Stimulation of mitochondrial pyruvate transport in rat renal cortex by phenylephrine.


:Phenylephrine effect on liver and kidney cortex mitochondrial pyruvate concentration was investigated. While in liver the alpha 1-adrenergic agent produced a decrease in pyruvate content, a significant increase was observed in kidney, even in the presence of 0.5 mM alpha-cyano-4-hydroxy-cinnamate. These changes were not observed when pyruvate was formed by intramitochondrial transamination of alanine, suggesting a role for the pyruvate transport across mitochondrial membranes in the regulation of mitochondrial pyruvate metabolism in kidney cortex. This was corroborated measuring the phenylephrine effect on pyruvate carboxylation.


Life Sci


Life sciences


Oliver J,Sola MM,Salto R,Vargas AM




Has Abstract


1990-01-01 00:00:00














  • Melanin concentrating hormone. III. Melanin concentrating hormone (MCH): the message sequence.

    abstract::Melanin concentrating hormone (MCH) is a heptadecapeptide synthesized by the hypothalamus and secreted by the neurohypophysis of the teleost pituitary gland. MCH stimulates melanosome aggregation within teleost melanocytes but also exhibits MSH-like (melanosome dispersing) activity on tetrapod (frog and lizard) melano...

    journal_title:Life sciences

    pub_type: 杂志文章


    authors: Castrucci AM,Lebl M,Hruby VJ,Matsunaga TO,Hadley ME

    更新日期:1989-01-01 00:00:00

  • Histone deacetylase inhibitor LMK-235-mediated HO-1 expression induces apoptosis in multiple myeloma cells via the JNK/AP-1 signaling pathway.

    abstract:AIMS:Histone deacetylase inhibitors (HDACis) are promising anticancer drugs that open new areas of epigenetic drug discovery. Multiple myeloma (MM) is a malignant tumor of the blood system that is difficult to cure and often relapses. Here, we investigated the in vitro effects of a novel HDACi, LMK-235, on MM cells, an...

    journal_title:Life sciences

    pub_type: 杂志文章


    authors: Li X,Guo Y,Kuang X,Zhao L,Li H,Cheng B,Wang W,Zhang Z,Liu P,Wang J

    更新日期:2019-04-15 00:00:00

  • The effect of intestinal alkaline phosphatase on intestinal epithelial cells, macrophages and chronic colitis in mice.

    abstract:AIMS:Intestinal alkaline phosphatase (IAP) is an intestinal brush border enzyme that is shown to function as a gut mucosal defense factor, but its defensive mechanism remains unclear. The aims of this study were to evaluate the effect of IAP on intestinal epithelial cells and macrophages, and on chronic colitis in inte...

    journal_title:Life sciences

    pub_type: 杂志文章


    authors: Lee C,Chun J,Hwang SW,Kang SJ,Im JP,Kim JS

    更新日期:2014-04-01 00:00:00

  • Leptin in osteoarthritis: Focus on articular cartilage and chondrocytes.

    abstract::Osteoarthritis (OA) is a complex joint disorder with a number of underlying physical, biochemical, biomechanical and genetic causes. Obesity is considered to be one of the major risk factors for the development and progression of OA. It actively contributes to the inflammatory status and to cartilage degradation in th...

    journal_title:Life sciences

    pub_type: 杂志文章,评审


    authors: Scotece M,Mobasheri A

    更新日期:2015-11-01 00:00:00

  • Ovarian acetylcholine and ovarian KCNQ channels: insights into cellular regulatory systems of steroidogenic granulosa cells.

    abstract::Acetylcholine (ACh) may be an ovarian signaling molecule, since ACh is produced by non-neuronal granulosa cells (GCs) derived from the antral follicle, and likely also by their in vivo counterparts in the growing follicle. Furthermore, muscarinic ACh receptors (MR) are present in GC membranes and in cultured human GCs...

    journal_title:Life sciences

    pub_type: 杂志文章


    authors: Kunz L,Roggors C,Mayerhofer A

    更新日期:2007-05-30 00:00:00

  • Nanoemulsions for targeting the neurodegenerative diseases: Alzheimer's, Parkinson's and Prion's.

