Effect of estradiol and relaxin on collagen and non-collagen protein synthesis by mammary fibroblasts.

abstract：:The ATP-binding cassette (ABC) and solute carrier (SLC) transporter families consist of common drug transporters that mediate the efflux and uptake of drugs, respectively, and play an important role in the absorption, distribution, metabolism and excretion of drugs in vivo. Rheumatoid arthritis (RA) is an autoimmune d...

journal_title：Life sciences

authors： Gao J,Wang C,Wei W

更新日期：2021-01-08 00:00:00

abstract：:Specific binding sites for atrial natriuretic peptide (ANP) were identified and characterized in primary cultures of human thyroid cells. Saturation analysis using [125I] alpha rat ANP as the ligand showed a single class of high affinity binding (Kd = 0.2 nM) which was inhibited by atriopeptin I and the alpha -human f...

journal_title：Life sciences

authors： Sellitti DF,Tseng YC,Wartofsky L

更新日期：1989-01-01 00:00:00

abstract：:This study demonstrates the formation of gamma-glutamyl peptides from glutamine and plasma amino acids, as catalyzed by gamma-glutamyl transpeptidase. It also establishes the effect of various amino acids in modulating the rate of glutamine utilization as well as the hydrolytic or transfer product formed. The mechanis...

journal_title：Life sciences

authors： Dass PD

更新日期：1983-10-31 00:00:00

abstract：:We have recently demonstrated that the hypertensinogenic and natriuretic actions of ACTHI-39 can be found in a non-steroidogenic fragment of ACTH, ACTH4-10. These effects of ACTH or ACTH4-10 may be due to their ability to act as weak agonists of gamma MSH. gamma MSH is found in the 16K N-terminus of pro-opiocortin, an...

journal_title：Life sciences

authors： Klein MC,Hutchins PM,Lymangrover JR,Gruber KA

更新日期：1985-02-25 00:00:00

abstract：:1-Aminocyclopropane carboxylic acid (ACPC), a partial agonist of the glycine site on the NMDA receptor, prevents tolerance to the mu opioid morphine and the delta ligand [D-Pen2,D-Pen5]enkephalin (DPDPE) when co-administered with the opioid. In contrast, ACPC does not significantly influence tolerance to the kappa1 op...

journal_title：Life sciences

authors： Kolesnikov YA,Maccechini ML,Pasternak GW

更新日期：1994-01-01 00:00:00

abstract：:The present study investigates the effect of a pituitary hormone (LH) and a thymic factor (Thymosin Fraction 5 = TF5) on in vitro and in vivo spleen cell proliferative response of 2, 6 and 8-month-old Balb/c mice. In vitro experiments showed that the addition of LH at various concentrations (0.5, 5, 50 or 500 ng/ml) t...

journal_title：Life sciences

authors： Rouabhia M,Ghanmi Z,Chakir J,Othmane O,Deschaux P

更新日期：1990-01-01 00:00:00

abstract：:Effects of PK 11195 and flumazenil on cardiac responses to diazepam, clonazepam and zolpidem were compared. Coronary flow rate was increased at relatively low doses of diazepam and decreased at higher doses. Clonazepam induced a dose-dependent increase, and zolpidem a decrease of coronary flow rate. PK 11195 reduced t...

journal_title：Life sciences

authors： Zeegers A,van Wilgenburg H,Leeuwin RS

更新日期：1998-01-01 00:00:00

abstract：:Vanadate has been suggested as an intracellular regulator of (Na+ + K+)-ATPase. To test this hypothesis we examined the stimulatory and inhibitory effects of vanadate on 86--Rb efflux and influx (measurements of the activity of the Na-pump) in rat ileum under conditions of normal, reduced and increased (Na+ + K+)-ATPa...

journal_title：Life sciences

authors： Hajjar JJ,Rowe WA,Tomicic TK

更新日期：1988-01-01 00:00:00

abstract：:Diltiazem, diazepam, and clonazepam effectively inhibit Na+-induced Ca2+ release from mitochondria isolated from rabbit heart and rat brain. At 10 mM NaCl, the 50% inhibition of the rate of Ca2+ release occurred at 5, 7, 40 and 350 microM of clonazepam d-cis-diltiazem, diazepam and 1-cis-diltiazem, respectively. Ro 15...

journal_title：Life sciences

authors： Matlib MA,Schwartz A

更新日期：1983-06-20 00:00:00

abstract：:Mitochondrial dysfunction caused by calcium overload is a vital factor for mediating cardiomyocyte death following ischemia/reperfusion (I/R) injury. The stromal interactive molecule 2 (STIM2) is a calcium sensor protein that regulates the store-operated calcium entry (SOCE). Whereas, whether STIM2 is associated with ...

journal_title：Life sciences

authors： Tu CC,Wan BY,Zeng Y

更新日期：2020-04-15 00:00:00

abstract：:This paper describes the use of complex liposomes as real membrane models to evaluate the potential benefits of several antioxidants in relation to lipid peroxidation. The xanthine oxidase/Fe(3+)-ADP-EDTA and the Fe(2+)/H2O2 systems have been used to generate hydroxyl radicals and the water soluble azo-compound 2,2'-a...

