[3H](+)-7-OH-DPAT and [3H]pramipexole binding in the striatum and nucleus accumbens of Sprague-Dawley and Fischer-344 rats.

abstract：:Meso-dimercaptosuccinic acid (DMSA) and the sodium salt of 2,3-dimercapto-1-propanesulfonic acid (DMPS) are analogous in chemical structure to dimercaprol (BAL, British Anti-Lewisite). Dimercaprol was among the first therapeutically useful metal chelating agents and was developed originally as an anti-lewisite agent. ...

journal_title：Life sciences

authors： Aposhian HV,Mershon MM,Brinkley FB,Hsu CA,Hackley BE

更新日期：1982-11-08 00:00:00

abstract：AIMS:The aim of this study was to find out a mesenchymal stem cells (MSCs) source from human dental tissues of the same donor (follicle, papilla and pulp), which exhibits higher neurogenic differentiation potential in vitro. MAIN METHODS:MSCs were isolated from dental tissues (follicle, papilla and pulp) by digestion ...

journal_title：Life sciences

authors： Ullah I,Subbarao RB,Kim EJ,Bharti D,Jang SJ,Park JS,Shivakumar SB,Lee SL,Kang D,Byun JH,Park BW,Rho GJ

更新日期：2016-06-01 00:00:00

abstract：AIMS:Thiamine is an important cofactor present in many biochemical reactions, and its deprivation can lead to heart dysfunction. Little is known about the influence of thiamine deprivation on the electrophysiological behavior of the isolated heart cells and information about thiamine deficiency in heart morphology is c...

journal_title：Life sciences

authors： Roman-Campos D,Campos AC,Gioda CR,Campos PP,Medeiros MA,Cruz JS

更新日期：2009-06-05 00:00:00

abstract：:By using multiple time-point constant-rate infusions of deuterium-labeled phosphorylcholine, appropriate kinetic parameters were obtained for use in the calculation of the turnover rate of acetylcholine (TRACh) in selected mouse brain regions. After obtaining these data, the relationship between the analgesic agent co...

journal_title：Life sciences

authors： Chen R,Robinson SE

更新日期：1992-01-01 00:00:00

abstract：AIMS:The beneficial effects of cannabinoid type 2 receptor (CB2R) activation have been verified in various tissue repair processes. Our recent study revealed CB2R activation promotes myogenesis partly through Nrf2 signaling in a mouse skeletal muscle ischemia-reperfusion (IR) injury model. Other relevant mechanisms nee...

journal_title：Life sciences

authors： Jiang P,Wang L,Zhang M,Zhang M,Wang C,Zhao R,Guan D

更新日期：2020-09-01 00:00:00

abstract：:The metabolism of phosphoinositides plays an important role in the signal transduction pathways. We report here that naturally occurring polyamines affect the activities of phosphatidylinositol (PI) 3-kinase and PI 4-phosphate (PIP) 5-kinase differently. While polyamines inhibited the PI 3-kinase activity, they stimul...

journal_title：Life sciences

authors： Singh SS,Chauhan A,Brockerhoff H,Chauhan VP

更新日期：1995-01-01 00:00:00

abstract：:Previous behavioral studies on triazolam (TZ), which are small in number, could only speculate about tolerance to the anxiolytic effect of TZ, as the experiments did not cover sufficient time (of 4 to 7 days) for tolerance to develop. Therefore longer time for chronic TZ administration is used. We investigated the eff...

journal_title：Life sciences

authors： Aburawi SM,Elhwuegi AS,Ahmed SS,Saad SF,Attia AS

更新日期：2003-10-31 00:00:00

abstract：:To examine the physiological significance of plasma ghrelin in generating pulsatile growth hormone (GH) secretion in rats, plasma GH and ghrelin levels were determined in freely moving male rats. Plasma GH was pulsatilely secreted as reported previously. Plasma ghrelin levels were measured by both N-RIA recognizing th...

journal_title：Life sciences

authors： Okimura Y,Ukai K,Hosoda H,Murata M,Iguchi G,Iida K,Kaji H,Kojima M,Kangawa K,Chihara K

更新日期：2003-04-18 00:00:00

abstract：AIMS:Obesity represents a global health problem. Excessive caloric intake promotes the release of inflammatory mediators by hypertrophic adipocytes and obesity-induced inflammation is now recognized as a risk factor for the development of several diseases, such as cardiovascular diseases, insulin resistance, type-II di...

journal_title：Life sciences

authors： Sardi C,Martini E,Mello T,Camelliti S,Sfondrini L,Marcucci F,Kallikourdis M,Sommariva M,Rumio C

更新日期：2021-01-01 00:00:00

abstract：:The Sertoli cells play an essential role in the maintenance and control of spermatogenesis. The ecto-nucleoside triphosphate diphosphohydrolase (E-NTPDase) and 5'-nucleotidase activities can modulate the extracellular adenine nucleotide levels, controlling nucleotide-mediated signaling events in Sertoli cells. Since t...

