Spontaneous reactivation of phosphinylated human erythrocyte acetylcholinesterase and human serum butyrylcholinesterase.

abstract：:Although one of the major genes which cause type 1 (insulin-dependent) diabetes mellitus is located in the class II HLA region in humans, its precise location is still unknown. In order to investigate whether TAP (Transporter associated with Antigen Processing) and LMP (Low Molecular Weight Polypeptide) genes, which a...

journal_title：Life sciences

authors： Kawaguchi Y,Ikegami H,Fukuda M,Takekawa K,Fujioka Y,Fujisawa T,Ueda H,Ogihara T

更新日期：1994-01-01 00:00:00

abstract：:In an attempt to investigate the role of nucleoside transporter function in the hypertensive state, we have compared the binding of [3H]nitrobenzylthioinosine ([3H]NBMPR), a nucleoside transporter probe, in membranes prepared from platelet, renal, pulmonary, cardiac and brain tissues of spontaneously hypertensive rats...

journal_title：Life sciences

authors： Williams EF,Udofia UP,Brooks GR,Hawk NN

更新日期：1990-01-01 00:00:00

abstract：:We evaluated the effect of several classes of calmodulin inhibitors on the activity of calmodulin prepared from C6 astrocytoma cells and studied the activity of these drugs as inhibitors of the growth of C6 cells in tissue culture. There was a good correlation between the activity of the drugs as inhibitors of calmodu...

journal_title：Life sciences

authors： Lee GL,Hait WN

更新日期：1985-01-28 00:00:00

abstract：AIMS:Normal human cells in culture progressively lose their capacity for replication, ending in an irreversible arrested state known as replicative senescence. Senescence has been functionally associated to the process of organismal ageing and is also considered a major tumor-suppressing mechanism. Although a great dea...

journal_title：Life sciences

authors： Maeda M,Scaglia N,Igal RA

更新日期：2009-01-16 00:00:00

abstract：BACKGROUND/AIMS:Previous studies have demonstrated that Galactooligosaccharides (GOS), known as "bifidus factor", has anti-inflammatory effects. Colitis, a kind of colonic inflammatory damage could be induced by different chemicals. The pathogenesis and mechanism of colitis remains unclear, and may be related to intest...

journal_title：Life sciences

authors： Chu H,Tao X,Sun Z,Hao W,Wei X

更新日期：2020-02-01 00:00:00

abstract：AIMS:Transplantation of bone marrow mononuclear cells (BMMCs) exerts neuroprotection against cerebral ischemia. We examined the therapeutic timepoint of allogeneic BMMC transplantation in a rat model of focal cerebral ischemia, and determined the effects of repeated transplantation outside the therapeutic window. MAIN...

journal_title：Life sciences

authors： Kamiya F,Ueda M,Nito C,Kamiya N,Inaba T,Suda S,Saito T,Muraga K,Katayama Y

更新日期：2014-01-24 00:00:00

abstract：:The effects of various vasorelaxant agents on aortas from control and genetically diabetic rats were examined. The concentration-response curves for the isoproterenol (ISO)-induced relaxation of both aortic strips with and without endothelium are shifted to the right in diabetic rats. The relaxation responses of diabe...

journal_title：Life sciences

authors： Miyata N,Yamaura H,Tsuchida K,Otomo S,Kamata K,Kasuya Y

更新日期：1992-01-01 00:00:00

abstract：AIMS:Gastrointestinal cancers are a kind of deadly malignancy afflicting close to a million peoples worldwide. 5-Fluorouracil (5-Fu) is a main chemotherapeutic agent for cancer treatment. However, prolonged exposure of 5-Fu to cancer cells may cause chemoresistance and decrease the therapeutic potential of 5-Fu. MAIN ...

journal_title：Life sciences

authors： Zhu Y,Yi Y,Bai B,Li L,You T,Sun W,Yu Y

更新日期：2018-05-15 00:00:00

abstract：AIMS:Serotonergic neurons and amino acid neurons are involved in the central nervous control of lower urinary tract function. We investigated the role of the serotonergic system in the central regulation of micturition, as well as the relationship between serotonergic neurons and amino acid neurons in the lumbosacral c...

journal_title：Life sciences

authors： Kadekawa K,Nishijima S,Sugaya K,Miyazato M,Saito S

更新日期：2009-10-07 00:00:00

abstract：AIMS:Absent in melanoma 2 (AIM2) is a cytosolic DNA sensor which plays an important role in inflammasome formation and is involved in various cellular functions including pyroptosis, fibrosis, and tissue injury. Our study aimed to investigate whether AIM2 plays a role in diabetic cardiomyopathy (DCM) and to explore its...