journal_title：Life sciences

authors： Gutiérrez ME,García AF,Africa de Madariaga M,Sagrista ML,Casadó FJ,Mora M

更新日期：2003-04-11 00:00:00

abstract：:Lewis rats were trained to self-stimulate the medial forebrain bundle (MFB) using a rate-frequency paradigm. They were then tested for the effects of the cannabinoid receptor agonist CP 55,940, the selective cannabinoid receptor antagonist SR 141716 and the dopamine D1 receptor antagonist SCH 23390. CP 55,940 (0, 10, ...

journal_title：Life sciences

authors： Arnold JC,Hunt GE,McGregor IS

更新日期：2001-11-21 00:00:00

abstract：:Using a specific radioimmunoassay, we measured concentrations of plasma 7B2 (a novel pituitary polypeptide) immunoreactivity (7B2-IR) in normal human subjects, patients with chronic renal failure and those with liver cirrhosis. Mean (+/- SEM) values of plasma 7B2-IR in normal healthy men and women were 55.8 +/- 1.2 pg...

journal_title：Life sciences

authors： Natori S,Iguchi H,Nawata H,Kato K,Ibayashi H,Chrétian M

更新日期：1987-08-24 00:00:00

abstract：:Nociceptin/orphanin FQ (=N/OFQ), the endogenous ligand of ORL1 receptor (=NOP), has been reported to induce, in rodents, after intracerebroventricular (i.c.v.) administration, anti-stress and anxiolytic effects. We have observed that the handling of mice followed by an i.c.v. injection of saline, induced a marked incr...

journal_title：Life sciences

authors： Le Cudennec C,Naudin B,Do Rego JC,Costentin J

更新日期：2002-11-29 00:00:00

abstract：:Visual evoked responses (VER) to counterphased gratings were recorded from area 17 of cat visual cortex prior to and following administration of diisopropylfluorophosphate (DFP). The VER and acetylcholinesterase (AChE) activity of blood, retina, and visual cortex were reduced significantly following DFP administration...

journal_title：Life sciences

authors： Kirby AW,Harding TH,Wiley RW

更新日期：1987-12-14 00:00:00

abstract：AIMS:This study evaluates ocular (iris, ciliary body and ciliary process) and nonocular (atria and lung) beta-adrenoceptors in rabbit to characterize the plasma membrane beta-adrenoceptors and binding affinities of beta-adrenoceptor antagonists. MAIN METHODS:The tissue segment binding method with a hydrophilic radioli...

journal_title：Life sciences

authors： Horinouchi T,Morishima S,Tanaka Y,Koike K,Miwa S,Muramatsu I

更新日期：2009-01-30 00:00:00

abstract：:Renal handling of the aminoglycoside antibiotics gentamicin and tobramycin were studied before and after one hour of constant intravenous infusions adjusted to maintain a concentration of 15 micrograms/mL. A solitary renal autotransplant model in four conscious volume replete 40 Kg sheep was used. This unique surgical...

journal_title：Life sciences

authors： Bennett WM,McDougall J,Potocnik S,Wright RD,Whitworth JA

更新日期：1983-01-17 00:00:00

abstract：:In recent years, natural products have increasingly attracted more attention because of their potential anticancer activity and low intrinsic toxicity. Hispidulin is a natural flavonoid with a wide range of biological activities, including anti-inflammatory, antifungal, antiplatelet, anticonvulsant, anti-osteoporotic,...

journal_title：Life sciences

authors： Liu K,Zhao F,Yan J,Xia Z,Jiang D,Ma P

更新日期：2020-10-15 00:00:00

abstract：:In the present study the effects of Granulocyte-Macrophage Colony Stimulating Factor (GM-CSF) on fibroblast growth and activity have been studied. In this regard the AA have evaluated in primary cultures of human gengival normal fibroblasts (PG1 cells): a)-the expression of GM-CSF receptor (GM-CSFR) (alfa unit) on the...

journal_title：Life sciences

authors： Postiglione L,Montagnani S,Riccio A,Ladogana P,Salzano S,Vallefuoco L,Rossi G

更新日期：1998-01-01 00:00:00

abstract：:A recent neuropathological study has reported decreased levels of dynorphin A immunoreactivity in striato-pallidal fibers in the brain of a patient with severe Gilles de la Tourette's syndrome (TS). This observation, taken with the neuroanatomic distribution of dynorphin and its broad range of motor and behavioral eff...

journal_title：Life sciences

authors： Leckman JF,Riddle MA,Berrettini WH,Anderson GM,Hardin M,Chappell P,Bissette G,Nemeroff CB,Goodman WK,Cohen DJ

更新日期：1988-01-01 00:00:00

abstract：:Hyaluronic acid (HA), a major glycosaminoglycan component of the extracellular matrix, has regulatory influences on cells and cellular activities. To explore the effects of a high concentration (1 mg/mL) of high molecular weight HA (500-730 kD) on U937 macrophage growth dynamics, three factors that influence overall c...

