Absence of association of TAP and LMP genes with type 1 (insulin-dependent) diabetes mellitus.

abstract：:Monocyte chemoattractant protein-1 (MCP-1) is a 76-amino-acid chemokine thought to be the major chemotactic factor for monocytes. MCP-1 is found in macrophage-rich areas of atherosclerotic lesions. Recent report indicates that MCP-1 is induced by glucose-stimulation, raising the important link between diabetes mellitu...

journal_title：Life sciences

authors： Murao K,Yu X,Cao WM,Imachi H,Chen K,Muraoka T,Kitanaka N,Li J,Ahmed RA,Matsumoto K,Nishiuchi T,Tokuda M,Ishida T

更新日期：2007-07-26 00:00:00

abstract：AIMS:The objective of this study is to investigate glucosamine (GlcN) as a transcriptional regulator of iNOS and other genes in association with the dynamic O-GlcNAcylation of RNA polymerase II (RNAPII). MAIN METHODS:The LPS- and/or GlcN-stimulated transcriptional activities of various Gal4-binding site/TATA-box-conta...

journal_title：Life sciences

authors： Hwang JS,Hwang SY,Han IO

更新日期：2014-08-21 00:00:00

abstract：:An increase in the weight of the thyroid gland, accompanied by reductions in uptake and release of 1311, serum T3 and reverse T3 concentrations and an increase in serum TSH concentration, occurs during the development of renal hypertension in rats. Renal function, as assessed by BUN, serum and urinary creatinine conce...

journal_title：Life sciences

authors： Fregly MJ,Threatte RM

更新日期：1982-02-15 00:00:00

abstract：:S-adenosylmethionine and adenosine levels in the rat pineal gland were determined by high-performance liquid chromatography after fractionation of the pineal extracts. The concentration of S-adenosylmethionine follows a circadian rhythm and is about three times higher during the day (2.5 nmol/gland) than the night (1....

journal_title：Life sciences

authors： Chabannes B,Sarda N,Cronenberger L,Pacheco H

更新日期：1984-08-06 00:00:00

abstract：:Endogenous levels of salsolinol and dopamine were measured by a gas chromatography/mass spectrometry (GC/MS) - selected ion monitoring technique using deuterated internal standards in Long Evans rats chronically exposed to ethanol for ten months. Chronic ethanol exposure produced significant increases of dopamine and ...

journal_title：Life sciences

authors： Myers WD,Mackenzie L,Ng KT,Singer G,Smythe GA,Duncan MW

更新日期：1985-01-28 00:00:00

abstract：:It was demonstrated in the previous study that the microinjection of antisense oligodeoxynucleotide (AS ODN) against mu-opioid receptor (MOR) into periaqueductal gray (PAG) of rat brain selectively decreased the MOR mRNA content in PAG, and the decrease in MOR mRNA content was enhanced by pretreatment of the PAG with ...

journal_title：Life sciences

authors： Oka T,Yoshikawa M,Kobayashi T,Kitamura K,Iwao K,Kobayashi H

更新日期：2001-04-06 00:00:00

abstract：:Radio-binding assay, bioassay and HPLC detection were used to observe the antagonistic effects of dextrorphan on PCP's actions. Dextrorphan displayed high affinity to PCP receptor in the rabbit mesenteric blood vessels. It had weak PCP-like bioactivity, but could antagonize PCP's action dose-dependently in vitro study...

journal_title：Life sciences

authors： Sun FY,Zhu H,Zhang LM,Xu XR,Zhang AZ

更新日期：1987-06-15 00:00:00

abstract：AIM:The effects of local applied NO-active compounds on glutamate (GLU)-evoked responses were investigated in globus pallidus (GP) neurons. MAIN METHODS:Extracellularly recorded single units from anesthetized rats were treated with GLU before and during the microiontophoretic application of S-nitrosoglutathione (SNOG)...

journal_title：Life sciences

authors： Sardo P,Carletti F,Rizzo V,Lonobile G,Friscia S,Ferraro G

更新日期：2011-06-20 00:00:00

abstract：:SDZ PGU 693 acts as a hypoglycemic agent by stimulating glucose utilisation in insulin-sensitive peripheral tissues, such as skeletal muscle and fat. In a 28 day toxicity study the compound was found to induce hepatocellular hypertrophy in Wistar rats treated with 300 mg/kg/day. To gain insights into the pathomechanis...

journal_title：Life sciences

authors： Arce A,Aicher L,Wahl D,Anderson NL,Meheus L,Raymackers J,Cordier A,Steiner S

更新日期：1998-01-01 00:00:00

abstract：AIMS:Benidipine, a dihydropyridine Ca(2+) channel blocker, has been reported to block T-type Ca(2+) channels; however, the mechanism underlying this effect was unclear. In this study, we characterized the mechanism responsible for this blocking activity. Furthermore, the blocking activity was compared between two enant...

