Cross tolerance between morphine and beta-endorphin in the in vivo vasodilating effect in the hamster cheek pouch.

abstract：:Acute ingestion of ethanol impairs memory, an effect which might be related to ethanol-induced inhibition of vasopressin release. This was studied using tests of memory and cognitive function in 26 normal subjects before and after ethanol ingestion. Equal numbers of subjects received randomly, by double-blind intranas...

journal_title：Life sciences

authors： Eisenhofer G,Lambie DG,Robinson BJ

更新日期：1985-12-30 00:00:00

abstract：:Effects of lithium (Li) deficiency and/or immobilization stress on the thymus weight and differential blood count of rats were studied. The thymus weight of the rats fed a low Li diet were lighter than those of rats fed a Li supplemented diet, whether the rats were exposed to stress or not. Of the rats not exposed to ...

journal_title：Life sciences

authors： Ono T,Iijima M,Shinoda S,Wada O

更新日期：1997-01-01 00:00:00

abstract：AIMS:The molecular pathogenesis of COVID-19 is similar to other coronavirus (CoV) infections viz. severe acute respiratory syndrome (SARS) in human. Due to scarcity of the suitable treatment strategy, the present study was undertaken to explore host protein(s) targeted by potent repurposed drug(s) in COVID-19. MATERIA...

journal_title：Life sciences

authors： Hazra S,Chaudhuri AG,Tiwary BK,Chakrabarti N

更新日期：2020-09-15 00:00:00

abstract：AIMS:Cyclooxygenase-2 (COX-2)-controlled production of prostaglandin E(2) (PGE(2)) has been implicated in cell growth and metastasis in many cancers. Recent studies have found that COX-2 is co-expressed with survivin in many cancers. Survivin is a member of the inhibitor-of-apoptosis protein family. Some COX-2 inhibito...

journal_title：Life sciences

authors： Bai XM,Jiang H,Ding JX,Peng T,Ma J,Wang YH,Zhang L,Zhang H,Leng J

更新日期：2010-01-30 00:00:00

abstract：:The binding of 3H-ouabain to human erythrocytes was analyzed in a population of hospitalized male ethanol addicted patients under long term digitalis treatment. In the non-alcoholic patient group the long term digitalis treatment induced an increase in Bmax and Kd values; such modification was not observed in the alco...

journal_title：Life sciences

authors： Battaini F,Govoni S,Mauri A,Civelli L,Trabucchi M

更新日期：1987-06-29 00:00:00

abstract：:An animal model of haloperidol-induced tardive dyskinesia was studied in relation to the dietary manipulation of tryptophan and its effect on the movement disorder. This study showed a significant negative behavioral response to the neuroleptic drug, haloperidol. Increased dietary tryptophan (1.0 vs. 0.3%) significant...

journal_title：Life sciences

authors： Kozell L,Sandyk R,Wagner GC,Fisher H

更新日期：1987-10-05 00:00:00

abstract：:Gradual increases in the electrical stimulation of the inferior colliculus produces progressive aversive responses from vigilance, through freezing, until escape. These responses are probably mediated by excitatory amino acids (EAA) mechanisms as microinjection of glutamate into the inferior colliculus can trigger fre...

journal_title：Life sciences

authors： Nobre MJ,Borelli KG,Brandão ML

更新日期：2002-11-08 00:00:00

abstract：AIM:There is a specific frequency of extremely low-frequency electromagnetic field (ELF-EMF) that promotes neuronal differentiation. Although several mechanisms are known to regulate ELF-EMF-induced neuronal differentiation, a key factor that mediates neurogenic potentials by the ELF-EMF is largely unknown. Also, the p...

journal_title：Life sciences

authors： Seong Y,Moon J,Kim J

更新日期：2014-04-25 00:00:00

abstract：AIM:The impact of the sympathetic nervous system (SNS) on the regulation of circadian rhythm and physiological functions is still not clear. Previous studies have found that essence of chicken (EC) supplementation facilitated the physiological adaption and circadian resetting in rats subjected to jet lag. Herein, the e...

journal_title：Life sciences

authors： Ni Y,Ma L,Wu T,Lim AL,Zhang W,Yang L,Nakao Y,Fu Z

更新日期：2018-05-15 00:00:00

abstract：:A simple and sensitive method using high performance liquid chromatography with fluorometric detection has been developed for the identification and quantitation of the endogeneous tryptamine metabolites, indoleacetic acid (IAA) and tryptophol (TOL) in the normal mouse brain. The limits of sensitivity are 5pg for both...

