Orchiectomy upregulates rabbit prostate peripheral benzodiazepine receptors.

abstract：:The biochemical integrity of hepatocellular mitochondria was investigated in rats treated with small doses of human recombinant tumor necrosis factor-alpha (Hur-TNF;50-100 micrograms/kg/d injected intraperitoneally for 5 d) by measuring the activities of three mitochondrial enzymes, glutamate dehydrogenase, succinate ...

journal_title：Life sciences

authors： Yasmineh WG,Tsai MY,Theologides A

更新日期：1995-01-01 00:00:00

abstract：:We studied the effects of caffeine on intracellular calcium in a clonal insulin-secreting cell line RINm5F. Caffeine (1-30 mM) induced a dose-dependent intracellular Ca2+ release and Ca2+ influx. Pretreatment with combination of ryanodine (10 microM) and caffeine (10 mM), but not ryanodine alone, abolished subsequent ...

journal_title：Life sciences

authors： Chen TH,Lee B,Yang C,Hsu WH

更新日期：1996-01-01 00:00:00

abstract：AIMS:Cortisol is a glucocorticoid in mammals, but has both gluco- and mineralocorticoid activities in teleost fish. Our previous in vivo studies on osmoregulatory esophagi of euryhaline fish showed that epithelial apoptosis for the simple epithelium in seawater and cell proliferation for the stratified epithelium in fr...

journal_title：Life sciences

authors： Takagi C,Takahashi H,Kudose H,Kato K,Sakamoto T

更新日期：2011-01-31 00:00:00

abstract：:Plasma levels of prolactin, growth hormone, glucagon insulin and glucose were measured in non-treated control rats, bromocriptine-treated control rats and GH3-cell-tumor-bearing rats with and without bromocriptine treatment. Bromocriptine treatment increased plasma levels of glucagon, insulin and glucose in control ra...

journal_title：Life sciences

authors： Knudtzon J,Johansen PW,Haug E,Gautvik K

更新日期：1986-08-18 00:00:00

abstract：:Acute effect of streptozotocin-induced diabetes on several parameters of glucose metabolism was investigated in thymus lymphocytes (thymocytes). The cells from diabetics rats accumulated in vitro about 2-fold more fructose 2,6-bisphosphate (Fru-2, 6-P2) in the presence of increasing glucose concentration than cells fr...

journal_title：Life sciences

authors： Moreno-Aurioles VR,Montaño R,Conde M,Bustos R,Sobrino F

更新日期：1996-01-01 00:00:00

abstract：:Tumor angiogenesis and lymphangiogenesis are key features of tumor progression and metastasis. The role of tumor cells-derived factors in the promotion of associated angiogenesis and lymphangiogenesis is much studied and, no doubt, very important for the understanding of cancer progression. This review aims to present...

journal_title：Life sciences

authors： Gomes FG,Nedel F,Alves AM,Nör JE,Tarquinio SB

更新日期：2013-02-07 00:00:00

abstract：:The role of extracellular acidosis in inflammatory airway diseases is not well known. One consequence of tissue acidification is the stimulation of sensory nerves via the polymodal H(+)-gated transmembrane channels ASICs and TRPV1 receptor. The present study investigated the effect of acidosis on airway basal tone and...

journal_title：Life sciences

authors： Faisy C,Planquette B,Naline E,Risse PA,Frossard N,Fagon JY,Advenier C,Devillier P

更新日期：2007-09-08 00:00:00

abstract：:Intravenous injection of prostacyclin (100 micrograms/kg) in rats resulted in a decrease of systolic blood pressure within 2 minutes. Concentrations of cAMP in 15 brain regions and nuclei were determined by radioimmunoassay. In lower brain stem nuclei, such as the nucleus of the solitary tract and the lateral reticula...

journal_title：Life sciences

authors： Schmid G,Bahner U,Palkovits M,Geiger H,Heidland A

更新日期：1987-12-07 00:00:00

abstract：:Ischemia-reperfusion of organs such as the kidney produces reactive oxygen and free radical species in tissues and leads to injury of intracellular molecules critical to cell homeostasis. Ischemia-reperfusion affects the NADPH-dependent monooxygenase system including P450 system, which is also a source of reactive oxy...

journal_title：Life sciences

authors： Tamura Y,Imaoka S,Gemba M,Funae Y

更新日期：1997-01-01 00:00:00

abstract：:The effects of two benzodiazepine derivatives (diazepam, 0.5-1 mg/kg; alprazolam, 1.25-2.5 mg/kg) on ultrasonic calling elicited in adult rats by unavoidable aversive stimuli (footshocks) were investigated. The results show that either diazepam or alprazolam affected the duration of ultrasonic calls. In particular, a ...