journal_title：Life sciences

authors： Sheehan KM,DeLott LB,West RA,Bonnema JD,DeHeer DH

更新日期：2004-11-12 00:00:00

abstract：:[3H]A-69024 has been prepared as a radioligand for studying the dopamine D1 receptor. [3H]A-69024 binds to rat striatal membranes with a KD = 14.3 +/- 3.2 nM (mean +/- SEM; n = 3) and Bmax = 63.5 +/- 12.8 fmol/mg wet tissue (1.8 +/- 0.3 pmol/mg protein). This ligand binds to only one site with a Hill coefficient close...

journal_title：Life sciences

authors： Kassiou M,Scheffel UA,Musachio JL,Stathis M,Dannals RF

更新日期：1995-01-01 00:00:00

abstract：:As soon as a pathogen invades through the physical barriers of its corresponding host, host mounts a series of protective immune response to get rid of the invading pathogen. Host's pattern recognition receptors (PRR), localized at the cellular surface, cytoplasm and also in the nucleus; recognises pathogen associated...

journal_title：Life sciences

authors： Rai RC

更新日期：2020-01-01 00:00:00

abstract：:C57BL6/J (B6) mice lacking Se-dependent GSH peroxidase 1 and 2 (GPx1/2-DKO) develop mild to moderate ileocolitis around weaning. These DKO mice have a disease resembling human very-early-onset inflammatory bowel disease (VEOIBD), which is associated with mutations in NADPH oxidase genes. Drugs including dexamethasone ...

journal_title：Life sciences

authors： Chu FF,Esworthy RS,Shen B,Gao Q,Doroshow JH

更新日期：2019-12-15 00:00:00

abstract：:The outbreak of COVID-19 in December 2019, has become an urgent and serious public health emergency. At present, there is no effective treatment or vaccine for COVID-19. Therefore, there is a crucial unmet need to develop a safe and effective treatment for COVID-19 patients. Mesenchymal stem cells (MSCs) are widely us...

journal_title：Life sciences

authors： Sadeghi S,Soudi S,Shafiee A,Hashemi SM

更新日期：2020-12-01 00:00:00

abstract：AIMS:Cisplatin (CDDP) is a potent anticancer agent, but severe renal toxicity can limit its use. We investigated the protective effect of cepharanthin (CE), a biscoclaurin alkaloid, on the renal toxicity of CDDP. MAIN METHODS:Mice were given CDDP along with CE. Effects of CE on CDDP toxicity were investigated by assay...

journal_title：Life sciences

authors： Sogawa N,Hirai K,Sogawa C,Ohyama K,Miyazaki I,Tsukamoto G,Asanuma M,Sasaki A,Kitayama S

更新日期：2013-04-09 00:00:00

abstract：AIMS:This study analyzed in pithed rats the effect of several acute and prophylactic antimigraine drugs on the CGRPergic vasodepressor sensory outflow, in an attempt to investigate systemic cardiovascular effects in a model unrelated to migraine. MAIN METHODS:Male Wistar pithed rats were pretreated with continuous i.v...

journal_title：Life sciences

authors： Lozano-Cuenca J,González-Hernández A,Muñoz-Islas E,Sánchez-López A,Centurión D,Cobos-Puc LE,Villalón CM

更新日期：2009-01-30 00:00:00

abstract：:We examined the effects of cyrneine A, a novel diterpene isolated from the mushroom Sarcodon cyrneus, on morphology of rat pheochromocytoma cells (PC12). In response to cyrneine A, PC12 cells extended their neurites, an effect partially blocked by the extracellular signal-regulated kinase (ERK) kinase inhibitor PD9805...

journal_title：Life sciences

authors： Obara Y,Hoshino T,Marcotullio MC,Pagiotti R,Nakahata N

更新日期：2007-04-10 00:00:00

abstract：:Cardiovascular effects of the essential oil of Croton zehntneri (EOCZ) were investigated in conscious rats. In these preparations, intravenous (i.v.) injections of EOCZ (1-20 mg kg(-1)) and its main constituents anethole and estragole (both at 1-10 mg kg(-1)) elicited brief and dose-dependent hypotension and bradycard...

journal_title：Life sciences

authors： de Siqueira RJ,Magalhães PJ,Leal-Cardoso JH,Duarte GP,Lahlou S

更新日期：2006-04-11 00:00:00

abstract：:We studied the effects of cAMP on cytokine (interferon-gamma plus tumor necrosis factor-alpha)-induced stimulation of tetrahydrobiopterin (BH4) synthesis in human umbilical vein endothelial cells (HUVEC). The cytokine mixture caused a marked increase in the biosynthesis and release of BH4 by HUVEC. Dibutyryl-cAMP prod...

journal_title：Life sciences

authors： Ohtsuki M,Shiraishi H,Kato T,Kuroda R,Tazawa M,Sumi-Ichinose C,Tada S,Udagawa Y,Itoh M,Hishida H,Ichinose H,Nagatsu T,Hagino Y,Nomura T

更新日期：2002-03-22 00:00:00