Abstract：
:Several antihistamines were evaluated for their ability to interact with sigma, muscarinic and histaminic H1 binding sites in rat brain preparations. All of the antihistamines were able to interact with the sigma site, as well as the other two sites. In addition, tripelennamine was found to elicit sigma-like behaviors when administered to rats. This affinity for the sigma site suggests that the compounds may elicit some of their undesirable CNS side effects via this interaction.
journal_name
Life Scijournal_title
Life sciencesauthors
Gray NM,Contreras PC,Allen SE,Taylor DPdoi
10.1016/0024-3205(90)90231-fsubject
Has Abstractpub_date
1990-01-01 00:00:00pages
175-80issue
2eissn
0024-3205issn
1879-0631pii
0024-3205(90)90231-Fjournal_volume
47pub_type
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