journal_title：Life sciences

authors： Wang X,Pan J,Liu H,Zhang M,Liu D,Lu L,Tian J,Liu M,Jin T,An F

更新日期：2019-03-15 00:00:00

abstract：:Effects of sophoricoside and its analogs on proinflammatory cytokines have been investigated. Sophoricoside, genistein and orobol exhibited inhibitory effects on IL-5, IL-3, GM-CSF and IL-6 bioactivities. Genistin showed inhibitory effects on IL-5 and IL-3 bioactivities, but did not inhibit GM-CSF and IL-6 bioactiviti...

journal_title：Life sciences

authors： Yun J,Lee CK,Chang IM,Takatsu K,Hirano T,Min KR,Lee MK,Kim Y

更新日期：2000-10-27 00:00:00

abstract：:Sodium spirulan (Na-SP) is a sulfated polysaccharide with M(r) approximately 220,000 isolated from the blue-green alga Spirulina platensis. The polysaccharide consists of two types of disaccharide repeating units, O-hexuronosyl-rhamnose (aldobiuronic acid) and O-rhamnosyl-3-O-methylrhamnose (acofriose) with sulfate gr...

journal_title：Life sciences

authors： Kaji T,Okabe M,Shimada S,Yamamoto C,Fujiwara Y,Lee JB,Hayashi T

更新日期：2004-03-26 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is the most prevalent neuromuscular disease worldwide. It is a lethal and progressive neurodegenerative disease, principally affecting motor neurons; patient clinical characteristics are muscle weakness, dysphagia and respiratory failure. The mean age is related to family history (4...

journal_title：Life sciences

authors： Recabarren-Leiva D,Alarcón M

更新日期：2018-01-15 00:00:00

abstract：:Mitochondria are known to develop a series of abnormalities as a result of ischemia. The inability of mitochondria to resume normal function following reperfusion has been implicated as an important factor in irreversible cell damage. However, the mechanism of mitochondrial injury after ischemic brain insult is poorly...

journal_title：Life sciences

authors： Kariman K

更新日期：1985-07-08 00:00:00

abstract：:In vitro studies showed that organophosphate insecticides have different IC50 values (i.e., concentration of inhibitor required to inhibit 50% enzyme activity) for acetylcholinesterases (AChE's) from different species. Since previous reports indicated that the binding of active cholinesterase inhibitors to non-critica...

journal_title：Life sciences

authors： Wang C,Murphy SD

更新日期：1982-07-12 00:00:00

abstract：:The ability of metformin (MF) to acutely relax phenylephrine (PE)-induced contraction in the isolated rat tail artery is reported to be accompanied by repolarization of the arterial smooth muscle cell (SMC) membranes. These membranes contain potassium (K) channels which if opened could mediate such repolarization and ...

journal_title：Life sciences

authors： Peuler JD,Lee JM,Smith JM

更新日期：1999-10-29 00:00:00

abstract：:The use of xenon as an almost ideal anesthetic with very little side effects is gaining clinical acceptance, yet its effects on the cellular level are still unclear. It affects intracellular Ca2+-homeostasis but up to now no cellular event or Ca2+-signaling system has been described to be specifically sensitive to xen...

journal_title：Life sciences

authors： Petzelt C,Taschenberger G,Schmehl W,Hafner M,Kox WJ

更新日期：1999-01-01 00:00:00

abstract：AIMS:The aims of this study were to examine the role of endothelin-1 (ET-1), a pleiotropic peptide found at elevated levels in a number of malignancies and which has been shown to influence oral cancer cell behaviour via paracrine signalling pathways, on the phenotype of oral fibroblasts. MAIN METHODS:The effect of ET...

journal_title：Life sciences

authors： Hinsley EE,Kumar S,Hunter KD,Whawell SA,Lambert DW

更新日期：2012-10-15 00:00:00

abstract：AIM:Nuclear factor-kappa B inhibitor alpha (IκBα) polymorphisms were found to be associated with inflammatory diseases. However, the association between IκBα polymorphisms with gastric cancer is still unknown. We aim to investigate the association between IκBα polymorphisms and gastric cancer risk in a large population...

journal_title：Life sciences

authors： Wang S,Zhang M,Zeng Z,Tian L,Wu K,Chu J,Fan D,Hu P,Sung JJ,Yu J

更新日期：2011-04-25 00:00:00

abstract：:The ontogeny and regulation by isoproterenol of type II thyroxine 5'-deiodinase, N-acetyltransferase, and hydroxyindole-O-methyltransferase activities were studied in the rat Harderian gland. Both 5'-deiodinase and N-acetyltransferase activities exhibited maximal values at the first week of age. These activities gradu...

