Protein kinase C inhibitor chelerythrine attenuates the morphine-induced excitatory amino acid release and reduction of the antinociceptive effect of morphine in rats injected intrathecally with pertussis toxin.

abstract：AIMS:The long non-coding RNA (lncRNA) was reported to be involved in the progress of various cancers, however, its effect in colorectal cancer (CRC) remains unknown. The goal of the present study is to investigate the function role of lncRNA PCAT-1 in colorectal cancer. MAIN METHODS:The expression of lncRNA PCAT-1 in ...

journal_title：Life sciences

authors： Qiao L,Liu X,Tang Y,Zhao Z,Zhang J,Feng Y

更新日期：2017-11-01 00:00:00

abstract：:Morning urine samples were assayed for human EGF (hEGF) in 137 non-insulin dependent diabetic patients with normal serum creatinine and beta 2-microglobulin levels. Serving as controls, 80 age- and sex-matched healthy subjects were also examined. A significant positive correlation between hEGF excretion and the level ...

journal_title：Life sciences

authors： Kawaguchi M,Kamiya Y,Ito J,Fujii T,Hayakawa F,Sakuma N,Fujinami T

更新日期：1993-01-01 00:00:00

abstract：:The Wiskott-Aldrich syndrome (WAS), X-linked severe combined immunodeficiency (SCIDX1), and X-linked agammaglobulinemia (XLA) are severe congenital immunodeficiencies with X-linked inheritance. Although rare, they are all associated with severe infections from early in life, and high morbidity and mortality. Female ca...

journal_title：Life sciences

authors： Wengler GS,Parolini O,Fiorini M,Mella P,Smith H,Ugazio AG,Notarangelo LD

更新日期：1997-01-01 00:00:00

abstract：:We have reported that Sho-saiko-to (TJ-9) prevents liver fibrosis in vivo. To gain further insights into the effect of TJ-9, the matrix metalloproteinases (MMPs)/tissue inhibitors of metalloproteinases (TIMPs) balance was examined. Hepatic stellate cells (HSCs) were isolated from male Wistar rats and cultured with TJ-...

journal_title：Life sciences

authors： Sakaida I,Hironaka K,Kimura T,Terai S,Yamasaki T,Okita K

更新日期：2004-03-19 00:00:00

abstract：:Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1), an adhesion molecule of the immunoglobulin superfamily, has been characterized as a putative tumor suppressor because it is frequently down-regulated in aggressive types of cancer cells. Recently, however, several studies have shown that CEACAM1 acti...

journal_title：Life sciences

authors： Hokari M,Matsuda Y,Wakai T,Shirai Y,Sato M,Tsuchiya A,Takamura M,Yamagiwa S,Suzuki K,Ohkoshi S,Ichida T,Kawachi H,Aoyagi Y

更新日期：2007-07-04 00:00:00

abstract：:The binding of the D2-like agonists, (+)-7-hydroxy-N,N-di-n-[3H]propyl-2-aminotetralin (7-OH-DPAT) and [3H]pramipexole (2-amino-4,5,6-tetrahydro-6-propylaminobenzthiazole; MIRAPEX) were determined in membranes from adult male Sprague-Dawley and Fischer-344 rats. Saturation analysis, which optimized binding to D3 recep...

journal_title：Life sciences

authors： Wallace DR,Owens J,Booze RM

更新日期：1998-01-01 00:00:00

abstract：:LncRNA small nucleolar RNA host gene 3 (Snhg3) has been involved in cell proliferation and migration in malignant cells. However, its role in regulating functions of non-malignant cells has been hardly reported. Here, we found Snhg3 expression was sharply induced in primary brain microvascular endothelial cells (BMVEC...

journal_title：Life sciences

authors： Zhang J,Dong B,Hao J,Yi S,Cai W,Luo Z

更新日期：2019-11-15 00:00:00

abstract：:Two-dimensional and line-scan analyses of the early phase Ca2+ transients in rat cardiomyocytes were performed with a rapid-scanning laser confocal microscope and fluo-3 to elucidate the mechanism of activation of Ca2+ release from the sarcoplasmic reticulum in atrial myocytes which lack a well developed T-tubular net...

journal_title：Life sciences

authors： Tanaka H,Masumiya H,Sekine T,Kase J,Kawanishi T,Hayakawa T,Miyata S,Sato Y,Nakamura R,Shigenobu K

更新日期：2001-12-28 00:00:00

abstract：:We investigated the involvement of alpha 1-adrenoceptor subtypes in the positive chronotropic response to norepinephrine (NE) in neonatal rat cardiac myocytes at day 3 of culture. The cardiac myocytes at day 3 of culture exhibited a dose-dependent positive chronotropic response to NE in the presence of propranolol, a ...

