Recovery of the visual evoked response in the cat following administration of diisopropylfluorophosphate, an irreversible cholinesterase inhibitor.

abstract：:A mechanism of antidepressant activity of beta-amyrin palmitate was studied using the forced swimming method in mice. Beta-amyrin palmitate (10 mg/kg) reduced the increase in the duration of immobility induced by tetrabenazine (100 and 200 mg/kg), but showed no effect on that in mice treated with alpha-methyl-para-tyr...

journal_title：Life sciences

authors： Subarnas A,Tadano T,Nakahata N,Arai Y,Kinemuchi H,Oshima Y,Kisara K,Ohizumi Y

更新日期：1993-01-01 00:00:00

abstract：:Brief electrical pulses applied to the rat tail elicit a complex vocal response which includes audible (peeps, chatters) and ultrasonic (USV) components. Aspirin and amitriptyline had no effect on the vocal responses. Morphine showed a dose-dependent and naloxone reversible antinociceptive effect on the 1st and 2nd au...

journal_title：Life sciences

authors： Jourdan D,Ardid D,Chapuy E,Le Bars D,Eschalier A

更新日期：1998-01-01 00:00:00

abstract：AIMS:Major depressive disorder, as a destructive mental health disorder, is a major contributor to disability and death. Numerous studies have illustrated that activation of inflammation and fluctuating immune reactions play a crucial role in the physiopathology of depression. The effectiveness of antidepressants is af...

journal_title：Life sciences

authors： Lan T,Bai M,Chen X,Wang Y,Li Y,Tian Y,He Y,Wu Z,Yu H,Chen Z,Chen C,Yu Y,Cheng K,Xie P

更新日期：2020-12-01 00:00:00

abstract：AIMS:In our model, we aimed to explore the cytotoxicity of 5-Aza-2'-deoxycytidine (5-Aza-CdR) against the colorectal cell line, Lovo, and further characterize the possible mechanisms. MAIN METHODS:After Lovo cells were treated with 5-Aza-CdR at different concentrations for different periods of time, the cell viability...

journal_title：Life sciences

authors： Deng T,Zhang Y

更新日期：2009-02-27 00:00:00

abstract：AIMS:Histone deacetylase inhibitors (HDACis) are promising anticancer drugs that open new areas of epigenetic drug discovery. Multiple myeloma (MM) is a malignant tumor of the blood system that is difficult to cure and often relapses. Here, we investigated the in vitro effects of a novel HDACi, LMK-235, on MM cells, an...

journal_title：Life sciences

authors： Li X,Guo Y,Kuang X,Zhao L,Li H,Cheng B,Wang W,Zhang Z,Liu P,Wang J

更新日期：2019-04-15 00:00:00

abstract：AIMS:Insulinoma-associated protein 2β (IA-2β) is considered to play a significant role in regulated secretion. Recent studies have shown that the mouse brain expresses three major isoforms of IA-2β, named IA-2β60, IA-2β64, and IA-2β71. In this study, we analyzed the tissue-, cell- and organelle-specific distributions o...

journal_title：Life sciences

authors： Nakajima K,Wu G,Sakudo A,Onodera T,Takeyama N

更新日期：2011-04-25 00:00:00

abstract：:The pure estrogen antagonist ICI-182780, at doses above 50 micrograms/kg, effectively inhibited the initiation of embryo implantation in rats when administered on day 4 of pregnancy (day 1 = sperm positive). The same dose inhibited the implantation initiating effect of intravenous 25 ng of estradiol-17 beta in delayed...

journal_title：Life sciences

authors： Chatterjee S,Johnson DC

更新日期：1993-01-01 00:00:00

abstract：AIM:Despite recent advances in therapeutic strategies, cancer is still a leading cause of mortality worldwide. Mitochondrial dysfunction is implicated in cancer initiation and metastasis, and even in chemo- and radio-resistance. However, the precise role of mitochondria in cancer is crosstalk and controversial. This st...

journal_title：Life sciences

authors： Kheirandish-Rostami M,Roudkenar MH,Jahanian-Najafabadi A,Tomita K,Kuwahara Y,Sato T,Roushandeh AM

更新日期：2020-03-01 00:00:00

abstract：:In order to better understand the mechanisms underlying the reduction in GH secretion in diabetic rats, we have characterized and measured SRIH receptors in the hypothalamus and anterior pituitary gland 5 and 9 days after induction of diabetes in the rat. Experimental diabetes was induced by an intraperitoneal injecti...

journal_title：Life sciences

authors： Pesce G,Guillaume V,Dutour A,Dadoun F,Joanny P,Steinberg J,Oliver C

更新日期：1994-01-01 00:00:00

abstract：:Alpha(1)-adrenergic receptors are one of the three subfamilies of G protein coupled receptors activated by epinephrine and norepinephrine to control important functions in many target organs. Three human subtypes (alpha(1A), alpha(1B), alpha(1D)) are derived from separate genes and are highly homologous in their trans...

