Central nervous system lipid alterations in rats with experimental allergic encephalomyelitis and its suppression by immunosuppressive drugs.

abstract：:Following a report that nortriptyline was found useful in the control of enuresis in adults, presumably as an anticholinergic, its likely mechanism of action and apparent bladder specificity have now been investigated in vitro. The ratios of anticholinergic potencies (reciprocal of dissociation contents, Ki) for four ...

journal_title：Life sciences

authors： Rehavi M,Weiss H,Nissenkorn I,Rubinstein R,Cohen S

更新日期：1987-05-04 00:00:00

abstract：AIM:Cyclophosphamide (CYP) chemotherapy induces bladder toxicity and hemorrhagic cystitis in cancer patients constituting a current clinical concern. Oxidative inflammatory cascades have been implicated as the mechanism contributing to CYP bladder urotoxicity. We thus assayed to explore whether zinc (Zn) supplementatio...

journal_title：Life sciences

authors： Famurewa AC,Edeogu CO,Offor FI,Besong EE,Akunna GG,Maduagwuna EK

更新日期：2021-02-01 00:00:00

abstract：:The effects of 1,3-dipropyl-8(p-sulfophenyl)xanthine (DPSPX) and enprofylline on the respiratory responses to bilateral occlusions of the common carotid arteries (CCO) were studied in rats anesthetized with sodium pentobarbitone and breathing spontaneously. CCO during periods of 5, 10 and 15 s caused increases in tida...

journal_title：Life sciences

authors： Monteiro EC,Ribeiro JA

更新日期：1989-01-01 00:00:00

abstract：:Although exposure to broad band (0.2-20 MHz) electromagnetic fields (EMF) is part of the treatment of several diseases, little is known as to their effects on myocardial protein expression and resistance to ischemia-reperfusion (I/R). We exposed Sprague-Dawley rats to either high (H, 10 min/day at 200 V/m, 36.1 microT...

journal_title：Life sciences

authors： Ronchi R,Marano L,Braidotti P,Bianciardi P,Calamia M,Fiorentini C,Samaja M

更新日期：2004-09-03 00:00:00

abstract：:The anthropogenic chemicals nonylphenol, bisphenol A, phthalic acid benzyl n-butyl ester, phthalic acid di-n-butyl ester and phthalic acid di(2-ethylhexyl) ester have been shown to possess sex hormone-like activity. To explore the possible actions of these chemicals on the autacoid synthesis in the body, we investigat...

journal_title：Life sciences

authors： Fujimoto Y,Sakuma S,Inoue T,Uno E,Fujita T

更新日期：2002-03-29 00:00:00

abstract：AIM:The action of oestrogen has traditionally been attributed to the activation of nuclear receptors (ERα and ERβ). A third receptor, the G protein-coupled oestrogen receptor (GPER), has been described as mediator of the rapid action of oestrogen. Based on the possible protective role of oestrogen in the cardiovascular...

journal_title：Life sciences

authors： Peixoto P,Aires RD,Lemos VS,Bissoli NS,Santos RLD

更新日期：2017-08-15 00:00:00

abstract：:Protein kinase C (PKC)-dependent phosphorylation of endogenous substrates was measured in electrically permeabilised rat islets of Langerhans. The PKC-activating phorbol ester, 4 beta-phorbol myristate acetate (PMA), caused a slow but prolonged increase in insulin secretion from permeabilised islets, which was accompa...

journal_title：Life sciences

authors： Jones PM,Persaud SJ,Howell SL

更新日期：1992-01-01 00:00:00

abstract：:We measured the concentration of immunoreactive (IR) hEGF in various body fluids by radioimmunoassay (RIA) and evaluated its size heterogeneity by size exclusion high performance liquid chromatography combined with RIA or with time-resolved immunofluorometric assay (TR-IFMA). Mean concentration was 80 ng/ml in urine, ...

journal_title：Life sciences

authors： Pesonen K,Viinikka L,Koskimies A,Banks AR,Nicolson M,Perheentupa J

更新日期：1987-06-29 00:00:00

abstract：:Sorbitol levels in heart were determined in streptozotocin-induced diabetic rats. Significantly higher levels were found in hearts of diabetic rats compared to normal rats. The findings are compatible with either significantly higher de novo synthesis of sorbitol in heart than is generally believed or uptake of circul...

journal_title：Life sciences

authors： Nakada T,Kwee IL

更新日期：1989-01-01 00:00:00

abstract：AIMS:The natural phenolic oil compound hydroxytyrosol (HTy) is widely studied because of its antioxidant and neuroprotective properties. Nitroderivatives of HTy have been studied in order to evaluate their putative effects on catechol-O-methyltransferase (COMT) activity. MAIN METHODS:To study its effect on dopamine me...

