACAT inhibitor, FR145237, on diet-induced hypercholesterolemia were examined in streptozotocin (STZ)-induced ...

journal_title：Life sciences

authors： Sakuma Y,Hagihara H,Nagayoshi A,Ohne K,Mutoh S,Ito Y,Nakahara K,Notsu Y,Okuhara M

更新日期：1997-01-01 00:00:00

abstract：:An improved two-dimensional HPTLC procedure was developed for separating phospholipids including individual phosphoinositides, phosphatidic acids and plasmalogens. This procedure was used to examine the time course for uptake of label by phospholipids in brain subcellular membranes after intracerebral injection of [ga...

journal_title：Life sciences

authors： Sun GY,Lin TN

更新日期：1989-01-01 00:00:00

abstract：:Rats, trained to discriminate 1.5 mg/kg of the hallucinogenic agent 5-methoxy-N,N-dimethyltryptamine (5-OMe DMT) from saline in a two-lever drug discrimination task, were challenged with various doses of the 4-methoxy, 4-methylthio and 5-methylthio derivatives of DMT. The 5-OMe DMT cue was found to generalize to all t...

journal_title：Life sciences

authors： Glennon RA,Young R,Benington F,Morin RD

更新日期：1982-02-01 00:00:00

abstract：:The effect of fluoride ion on the binding of the specific muscarinic agonist ligand [3H]cis methyldioxolane ([3H]CD) to the mouse cardiac muscarinic receptor was investigated. Utilizing equilibrium ligand binding experiments, sodium fluoride (10mM) was shown to decrease [3H]CD binding, measured at a concentration of 2...

journal_title：Life sciences

authors： Barritt D,Yamamura HI,Roeske WR

更新日期：1982-03-08 00:00:00

abstract：:The effects of elevated glucose and aldose reductase inhibitor (ARI:ONO-2235) on nitric oxide (NO) production in cultured human umbilical endothelial cells (HUVEC) were evaluated. Aldose reductase and nitric oxide synthase(NOS) share NADPH as an obligate cofactor, therefore it is suggested that the enhanced of glucose...

journal_title：Life sciences

authors： Okuda Y,Kawashima K,Suzuki S,Asakura Y,Asano M,Tsurumaru K,Dai H,Tachi Y,Bannai C,Saitoh M,Yamashita K

更新日期：1997-01-01 00:00:00

abstract：:Hypotensive responses to tryptophan and 5-hydroxytryptophan infusions were studied in normotensive male Sprague-Dawley rats. Results showed that 5-hydroxytryptophan but not tryptophan lowered pressure in a dose dependent way in direct relation to the production of brain serotonin and 5-HIAA. Intrinsic release of serot...

journal_title：Life sciences

authors： Freed CR,Echizen H,Bhaskaran D

更新日期：1985-11-11 00:00:00

abstract：AIMS:Hypercholesterolemia is a hazard for increasing susceptibility of the heart to myocardial infarction (MI) by inducing platelet hyperaggregability. Clopidogrel and prasugrel have documented cardioprotective effects in clinical studies. Herein, we investigated whether clopidogrel and prasugrel could protect against ...

journal_title：Life sciences

authors： Mohammad HMF,Makary S,Atef H,El-Sherbiny M,Atteia HH,Ibrahim GA,Mohamed AS,Zaitone SA

更新日期：2020-04-15 00:00:00

abstract：:Several serotonin (5-HT) receptor antagonists with varying specificities for the 5-HT receptor types, were studied with regard to their effects on blood glucose levels in mice. The non-selective antagonists, metergoline and methysergide, proved to be hyperglycemic at doses commonly used to antagonize 5-HT receptors. I...

journal_title：Life sciences

authors： Wozniak KM,Linnoila M

更新日期：1991-01-01 00:00:00