journal_title：Life sciences

authors： Kimura H,Kawana S,Kanaya N,Sakano S,Miyamoto A,Ohshika H

更新日期：1994-01-01 00:00:00

abstract：:Activation of polyamine metabolism may be important to initiation of pancreatic cell growth. We are reporting that such activation did occur during pancreatic growth initiation by caerulein, a cholecystokinin analog. Maximal increases in total putrescine (319%), spermidine (63%) and spermine (50%) were observed 12, 96...

journal_title：Life sciences

authors： Morisset J,Benrezzak O

更新日期：1984-12-10 00:00:00

abstract：:The endogenous cannabinoid anandamide (AEA) exerts the majority of its effects at CB1 and CB2 receptors and is degraded by fatty acid amide hydrolase (FAAH). FAAH KO mice and animals treated with FAAH inhibitors are impaired in their ability to hydrolyze AEA and other non-cannabinoid lipid signaling molecules, such as...

journal_title：Life sciences

authors： Muldoon PP,Lichtman AH,Parsons LH,Damaj MI

更新日期：2013-03-19 00:00:00

abstract：:To examine the therapeutic effect of 4-(o-benzylphenoxy)-N-methylbutylamine hydrochloride (bifemelane) on neuronal ischemia-reperfusion injury, we evaluated the neurological score in gerbils subjected to unilateral common carotid occlusion. Using the neurological score method, we selected animals which showed stroke s...

journal_title：Life sciences

authors： Hata R,Matsumoto M,Kitagawa K,Tagaya M,Matsuyama T,Sugita M,Kamada T

更新日期：1995-01-01 00:00:00

abstract：AIMS:We sought to reveal the key molecular signature in subcutaneous adipose tissue (scAT) following Roux-en-Y gastric bypass (RYGB), through bioinformatics analysis and further verification in vivo. MAIN METHODS:We obtained a transcriptome data of scAT from RYGB and sham-operated rats from the Gene Expression Omnibus...

journal_title：Life sciences

authors： Chen X,Gong L,Li Q,Hu J,Liu X,Wang Y,Bai J,Ran X,Wu J,Ge Q,Li R,Xiao X,Li X,Zhang J,Wang Z

更新日期：2019-02-01 00:00:00

abstract：:Flavonoids are frequently found in fruits and vegetables, and are currently under investigation as potential chemopreventive agents. The present study reports the inhibitory effects of six flavonoids, quercetin, genistein, daidzein, equol, (+)-catechin and flavone, on sulphation of p-nitrophenol, a model substrate for...

journal_title：Life sciences

authors： Ghazali RA,Waring RH

更新日期：1999-01-01 00:00:00

abstract：BACKGROUND:Cigarette smoke extract (CSE) affects the expression of non-neuronal components of cholinergic system in bronchial epithelial cells and, as PEBP1/Raf-mediated MAPK1/2 and ERK1/2 pathway, promotes inflammation and oxidative stress. AIMS:We studied whether Acetylcholine (ACh) is involved in the mechanism of c...

journal_title：Life sciences

authors： Albano GD,Bonanno A,Moscato M,Anzalone G,Di Sano C,Riccobono L,Wenzel SE,Profita M

更新日期：2018-01-01 00:00:00

abstract：AIMS:The aim of this study was to comparatively investigate the potential gastroprotective effect and underlying mechanisms of coptisine free base (CFB, 8-hydroxy-7, 8-dihydrocoptisine), berberine and lansoprazole against indomethacin-induced gastric ulcer in rats. MATERIALS AND METHODS:CFB (10, 20 and 40mg/kg), berbe...

journal_title：Life sciences

authors： Luo C,Chen H,Wang Y,Lin G,Li C,Tan L,Su Z,Lai X,Xie J,Zeng H

更新日期：2018-01-15 00:00:00

abstract：:Using absorption spectroscopy we have found that metallothionein I at concentrations as low as 1 microM reduces ferricytochrome c. This reduction is more potent than that of another abundant intracellular thiol, glutathione. Also, oxidation of ferricytochrome c which had been reduced by metallothionein I occurs more s...

journal_title：Life sciences

authors： Simpkins C,Eudaric P,Torrence C,Yang Z

更新日期：1993-01-01 00:00:00

abstract：:This study characterizes several proteins in rat spleen lymphocyte lysates and conditioned medium that are recognized by antiserum to purified rat pituitary prolactin (PRL). One of these proteins, rat prolactin-immunoreactive protein (rPIP-43), has a relative molecular mass (Mr) of 43,000 and is strongly induced by mi...

journal_title：Life sciences

authors： Masten SA,Shiverick KT

更新日期：1997-01-01 00:00:00

abstract：:The anti-secretory activity of the competitive H2-antagonist HUK 978 was determined in rat, guinea-pig and dog. In all systems examined, HUK 978 was more potent than cimetidine and ranitidine both intravenously and orally. In addition, the compound at approximately equipotent doses as these established H2-antagonists ...