journal_title：Life sciences

authors： Inayoshi A,Sugimoto Y,Funahashi J,Takahashi S,Matsubara M,Kusaka H

更新日期：2011-05-09 00:00:00

abstract：:[3H]ET (etorphine), which is considered either as an "universal" ligand or a mu agonist, interacts with identical affinities KD = 0.33-0.38 nM to hybrid cells and rabbit cerebellum, pure delta and mu-enriched opioid receptor preparations, respectively. In rat brain tissue, [3H]ET binding is inhibited by DAGO (Tyr-D-Al...

journal_title：Life sciences

authors： Delay-Goyet P,Roques BP,Zajac JM

更新日期：1987-08-10 00:00:00

abstract：:As the relationship between emotional behavior and electrocardiographic (ECG) change induced by hypothalamic stimulation is poorly understood, eighty-four points in various areas within the hypothalamus in conscious cats were stimulated electrically through chronically implanted electrodes, the objective being to clar...

journal_title：Life sciences

authors： Tashiro N,Tanaka T,Fukumoto T,Hirata K,Nakao H

更新日期：1985-03-18 00:00:00

abstract：:Brain noradrenaline takes part in the regulation of several brain functions. The formation of brain noradrenaline depends on brain tyrosine (Tyr) levels, which associates with the ratio in plasma of Tyr to other large, neutral amino acids (LNAA). Tyr metabolism has been studied in users of the new generation combined ...

journal_title：Life sciences

authors： Møller SE,Maach-Møller B,Olesen M,Madsen B,Madsen P,Fjalland B

更新日期：1995-01-01 00:00:00

abstract：:This work analyzes the 24-hour changes of hypothalamic-pituitary-adrenal (HPA) axis activity and leptin release in aged rats. Three- and 22-month-old male Wistar rats were killed at 6 time intervals during a 24-hour cycle (n=8-10 rats/group). Aging augmented plasma ACTH while it decreased plasma and adrenal gland cort...

journal_title：Life sciences

authors： Cano P,Cardinali DP,Spinedi E,Esquifino AI

更新日期：2008-07-18 00:00:00

abstract：:Circadian rhythms might be involved in addictive behaviors. The pineal secretory product melatonin decreases cocaine sensitization in rats; mice mutant for the critical melatonin-synthesizing enzyme, arylalkylamine N-acetyltransferase (AANAT), exhibit altered behaviors. We hypothesized that AANAT/melatonin system, whi...

journal_title：Life sciences

authors： Uz T,Javaid JI,Manev H

更新日期：2002-05-10 00:00:00

abstract：:Rats were administered intravenously liposome-encapsulated or free cobalt, and the organ distribution of the metal was explored using Co57 tracer. Two hours after administration, the cobalt level in the heart was about 40% of the control when given in sphingomyelin (SM)/cholesterol (CH) (1:1 mole ratio) liposomes. The...

journal_title：Life sciences

authors： Szebeni J,Garcia R,Eskelson CD,Chvapil M

更新日期：1989-01-01 00:00:00

abstract：:Although renin-angiotensin system (RAS) imbalance is manifested in cardiomyopathies with different etiologies, the impact of RAS effectors on Chagas cardiomyopathy and skeletal myositis is poorly understood. Given that diminazene aceturate (DMZ) shares trypanocidal, angiotensin-converting enzyme 2 (ACE2) and angiotens...

journal_title：Life sciences

authors： Souza-Silva TG,Vilas-Boas DF,Gonçalves-Santos E,Mazzeti AL,Caldas IS,Gonçalves RV,Diniz LF,Novaes RD

更新日期：2020-09-15 00:00:00

abstract：:Ten neuropeptides were measured by RIA in human cerebrospinal fluid obtained from 30 normal volunteers. The levels of seven peptides (corticotropin releasing factor, adrenocorticotropin, vasoactive intestinal peptide, somatostatin, beta-endorphin, beta-lipotropin, and the N-terminal fragment of proopiomelanocortin) we...

journal_title：Life sciences

authors： Berrettini WH,Nurnberger JI Jr,Gold PW,Chretien M,Chrousos GP,Chan JS,Goldin LR,Gershon ES

更新日期：1985-09-30 00:00:00

abstract：:Effects of sub-acute cocaine treatment on 3H-naloxone binding to 6 brain regions were examined in spontaneously hypertensive (SHR) and Wistar-Kyoto (WKY) rats. Cocaine hydrochloride (3 mg/kg, i.v.) was given by bolus injection daily for five days. Rats were decapitated 24 hr following the final injection and crude mem...

journal_title：Life sciences

authors： Ishizuka Y,Rockhold RW,Hoskins B,Ho IK

更新日期：1988-01-01 00:00:00

abstract：:Histogranin is a naturally-occurring pentadecapeptide with a structure 80% homologous with that a fragment-(86-100) of histone H4. First isolated from bovine adrenal medulla, the peptide was also shown to be present in the pituitary, brain, adrenal glands, blood plasma, lungs and spleen. At the subcellular level, hist...