journal_title：Life sciences

authors： Cuomo V,Cagiano R,De Salvia MA,Maselli MA,Renna G,Racagni G

更新日期：1988-01-01 00:00:00

abstract：:Neuron specific enolase (NSE), an isoenzyme of the glycolytic enzyme enolase, has been established by immunocytochemical means as a marker of morphological and functional maturation in central neurons and appears late in development. However, little is known about the presence of NSE in developing peripheral neurons a...

journal_title：Life sciences

authors： Sheppard MN,Marangos PJ,Bloom SR,Polak JM

更新日期：1984-01-16 00:00:00

abstract：:Neurotensin (NT) administered intracerebroventricularly (i.c.v.) to rats, blocks intestinal transit (tested by charcoal meal) in linear relation to the log of the doses within the range of 0.6-2.5 nmoles/rat. NT in this test is about 40 times more active than morphine (M) and 6 times less active than dermorphin (DM) o...

journal_title：Life sciences

authors： Parolaro D,Sala M,Crema G,Spazzi L,Gori E

更新日期：1983-01-01 00:00:00

abstract：:We examined the effects of repeated administration of the selective serotonin uptake inhibitor (SSRI) fluoxetine (Flx) (5, 10, or 15 mg/kg i.p., twice daily for 21 days) on brain and plasma concentrations of the parent drug and its active desmethyl metabolite, norfluoxetine (NFlx), in rats during the 21-day regimen as...

journal_title：Life sciences

authors： Gardier AM,Lepoul E,Trouvin JH,Chanut E,Dessalles MC,Jacquot C

更新日期：1994-01-01 00:00:00

abstract：:Chronic voluntary running of mice is known to increase the circadian peak of plasma corticosterone without change in the level of adrenocorticotropic hormone (ACTH). In order to investigate how chronic exercise modulates the circadian HPA axis, we used two weeks of voluntary wheel running of mice and confirmed the sig...

journal_title：Life sciences

authors： Otawa M,Arai H,Atomi Y

更新日期：2007-01-30 00:00:00

abstract：:The metabolism of phosphoinositides plays an important role in the signal transduction pathways. We report here that naturally occurring polyamines affect the activities of phosphatidylinositol (PI) 3-kinase and PI 4-phosphate (PIP) 5-kinase differently. While polyamines inhibited the PI 3-kinase activity, they stimul...

journal_title：Life sciences

authors： Singh SS,Chauhan A,Brockerhoff H,Chauhan VP

更新日期：1995-01-01 00:00:00

abstract：AIMS:Hypertension is one of the leading causes of cardiovascular mortality and morbidity. It is associated with severe cardiac and vascular dysfunction. Double-stranded RNA-dependent protein kinase (PKR), is a known inducer of inflammation and apoptosis. However, no research has been done to elucidate the role of the P...

journal_title：Life sciences

authors： Kalra J,Dasari D,Bhat A,Mangali S,Goyal SG,Jadhav KB,Dhar A

更新日期：2020-12-01 00:00:00

abstract：AIM:Physical exercise is important in the prevention and treatment of cardiovascular diseases. Nevertheless, controversy remains around type and intensity of effort required for significant biochemical protective changes. This study investigates two exercise protocols on ventricular oxidative parameters in rats post-in...

journal_title：Life sciences

authors： Pinho CA,Tromm CB,Tavares AM,Silva LA,Silveira PC,Souza CT,Benetti M,Pinho RA

更新日期：2012-04-09 00:00:00

abstract：AIMS:Clostridium difficile is an important pathogen in nosocomial infections. Although C. difficile toxins are considered to be major virulence factors, pathogenesis of C. difficile associated diseases remains to be determined. In this study, we investigated whether C. difficile flagellin is involved in the pathogenesi...

journal_title：Life sciences

authors： Yoshino Y,Kitazawa T,Ikeda M,Tatsuno K,Yanagimoto S,Okugawa S,Yotsuyanagi H,Ota Y

更新日期：2013-02-27 00:00:00

abstract：:Increased oxidative stress and antioxidant deficit have been suggested to play a major role in adriamycin induced cardiomyopathy and congestive heart failure due to multiple treatments with adriamycin. In this study the cardio protective effect of Centella asiatica on myocardial marker enzymes and antioxidant enzymes ...

journal_title：Life sciences

authors： Gnanapragasam A,Ebenezar KK,Sathish V,Govindaraju P,Devaki T

更新日期：2004-12-17 00:00:00

abstract：:Mitochondrial dysfunction caused by calcium overload is a vital factor for mediating cardiomyocyte death following ischemia/reperfusion (I/R) injury. The stromal interactive molecule 2 (STIM2) is a calcium sensor protein that regulates the store-operated calcium entry (SOCE). Whereas, whether STIM2 is associated with ...

