The blood pressure effects of alpha-adrenoceptor antagonists injected in the medullary site of action of clonidine: the nucleus reticularis lateralis.

abstract：:The phenomenon has raised the concerns about the safety of an extended manned mission into deep space due to the high potential for exposure to high-LET radiation during space missions. Heavy ions such as (56)Fe are main radiation sources in deep space, which could pose a significant hazard to space flight crews durin...

journal_title：Life sciences

authors： Zhao Q,Mao A,Yan J,Si J,Zhou R,Gan L,Liu Y,Zhang H

更新日期：2016-07-15 00:00:00

abstract：AIMS:Chloropropanol is a contaminant produced during food processing, and 1,3-dichloro-2-propanol (1,3-DCP) is one of the most-studied and most common chloropropanol-related food contaminants. Epigallocatechin-3-gallate (EGCG) is the most abundant ester catechin in tea polyphenols. We studied the potential therapeutic ...

journal_title：Life sciences

authors： Lu J,Fang B,Huang Y,Tao S,Sun B,Guan S,Jin Y

更新日期：2018-09-15 00:00:00

abstract：:We reported previously that acetylcholine (ACh)-induced endothelium-dependent relaxation of rat mesenteric microvessels depended both on nitric oxide (NO) and on a charybdotoxin (CTX)-sensitive endothelium-derived hyperpolarizing vasodilator. Cytochrome P450 (CYP)-dependent arachidonic acid metabolites act in some sys...

journal_title：Life sciences

authors： Davidson-Garcia CA,Nalbantian-Brandt C,Umans JG

更新日期：2000-02-11 00:00:00

abstract：:Calcium mobilization has been demonstrated to possess functional importance in myocardial excitation-contraction as well as cellular metabolism. So far, much progress has been made to explore the possibility of involvement of guanine nucleotide binding regulatory protein in the opening and closing of calcium channels ...

journal_title：Life sciences

authors： Fu LX,Waagstein F,Hjalmarson A

更新日期：1991-01-01 00:00:00

abstract：AIMS:The protein kinase C (PKC) family of enzymes has been implicated in cellular proliferation, differentiation, and apoptosis. However, the distribution of specific PKC isoforms with varying functions in normal and malignant human tissues remains to be determined. The objective of this study was to investigate the ex...

journal_title：Life sciences

authors： Ali S,Al-Sukhun S,El-Rayes BF,Sarkar FH,Heilbrun LK,Philip PA

更新日期：2009-05-22 00:00:00

abstract：:This study was designed to document possible changes in bupivacaine and its main metabolite, des-butyl-bupivacaine (PPX) kinetics in mice after a single 5 mg/kg injection of diltiazem. After a single 20 mg/kg i.p. dose of bupivacaine, kinetic parameters of bupivacaine were not statistically different but the ratio AUC...

journal_title：Life sciences

authors： Bruguerolle B,Lorec AM

更新日期：1994-01-01 00:00:00

abstract：:Identification of the neural substrates subserving audiogenic convulsions in the GEPR is an important task and while it is not yet complete, many laboratories employing various techniques have contributed importantly to our current understanding. The present review focuses on the use of lesions to identify the neural ...

journal_title：Life sciences

authors： Browning RA

更新日期：1986-09-08 00:00:00

abstract：:The present investigation examined the correlation between the regulation of mucosal prostaglandin (PG) biosynthesis and the release of the neuropeptide substance P (SP) in rat stomachs by indomethacin, a cyclooxygenase inhibitor. When given subcutaneously at the dose of 5 mg/kg, indomethacin reduced mucosal biosynthe...

journal_title：Life sciences

authors： Ko JK,Tang F,Cho CH

更新日期：1997-01-01 00:00:00

abstract：:The effects of glucagon-(1-21)-peptide on pancreatic exocrine secretion and plasma glucose levels were studied and compared with those of native glucagon in anesthetized dogs. Intravenous bolus administration of 1 nmol or 10 nmol/kg of glucagon-(1-21)-peptide evoked a significant inhibition of secretin-stimulated panc...

journal_title：Life sciences

authors： Itoh H,Matsuyama T,Namba M,Watanabe N,Komatsu R,Kono N,Tarui S

更新日期：1989-01-01 00:00:00

abstract：AIMS:Absent in melanoma 2 (AIM2) is a cytosolic DNA sensor which plays an important role in inflammasome formation and is involved in various cellular functions including pyroptosis, fibrosis, and tissue injury. Our study aimed to investigate whether AIM2 plays a role in diabetic cardiomyopathy (DCM) and to explore its...

