Abstract：
:Microiontophoretic study was performed to elucidate dopaminergic mechanism in the nucleus accumbens (Acc) of rats anesthetized with chloral hydrate. Iontophoretically applied dopamine produced an inhibition of glutamate-induced firing in 28 (62%) out of 45 Acc neurons tested. The dopamine-induced inhibition of 14 Acc neurons was clearly antagonized by simultaneous application of haloperidol, and a partial antagonism by sulpiride was observed in 3 out of 10 Acc neurons. These results indicate that dopamine produces an inhibition of the Acc neuron and that, compared to haloperidol, sulpiride is a less potent blocker of the postsynaptic dopamine receptor involved in the dopamine-induced inhibition.
journal_name
Life Scijournal_title
Life sciencesauthors
Akaike A,Sasa M,Takaori Sdoi
10.1016/0024-3205(83)90356-9subject
Has Abstractpub_date
1983-06-06 00:00:00pages
2649-53issue
23eissn
0024-3205issn
1879-0631pii
0024-3205(83)90356-9journal_volume
32pub_type
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