    abstract::Neurodegenerative diseases need the drugs to be delivered right inside the brain to maximizing the therapeutic effects. This can be achieved by use of novel targeted delivery systems such as nanoemulsions. Nanoemulsions (NE) are nano-sized emulsions that are manufactured for enhancing the delivery of drugs to the targ...

    journal_title:Life sciences

    pub_type: 杂志文章,评审


    authors: Nirale P,Paul A,Yadav KS

    更新日期:2020-03-15 00:00:00

  • Inhibition by talipexole, a thiazolo-azepine derivative, of dopaminergic neurons in the ventral tegmental area.

    abstract::A microiontophoretic study using rats anesthetized with chloral hydrate and immobilized with gallamine triethiodide was carried out to compare the effect of talipexole (B-HT 920 CL2:2-amino-6-allyl-5,6,7,8-tetrahydro-4H-thiazolo [4,5-d]-azepine-dihydrochloride), a dopamine autoreceptor agonist, on dopaminergic neurons...

    journal_title:Life sciences

    pub_type: 杂志文章


    authors: Momiyama T,Sasa M,Takaori S

    更新日期:1991-01-01 00:00:00

  • Branched-chain amino acid supplementation ameliorates angiotensin II-induced skeletal muscle atrophy.

    abstract:AIMS:Sarcopenia is characterized by muscle mass and strength loss and reduced physical activity. Branched-chain amino acids (BCAAs) were recently described as an activator of protein synthesis via mammalian target of rapamycin (mTOR) signaling for muscle atrophy. In cardiovascular diseases, excessive activation of the ...

    journal_title:Life sciences

    pub_type: 杂志文章


    authors: Yamanashi K,Kinugawa S,Fukushima A,Kakutani N,Takada S,Obata Y,Nakano I,Yokota T,Kitaura Y,Shimomura Y,Anzai T

    更新日期:2020-06-01 00:00:00

  • Recent advances in studies of molecular hydrogen in the treatment of pancreatitis.

    abstract::Pancreatitis is an inflammatory disease of the pancreas characterized by acinar cell injury and is associated with the abnormal release of trypsin, which results in high mortality due to systemic inflammatory response syndrome (SIRS) and multiple organ dysfunction syndrome (MODS). The inflammatory response, impaired a...

    journal_title:Life sciences

    pub_type: 杂志文章,评审


    authors: Li Y,Li G,Suo L,Zhang J

    更新日期:2021-01-01 00:00:00

  • Isolation of anti-leukemia compounds from Citrus reticulata.

    abstract::In vitro effects of medicinal plant extracts from the pericarpium of Citrus reticulata (cv Jiao Gan) (PCRJ) on the growth and differentiation of a recently characterized murine myeloid leukemic cell clone WEHI 3B (JCS) were investigated. Extracts of PCRJ not only inhibited the proliferation of JCS cells in a dose depe...

    journal_title:Life sciences

    pub_type: 杂志文章


    authors: Mak NK,Wong-Leung YL,Chan SC,Wen J,Leung KN,Fung MC

    更新日期:1996-01-01 00:00:00

  • The effect of diabetes mellitus on aortic prostanoid synthesis and serum cholesterol levels in the rat fed a high cholesterol diet.

    abstract::The effect of diabetes mellitus on serum cholesterol and aortic microsomal prostanoid synthesis was studied in cholesterol fed male Lewis rats. Normal, diabetic and diabetic rats treated with pancreatic islets were divided into three diet subgroups, control diet, control +2% cholesterol for 8 weeks and control +2% cho...

    journal_title:Life sciences

    pub_type: 杂志文章


    authors: Myers SI,Bartula L,Linzel M,Phan T,Jung PJ,Merrell RC

    更新日期:1990-01-01 00:00:00

  • Role of Angiotensin II type 1 receptor on renal NAD(P)H oxidase, oxidative stress and inflammation in nitric oxide inhibition induced-hypertension.