journal_title：Life sciences

authors： Tu CC,Wan BY,Zeng Y

更新日期：2020-04-15 00:00:00

abstract：:The effects of methylprednisolone (m-PSL) on IL-1beta-induced neutrophil-endothelial cell interactions, which are normally mediated by increased expression of both intercellular adhesion molecule-1 (ICAM-1) and E-selectin on endothelial cells, were examined using an in vitro flow system. Human neutrophilic polymorphon...

journal_title：Life sciences

authors： Yoshida N,Yoshikawa T,Nakamura Y,Takenaka S,Sakamoto K,Manabe H,Nakagawa S,Kondo M

更新日期：1997-01-01 00:00:00

abstract：:In the biosynthesis of adrenomedullin (AM), glycine-extended AM, an intermediate form (iAM) processed from proAM is converted to AM[1-52]-NH2, the bioactive mature form of AM (mAM), by enzymatic amidation. We earlier showed that both molecular forms of AM circulate in human plasma. In the present study, to investigate...

journal_title：Life sciences

authors： Hirayama N,Kitamura K,Imamura T,Kato J,Koiwaya Y,Eto T

更新日期：1999-01-01 00:00:00

abstract：:Acyl glucuronides are reactive electrophilic metabolites of carboxylate drugs, capable of undergoing hydrolysis, rearrangement and covalent binding reactions with proteins in vivo. Such covalent drug-protein adducts may be prerequisites for certain idiosyncratic immune and toxic responses in susceptible individuals. T...

journal_title：Life sciences

authors： Wang M,Dickinson RG

更新日期：2000-12-22 00:00:00

abstract：:Herba Epimedii is an important medicinal plant which has been used in various traditional Chinese formulations for thousands of years as well as in modern proprietary traditional Chinese medicine products. It has extensive clinical indications, especially for the treatment of sexual dysfunction and osteoporosis. There...

journal_title：Life sciences

authors： Li C,Li Q,Mei Q,Lu T

更新日期：2015-04-01 00:00:00

abstract：:Further confirmation that the LHRH/LHRH agonist-induced ovulation in the hypophysectomized (hypx) rat is due to a direct ovarian effect and not mediated by LH release from residual pituitary tissue or other CNS sites is provided by the persistence of this effect despite concomitant median eminence lesion or passive im...

journal_title：Life sciences

authors： Bex FJ,Corbin A

更新日期：1984-08-27 00:00:00

abstract：:The traditional Chinese medicines have been used clinically for a long time in some Asian countries, however, very few studies have been done to demonstrate the working mechanisms of these medicines using recently developed biochemical methodologies. In this study, we examined the anti-inflammatory effect of Huang-Lia...

journal_title：Life sciences

authors： Dai Y,Miki K,Fukuoka T,Tokunaga A,Tachibana T,Kondo E,Noguchi K

更新日期：2000-01-01 00:00:00

abstract：:An acute injection of an intoxicating dose of alcohol to male rats 24 hours prior to breeding with drug-naive females produced no discernible effect on copulatory activity, as reflected in vaginal plugs, but resulted in markedly (> 50%) reduced pregnancy rates. Fetal outcome was also markedly affected in offspring sir...

journal_title：Life sciences

authors： Cicero TJ,Nock B,O'Connor LH,Sewing BN,Adams ML,Meyer ER

更新日期：1994-01-01 00:00:00

abstract：:Evidence for the ability of the opiate antagonist naloxone to block a variety of metabolic effects exerted by morphine and non-opiate drugs is reviewed. Naloxone prevents or reverses the following effects in the rat: (a) the chronic morphine-induced increase in liver [NADPH]; (b) the consequent chronic morphine-induce...

journal_title：Life sciences

authors： Badawy AA,Evans M,Punjani NF,Morgan CJ

更新日期：1983-01-01 00:00:00

abstract：:Neuropathic pain syndromes respond poorly to opioid treatment. In our previous studies, we found that intrathecal (i.t.) injection of pertussis toxin (PTX) produces thermal hyperalgesia, which is poorly responsive to morphine and is accompanied by an increase in cerebrospinal fluid (CSF) levels of excitatory amino aci...

journal_title：Life sciences

authors： Wu GJ,Wen ZH,Chang YC,Yang SN,Tao PL,Wong CS

更新日期：2006-03-13 00:00:00

abstract：:The rate of oxidation of sparteine by the 9000 x g supernatant fraction of a human liver was measured in the presence of various drugs which exert cardiovascular effects. Hexamethonium, ouabain, caffeine and isoproterenol had no effect on this rate, while alprenolol, metoprolol, oxprenolol, propranolol, timolol, pindo...

journal_title：Life sciences

authors： Otton SV,Inaba T,Kalow W

更新日期：1984-01-02 00:00:00