journal_title：Life sciences

authors： Gallardo E,Madrona A,Palma-Valdés R,Espartero JL,Santiago M

更新日期：2015-08-01 00:00:00

abstract：AIM:Ischemia/reperfusion (I/R) injury is the major cause of neurological deficit following stroke. Our previous study showed neuroprotective effects of hispidulin against cerebral ischemia reperfusion injury (IRI). In this study, we further examined the involvement of pyroptosis in this neuroprotective function. MATER...

journal_title：Life sciences

authors： An P,Xie J,Qiu S,Liu Y,Wang J,Xiu X,Li L,Tang M

更新日期：2019-09-01 00:00:00

abstract：AIMS:Glycation of proteins leads to the formation of advanced glycation end products (AGEs, which have significant role in the pathophysiology of diabetes complications. d-ribose appears to be the most reactive among the naturally occurring sugars and contribute significantly to the generation of AGEs. Glycation also r...

journal_title：Life sciences

authors： Akhter F,Khan MS,Alatar AA,Faisal M,Ahmad S

更新日期：2016-04-15 00:00:00

abstract：:We reported previously that acetylcholine (ACh)-induced endothelium-dependent relaxation of rat mesenteric microvessels depended both on nitric oxide (NO) and on a charybdotoxin (CTX)-sensitive endothelium-derived hyperpolarizing vasodilator. Cytochrome P450 (CYP)-dependent arachidonic acid metabolites act in some sys...

journal_title：Life sciences

authors： Davidson-Garcia CA,Nalbantian-Brandt C,Umans JG

更新日期：2000-02-11 00:00:00

abstract：:The characteristics and distribution of putative thyrotropin releasing hormone (TRH) receptors were studied in rat central nervous system using the TRH analogue 3H-(3MeHis2)TRH as a radiolabeled ligand. The analogue had a dissociation constant of 2.3 +/- 0.2 nM and a receptor density of 34 +/- 2 fm/mg protein in whole...

journal_title：Life sciences

authors： Simasko SM,Horita A

更新日期：1982-05-24 00:00:00

abstract：:Inhaled antimuscarinics, often called anticholinergics in clinical medicine, are established as first line bronchodilators in COPD. Tiotropium has been developed as a new generation antimuscarinic following ipratropium. Tiotropium is a specific, highly potent antimuscarinic, demonstrating very slow dissociation from m...

journal_title：Life sciences

authors： Disse B,Speck GA,Rominger KL,Witek TJ Jr,Hammer R

更新日期：1999-01-01 00:00:00

abstract：AIMS:To explore the role of chemokine CC motif ligand 2 (CCL2) in spatial memory and cognition impairment, and the underlying mechanisms focused on inflammatory, glutamate metabolistic and apoptotic- associated mRNA expression. MATERIALS AND METHODS:Stereotaxic surgery was performed here to establish a rat model by bi...

journal_title：Life sciences

authors： Chen J,Tan L,Liao Y,Long J,Zhou Y,Wei J,Zhou Y

更新日期：2020-08-15 00:00:00

abstract：:We studied the effects of caffeine on intracellular calcium in a clonal insulin-secreting cell line RINm5F. Caffeine (1-30 mM) induced a dose-dependent intracellular Ca2+ release and Ca2+ influx. Pretreatment with combination of ryanodine (10 microM) and caffeine (10 mM), but not ryanodine alone, abolished subsequent ...

journal_title：Life sciences

authors： Chen TH,Lee B,Yang C,Hsu WH

更新日期：1996-01-01 00:00:00

abstract：AIMS:The prognoses of patients with gastric cancer(GC) vary in different stages, which is mainly due to the great differences in tumor and tumor microenvironment. This study is aimed to explore the specific differences. MAIN METHODS:Based on RNAseq-based expression data from The Cancer Genome Atlas database and GSE154...

journal_title：Life sciences

authors： Wan L,Tan N,Zhang N,Xie X

更新日期：2020-11-15 00:00:00

abstract：:Neuropathic pain syndromes respond poorly to opioid treatment. In our previous studies, we found that intrathecal (i.t.) injection of pertussis toxin (PTX) produces thermal hyperalgesia, which is poorly responsive to morphine and is accompanied by an increase in cerebrospinal fluid (CSF) levels of excitatory amino aci...

journal_title：Life sciences

authors： Wu GJ,Wen ZH,Chang YC,Yang SN,Tao PL,Wong CS

更新日期：2006-03-13 00:00:00

abstract：AIMS:To investigate whether hypoxia-inducible factor (HIF) 1alpha and cyclosporin A (CsA) can regulate MICA/B expression and affect NK cytotoxicity during ischemia/reperfusion (I/R) injury. MAIN METHODS:We generated an HIF-1alphaDeltaODD-expressing adenovirus which can functionally and steadily express HIF-1alpha duri...