    abstract:AIMS:Activation of the renin-angiotensin system (RAS), renal oxidative stress and inflammation are constantly present in experimental hypertension. Nitric oxide (NO) inhibition with N(w)-nitro-L-arginine methyl ester (L-NAME) has previously been reported to produce hypertension, increased expression of Angiotensin II (...

    journal_title:Life sciences

    pub_type: 杂志文章


    authors: Rincón J,Correia D,Arcaya JL,Finol E,Fernández A,Pérez M,Yaguas K,Talavera E,Chávez M,Summer R,Romero F

    更新日期:2015-03-01 00:00:00

  • Pharmacological characterization of Abbott-81282, a novel, non-peptide angiotensin-II antagonist selective for type-1 receptors.

    abstract::Abbott-81282 (A-81282) has been identified among a series of related compounds as being a highly potent and selective antagonist of angiotensin receptors. At AT1 receptors of the rabbit aorta, A-81282 exhibited a pA2 of 9.64 (+/- 0.33) vs. angiotensin-II, and demonstrated characteristics consistent with competitive an...

    journal_title:Life sciences

    pub_type: 杂志文章


    authors: Hancock AA,Buckner SA,Lee JY,Brune M,Morse PA,Oheim K,Warner RB,Winn M,Zydowsky TM,De B

    更新日期:1993-01-01 00:00:00

  • Inhibition of immune cell proliferation with haloperidol and relationship of tyrosine hydroxylase expression to immune cell growth.

    abstract::Previous studies indicated that exogenous dopamine and its agonists directly regulated mitogen-induced immune cell proliferation. In this study, we further investigated role of endogenous dopamine in immune cell growth. Haloperidol, a general antagonist for dopamine receptors, could reduce the cell growth rate of T ce...

    journal_title:Life sciences

    pub_type: 杂志文章


    authors: Tsao CW,Lin YS,Cheng JT

    更新日期:1998-01-01 00:00:00

  • A new method of purification and sensitive bioassay of platelet-activating factor (PAF) in human whole blood.

    abstract::There is no satisfactory assay procedure of PAF in human whole blood in terms of sensitivity, reproducibility and simplicity. This is due to coexisting lipids from plasma and cellular membranes which inhibit measurement of PAF in various assay procedures, including bioassay. In the present study, an attempt was made t...

    journal_title:Life sciences

    pub_type: 杂志文章


    authors: Shinozaki K,Kawasaki T,Kambayashi J,Sakon M,Shiba E,Uemura Y,Ou M,Iwamoto N,Mori T

    更新日期:1994-01-01 00:00:00

  • Homocysteine accelerates atherosclerosis via inhibiting LXRα-mediated ABCA1/ABCG1-dependent cholesterol efflux from macrophages.

    abstract:AIMS:Macrophage-derived foam-cell formation plays a crucial role in the development of atherosclerosis, and liver X receptor alpha (LXRα) is a key regulator of lipid metabolism in macrophages. Homocysteine (Hcy) is an independent risk factor of atherosclerosis; however, the regulation of lipid metabolism and role of LX...

    journal_title:Life sciences

    pub_type: 杂志文章


    authors: Jin P,Bian Y,Wang K,Cong G,Yan R,Sha Y,Ma X,Zhou J,Yuan Z,Jia S

    更新日期:2018-12-01 00:00:00

  • Discriminative stimulus effects of caffeine: tolerance and cross-tolerance with methylphenidate.

    abstract::Twice daily injection of caffeine (30 mg/kg) for 3-1/2 days shifted the caffeine stimulus generalization curve to the right by 3-fold in rats trained to discriminate saline from 30 mg/kg of caffeine, and by 4-fold in rats trained to discriminate saline from 10 mg/kg of caffeine. The latter group was also tested for cr...

    journal_title:Life sciences

    pub_type: 杂志文章


    authors: Holtzman SG

    更新日期:1987-01-26 00:00:00

  • Effect of exogenous ascorbic acid intake on biosynthesis of ascorbic acid in mice.