journal_title：Life sciences

authors： Yamada J,Sugimoto Y,Horisaka K

更新日期：1983-11-14 00:00:00

abstract：:Leptin-deficient Ob/Ob mice are hypometabolic and have reduced fat cell expression of beta-3 adrenoceptors (ARs). To determine whether leptin repletion restores beta-3 AR number, C57BL/6J Ob/Ob mice were given exogenous leptin (5 mg/kg I.P. daily) for 21 days. Leptin administration reduced body weight from 43.1+/-3.7 ...

journal_title：Life sciences

authors： Breslow MJ,An Y,Berkowitz DE

更新日期：1997-01-01 00:00:00

abstract：:Effects of PK 11195 and flumazenil on cardiac responses to diazepam, clonazepam and zolpidem were compared. Coronary flow rate was increased at relatively low doses of diazepam and decreased at higher doses. Clonazepam induced a dose-dependent increase, and zolpidem a decrease of coronary flow rate. PK 11195 reduced t...

journal_title：Life sciences

authors： Zeegers A,van Wilgenburg H,Leeuwin RS

更新日期：1998-01-01 00:00:00

abstract：:Mitochondrial dysfunction caused by calcium overload is a vital factor for mediating cardiomyocyte death following ischemia/reperfusion (I/R) injury. The stromal interactive molecule 2 (STIM2) is a calcium sensor protein that regulates the store-operated calcium entry (SOCE). Whereas, whether STIM2 is associated with ...

journal_title：Life sciences

authors： Tu CC,Wan BY,Zeng Y

更新日期：2020-04-15 00:00:00

abstract：:According to the two-state model of G-protein-coupled receptor (GPCR) activation, GPCRs isomerize from an inactive (R) state to an active (R*) state. In the R* state, GPCRs activate G-proteins. Agonist-independent R/R* isomerization is referred to as constitutive activity and results in an increase in basal G-protein ...

journal_title：Life sciences

authors： Seifert R,Wenzel-Seifert K

更新日期：2003-09-19 00:00:00

abstract：AIMS:Reduced cardiac β-adrenoceptors (β-AR) and cardiovascular (CV) dysfunction occur in diabetes mellitus (DM) and can be normalized by insulin. It is unclear how the duration of untreated hyperglycemia prior to intervention impacts insulin's effects. This study assesses insulin's effect on reduced myocardial β-AR and...

journal_title：Life sciences

authors： Haley JM,Thackeray JT,Kolajova M,Thorn SL,DaSilva JN

更新日期：2015-07-01 00:00:00

abstract：AIMS:Fenofibrate is a peroxisome proliferator-associated receptor alpha agonist (PPARα) used clinically for the management of dyslipidemia and is a myocardial fatty acid oxidation stimulator. It has also been shown to have cardiac anti-hypertrophic properties but the effects of fenofibrate on the development of eccentr...

journal_title：Life sciences

authors： Dhahri W,Couet J,Roussel É,Drolet MC,Arsenault M

更新日期：2013-01-17 00:00:00

abstract：:Reabsorption of 125I labeled unmodified and glycated albumin by the proximal tubule was studied using micropuncture technique in wistar rats of different ages. The data show a significant reabsorption of unmodified albumin while the glycated albumin was virtually excluded from reabsorption process. Among different exp...

journal_title：Life sciences

authors： Kowluru A,Kowluru RA,Solomon S,Martinez L

更新日期：1992-01-01 00:00:00

abstract：:Sustained levels of leucine comparable to those of human Maple Syrup Urine Disease (MSUD) were achieved in blood and brain of rats by subcutaneous leucine administration twice a day from the 6th to the 28th day of life. Control rats were treated with saline in the same volumes. Behavioral studies using aversive and no...

journal_title：Life sciences

authors： Mello CF,Feksa L,Brusque AM,Wannmacher CM,Wajner M

更新日期：1999-01-01 00:00:00

abstract：:Dietary guidelines published in the past two decades have acknowledged the beneficial effects of myricetin, an important and common type of herbal flavonoid, against several human diseases such as inflammation, cardiovascular pathologies, and cancer. An increasing number of studies have shown the beneficial effects of...

journal_title：Life sciences

authors： Devi KP,Rajavel T,Habtemariam S,Nabavi SF,Nabavi SM

更新日期：2015-12-01 00:00:00

abstract：:Levels of delta-sleep-inducing peptide-like immunoreactivity (DSIP-LI) in rat plasma were measured by radioimmunoassay and found to exhibit a circadian rhythm that parallelled the normal rhythm for corticosterone. The maximal plasma levels of both substances were observed to occur at about 1700h. The lowest concentrat...

journal_title：Life sciences

authors： Fischman AJ,Kastin AJ,Graf MV

更新日期：1984-11-12 00:00:00

abstract：PURPOSE:Doxorubicin, as an effective chemotherapeutic drug, is commonly used for combating various solid and hematological tumors. However, doxorubicin-induced cardiotoxicity is considered as a serious adverse effect, and it limits the clinical use of this chemotherapeutic drug. The use of melatonin can lead to a decre...