journal_title：Life sciences

authors： Wang X,Pan J,Liu H,Zhang M,Liu D,Lu L,Tian J,Liu M,Jin T,An F

更新日期：2019-03-15 00:00:00

abstract：:Cancer is a disease of high complexity. Resistance to therapy is a major challenge in cancer targeted therapies. Overcoming this resistance requires a deep knowledge of the cellular interactions within tumor. Natural killer (NK) cells and cytotoxic T lymphocytes (CTLs) are the main anti-cancer immune cells, while T re...

journal_title：Life sciences

authors： Mortezaee K,Potes Y,Mirtavoos-Mahyari H,Motevaseli E,Shabeeb D,Musa AE,Najafi M,Farhood B

更新日期：2019-12-01 00:00:00

abstract：:The infection epidemic event of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was formally declared a pandemic by World Health Organization on March 11th, 2020. Corona Virus Disease 2019 (COVID-19) is caused by SARS-CoV-2, a new type of coronavirus, which has high contagion and mainly causes respira...

journal_title：Life sciences

authors： Peng W,Wu H,Tan Y,Li M,Yang D,Li S

更新日期：2020-12-01 00:00:00

abstract：:Tardive dyskinesia (TD) is a serious side-effect of neuroleptic treatment. In order to describe and analyse more thoroughly the rat model of TD, the behavior of the rats during cage testing was studied after acute and during long-term haloperidol (HAL) treatment. Rats were injected with HAL i.p. in an acute experiment...

journal_title：Life sciences

authors： Andreassen OA,Jørgensen HA

更新日期：1995-01-01 00:00:00

abstract：:It has been reported that while bacteria and higher plants possess two different pathways for the biosynthesis of putrescine, via ornithine decarboxylase (ODC) and arginine decarboxylase (ADC); the fungi, like animals, only use the former pathway. We found that contrary to the earlier reports, two of the phytopathogen...

journal_title：Life sciences

authors： Khan AJ,Minocha SC

更新日期：1989-01-01 00:00:00

abstract：:Protein binding determination in post heparin plasma samples is complicated by the continued post heparin lipase activity, in vitro, during the binding analysis. The decomposition of lipoproteins and accumulation of nonesterified fatty acids (NEFA) results in artifically elevated free fractions of many drugs. This art...

journal_title：Life sciences

authors： Pearce GA,Brown KF

更新日期：1983-10-10 00:00:00

abstract：:In recent years, natural products have increasingly attracted more attention because of their potential anticancer activity and low intrinsic toxicity. Hispidulin is a natural flavonoid with a wide range of biological activities, including anti-inflammatory, antifungal, antiplatelet, anticonvulsant, anti-osteoporotic,...

journal_title：Life sciences

authors： Liu K,Zhao F,Yan J,Xia Z,Jiang D,Ma P

更新日期：2020-10-15 00:00:00

abstract：:Leucogenenol a heterocyclic enolic thymothyroid hormone (MW 383) whose concentration in the serum regulates the rate at which already committed cells of the bone marrow develop into functional cells, was found to be associated in the thymus with a carrier protein. The carrier protein for leucogenenol is not precipitat...

journal_title：Life sciences

authors： Rice FA,McCurdy JD,Heath JR

更新日期：1984-07-30 00:00:00

abstract：:Although both the incidence and the mortality rate of breast cancer is rising, there is no potent and practical option for the treatment of these patients, particularly in advanced stages. One of the most critical challenges for treatment is the presence of complicated and extensive tumor escape mechanisms in the tumo...

journal_title：Life sciences

authors： Bastaki S,Irandoust M,Ahmadi A,Hojjat-Farsangi M,Ambrose P,Hallaj S,Edalati M,Ghalamfarsa G,Azizi G,Yousefi M,Chalajour H,Jadidi-Niaragh F

更新日期：2020-04-15 00:00:00

abstract：:Using liposomes differing in size and lipid composition, we have studied the uptake characteristics of the liver parenchymal and Kupffer cells. Desferal labeled with iron-59 was chosen as a radiomarker for the liposomal content, because Desferal in its free form does not cross cellular membranes. At various time inter...

journal_title：Life sciences

authors： Rahman YE,Cerny EA,Patel KR,Lau EH,Wright BJ

更新日期：1982-11-08 00:00:00

abstract：:Psychostimulants including amphetamine and cocaine induce locomotion and stereotypy and suppress eating. Although the capacity of cocaine to alter locomotion is usually viewed as related to dopamine neurotransmission, recent studies suggest that norepinephrine, acting through alpha1-adrenergic receptors (alpha1-ARs) c...

journal_title：Life sciences

authors： Clifford PS,Davis KW,Elliott AE,Wellman PJ

更新日期：2007-09-08 00:00:00

abstract：AIMS:Multiple sclerosis (MS) is one of the commonest neurologic disorders globally. LncRNA OIP5-AS1 has been found to be implicated in the etiology of MS. This study was to explore the roles and molecular mechanisms of OIP5-AS1 in the development of MS. MATERIALS AND METHODS:RT-qPCR assay was used to measure expressio...