journal_title：Life sciences

authors： Lemaire S,Rogers C,Dumont M,Shukla VK,Lapierre C,Prasad J,Lemaire I

更新日期：1995-03-03 00:00:00

abstract：:A time course study on the effects of an interferon inducing agent, polyriboinosinic polyribocytidylic acid (poly rIrC) on the hepatic cytochrome P-450 dependent progesterone metabolism was performed. Administration of a single dose of poly rIrC (10 mg/kg i.p.) to adult male Wistar rats caused a time dependent effect ...

journal_title：Life sciences

authors： Wong JY,Lee EJ,Moochhala SM

更新日期：1993-01-01 00:00:00

abstract：:Extracts of increasing polarity of 6 Venezuelan plants belonging to the Chrysobalanaceae family were tested for possible letal toxicity against Biomphalaria glabrata Say, a snail intermediate hosts of Schistosoma mansoni Sambon. The piscicidal toxicity of the active extracts was also evaluated with the aim of findings...

journal_title：Life sciences

authors： Bilia AR,Braca A,Mendez J,Morelli I

更新日期：2000-01-01 00:00:00

abstract：AIMS:A bridging ligand 2,4,6-pyridine tricarboxylic acid (H(3)ptc) and its manganese(II) complex [Mn(Hptc)(phen)(OH)]n(Hptc=2,4,6-pyridine tricarboxylic acid, phen=1,10-phenanthroline) have been synthesized and characterized. MAIN METHODS:The interaction with DNA (HeLa and KB) was carried out by fluorescence spectrum ...

journal_title：Life sciences

authors： Zhu M,He W,Gao E,Lin L,Zhang Y,Dai L,Wang R,Wang B,Wang M

更新日期：2012-04-09 00:00:00

abstract：:The distribution of immunoreactive-dynorphin (ir-Dyn) in isolated subpopulations of bovine adrenal chromaffin cells was examined and compared with that of adrenaline (A), noradrenaline (NA) and ir-Leucine-Enkephalin (ir-Leu-Enk). Using a stepwise bovine serum albumin (BSA) gradient, various populations of catecholamin...

journal_title：Life sciences

authors： Dumont M,Day R,Lemaire S

更新日期：1983-01-17 00:00:00

abstract：:Using hot plate method, analgesia induced by noncatecholic phenylethylamines, phenethylamine, phenylethanolamine and amphetamine, was inhibited by naloxone, reserpine, apomorphine and p-chlorophenylalanine, while potentiated by haloperidol. These results suggest that phenylethylamines induced analgesia involves centra...

journal_title：Life sciences

authors： Kubota K,Matsuoka Y,Sakuma M,Satoh S,Uruno T,Sunagane N

更新日期：1982-09-20 00:00:00

abstract：:Individuals have an inherent capacity to cope with stressors in the form of stress adaptation. Apart from stress adaptation there is another well documented phenomenon known as cross stress adaptation. In this, there is a reduction in stress responsiveness to a novel stressor (in which the adapted organism had never e...

journal_title：Life sciences

authors： Chauhan E,Bali A,Singh N,Jaggi AS

更新日期：2015-09-15 00:00:00

abstract：AIMS:Transplantation of bone marrow mononuclear cells (BMMCs) exerts neuroprotection against cerebral ischemia. We examined the therapeutic timepoint of allogeneic BMMC transplantation in a rat model of focal cerebral ischemia, and determined the effects of repeated transplantation outside the therapeutic window. MAIN...

journal_title：Life sciences

authors： Kamiya F,Ueda M,Nito C,Kamiya N,Inaba T,Suda S,Saito T,Muraga K,Katayama Y

更新日期：2014-01-24 00:00:00

abstract：:Drug-induced refractoriness of alpha-adrenergic receptor-mediated vasoconstriction may be a clinically important phenomenon. We have investigated the possible molecular mechanisms underlying this phenomenon in cultured vascular smooth muscle cells derived from the rabbit aorta. alpha 1-Adrenergic receptors were identi...

journal_title：Life sciences

authors： Wikberg JE,Akers M,Caron MG,Hagen PO

更新日期：1983-10-03 00:00:00

abstract：:Calcium entry from extracellular space to acetylcholine (ACh)-sensitive internal stores was investigated in beta-escin permeabilized bovine tracheal smooth muscle. Cyclopiazonic acid (CPA), a selective inhibitor of the sarcoplasmic reticulum (SR) calcium pump, and nifedipine, both inhibited the refilling, and inhibiti...

journal_title：Life sciences

authors： Qian Y,Bourreau JP

更新日期：1999-01-01 00:00:00

abstract：AIMS:Ovarian cancer is the most leading cause of deaths among gynecologic malignancies, and Neuron-restrictive silencer factor (NRSF) can be upregulated or downregulated according to the type of tumor. However, the expression and function of NRSF in ovarian cancer is still unknown. MAIN METHODS:Expression of NRSF in n...

journal_title：Life sciences

authors： Deng P,Zuo Y,Feng S,Li Z,Chen W,Li H,Wang X

更新日期：2018-12-15 00:00:00