journal_title：Life sciences

authors： Hague C,Chen Z,Uberti M,Minneman KP

更新日期：2003-12-12 00:00:00

abstract：AIMS:To assess the relationship between endothelial dysfunction, endothelin 1 (ET-1) plasma levels and subclinical inflammation in primary open angle glaucoma (POAG) patients. MAIN METHODS:We enrolled 40 POAG patients with progressive visual field damage, although well controlled intraocular pressure (IOP) and compare...

journal_title：Life sciences

authors： Cellini M,Strobbe E,Gizzi C,Balducci N,Toschi PG,Campos EC

更新日期：2012-10-15 00:00:00

abstract：:DNA is considered to be one of the most promising targets for anticancer agents. Acridine analogues have anticancer activity based on DNA binding and topoisomerases inhibition. However, due to the side effects, resistance and low bioavailability, a few have entered into clinical usage and the mechanisms of action are ...

journal_title：Life sciences

authors： Zhou Q,You C,Zheng C,Gu Y,Gu H,Zhang R,Wu H,Sun B

更新日期：2018-08-01 00:00:00

abstract：:To assess the possible role of altered central serotonin function in psychiatric disorders, investigators have utilized pharmacological challenge testing with an amino acid mixture to decrease blood tryptophan concentration and, indirectly, brain serotonin levels. The aim of this pilot study was to assess the effectiv...

journal_title：Life sciences

authors： Wolfe BE,Metzger ED,Jimerson DC

更新日期：1995-03-17 00:00:00

abstract：:Activation of GABA(B) receptors produces analgesia in acute and chronic pain models. Data indicate that a possible mechanism for this effect is a GABA(B) receptor-induced blockade of neurokinin-1 (NK-1) receptor gene expression in the spinal cord. While much more potent GABA(B) receptor agonists (CGP 44532) have been ...

journal_title：Life sciences

authors： Enna SJ,Harstad EB,McCarson KE

更新日期：1998-01-01 00:00:00

abstract：:We examined, in young adult women, the association between current low dose oral contraceptive (OC) use and plasma levels of C-reactive protein (CRP), an acute phase reactant predictive of cardiovascular disease risk. We conducted a cross-sectional analysis of 30 healthy, non-smoking, non-obese women (18 OC users and ...

journal_title：Life sciences

authors： Dreon DM,Slavin JL,Phinney SD

更新日期：2003-07-25 00:00:00

abstract：:Hyperglycemia and oxidative stress are the primary stressors that elicit mitochondria specific cell stress in diabetes. Here we hypothesized that elevated level of ROS in high glucose (HG) environment, trigger mitochondrial stress by damaging mitochondrial DNA (mtDNA), altering inflammatory mediators, and neurodegener...

journal_title：Life sciences

authors： Pal S,Rao GN,Pal A

更新日期：2020-09-01 00:00:00

abstract：:In an attempt to investigate the role of nucleoside transporter function in the hypertensive state, we have compared the binding of [3H]nitrobenzylthioinosine ([3H]NBMPR), a nucleoside transporter probe, in membranes prepared from platelet, renal, pulmonary, cardiac and brain tissues of spontaneously hypertensive rats...

journal_title：Life sciences

authors： Williams EF,Udofia UP,Brooks GR,Hawk NN

更新日期：1990-01-01 00:00:00

abstract：:Although effects of a metastasis suppressor gene, KiSS-1, have been postulated to be mediated by its receptor, hOT7T175, the mechanism of such effects remains unknown. This study was designed to evaluate the mechanism of how KiSS-1 works and to assess effects of a synthesized truncated KiSS-1 protein on the invasive a...

journal_title：Life sciences

authors： Yoshioka K,Ohno Y,Horiguchi Y,Ozu C,Namiki K,Tachibana M

更新日期：2008-08-29 00:00:00

abstract：:The number of GABAergic neurons as determined by GAD immunocytochemistry and total neurons as determined from Nissl preparations were counted and classified at the light microscopic level in the inferior colliculus (IC) of the genetically epilepsy prone rat (GEPR) and the non-epileptic Sprague-Dawley (SD) strain of ra...

journal_title：Life sciences

authors： Roberts RC,Ribak CE

更新日期：1986-09-01 00:00:00

abstract：:Obesity, the metabolic syndrome (MetS), and type 2 diabetes (T2DM) are associated with heightened cardiovascular risk. Given the vasoconstrictor and proatherogenic properties of endothelin (ET)-1, increased ET-1 activity has been postulated to participate in the derangement of adiposity-related vascular homeostasis. T...

journal_title：Life sciences

authors： Campia U,Tesauro M,Di Daniele N,Cardillo C

更新日期：2014-11-24 00:00:00

abstract：:Ten neuropeptides were measured by RIA in human cerebrospinal fluid obtained from 30 normal volunteers. The levels of seven peptides (corticotropin releasing factor, adrenocorticotropin, vasoactive intestinal peptide, somatostatin, beta-endorphin, beta-lipotropin, and the N-terminal fragment of proopiomelanocortin) we...

