当前位置： SCI文献检索 > LIFE SCIENCES期刊下所有文献 > Effects of C-reactive protein on human neutrophil granulocytes challenged with N-formyl-methionyl-leucyl-phenylalanine and platelet-activating factor.

Effects of C-reactive protein on human neutrophil granulocytes challenged with N-formyl-methionyl-leucyl-phenylalanine and platelet-activating factor.

Abstract：

:The effects of C-reactive protein (CRP), the prototypical acute-phase reactant were studied on human polymorphonuclear leukocytes (PMNL) challenged with N-formyl-methionyl-leucyl-phenylalanine (fMLP) and platelet-activating factor (PAF). CRP at 8-64 micrograms/ml concentrations inhibited degranulation and superoxide production by PMNL in time-, and dose-dependent manner and stabilized PMNL membranes against the lytic effect of lysophosphatidylcholine. CRP was also capable of binding PAF and in lesser extent fMLP. Furthermore, CRP, 32 micrograms/ml, diminished specific binding of [3H]-fMLP and [3H]-PAF to PMNL. These findings imply that CRP may play an important protective role during the early phase of acute inflammatory reactions.

journal_name

Life Sci

journal_title

Life sciences

authors

Filep J,Földes-Filep E

doi

10.1016/0024-3205(89)90613-9

subject

Has Abstract

pub_date

1989-01-01 00:00:00

pages

517-24

issue

8

eissn

0024-3205

issn

1879-0631

pii

0024-3205(89)90613-9

journal_volume

44

pub_type

杂志文章

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