journal_title：Life sciences

authors： Osuna C,Rubio A,Goberna R,Guerrero JM

更新日期：1990-01-01 00:00:00

abstract：:According to recent epidemiological reports, almost 40% of American population use complimentary and alternative medicine (CAM) during their lifetime. Patients detected with HIV or cancer often consume herbal products especially St. John's wort (SJW) for antidepressants in combination with prescription medicines. Such...

journal_title：Life sciences

authors： Pal D,Mitra AK

更新日期：2006-03-27 00:00:00

abstract：AIMS:We investigated the involvement of the renin angiotensin system (RAS) on the cardiorespiratory control in rats from dams fed with a low-protein diet. MAIN METHODS:Male offspring were obtained from dams fed a normoprotein diet (NP, 17% casein) and low-protein diet (LP, 8% casein) during pregnancy and lactation. Di...

journal_title：Life sciences

authors： Barros MAV,de Brito Alves JL,Barros RGN,Santana E Silva M,Nasser S,Tourneur Y,Leandro CVG,Vidal H,Pirola L,Costa-Silva JH

更新日期：2020-12-15 00:00:00

abstract：:Dietary guidelines published in the past two decades have acknowledged the beneficial effects of myricetin, an important and common type of herbal flavonoid, against several human diseases such as inflammation, cardiovascular pathologies, and cancer. An increasing number of studies have shown the beneficial effects of...

journal_title：Life sciences

authors： Devi KP,Rajavel T,Habtemariam S,Nabavi SF,Nabavi SM

更新日期：2015-12-01 00:00:00

abstract：:Anandamide (arachidonylethanolamide; AEA) is an endogenous ligand for the cannabinoid receptor and its pharmacological effects are under intensive study. However, AEA has a low aqueous solubility and stability which may restrict its use and may eventually endanger the reliability of the obtained results. In the presen...

journal_title：Life sciences

authors： Jarho P,Urtti A,Järvinen K,Pate DW,Järvinen T

更新日期：1996-01-01 00:00:00

abstract：:A previously unreported anti-bacterial activity against Escherichia coli has been found in porcine and bovine sera, but not in human or chicken sera. The activity is not affected by heat inactivation of the complement system, and is bacteriostatic rather than bactericidal. Growth inhibition is reversible by addition o...

journal_title：Life sciences

authors： Lenard J,VanDeroef R

更新日期：1995-01-01 00:00:00

abstract：:The secretagogue action of lipophilic, GABA-mimetic, beta-(p-chlorophenyl)-gamma-aminobutyric acid (PCPGABA) was studied in the rat in relation to body temperature. PCPGABA (2 to 8 mg/kg s.c.) stimulated acid output in the urethane-anesthetized rat whose core temperature ranged between 28 to 30 degrees C. However, thi...

journal_title：Life sciences

authors： Hara N,Hara Y,Goto Y

更新日期：1990-01-01 00:00:00

abstract：:The potential effect of maternal caffeine ingestion upon total brain protein and the concentration of two prototype neuropeptides, thyrotropin-releasing hormone (TRH) and its derivative, cyclo (His-Pro) in neonates was examined during the nursing period in the context of variable maternal protein intake. Maternal caff...

journal_title：Life sciences

authors： Mori M,Wilber JF,Nakamoto T

更新日期：1983-11-21 00:00:00

abstract：:Abbott-81282 (A-81282) has been identified among a series of related compounds as being a highly potent and selective antagonist of angiotensin receptors. At AT1 receptors of the rabbit aorta, A-81282 exhibited a pA2 of 9.64 (+/- 0.33) vs. angiotensin-II, and demonstrated characteristics consistent with competitive an...

journal_title：Life sciences

authors： Hancock AA,Buckner SA,Lee JY,Brune M,Morse PA,Oheim K,Warner RB,Winn M,Zydowsky TM,De B

更新日期：1993-01-01 00:00:00

abstract：:The objective of this study was to investigate whether age induces changes on vasodilator response induced by cromakalim, an ATP-sensitive K+ (K(ATP)) channel opener, as well as the underlying mechanism involved in this possible alteration. For this purpose, aortic segments from young (3-5 months) and old (3 years) ra...

journal_title：Life sciences

authors： Ferrer M,Tejera N,Marín J,Balfagón G

更新日期：1998-01-01 00:00:00

abstract：:In the present study the formation of thrombin-antithrombin-complexes (TAT) during incubation of thrombin (0.89, 4.5, 8.9 nmol/l) and antithrombin (4.6 micromol/l) on the surface of cultured human EC, derived from different parts of the circulation, and on the surface of human vessel segments was studied. In the absen...

journal_title：Life sciences

authors： Ruzicka K,Wojta J,Artemiou O,Birsan T,Quehenberger P,Kapiotis S,Hofbauer R,Speiser W

更新日期：1998-01-01 00:00:00