journal_title：Life sciences

authors： Berrettini WH,Nurnberger JI Jr,Gold PW,Chretien M,Chrousos GP,Chan JS,Goldin LR,Gershon ES

更新日期：1985-09-30 00:00:00

abstract：AIMS:We investigated the involvement of the renin angiotensin system (RAS) on the cardiorespiratory control in rats from dams fed with a low-protein diet. MAIN METHODS:Male offspring were obtained from dams fed a normoprotein diet (NP, 17% casein) and low-protein diet (LP, 8% casein) during pregnancy and lactation. Di...

journal_title：Life sciences

authors： Barros MAV,de Brito Alves JL,Barros RGN,Santana E Silva M,Nasser S,Tourneur Y,Leandro CVG,Vidal H,Pirola L,Costa-Silva JH

更新日期：2020-12-15 00:00:00

abstract：:The profile of endogenous opioid peptides in the peptide-rich fraction obtained from a homogenate of an ACTH-secreting human pituitary tumor is presented. Gradient RP-HPLC is used to separate the mixture into peptide constituents. A preparation of opioid receptors is used in a radioreceptor assay with ethorphine - a r...

journal_title：Life sciences

authors： Desiderio DM,Cezayirli RC,Fridland G,Robertson JT,Sacks H

更新日期：1985-11-11 00:00:00

abstract：AIM:Nontuberculous mycobacterial (NTM) infection such as endophthalmitis, dacryocystitis, and canaliculitis are pervasive across the globe and are currently managed by antibiotics. However, the recent cases of Mycobacteroides developing drug resistance reported along with the improper practice of medicine intrigued us ...

journal_title：Life sciences

authors： Satyam R,Bhardwaj T,Jha NK,Jha SK,Nand P

更新日期：2020-06-01 00:00:00

abstract：AIMS:Asymmetric dimethylarginine (ADMA) is an endogenous competitive inhibitor of nitric oxide (NO) synthase, an enzyme responsible for the generation of NO. Plasma concentrations of ADMA increase in the elderly and in postmenopausal women. In fact, an elevated ADMA level is a risk factor of cardiovascular disease. Aer...

journal_title：Life sciences

authors： Tanahashi K,Akazawa N,Miyaki A,Choi Y,Ra SG,Matsubara T,Kumagai H,Oikawa S,Miyauchi T,Maeda S

更新日期：2014-07-11 00:00:00

abstract：:We evaluated whether fish oil or vitamin E administration affected ethanol-induced changes in membrane ATPases. Male Wistar rats (225-250 g) were fed, through a gastric tube a liquid diet containing fish oil (25% of calories) and ethanol for one month. Another group of animals was given supplemental vitamin E (300 u/k...

journal_title：Life sciences

authors： Nanji AA,Sadrzadeh SM

更新日期：1994-01-01 00:00:00

abstract：AIMS:Cisplatin (CDDP) is a potent anticancer agent, but severe renal toxicity can limit its use. We investigated the protective effect of cepharanthin (CE), a biscoclaurin alkaloid, on the renal toxicity of CDDP. MAIN METHODS:Mice were given CDDP along with CE. Effects of CE on CDDP toxicity were investigated by assay...

journal_title：Life sciences

authors： Sogawa N,Hirai K,Sogawa C,Ohyama K,Miyazaki I,Tsukamoto G,Asanuma M,Sasaki A,Kitayama S

更新日期：2013-04-09 00:00:00

abstract：:In order to explore the effect of neonatal androgen administration on oocyte quality, ovulation induction and in vitro fertilization (IVF) were performed in androgen-sterilized mice. Androgen sterilized mice were produced by the subcutaneous injection of testosterone propionate (TP) at 5 days of age and ovulation indu...

journal_title：Life sciences

authors： Kamijo T,Mizunuma H,Yamada K,Ibuki Y

更新日期：1994-01-01 00:00:00

abstract：:We examined the effects of cyrneine A, a novel diterpene isolated from the mushroom Sarcodon cyrneus, on morphology of rat pheochromocytoma cells (PC12). In response to cyrneine A, PC12 cells extended their neurites, an effect partially blocked by the extracellular signal-regulated kinase (ERK) kinase inhibitor PD9805...

journal_title：Life sciences

authors： Obara Y,Hoshino T,Marcotullio MC,Pagiotti R,Nakahata N

更新日期：2007-04-10 00:00:00

abstract：:The relative potencies of the in vivo vasodilating effect on the arterioles of the hamster cheek pouch of morphine and beta-endorphin decreased significantly after chronic morphine injection, indicating the existence of tolerance to morphine and cross tolerance between morphine and beta-endorphin. The apparent pA2 val...

journal_title：Life sciences

authors： Koo A,Wong TM

更新日期：1983-01-31 00:00:00