Circadian differences in behavioral sensitization to cocaine: putative role of arylalkylamine N-acetyltransferase.

abstract：:We have investigated the possible involvement of arachidonic acid metabolites in dopamine-induced inhibition of adrenocortical steroidogenesis. Administration of dopamine (5 x 10(-5) M) for 20 min to perifused frog adrenal slices caused a marked reduction of the release of both prostaglandin E2 (PGE2) and 6-keto-PGF1 ...

journal_title：Life sciences

authors： Morra M,Leboulenger F,Homo-Delarche F,Netchitalo P,Vaudry H

更新日期：1989-01-01 00:00:00

abstract：:In the biosynthesis of adrenomedullin (AM), glycine-extended AM, an intermediate form (iAM) processed from proAM is converted to AM[1-52]-NH2, the bioactive mature form of AM (mAM), by enzymatic amidation. We earlier showed that both molecular forms of AM circulate in human plasma. In the present study, to investigate...

journal_title：Life sciences

authors： Hirayama N,Kitamura K,Imamura T,Kato J,Koiwaya Y,Eto T

更新日期：1999-01-01 00:00:00

abstract：:Clinical reports suggest that EGFR-mutated lung cancer usually respond significantly towards small molecule tyrosine kinase inhibitors. Same studies also report the eventual development of acquired resistance within a median time interval of 9 to 14months. One of the major mechanisms involved in this acquired resistan...

journal_title：Life sciences

authors： Singh PK,Silakari O

更新日期：2017-10-01 00:00:00

abstract：:This review aims to systematically review and synthesize scientific evidence for the influence of air pollution exposure and outdoor exercise on health. We conducted a literature search in the PubMed, Cochrane, EMBASE, and Web of Science for articles that evaluated the combination effect of air pollution exposure and ...

journal_title：Life sciences

authors： Qin F,Yang Y,Wang ST,Dong YN,Xu MX,Wang ZW,Zhao JX

更新日期：2019-02-01 00:00:00

abstract：:We previously reported the discovery and partial characterization of bovine atrial granule serine proteinase, a candidate processing enzyme of pro-atrial natriuretic factor, which is associated with atrial granule membranes. We now report the physicochemical properties of electrophoretically homogeneous enzyme purifie...

journal_title：Life sciences

authors： Wypij DM,Harris RB

更新日期：1992-01-01 00:00:00

abstract：:The concentrations of the trace amines, m-tyramine, p-tyramine, phenylethylamine and tryptamine, were measured in the striatum of the brain and in the kidney of adult rats treated with alpha-monofluoromethyldopa (MFMD), an inhibitor of aromatic amino acid decarboxylase. While MFMD decreased the levels of all four amin...

journal_title：Life sciences

authors： Dyck LE

更新日期：1987-02-09 00:00:00

abstract：:The N-terminus portion of the POMC leader sequence (signal peptide) was synthesized, and an antiserum was raised against it. A radioimmunoassay was developed which is effective at a dilution of 1:500,000, and sensitive at less than 1 fmole/tube. Since leader sequences often exhibit structural homologies, and since syn...

journal_title：Life sciences

authors： Akil H,Shiomi H,Thompson R,Lax S,Coy D,Watson S

更新日期：1982-11-15 00:00:00

abstract：:Defects in the mitochondrial genome have been associated with Parkinson's and Alzheimer's disease, and apoptosis can be triggered by the presence of energetically compromised mitochondria. Thus, in this study we have examined whether the divalent cations Cu2+ and Mn2+ could influence mitochondrial function in vitro. M...

journal_title：Life sciences

authors： Heron P,Cousins K,Boyd C,Daya S

更新日期：2001-02-23 00:00:00

abstract：AIM:MicroRNAs (miRNAs) function as oncogenes or tumor suppressors in an extensive variety of human cancers, including prostate cancer (PCa). Herein, the aim of this study is to investigate the effect of miR-381 on autophagy and apoptosis of PCa cells through the reelin (RELN)-mediated the PI3K/AKT/mTOR signaling pathwa...

journal_title：Life sciences

authors： Liao W,Zhang Y

更新日期：2020-08-01 00:00:00

abstract：:Brain noradrenaline takes part in the regulation of several brain functions. The formation of brain noradrenaline depends on brain tyrosine (Tyr) levels, which associates with the ratio in plasma of Tyr to other large, neutral amino acids (LNAA). Tyr metabolism has been studied in users of the new generation combined ...

