Abstract：
:Because of the low selectivity of available ligands, pharmacological approaches to elucidate the functional difference among muscarinic acetylcholine receptor (mAChR) subtypes have been problematic. As an alternative approach, we have established a series of mutant mouse lines deficient in each mAChR subtype (mAChR KO mice). The systematic analyses of these mice have been useful in revealing the functional difference among mAChR subtypes. Here, we review our prior research on these mutant mice and also some notable findings reported by other research groups.
journal_name
Life Scijournal_title
Life sciencesauthors
Matsui M,Yamada S,Oki T,Manabe T,Taketo MM,Ehlert FJdoi
10.1016/j.lfs.2004.05.034subject
Has Abstractpub_date
2004-11-05 00:00:00pages
2971-81issue
25eissn
0024-3205issn
1879-0631pii
S0024-3205(04)00745-3journal_volume
75pub_type
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