journal_title：Life sciences

authors： Zamoner A,Bruno AN,Casali EA,Corbelini PF,Diniz GP,Barreto-Chaves ML,Silva FR,Sarkis JJ,Pessoa-Pureur R

更新日期：2006-12-03 00:00:00

abstract：:We have previously shown that transforming growth factor-beta1 (TGF-beta1) is involved in the fibroblast-induced organization and differentiation of transformed phenotypically crypt-like T84 intestinal epithelial cells into absorptive enterocyte-like cells, when cultured within a three-dimensional collagen gel. We hav...

journal_title：Life sciences

authors： Lindfors K,Halttunen T,Kainulainen H,Mäki M

更新日期：2001-08-10 00:00:00

abstract：:The effects of C-reactive protein (CRP), the prototypical acute-phase reactant were studied on human polymorphonuclear leukocytes (PMNL) challenged with N-formyl-methionyl-leucyl-phenylalanine (fMLP) and platelet-activating factor (PAF). CRP at 8-64 micrograms/ml concentrations inhibited degranulation and superoxide p...

journal_title：Life sciences

authors： Filep J,Földes-Filep E

更新日期：1989-01-01 00:00:00

abstract：:Levels of delta-sleep-inducing peptide-like immunoreactivity (DSIP-LI) in rat plasma were measured by radioimmunoassay and found to exhibit a circadian rhythm that parallelled the normal rhythm for corticosterone. The maximal plasma levels of both substances were observed to occur at about 1700h. The lowest concentrat...

journal_title：Life sciences

authors： Fischman AJ,Kastin AJ,Graf MV

更新日期：1984-11-12 00:00:00

abstract：:In a partially depolarized guinea pig papillary muscle preparation, BAY K8644 stimulated voltage-operated calcium channels, promoting slow action potentials; this effect was dose-dependent over a concentration range of 3 X 10(-7) M to 3 X 10(-6) M. Isoproterenol and histamine also induced slow action potentials by sti...

journal_title：Life sciences

authors： Mestre M,Carriot T,Néliat G,Uzan A,Renault C,Dubroeucq MC,Guérémy C,Doble A,Le Fur G

更新日期：1986-07-28 00:00:00

abstract：:Repeated, low-intensity electrical stimulation of the heart gradually leads to the development of electrocardiographic abnormalities that culminate in cardiac arrhythmias, mainly A-V block in the isolated heart frog and ventricular and supraventricular tachyarrhythmias in the canine heart in situ. The pattern of devel...

journal_title：Life sciences

authors： García-Márquez F,Moreno JA,Luján M,Rodríguez R

更新日期：1988-01-01 00:00:00

abstract：:This study was undertaken to examine the receptor selectivity of Met-enkephalin-Arg6-Phe7 (MERF) employing radioreceptor binding assays in human cerebral cortex membranes, and to elucidate the responsible receptors that mediate the regulatory action of MERF on high (20 mM) K+-stimulated release of [3H]norepinephrine (...

journal_title：Life sciences

authors： Kim KW,Woo RS,Kim CJ,Cheong YP,Kim JK,Kwun J,Cho KP

更新日期：2000-05-26 00:00:00

abstract：:Chemokines constitute a large family of structurally-related small cytokines originally identified as factors regulating the migration of leukocytes in inflammatory and immune responses. Production of chemokines and their receptors in the brain has been reported under various pathological conditions. We revealed that ...

journal_title：Life sciences

authors： Minami M,Satoh M

更新日期：2003-12-05 00:00:00

abstract：:The heterogeneity of muscarine receptors was examined in two brain regions (cerebral cortex and cerebellum) and in some parasympathetically innervated peripheral tissues (heart, salivary gland and intraorbital lacrimal gland), by in vitro binding techniques. As a tool, we used a new antimuscarinic compound, AF-DX 116 ...

journal_title：Life sciences

authors： Hammer R,Giraldo E,Schiavi GB,Monferini E,Ladinsky H

更新日期：1986-05-05 00:00:00

abstract：:Peptide nucleic acids (PNAs) are uncharged DNA analogs that hybridize to complementary sequences with high affinity and stability. We previously showed that PNAs, after intraperitoneal injection into rats, are effective antisense compounds in vivo. The present study was designed to test whether PNAs also have antigene...

journal_title：Life sciences

authors： McMahon BM,Stewart JA,Bitner MD,Fauq A,McCormick DJ,Richelson E

更新日期：2002-06-07 00:00:00

abstract：:A highly purified rat urinary bladder smooth muscle cell culture was obtained by a modified enzymic isolation method, and the presence of functional muscarinic as well as beta-adrenergic receptors were subsequently determined. At 7-10 days of culture, cells became elongated and spindle-shaped showing a typical "hills ...