    abstract::The effect of exogenous ascorbic acid intake on biosynthesis of ascorbic acid in mice has been studied. After the mice were on diets containing added ascorbic acid for two months, the activities of ascorbic acid synthesizing enzymes in the mouse liver homogenates were measured using L-gulono-gamma-lactone as a substra...

    journal_title:Life sciences

    pub_type: 杂志文章


    authors: Tsao CS,Young M

    更新日期:1989-01-01 00:00:00

  • Treatment with polyamines can prevent monosodium glutamate neurotoxicity in the rat retina.

    abstract::It has been previously shown that treatment of newborn rats with the polyamines putrescine, spermidine and spermine can rescue sympathetic neurons from naturally occurring cell death and from induced death after axotomy or immunosympathectomy. The present study demonstrates that polyamine treatment can also prevent th...

    journal_title:Life sciences

    pub_type: 杂志文章


    authors: Gilad GM,Gilad VH

    更新日期:1989-01-01 00:00:00

  • Comparison of growth and exploratory behavior in mice fed an exclusively milk formula diet and mice fed a food-pellet diet post weaning.

    abstract::An exclusively milk formula diet stunted the growth of mice immediately following weaning. Milk-fed mice displayed a low-frequency profile of exploratory behavior, while pellet-fed mice showed high-frequency exploration. In contrast to exploratory behavior, feeding behavior did not differ significantly between milk- a...

    journal_title:Life sciences

    pub_type: 杂志文章


    authors: Ishii T,Itou T,Nishimura M

    更新日期:2005-11-26 00:00:00

  • Effects of pituitary adenylate-cyclase activating peptide (PACAP) on the rat adrenal secretory activity: preliminary in-vitro studies.

    abstract::PACAP did not affect secretory activity of dispersed rat adrenocortical cells, but it markedly raised aldosterone (ALDO) and corticosterone (B) production by adrenal slices, containing both medullary and cortical tissues. The secretagogue effects of PACAP were suppressed by PACAP(6-38), a specific competitive antagoni...

    journal_title:Life sciences

    pub_type: 杂志文章


    authors: Andreis PG,Malendowicz LK,Belloni AS,Nussdorfer GG

    更新日期:1995-01-01 00:00:00

  • Cross tolerance between morphine and beta-endorphin in the in vivo vasodilating effect in the hamster cheek pouch.

    abstract::The relative potencies of the in vivo vasodilating effect on the arterioles of the hamster cheek pouch of morphine and beta-endorphin decreased significantly after chronic morphine injection, indicating the existence of tolerance to morphine and cross tolerance between morphine and beta-endorphin. The apparent pA2 val...

    journal_title:Life sciences

    pub_type: 杂志文章


    authors: Koo A,Wong TM

    更新日期:1983-01-31 00:00:00

  • Type II diabetes promotes a myofibroblast phenotype in cardiac fibroblasts.

    abstract:AIMS:Cardiovascular disease is the leading cause of death for individuals diagnosed with type II diabetes mellitus (DM). Changes in cardiac function, left ventricular wall thickness and fibrosis have all been described in patients and animal models of diabetes; however, the factors mediating increased matrix deposition...

    journal_title:Life sciences

    pub_type: 杂志文章


    authors: Fowlkes V,Clark J,Fix C,Law BA,Morales MO,Qiao X,Ako-Asare K,Goldsmith JG,Carver W,Murray DB,Goldsmith EC

    更新日期:2013-03-28 00:00:00

  • An immune landscape based prognostic signature predicts the immune status and immunotherapeutic responses of patients with colorectal cancer.

    abstract:AIMS:Colorectal cancer (CRC) is one of the most common cancers with poor prognosis worldwide. The advent of immunotherapy has greatly improved survival in refractory patients of CRC. In this study, we aimed to identify reliable immune classification and biomarkers that predict immunotherapeutic responses in CRC patient...

    journal_title:Life sciences

    pub_type: 杂志文章


    authors: Li M,Li W,Yang X,Wang H,Peng Y,Yin J,Lu Y,Liu L,Shang J,Zhao Q

    更新日期:2020-11-15 00:00:00

  • 17-DMAG, an Hsp90 inhibitor, ameliorates ovariectomy-induced obesity in rats.