journal_title：Life sciences

authors： Møller SE,Maach-Møller B,Olesen M,Madsen B,Madsen P,Fjalland B

更新日期：1995-01-01 00:00:00

abstract：:Male Sprague-Dawley rats were castrated and given daily sc. injections of estradiol (E2, 10 micrograms/day), testosterone propionate (TP, 1.0 mg/day), dihydrotestosterone (DHT, 1.0 mg/day) or sesame oil (SO, 0.2 ml/day). A group of sham castrate males received daily sc. injections of SO (0.2 ml/day). On day 8 of stero...

journal_title：Life sciences

authors： Haisenleder DJ,Lawson DM,Gala RR

更新日期：1984-01-02 00:00:00

abstract：:This study investigated the effects of captopril, hydralazine and losartan on the locomotor activity, tailflick and hot plate latencies in spontaneously hypertensive rats (SHR) and their genetic controls the Wistar-Kyoto rat (WKY). The increased hot plate latencies normally exhibited by the spontaneously hypertensive ...

journal_title：Life sciences

authors： Irvine RJ,White JM,Head RJ

更新日期：1995-02-17 00:00:00

abstract：AIMS:Smooth muscle cells (SMCs) play a role in medial vascular calcification, which can be stimulated by high levels of serum phosphate and inflammatory mediators. The aim of this study was to investigate whether mitogen-activated protein kinases (MAPKs) (p38 MAPK, ERK1/2, and JNK) and protein kinase A (PKA) can partic...

journal_title：Life sciences

authors： Toita R,Otani K,Kawano T,Fujita S,Murata M,Kang JH

更新日期：2018-09-15 00:00:00

abstract：AIMS:The aim of the present study was to evaluate the possible antioxidant role of oleic acid (OA) against Cd-induced injuries in the heart and liver tissues of male Wistar rats. MAIN METHODS:Rats were treated with either vehicle (control), or OA (10 mg/kg b.w., fed orally), or Cd (0.44 mg/kg b.w., s.c.), or both (OA ...

journal_title：Life sciences

authors： Bhattacharjee B,Pal PK,Chattopadhyay A,Bandyopadhyay D

更新日期：2020-03-01 00:00:00

abstract：:To determine the mechanism of anoxic vasoconstriction, precontracted rat aortic rings were exposed to 95% N2, which caused additional contraction. Reoxygenation (95% O2) resulted in initial relaxation followed by contraction. Indomethacin did not affect anoxic contraction or reoxygenation-mediated events, but NG-monom...

journal_title：Life sciences

authors： Mehta JL,Lawson DL,Yang BC,Haught WH,Hintze T

更新日期：1991-01-01 00:00:00

abstract：:Serotonin (5HT) stimulates phosphoinositide turnover in a number of tissues, but it is not known whether this effect is due to activation of a 5HT receptor which is coupled to phosphoinositide hydrolysis or if the effect is secondary to 5HT stimulated arachidonate metabolism or to the release of another neurotransmitt...

journal_title：Life sciences

authors： Conn PJ,Sanders-Bush E

更新日期：1986-02-17 00:00:00

abstract：:Iron imbalance has been implicated in oxidative injury associated with many brain diseases. The present study investigated the importance of iron location in hydroxyl radical (.OH) generation and the link between .OH production evaluated by the salicylate method and lipid peroxidation monitored by thiobarbituric acid-...

journal_title：Life sciences

authors： Demougeot C,Marie C,Beley A

更新日期：2000-06-16 00:00:00

abstract：:The multiple functions of the blood-brain barrier (BBB) consist mostly in membrane properties controlling the bidirectional exchange of molecules between the general circulation and the central nervous system. As lipophilic molecules are able to easily penetrate the membrane of brain microvessels endothelial cells, an...

journal_title：Life sciences

authors： Ghersi-Egea JF,Minn A,Siest G

更新日期：1988-01-01 00:00:00

abstract：AIMS AND METHODS:We previously reported that angiotensin II (AngII) restores the vascular reactivity diminished by hemorrhagic shock. In this study, we investigated whether the beneficial effects of AngII are related to regulation of gap junctions (GJs) and connexin43 (Cx43), and the implication of MAPK signaling and m...

journal_title：Life sciences

authors： Lei Y,Peng X,Li T,Liu L,Yang G

更新日期：2019-01-01 00:00:00

abstract：:Amniotic fluid and placenta contain a substance (POEF, for Placental Opioid-Enhancing Factor) that, when ingested, enhances opioid-mediated analgesia in nonpregnant rats; ingestion of the substance by rats not experiencing opioid-mediated analgesia, however, does not produce analgesia. It is highly likely that peripar...

journal_title：Life sciences

authors： Kristal MB,Thompson AC,Abbott P,Di Pirro JM,Ferguson EJ,Doerr JC

更新日期：1990-01-01 00:00:00

abstract：AIMS:We performed a systematic review and meta-analysis on the effect of HIV infection and antiretroviral therapy (ART) on carotid intima-media thickness (cIMT) to elucidate the role of HIV infection and ART. Also, an analysis on the role of ethnicity and gender on cIMT in HIV-infected populations was performed. MAIN ...

