Vitamin D receptor gene expression in human pituitary gland.

abstract：AIMS:The steroid and xenobiotic receptor (SXR) regulates the transcription of its target genes by interacting with various nuclear receptor cofactors. We have previously shown that silencing mediator for retinoid and thyroid receptors (SMRT) interacts with SXR even in the presence of rifampicin on cytochrome P450 monoo...

journal_title：Life sciences

authors： Hirooka-Masui K,Lesmana R,Iwasaki T,Xu M,Hayasaka K,Haraguchi M,Takeshita A,Shimokawa N,Yamamoto K,Koibuchi N

更新日期：2013-05-20 00:00:00

abstract：:Following severe thermal injury, patients are resistant to non-depolarizing muscle relaxants. Although this resistance has been well documented clinically, little is known about its etiology. We have tested the hypothesis that circulating factors contribute to the decreased potency of neuromuscular blockers following ...

journal_title：Life sciences

authors： Storella RJ,Martyn JA,Bierkamper GG

更新日期：1988-01-01 00:00:00

abstract：:Rats with experimental allergic encephalomyelitis (EAE) induced with myelin or spinal cord show decreases in the content of sulphatides and cerebrosides and increases in the level of esterified cholesterol in the CNS. In this work it is shown that brain sulphatide changes can be obtained by injection of mixtures conta...

journal_title：Life sciences

authors： Roth GA,Monferran CG,Maggio B,Cumar FA

更新日期：1982-03-08 00:00:00

abstract：:High concentrations of cocaethylene (EC), the ethyl ester of benzoylecgonine, were measured in the blood of individuals who had concurrently used cocaine and ethanol. Since the powerful reinforcing effects of cocaine appear to be dependent on inhibition of dopamine reuptake in brain, we compared the effects of EC on t...

journal_title：Life sciences

authors： Jatlow P,Elsworth JD,Bradberry CW,Winger G,Taylor JR,Russell R,Roth RH

更新日期：1991-01-01 00:00:00

abstract：:Two analogues of [Nle28,31]-CCK26-33 containing an N-terminal acetyl or N-terminal hydroxysulfonyl moiety were prepared and characterized. Both analogues were equipotent to native CCK26-33 in four bioassays, demonstrating that N-terminal sulfation of CCK26-33 analogues is compatible with full biological activity. ...

journal_title：Life sciences

authors： Sugg EE,Shook JE,Serra M,Korc M,Yamamura HI,Burks TF,Hruby VJ

更新日期：1986-11-03 00:00:00

abstract：:Beriberi is a disease caused by thiamine deficiency (TD), which may lead to heart problems, including heart failure. Despite the fact that thiamine prevalence is reduced in the industrialized world, it remains a health hazard especially due to chronic alcohol consumption. Diagnosing the presence of TD based on both el...

journal_title：Life sciences

authors： Roman-Campos D,Cruz JS

更新日期：2014-03-07 00:00:00

abstract：AIMS:This experiment investigated the effects of sub-chronic aluminum chloride (AlCl3) exposure on rat ovaries. MAIN METHODS:Eighty female Wistar (5weeks old) rats, weighed 110-120g, were randomly divided into four treatment groups: control group (CG), low-dose group (LG, 64mg/kg BW AlCl3), mid-dose group (MG, 128mg/k...

journal_title：Life sciences

authors： Fu Y,Jia FB,Wang J,Song M,Liu SM,Li YF,Liu SZ,Bu QW

更新日期：2014-03-28 00:00:00

abstract：:The colchicine-induced accumulation of vasopressin (AVP) and oxytocin (OXT) has recently been applied to estimate the synthesis and turnover rates for these neuropeptides in whole rat hypothalamus. In the present studies, this pharmacologic procedure has been examined as a potential method for estimating hypothalamic ...

journal_title：Life sciences

authors： Liu B,Kwok RP,Fernstrom JD

更新日期：1991-01-01 00:00:00

abstract：:Antinuclear antibodies (ANA) development was studied in male guinea pigs in response to chronic treatment with procainamide, hydralazine, acetanilide or caffeine. Acetanilide and caffeine have not previously been associated with ANA induction. Fifty-one weanling Hartley guinea pigs were divided into five groups which ...

journal_title：Life sciences

authors： Robinson CJ,Balazs T

更新日期：1982-01-11 00:00:00

abstract：:In this study, we have characterized quinone reductase (QR), glutathione (GSH), glutathione S-transferase (GST) and their induction by a chemoprotector, 1,2-dithiole-3-thione (D3T), in the human myeloid cell lines ML-1 and HL-60. In addition, we also examined the toxicity of hydroquinone (HQ), a benzene metabolite, to...