    abstract:AIMS:Obesity is not only associated with metabolic diseases but is also a symptom of menopause in women. To date, there are no effective drugs for the management of obesity, and it is important to find new agents with fewer side effects, for the treatment of obesity. This study aimed to determine the anti-obesity effec...

    journal_title:Life sciences

    pub_type: 杂志文章


    authors: Tsai YC,Leu SY,Chen SY,Kung CW,Lee YM,Liu YP,Yen MH,Cheng PY

    更新日期:2019-09-01 00:00:00

  • Evolution of the activity of UGT1A1 throughout the development and adult life in a rat.

    abstract::Biliary excretion is the main route of disposal of bilirubin and impaired excretion results in jaundice, a well recognisable symptom of liver disease. Conjugation of bilirubin in the liver is essential for its clearance. The glucuronidation of bilirubin is catalysed by the microsomal UDP-glucuronosyltransferase UGT1A1...

    journal_title:Life sciences

    pub_type: 杂志文章


    authors: Bustamante N,Cantarino MH,Arahuetes RM,Cubero FJ,Ortiz A

    更新日期:2006-03-06 00:00:00

  • Dipeptidyl peptidase IV is a target for covalent adduct formation with the acyl glucuronide metabolite of the anti-inflammatory drug zomepirac.

    abstract::The nonsteroidal anti-inflammatory drug zomepirac (ZP) is metabolised to a chemically reactive acyl glucuronide conjugate (ZAG) which can form covalent adducts with proteins. In vivo, such adducts could initiate immune or toxic responses. In rats given ZP, the major band detected in liver homogenates by immunoblotting...

    journal_title:Life sciences

    pub_type: 杂志文章


    authors: Wang M,Gorrell MD,McGaughan GW,Dickinson RG

    更新日期:2001-01-05 00:00:00

  • Szygium aromaticum (L.) Merr. Et Perry (Myrtaceae) flower bud induces apoptosis of p815 mastocytoma cell line.

    abstract::This study was conducted to investigate SAFB-induced apoptosis of mast cells as it pertains to both its basic drug mechanism and the potential therapeutics of the pathologic conditions accompanying mast cell proliferation. SAFB induced many apoptotic manifestations as evidenced by changes in cell morphology, generatio...

    journal_title:Life sciences

    pub_type: 杂志文章


    authors: Park HI,Jeong MH,Lim YJ,Park BS,Kim GC,Lee YM,Kim HM,Yoo KS,Yoo YH

    更新日期:2001-06-22 00:00:00

  • Prostaglandin E2 upregulates survivin expression via the EP1 receptor in hepatocellular carcinoma cells.

    abstract:AIMS:Cyclooxygenase-2 (COX-2)-controlled production of prostaglandin E(2) (PGE(2)) has been implicated in cell growth and metastasis in many cancers. Recent studies have found that COX-2 is co-expressed with survivin in many cancers. Survivin is a member of the inhibitor-of-apoptosis protein family. Some COX-2 inhibito...

    journal_title:Life sciences

    pub_type: 杂志文章


    authors: Bai XM,Jiang H,Ding JX,Peng T,Ma J,Wang YH,Zhang L,Zhang H,Leng J

    更新日期:2010-01-30 00:00:00

  • Identification of 14-hydroxy-retro-retinol and 4-hydroxy-retinol as endogenous retinoids in rats throughout neonatal development.

    abstract::14-Hydroxy-retro-retinol was previously described as an in vivo and in vitro metabolite of retinol. Furthermore, the retinoid 4-hydroxy-retinol was identified as an endogenous occurring retinoid in the amphibian organism and an in vitro metabolite of retinol. We describe in the present study that 14-hydroxy-retro-reti...

    journal_title:Life sciences

    pub_type: 杂志文章


    authors: Rühl R,Hamscher G,Garcia AL,Nau H,Schweigert FJ

    更新日期:2005-02-18 00:00:00