journal_title：Life sciences

authors： Msoka TF,Van Guilder GP,van Furth M,Smulders Y,Meek SJ,Bartlett JA,Vissoci JRN,van Agtmael MA

更新日期：2019-10-15 00:00:00

abstract：:This investigation examines the role of Angiotensin II in renal hemodynamic functions during acute unilateral ureteral obstruction (UUO) in a dog model. An electro magnetic flow probe was utilized to assess renal blood flow while the arteriovenous extraction technique of technetium 99m DTPA was utilized for the assess...

journal_title：Life sciences

authors： Katzberg RW,DiMarco PL,Morris TW,Harnish PP,Graves RF,Merguerian PA,Ventura JA,Proskin HM

更新日期：1988-01-01 00:00:00

abstract：AIMS:The aim of this study is to investigate the expression and cytoprotective function of a 72-kDa heat shock protein (HSP72) using a reflux esophagitis model in rats. MAIN METHODS:Expression of HSP60, HSP72, and HSP90 in rat esophageal mucosa was evaluated by Western blot analysis before and after hyperthermia (42.5...

journal_title：Life sciences

authors： Izumi Y,Otaka M,Takahashi T,Takada M,Shimada Y,Asaoka D,Nagahara A,Itoh H,Watanabe S

更新日期：2009-04-10 00:00:00

abstract：:Behavioral Hypersensitivity (BH) to dopamine agonists occurs following chronic treatment with most neuroleptics including haloperidol. In the present study we observed that the concurrent administration of thioridazine and haloperidol prevented the development of BH. In contrast, another neuroleptic, fluphenazine, coa...

journal_title：Life sciences

authors： Klawans HL,Carvey PM,Nelson D,Tanner CM,Goetz CG

更新日期：1986-05-12 00:00:00

abstract：AIMS:Vitamin D is a well-known endocrine regulator of calcium/phosphate homeostasis and has been reported as having a wide range of activities that are potentially beneficial for human health. This study aimed to investigate the effects of pretreatment of vitamin D3 (100, 1000, and 10,000 IU/kg) against lipopolysacchar...

journal_title：Life sciences

authors： Mokhtari-Zaer A,Hosseini M,Salmani H,Arab Z,Zareian P

更新日期：2020-07-15 00:00:00

abstract：:Melanin concentrating hormone (MCH) is a heptadecapeptide synthesized by the hypothalamus and secreted by the neurohypophysis of the teleost pituitary gland. MCH stimulates melanosome aggregation within teleost melanocytes but also exhibits MSH-like (melanosome dispersing) activity on tetrapod (frog and lizard) melano...

journal_title：Life sciences

authors： Castrucci AM,Lebl M,Hruby VJ,Matsunaga TO,Hadley ME

更新日期：1989-01-01 00:00:00

abstract：:The effect of gamma-aminobutyric acid (GABA) on the binding of PK 8165, a quinoline derivative, and CGS 8216, a pyrazoloquinoline, was assessed in two different regions of the rat brain. PK 8165, a compound with reported anxiolytic properties, inhibited [3H]-propyl beta-carboline-3-carboxylate labeled receptors in the...

journal_title：Life sciences

authors： Morelli M,Gee KW,Yamamura HI

更新日期：1982-07-05 00:00:00

abstract：AIMS:Proton Nuclear Magnetic Resonance (NMR) based metabolomics analysis is extensively used to explore the metabolic profiling of biofluids. This approach was used for the analysis of metabolites in serum of patients with major types of muscular dystrophy in early phase of the disease. MATERIAL AND METHODS:Proton NMR...

journal_title：Life sciences

authors： Srivastava NK,Annarao S,Sinha N

更新日期：2016-04-15 00:00:00

abstract：:Green tea and its major constituent epigallocatechin gallate (EGCG) have been extensively studied as a potential treatment for a variety of diseases, including cancer. Epidemiological data have suggested that EGCG may provide protective effects against hormone related cancers, namely breast or prostate cancer. Extensi...

journal_title：Life sciences

authors： Stuart EC,Scandlyn MJ,Rosengren RJ

更新日期：2006-11-17 00:00:00

abstract：:Cigarette smoke (CS) inhalation stimulates C-fibers to release sensory neuropeptides which mediate airway reflex responses to prevent irritants from entering the lower airways. When CS is inhaled via the upper airways, these airway defense responses may modulate the effect of CS on airway NEP activity and related airw...

journal_title：Life sciences

authors： Kuo HP,Lu LC

更新日期：1995-01-01 00:00:00