journal_title：Life sciences

authors： Li Y,Lafuente A,Trush MA

更新日期：1994-01-01 00:00:00

abstract：:In adult male Wistar rats submitted to a standardized noise stress, intravenous TRH induced a prolactin (PRL) secretory response. Prior IV naloxone administration not only lowered plasma PRL levels in those stressed rats but abolished also the stimulatory action of TRH. This effect was further studied by superfusion e...

journal_title：Life sciences

authors： Velkeniers B,Buydens P,Baldys A,De Boel S,Finné E,Golstein J,Vanhaelst L

更新日期：1987-06-22 00:00:00

abstract：AIMS:This study aims to identify by a molecular genetic approach potential targets in mast cells at which 1,4-benzodiazepines may cause their inhibitory effect on mast cell activity. MAIN METHODS:Gene expression analyses with microarray gene chip and/or quantitative PCR were performed using 1,4-benzodiazepine-treated ...

journal_title：Life sciences

authors： Haenisch B,Huber M,Wilhelm T,Steffens M,Molderings GJ

更新日期：2013-03-14 00:00:00

abstract：AIMS:Pulmonary hypertension (PH) leads to right ventricular (RV) adaptation and remodeling and has deleterious long-term effects on RV function. The endocannabinoid receptor CB2 has been associated with protective effects in adaptation and remodeling of the left ventricle after ischemia. Therefore, we investigated the ...

journal_title：Life sciences

authors： Duerr GD,Feißt A,Halbach K,Verfuerth L,Gestrich C,Wenzel D,Zimmer A,Breuer J,Dewald O

更新日期：2018-12-15 00:00:00

abstract：AIMS:Ginsenoside-Rg1 (G-Rg1), a saponin that is a primary component of ginseng, is very useful and important in traditional Chinese medicine for stroke. The objective of this study was to explore the mechanisms underlying the neuroprotective effect of G-Rg1 on focal cerebral ischemia/reperfusion. MAIN METHODS:Focal ce...

journal_title：Life sciences

authors： Xie CL,Li JH,Wang WW,Zheng GQ,Wang LX

更新日期：2015-01-15 00:00:00

abstract：:Recently, single-dose drug packaging systems, allowing the administration of multiple drugs in a single pill, have become popular for the convenience of the patient. The quality of drugs and an accurate measurement of their photostabilities within this system, however, have not been carefully addressed. Drugs that are...

journal_title：Life sciences

authors： Uwai K,Tani M,Ohtake Y,Abe S,Maruko A,Chiba T,Hamaya Y,Ohkubo Y,Takeshita M

更新日期：2005-12-12 00:00:00

abstract：:In recent years, natural products have increasingly attracted more attention because of their potential anticancer activity and low intrinsic toxicity. Hispidulin is a natural flavonoid with a wide range of biological activities, including anti-inflammatory, antifungal, antiplatelet, anticonvulsant, anti-osteoporotic,...

journal_title：Life sciences

authors： Liu K,Zhao F,Yan J,Xia Z,Jiang D,Ma P

更新日期：2020-10-15 00:00:00

abstract：AIMS:The effects of the novel water soluble, viscous fiber complex PolyGlycopleX® [(α-D-glucurono-α-D-manno-β-D-manno-β-D-gluco), (α-L-gulurono-β-D mannurono), β-D-gluco-β-D-mannan (PGX®)] on body weight, food consumption, glucose, insulin, and glucagon-like peptide (GLP-1) levels were determined in Zucker diabetic rat...

journal_title：Life sciences

authors： Grover GJ,Koetzner L,Wicks J,Gahler RJ,Lyon MR,Reimer RA,Wood S

更新日期：2011-02-28 00:00:00

abstract：:11Beta-hydroxyglucocorticoids (HGCs) are known to induce apoptosis in immature T cells. Here we show that 11-oxoglucocorticoids (OGCs), which are oxidized metabolites of HGCs, counteract the apoptosis-inducing effects of HGC in murine thymocytes in vitro. Corticosterone at concentrations ranging from 0.1-100 microM in...

journal_title：Life sciences

authors： Hirano T,Horigome H,Ishishita H,Uda S,Oka K

更新日期：2001-05-18 00:00:00

abstract：AIMS:Cisplatin is an anticancer agent marred by nephrotoxicity. Limiting this adverse effect may allow the use of higher doses to improve its efficacy. The Wnt/β-catenin signaling pathway plays a critical role in nephrogenesis and repair of renal diseases. BIO, a small molecule agonist of this pathway, exerted a protec...

journal_title：Life sciences

authors： Sun Z,Xu S,Cai Q,Zhou W,Jiao X,Bao M,Yu X

更新日期：2020-12-15 00:00:00

abstract：:SGK1 is one of the protein-serine/threonine kinases that is activated by insulin in a PI3K-dependent manner. Although SGK1 mediates a variety of biological activities, the mechanisms regulating its activity remain unclear. In this study, we examined the potential roles of calcium signaling in the activation of SGK1. T...