journal_title：Life sciences

authors： Wei L,Lu J,Feng L,Long D,Shan J,Li S,Li Y

更新日期：2010-07-17 00:00:00

abstract：BACKGROUND:Coronavirus disease 2019 (COVID-19) has become a severe public health problem around the globe. Various epidemiological, statistical, and laboratory-based studies have shown that the role of temperature and other environmental factors has important influence in the transmission of coronaviruses. Scientific r...

journal_title：Life sciences

authors： Fawad M,Mubarik S,Malik SS,Ren J

更新日期：2021-01-18 00:00:00

abstract：AIMS:Hypoxia-inducible factor-1α (HIF-1α) is a transcriptional regulator of cellular responses to hypoxic stress. MicroRNAs (miRNAs) play an essential role in hypoxia-mediated cellular responses. Previous studies have identified some let-7 family members as hypoxia-regulated miRNAs (HRMs). In the present study, we aime...

journal_title：Life sciences

authors： Huang CX,Chen N,Wu XJ,He Y,Huang CH,Liu H,Wang WM,Wang HL

更新日期：2017-02-15 00:00:00

abstract：:We investigated the mechanism by which glucose refeeding can reverse the enhancement of glycolysis caused by glucose starvation. Human fibroblasts were deprived of glucose for 18 hr and then refed for 1 hr with either (a) medium from sister glucose-starved cultures (controls), (b) fresh, glucose-containing medium (fre...

journal_title：Life sciences

authors： Sorger T,Oliveira M,Germinario RJ

更新日期：1989-01-01 00:00:00

abstract：:We investigated the mechanism underlying the priming effect of TNF-alpha on fMLP-stimulated superoxide production in human neutrophils. TNF-alpha enhanced fMLP-stimulated superoxide production in a concentration-dependent manner. TNF-alpha also induced sphingomyelin (SM) hydrolysis and increased the formation of its m...

journal_title：Life sciences

authors： Niwa M,Kozawa O,Matsuno H,Kanamori Y,Hara A,Uematsu T

更新日期：2000-01-01 00:00:00

abstract：:The aim of the present work was to study the effects of various durations of fasting (12, 24 and 72 hours) on brown adipose tissue (BAT) thermogenic parameters--cytrochrome-c-oxidase (COX) activity, GDP-binding activity and uncoupling protein (UCP1) content--and also on morphological features of different mitochondria...

journal_title：Life sciences

authors： Gianotti M,Clapés J,Lladó I,Palou A

更新日期：1998-01-01 00:00:00

abstract：:Anandamide (arachidonylethanolamide; AEA) is an endogenous ligand for the cannabinoid receptor and its pharmacological effects are under intensive study. However, AEA has a low aqueous solubility and stability which may restrict its use and may eventually endanger the reliability of the obtained results. In the presen...

journal_title：Life sciences

authors： Jarho P,Urtti A,Järvinen K,Pate DW,Järvinen T

更新日期：1996-01-01 00:00:00

abstract：:Hyperketonemia has been identified as an important factor in diabetic pregnancy affecting growth and development of the offspring. In order to assess the immediate metabolic alterations in embryos caused by excess ketone bodies, we studied rat embryonic neural tissue exposed to a high concentration of beta-hydroxybuty...

journal_title：Life sciences

authors： Yang X,Borg LA,Eriksson UJ

更新日期：1998-01-01 00:00:00

abstract：AIMS:it has been suggested that Chromium (Cr), one of the essential minerals, can be beneficial to type 2 diabetic patients because it lowers blood glucose levels by improving various steps in insulin action. A few studies reported that Cr might also have some beneficial effects in people with type 1 diabetes mellitus ...

journal_title：Life sciences

authors： Kwon MJ,Chung HS,Yoon CS,Ko JH,Jun HJ,Kim TK,Lee SH,Ko KS,Rhee BD,Kim MK,Park JH

更新日期：2010-09-25 00:00:00

abstract：:The effects of taurine on hepatic cholesterol metabolism were investigated in hamsters fed a high-fat diet or normal chow. Two weeks-treatment of taurine at 1% in drinking water prevented high-fat diet-induced increase in cholesterol levels of serum and liver. The decrease in serum cholesterol by taurine was due to de...

journal_title：Life sciences

authors： Murakami S,Kondo Y,Toda Y,Kitajima H,Kameo K,Sakono M,Fukuda N

更新日期：2002-04-05 00:00:00

abstract：AIMS:Obesity is associated with increased cardiovascular morbidity and mortality. It is accompanied by augmented O-linked β-N-acetylglucosamine (O-GlcNAc) modification of proteins via increasing hexosamine biosynthetic pathway (HBP) flux. However, the changes and regulation of the O-GlcNAc levels induced by obesity are...

journal_title：Life sciences

authors： Cui YL,Xue RQ,Xi He,Ming Zhao,Yu XJ,Liu LZ,Wu Q,Si Yang,Li DL,Zang WJ

更新日期：2019-04-01 00:00:00