journal_title：Life sciences

authors： Najafi M,Hooshangi Shayesteh MR,Mortezaee K,Farhood B,Haghi-Aminjan H

更新日期：2020-01-15 00:00:00

abstract：:The aim of the study was to explore the effect of an acute dose of creatine (Cr) ingestion on serum Cr and serum creatinine (Crn) concentrations. Sixteen healthy subjects ingested a single dose of Cr (20 g) followed by the measurement of serum Cr and Crn concentration for 3 h up to a maximum of 6 h (n=6). In response ...

journal_title：Life sciences

authors： Schedel JM,Tanaka H,Kiyonaga A,Shindo M,Schutz Y

更新日期：1999-10-29 00:00:00

abstract：:When injected into the substantia nigra reticulata of naive rats, dynorphin-(1-17) caused a dose dependent contralateral rotation which was inhibited by naloxone in a dose dependent manner. Met-enkephalin injected in the same coordinates as the ones used with dynorphin also induced rotation but of lower intensity, whi...

journal_title：Life sciences

authors： Herrera-Marschitz M,Hökfelt T,Ungerstedt U,Terenius L

更新日期：1983-01-01 00:00:00

abstract：AIMS:We have developed biochemical and cell based assays to characterize small therapeutic molecules that inhibit the DNA damage checkpoint enzyme, Chk1 (Checkpoint kinase 1). MAIN METHODS:To prepare a screen of large chemical libraries, we purified the full-length and the catalytic domain versions of human Chk1. We c...

journal_title：Life sciences

authors： Ferry G,Studeny A,Bossard C,Kubara PM,Zeyer D,Renaud JP,Casara P,de Nanteuil G,Wierzbicki M,Pfeiffer B,Prudhomme M,Leonce S,Pierré A,Boutin JA,Golsteyn RM

更新日期：2011-08-15 00:00:00

abstract：:The abdominal subcutaneous interstitium is easily accessible for monitoring glucose for Diabetes Mellitus research and management. The available glucose sensing devices demand frequent blood sampling by finger pricking for calibration. Moreover, there is controversy about the exact relationship between the levels of g...

journal_title：Life sciences

authors： Tiessen RG,Rhemrev-Boom MM,Korf J

更新日期：2002-04-21 00:00:00

abstract：:The biochemical integrity of hepatocellular mitochondria was investigated in rats treated with small doses of human recombinant tumor necrosis factor-alpha (Hur-TNF;50-100 micrograms/kg/d injected intraperitoneally for 5 d) by measuring the activities of three mitochondrial enzymes, glutamate dehydrogenase, succinate ...

journal_title：Life sciences

authors： Yasmineh WG,Tsai MY,Theologides A

更新日期：1995-01-01 00:00:00

abstract：:Nitric oxide (NO) is a potent regulator in the cardiovascular system; it is generated by the nitric oxide synthase (NOS) family of proteins. NO produced in endothelial cells plays a crucial role in vascular functions. The aim of this study was to clarify the effect of diabetes on aortic NO synthesis in a model of gene...

journal_title：Life sciences

authors： Ibrahim MA,Kanzaki T,Yamagata S,Satoh N,Ueda S

更新日期：2005-07-15 00:00:00

abstract：:Plasma levels of prolactin, growth hormone, glucagon insulin and glucose were measured in non-treated control rats, bromocriptine-treated control rats and GH3-cell-tumor-bearing rats with and without bromocriptine treatment. Bromocriptine treatment increased plasma levels of glucagon, insulin and glucose in control ra...

journal_title：Life sciences

authors： Knudtzon J,Johansen PW,Haug E,Gautvik K

更新日期：1986-08-18 00:00:00

abstract：AIMS:T lymphocytes synthesize acetylcholine (ACh) and express muscarinic and nicotinic ACh receptors (mAChR and nAChR, respectively) responsible for increases in the intracellular Ca2+ concentration ([Ca2+]i). Our aim in the present study was to assess whether autocrine ACh released from T lymphocytes regulates their p...

journal_title：Life sciences

authors： Mashimo M,Iwasaki Y,Inoue S,Saito S,Kawashima K,Fujii T

更新日期：2017-03-01 00:00:00

abstract：AIMS:Aristolochic acid (AA) nephrotoxicity is related to accumulation of methylglyoxal (MGO) and N(ε)-(carboxymethyl)lysine (CML) in the mouse kidney. We studied the activity of renal semicarbazide-sensitive amine oxidase (SSAO), a key enzyme involved in MGO generation, in AA-treated mice, and investigated nephroprotec...

journal_title：Life sciences

authors： Huang TC,Chen SM,Li YC,Lee JA

更新日期：2014-09-26 00:00:00