journal_title：Life sciences

authors： Imai S,Okayama N,Shimizu M,Itoh M

更新日期：2003-04-04 00:00:00

abstract：AIMS:Ischemia-reperfusion (I/R) event in vascular and nervous system has been documented to rising ischemic and vasculitic neuropathic pain, clinically resembles the complex regional pain syndrome (CRPS). The present study evaluated the effect of montelukast, a cysteinyl leukotriene receptor (Cys-LTC(4) and Cys-LTD(4))...

journal_title：Life sciences

authors： Muthuraman A,Ramesh M,Sood S

更新日期：2012-05-22 00:00:00

abstract：:While attempting to delineate the reason for the reported extreme variability of beta-endorphin-like immunoreactivity (beta-ir) in human plasma (eg., nondetectable to 1 ng/ml) by standard radioimmunoassay, we noted that a substantial portion of circulating beta-ir was associated with erythrocytes. That erythrocyte ass...

journal_title：Life sciences

authors： Fisher A,Comly M,Do R,Tamarkin L,Ghazanfari AF,Mukherjee AB

更新日期：1984-05-07 00:00:00

abstract：AIMS:Despite the advanced cancer treatments, there is increased resistance to chemotherapy and subsequent mortality. In lack of reliable data in monolayer cultures and animal models, researchers are shifting to 3D cancer spheroids, which represents the in vivo robust tumour morphology. Calcium is essential in cell sign...

journal_title：Life sciences

authors： Kumari N,Bhargava A,Rath SN

更新日期：2020-11-01 00:00:00

abstract：:This study, conducted on isolated guinea pig ileum, was designed to establish the mechanism of presynaptic alpha 2-adrenoreceptor blockade by the tetramine disulfides, benextramine and pyrextramine. At 1 microM these drugs irreversibly blocked norepinephrine (NE)-induced inhibition of the twitch response to electrical...

journal_title：Life sciences

authors： Brasili L,Cassinelli A,Angeli P,Melchiorre C

更新日期：1986-05-05 00:00:00

abstract：:NF-kappaB that plays an important role in iNOS expression is one of the targets of various potential anti-inflammatory agents including resveratrol. Resveratrol contains a structural similarity with estrogen, and there has been speculation about resveratrol as estrogen agonist. In this study, the mechanism and structu...

journal_title：Life sciences

authors： Cho DI,Koo NY,Chung WJ,Kim TS,Ryu SY,Im SY,Kim KM

更新日期：2002-09-13 00:00:00

abstract：:The effects of opioids on human subjective olfactory function have rarely been investigated. This is despite the fact that opioid receptors are widely distributed throughout the olfactory systems. Using an established validated test of subjective olfactory function, olfactory threshold, odor discrimination and odor id...

journal_title：Life sciences

authors： Lötsch J,Darimont J,Skarke C,Zimmermann M,Hummel T,Geisslinger G

更新日期：2001-09-28 00:00:00

abstract：:The present study was performed to determine if the attenuated pressor response to vasopressin in conscious non-estrous female rats is due in part to an enhanced V2-like receptor vasodilator action. In male rats, infusion of vasopressin at a rate of 1 ng.min(-1).kg body weight-1 (wt) resulted in an increase in mean ar...

journal_title：Life sciences

authors： Wang YX,Crofton JT,Liu H,Sato K,Share L

更新日期：1996-01-01 00:00:00

abstract：:Eleven patients with Raynaud's syndrome accompanied by monospecific IgG ANA, nine patients with Raynaud's syndrome in the absence of ANA, and nine normal volunteers were exposed to an ambient cold challenge during which time venous blood was continuously sampled. ANA negative patients were shown to have significantly ...

journal_title：Life sciences

authors： Surwit RS,Allen LM 3rd,Gilgor RS,Schanberg S,Kuhn C,Duvic M

更新日期：1983-02-28 00:00:00

abstract：:The effect of fluoride ion on the binding of the specific muscarinic agonist ligand [3H]cis methyldioxolane ([3H]CD) to the mouse cardiac muscarinic receptor was investigated. Utilizing equilibrium ligand binding experiments, sodium fluoride (10mM) was shown to decrease [3H]CD binding, measured at a concentration of 2...

journal_title：Life sciences

authors： Barritt D,Yamamura HI,Roeske WR

更新日期：1982-03-08 00:00:00

abstract：:Calcium spirulan (Ca-SP) is a novel sulfated polysaccharide isolated from a blue-green alga Spirulina platensis. Ca-SP inhibits thrombin by activation of heparin cofactor II. Therefore, it could serve as an origin of anti-atherogenic medicines. Since maintenance of vascular endothelial cell monolayers is important for...

journal_title：Life sciences

authors： Kaji T,Fujiwara Y,Inomata Y,Hamada C,Yamamoto C,Shimada S,Lee JB,Hayashi T

更新日期：2002-03-08 00:00:00