Stimulation of mitochondrial pyruvate transport in rat renal cortex by phenylephrine.

Abstract:

:Phenylephrine effect on liver and kidney cortex mitochondrial pyruvate concentration was investigated. While in liver the alpha 1-adrenergic agent produced a decrease in pyruvate content, a significant increase was observed in kidney, even in the presence of 0.5 mM alpha-cyano-4-hydroxy-cinnamate. These changes were not observed when pyruvate was formed by intramitochondrial transamination of alanine, suggesting a role for the pyruvate transport across mitochondrial membranes in the regulation of mitochondrial pyruvate metabolism in kidney cortex. This was corroborated measuring the phenylephrine effect on pyruvate carboxylation.

journal_name

Life Sci

journal_title

Life sciences

authors

Oliver J,Sola MM,Salto R,Vargas AM

doi

10.1016/0024-3205(90)90297-5

subject

Has Abstract

pub_date

1990-01-01 00:00:00

pages

401-6

issue

5

eissn

0024-3205

issn

1879-0631

pii

0024-3205(90)90297-5

journal_volume

47

pub_type

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