journal_title：Life sciences

authors： Ma FH,Higashira-Hoshi H,Itoh Y

更新日期：2002-01-25 00:00:00

abstract：:We conducted a study to determine whether angiotensin converting enzyme inhibitors (ACEIs) inhibit endothelin secretion from cultured human endothelial cells. Confluent umbilical vein endothelial cells were incubated in multi-well plates with culture medium containing either captopril (10(-6), 10(-5), 10(-4) M) or ena...

journal_title：Life sciences

authors： Yoshida H,Nakamura M

更新日期：1992-01-01 00:00:00

abstract：:Gradual increases in the electrical stimulation of the inferior colliculus produces progressive aversive responses from vigilance, through freezing, until escape. These responses are probably mediated by excitatory amino acids (EAA) mechanisms as microinjection of glutamate into the inferior colliculus can trigger fre...

journal_title：Life sciences

authors： Nobre MJ,Borelli KG,Brandão ML

更新日期：2002-11-08 00:00:00

abstract：BACKGROUND:Mesenchymal stem cells (MSCs) are widely applied in various clinical disorders, including acute lung injury (ALI). We aimed to investigate the effects of human umbilical cord blood-derived mesenchymal stem cells (UCB-MSCs)-derived exosomal microRNA-22-3p (miR-22-3p) on lipopolysaccharid (LPS)-induced ALI via...

journal_title：Life sciences

authors： Zheng Y,Liu J,Chen P,Lin L,Luo Y,Ma X,Lin J,Shen Y,Zhang L

更新日期：2021-01-06 00:00:00

abstract：AIM:Myocardial infarction (MI), an important cause of morbidity and mortality, can be followed by left ventricular dysfunction and cardiomyocyte loss. Cardiac repair mechanisms may subsequently improve left ventricular function. Exercise training has been suggested to have cardioprotective effects against MI damage, bu...

journal_title：Life sciences

authors： Naderi N,Hemmatinafar M,Gaeini AA,Bahramian A,Ghardashi-Afousi A,Kordi MR,Darbandi-Azar A,Karimzade F,Mohebbi H,Barati M

更新日期：2019-03-15 00:00:00

abstract：:In rat prefrontal cortical slices, the excitatory amino acids N-methyl-D-aspartate (NMDA), ibotenate, L-aspartate, quisqualate, kainate and L-glutamate inhibit carbachol-induced phosphoinositide hydrolysis as measured by the accumulation of [3H]inositol-1-phosphate ([3H]IP1). NMDA dose-dependently inhibited the carbac...

journal_title：Life sciences

authors： Noble EP,Sincini E,Bergmann D,ten Bruggencate G

更新日期：1989-01-01 00:00:00

abstract：:We demonstrate that injections of 1-methyl-4-phenyl-1,2,3,6-tetra-hydropyridine (MPTP), 1-methyl-4-phenyl-pyridinium ion (MPP+) and Paraquat (PQ+) produce in Rana Pipiens different behavioral, biochemical and skin pigmentation changes. MPTP causes in frogs the main symptoms of Parkinsonism (rigidity, akinesia and trem...

journal_title：Life sciences

authors： Barbeau A,Dallaire L,Buu NT,Poirier J,Rucinska E

更新日期：1985-10-21 00:00:00

abstract：:We assessed the anxiolytic effect of Kami-Shoyo-San (Jia-wei-xiao-yao-san; TJ-24), one of a traditional Chinese herbal medicine used for the treatment of menopausal anxiety, by the social interaction (SI) test in male mice. Acute administration of TJ-24 (25-100 mg/kg, p.o.), as well as the gamma-amino-butyric acidA/be...

journal_title：Life sciences

authors： Mizowaki M,Toriizuka K,Hanawa T

更新日期：2001-09-21 00:00:00

abstract：:The effect of oral administration of Clostridium butyricum Miyairi on the formation and dissolution of gallstones was examined in a mouse model of cholesterol cholelithiasis, in comparison with that of chenodeoxycholic acid (CDCA). A diet containing cholesterol and sodium cholate was used as a lithogenic diet. The fee...

journal_title：Life sciences

authors： Takeda Y,Itoh H,Kobashi K

更新日期：1983-01-31 00:00:00

abstract：:The protein inhibitor of nitric oxide synthase (PIN) was independently identified as an inhibitor of nitric oxide (NO) produced by neuronal nitric oxide synthase (nNOS), and as a member of the cellular dynein light chain family, dynein light chain 8 (LC8), responsible for intracellular protein trafficking. Mast cells ...

journal_title：Life sciences

authors： McCauley SD,Gilchrist M,Befus AD

更新日期：2007-02-13 00:00:00

abstract：:S-adenosylmethionine and adenosine levels in the rat pineal gland were determined by high-performance liquid chromatography after fractionation of the pineal extracts. The concentration of S-adenosylmethionine follows a circadian rhythm and is about three times higher during the day (2.5 nmol/gland) than the night (1....

journal_title：Life sciences

authors： Chabannes B,Sarda N,Cronenberger L,Pacheco H

更新日期：1984-08-06 00:00:00