Abstract：
:Amniotic fluid and placenta contain a substance (POEF, for Placental Opioid-Enhancing Factor) that, when ingested, enhances opioid-mediated analgesia in nonpregnant rats; ingestion of the substance by rats not experiencing opioid-mediated analgesia, however, does not produce analgesia. It is highly likely that periparturitional analgesia-enhancement is a significant benefit of ingestion of the afterbirth (placentophagia) during delivery. Here we report that prepartum ingestion of amniotic fluid (via orogastric infusion) does indeed enhance the endogenous-opioid-mediated analgesia evident at the end of pregnancy and during delivery; that the degree of enhancement is greater with 0.75 ml than with 0.25 ml; and that the prepartum enhancement of analgesia can be blocked with the opioid antagonist naloxone.
journal_name
Life Scijournal_title
Life sciencesauthors
Kristal MB,Thompson AC,Abbott P,Di Pirro JM,Ferguson EJ,Doerr JCdoi
10.1016/0024-3205(90)90074-2subject
Has Abstractpub_date
1990-01-01 00:00:00pages
693-8issue
10eissn
0024-3205issn
1879-0631pii
0024-3205(90)90074-2journal_volume
46pub_type
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