journal_title：Life sciences

authors： Liu R,Li Y,Zhou H,Wang H,Liu D,Wang H,Wang Z

更新日期：2021-01-27 00:00:00

abstract：:We have recently demonstrated that the hypertensinogenic and natriuretic actions of ACTHI-39 can be found in a non-steroidogenic fragment of ACTH, ACTH4-10. These effects of ACTH or ACTH4-10 may be due to their ability to act as weak agonists of gamma MSH. gamma MSH is found in the 16K N-terminus of pro-opiocortin, an...

journal_title：Life sciences

authors： Klein MC,Hutchins PM,Lymangrover JR,Gruber KA

更新日期：1985-02-25 00:00:00

abstract：:In this study, we have identified the E-NTPDase family members and ecto-5'-nucleotidase/CD73 in rat heart left ventricle. Moreover, we characterize the biochemical properties and enzyme activities from synaptosomes of the nerve terminal endings of heart left ventricle. We observe divalent cation-dependent enzymes that...

journal_title：Life sciences

authors： Rücker B,Almeida ME,Libermann TA,Zerbini LF,Wink MR,Sarkis JJ

更新日期：2008-02-27 00:00:00

abstract：:This study examined the role of marijuana smoking in the pathogenesis of human lung cancer by measuring DNA damage in alveolar macrophages (AM). The alkaline unwinding method was used to determine DNA single-strand breaks in AM lavaged from non-smokers [NS] and smokers of marijuana [MS], tobacco [TS] or cocaine [CS], ...

journal_title：Life sciences

authors： Sherman MP,Aeberhard EE,Wong VZ,Simmons MS,Roth MD,Tashkin DP

更新日期：1995-01-01 00:00:00

abstract：:The specific binding of 35S-t-butylbicyclophosphorothionate (TBPS) was studied in synaptosomal membranes of rat cerebral cortex. The displacing potencies of eleven CNS depressants and three convulsants were determined in the presence of 1 microM GABA and 10 nM R 5135. GABA enhanced the displacing potencies of depressa...

journal_title：Life sciences

authors： Maksay G,Ticku MK

更新日期：1988-01-01 00:00:00

abstract：:In this study, we evaluated whether butein can inhibit the effects of tumor necrosis factor alpha (TNF-alpha), an inflammatory mediator, in intestinal epithelial HT-29 cells. Butein significantly inhibited TNF-alpha-induced interleukin 8 (IL-8) secretion and mRNA expression. Moreover, butein suppressed the expression ...

journal_title：Life sciences

authors： Lee SH,Seo GS,Jin XY,Ko G,Sohn DH

更新日期：2007-11-10 00:00:00

abstract：OBJECTIVE:To investigate the expression and time-dependent manner of bradykinin (BK) as well as its receptors (Bradykinin receptors 1 and 2, B1R and B2R) in spinal cord ischemia-reperfusion injury (SCII) in rat model. METHODS:Sprague-Dawley (SD) rats were subjected to 1 h of infra-renal abdominal aorta occlusion and r...

journal_title：Life sciences

authors： Ma Z,Dong Q,Lyu B,Wang J,Quan Y,Gong S

更新日期：2019-02-01 00:00:00

abstract：:Sustained levels of leucine comparable to those of human Maple Syrup Urine Disease (MSUD) were achieved in blood and brain of rats by subcutaneous leucine administration twice a day from the 6th to the 28th day of life. Control rats were treated with saline in the same volumes. Behavioral studies using aversive and no...

journal_title：Life sciences

authors： Mello CF,Feksa L,Brusque AM,Wannmacher CM,Wajner M

更新日期：1999-01-01 00:00:00

abstract：AIMS:This study was performed to assess isolated and combined effects of nandrolone and resistance training on the blood pressure, cardiac electrophysiology, and expression of the β1- and β2-adrenergic receptors in the heart of rats. MAIN METHODS:Wistar rats were randomly divided into four groups and submitted to a 6-...

journal_title：Life sciences

authors： das Neves VJ,Tanno AP,Cunha TS,Fernandes T,Guzzoni V,da Silva CA,de Oliveira EM,Moura MJ,Marcondes FK

更新日期：2013-05-30 00:00:00

abstract：:This study was conducted to investigate SAFB-induced apoptosis of mast cells as it pertains to both its basic drug mechanism and the potential therapeutics of the pathologic conditions accompanying mast cell proliferation. SAFB induced many apoptotic manifestations as evidenced by changes in cell morphology, generatio...

journal_title：Life sciences

authors： Park HI,Jeong MH,Lim YJ,Park BS,Kim GC,Lee YM,Kim HM,Yoo KS,Yoo YH

更新日期：2001-06-22 00:00:00