当前位置： SCI文献检索 > LIFE SCIENCES期刊下所有文献 > Self-administration of dynorphin-[1-13] and D-ala2-dynorphin-[1-11] (kappa opioid agonists) in morphine (mu opioid agonist)-dependent rats.

Self-administration of dynorphin-[1-13] and D-ala2-dynorphin-[1-11] (kappa opioid agonists) in morphine (mu opioid agonist)-dependent rats.

Abstract：

:Adult female Sprague-Dawley rats were prepared with permanent cortical EEG and temporalis EMG electrodes and i.v. cannulae. They were made tolerant to and physically dependent on morphine by automatic, hourly injections. These physically dependent rats were then trained to lever press for 10 mg/kg injections of morphine on a fixed ratio (FR) schedule of reinforcement. Upon stabilization of morphine self-administration at a FR-10, dynorphin-[1-13] (DYN) or D-ala2-dynorphin-[1-11] (D-ala2-DYN) at doses of 125 or 250 micrograms/kg/inj was substituted for morphine. Rats self-administered these opioid-like peptides at both dose levels. As expected, self-injections were more numerous at the lower dose. No signs of morphine withdrawal were seen during the peptide substitutions. Following DYN or D-ala2-DYN abstinence, no withdrawal symptoms were noted. The question is raised as to whether DYN or D-ala2-DYN and morphine are producing their reinforcing effects in sustaining self-administration via the same receptor populations. Since morphine abstinence is associated with severe withdrawal symptoms and the peptides studied are not, the involvement of separate receptor populations in the process of dependence on morphine and these opioid-like peptides is indicated. In conclusion, both a mu and two kappa agonists exhibited an analogous reinforcing property in the rat. However, the degree of physical dependence and the intensity of withdrawal differed; being higher with the mu agonist and lower with the kappa agonists.

journal_name

Life Sci

journal_title

Life sciences

authors

Khazan N,Young GA,Calligaro D

doi

10.1016/0024-3205(83)90564-7

subject

Has Abstract

pub_date

1983-01-01 00:00:00

pages

559-62

eissn

0024-3205

issn

1879-0631

pii

0024-3205(83)90564-7

journal_volume

33 Suppl 1

pub_type

杂志文章

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