journal_title：Life sciences

authors： Coombes JD,Norris DB,Rising TJ,Ross BC,Steward A

更新日期：1985-11-04 00:00:00

abstract：:Nitric oxide (NO) plays an important role in glucose and lipid metabolism. We previously reported that NO synthesis inhibitors, such as NG-nitro-L-arginine methyl ester (L-NAME), deteriorate insulin sensitivity and lipid metabolism, while the addition of L-arginine reverses this deterioration. L-arginine is a precurso...

journal_title：Life sciences

authors： Kawano T,Nomura M,Nisikado A,Nakaya Y,Ito S

更新日期：2003-10-24 00:00:00

abstract：:The effect of silymarin on different functions of mitochondria isolated from rat kidneys was studied. Addition of silymarin to mitochondria oxidizing succinate, induced stimulation of the respiratory State 4; while in mitochondria oxidizing NAD-dependent substrates, the drug produced inhibition of the oxygen consumpti...

journal_title：Life sciences

authors： Chávez E,Bravo C

更新日期：1988-01-01 00:00:00

abstract：:It has been reported that while bacteria and higher plants possess two different pathways for the biosynthesis of putrescine, via ornithine decarboxylase (ODC) and arginine decarboxylase (ADC); the fungi, like animals, only use the former pathway. We found that contrary to the earlier reports, two of the phytopathogen...

journal_title：Life sciences

authors： Khan AJ,Minocha SC

更新日期：1989-01-01 00:00:00

abstract：AIMS:Perinatal hypoxic-ischemic insult has acute and long term deleterious effects on many organs including heart. Although tumor necrosis factor alpha (TNF-α) has been reported to increase soon after hypoxia, the inhibition of this mediator has not been documented. The aim of this study was to investigate the effects ...

journal_title：Life sciences

authors： Büyükakilli B,Atici A,Özkan A,Balli E,Güneş S,Turhan AH,Hallioglu O,Kanik A

更新日期：2012-06-06 00:00:00

abstract：:The loss of gamma-aminobutyric acid (GABA)-ergic medium spiny neurons (MSNs) in the striatum is the hallmark of Huntington disease (HD), an incurable neurodegenerative disorder characterized by progressive motor, psychiatric, and cognitive symptoms. Transplantation of MSNs or their precursors represents a promising tr...

journal_title：Life sciences

authors： Golas MM

更新日期：2018-09-15 00:00:00

abstract：:Previous studies demonstrated that intracerebroventricular (icv) injection of a kappa opioid receptor agonist decreased, and a mu agonist increased, body temperature (Tb) in rats. A dose-response study with the selective kappa antagonist nor-binaltorphimine (nor-BNI) showed that a low dose (1.25 nmol, icv) alone had n...

journal_title：Life sciences

authors： Chen X,McClatchy DB,Geller EB,Tallarida RJ,Adler MW

更新日期：2005-12-12 00:00:00

abstract：:In the present study we compared, in vivo in rats, the hepatobiliary transport of monovalent (silver:Ag) and divalent metals (zinc:Zn; cadmium:Cd) with that of copper (Cu). Cu can have two oxidation states in vivo, i.e. Cu(I) and Cu(II). Studies were performed in normal Wistar (NW) rats and mutant GY Wistar rats. The ...

journal_title：Life sciences

authors： Dijkstra M,Havinga R,Vonk RJ,Kuipers F

更新日期：1996-01-01 00:00:00

abstract：:Site-directed mutagenesis has been used to evaluate the roles of the key aspartate and arginine residues in transmembrane domain three of the muscarinic receptors. The results suggest that the formation of an ionic bond between the Asp carboxylate group and the onium headgroup is essential to anchor acetylcholine in i...

journal_title：Life sciences

authors： Hulme EC,Curtis CA,Page KM,Jones PG

更新日期：1995-01-01 00:00:00

abstract：:Despite reductions in beta-adrenoreceptor (beta-AR)-mediated inotropic effects induced by sustained sympathetic activation in cardiac disease, whether these changes necessarily result in reductions in systolic function under resting conditions (baseline function) is not clear. Moreover, possible compensatory mechanism...

journal_title：Life sciences

authors： Osadchii O,Woodiwiss A,Alves N,Norton G

更新日期：2005-12-12 00:00:00

abstract：AIMS:Naturally-derived farnesol has been reported for its chemopreventive and chemotherapeutic efficacy in various cancers. However, the mechanism of action of farnesol is still to be elucidated. The present study demonstrates the chemopreventive potential of farnesol on 9,10-dimethylbenz(a)anthracene (DMBA)-initiated ...

journal_title：Life sciences

authors： Chaudhary SC,Alam MS,Siddiqui MS,Athar M

更新日期：2009-07-31 00:00:00

abstract：:Benzodiazepines reliably produce overconsumption of food and fluids. Opiate antagonists, naloxone and naltrexone, block the benzodiazepine-induced hyperphagia and hyperdipsia at low doses. Hence, activation of endogenous opioid mechanisms may be closely involved in the benzodiazepine facilitatory effects on ingestiona...

journal_title：Life sciences

authors： Cooper SJ

更新日期：1983-03-07 00:00:00