Abstract：
:Cancer is a disease of high complexity. Resistance to therapy is a major challenge in cancer targeted therapies. Overcoming this resistance requires a deep knowledge of the cellular interactions within tumor. Natural killer (NK) cells and cytotoxic T lymphocytes (CTLs) are the main anti-cancer immune cells, while T regulatory cells (Tregs) and cancer associated fibroblasts (CAFs) facilitate immune escape of cancer cells. Melatonin is a natural agent with anti-cancer functions that has also been suggested as an adjuvant in combination with cancer therapy modalities such as chemotherapy, radiotherapy, immunotherapy and tumor vaccination. One of the main effects of melatonin is regulation of immune responses against cancer cells. Melatonin has been shown to potentiate the activities of anti-cancer immune cells, as well as attenuating the activities of Tregs and CAFs. It also has a potent effect on the mitochondria, which may change immune responses against cancer. In this review, we explain the mechanisms of immune regulation by melatonin involved in its anti-cancer effects.
journal_name
Life Scijournal_title
Life sciencesauthors
Mortezaee K,Potes Y,Mirtavoos-Mahyari H,Motevaseli E,Shabeeb D,Musa AE,Najafi M,Farhood Bdoi
10.1016/j.lfs.2019.116960subject
Has Abstractpub_date
2019-12-01 00:00:00pages
116960eissn
0024-3205issn
1879-0631pii
S0024-3205(19)30887-2journal_volume
238pub_type
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