当前位置： SCI文献检索 > LIFE SCIENCES期刊下所有文献 > Plasma ADMA concentrations associate with aerobic fitness in postmenopausal women.

Plasma ADMA concentrations associate with aerobic fitness in postmenopausal women.

Abstract：

AIMS:Asymmetric dimethylarginine (ADMA) is an endogenous competitive inhibitor of nitric oxide (NO) synthase, an enzyme responsible for the generation of NO. Plasma concentrations of ADMA increase in the elderly and in postmenopausal women. In fact, an elevated ADMA level is a risk factor of cardiovascular disease. Aerobic exercise has a beneficial effect on cardiovascular disease. However, the relationship between ADMA and aerobic fitness is unknown. The aim of this study was to determine whether plasma ADMA concentrations correlate with aerobic fitness levels in postmenopausal women. MAIN METHODS:Thirty healthy postmenopausal women aged 50-76 years participated in this study. We measured plasma concentrations of ADMA and oxygen consumption at the ventilatory threshold (VO2VT) as an index of aerobic fitness. Subjects were divided into the low aerobic fitness (Low fitness) and high aerobic fitness (High fitness) groups, and the dividing line was set at the median VO2VT value. KEY FINDINGS:VO2VT was significantly higher in the High fitness group than in the Low fitness group (P<0.01). The plasma ADMA concentrations in the High fitness group were significantly lower than those in the Low fitness group (P<0.05). There was a negative correlation between plasma ADMA concentrations and VO2VT (r=-0.532, P<0.01). SIGNIFICANCE:We found that plasma ADMA concentrations were associated with aerobic fitness in postmenopausal women. The results of this study suggest that habitual aerobic exercise may decrease plasma ADMA concentrations.

journal_name

Life Sci

journal_title

Life sciences

authors

Tanahashi K,Akazawa N,Miyaki A,Choi Y,Ra SG,Matsubara T,Kumagai H,Oikawa S,Miyauchi T,Maeda S

doi

10.1016/j.lfs.2014.05.003

subject

Has Abstract

pub_date

2014-07-11 00:00:00

pages

30-3

issue

1

eissn

0024-3205

issn

1879-0631

pii

S0024-3205(14)00474-3

journal_volume

108

pub_type

杂志文章

相关文献

LIFE SCIENCES文献大全
  • Ethanol consumption and serum lipid profiles in Sinclair(S-1) miniature swine.

    abstract：:Ethanol consumption was correlated with changes in acyl group profiles of phosphatidylcholine and triacylglycerols in serum of Sinclair(S-1) miniature boars. Serum triacylglycerols in the control pigs were high in linoleate (18:2) (48%) and low in stearate (18:0 (3%). Upon feeding with 10% (w/v) ethanol ad lib for two...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(84)90198-x

    authors： Foudin L,Tumbleson ME,Sun AY,Geisler RW,Sun GY

    更新日期：1984-02-27 00:00:00

  • Insulin therapy normalizes reduced myocardial β-adrenoceptors at both the onset and after sustained hyperglycemia in diabetic rats.

    abstract：AIMS:Reduced cardiac β-adrenoceptors (β-AR) and cardiovascular (CV) dysfunction occur in diabetes mellitus (DM) and can be normalized by insulin. It is unclear how the duration of untreated hyperglycemia prior to intervention impacts insulin's effects. This study assesses insulin's effect on reduced myocardial β-AR and...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2015.03.024

    authors： Haley JM,Thackeray JT,Kolajova M,Thorn SL,DaSilva JN

    更新日期：2015-07-01 00:00:00

  • Orthovanadate-induced cell death in RET/PTC1-harboring cancer cells involves the activation of caspases and altered signaling through PI3K/Akt/mTOR.

    abstract：AIMS:Oncogenic RET/PTC1 chromosomal rearrangements are hallmarks of thyroid papillary carcinoma. The resulting protein, mainly through tyrosine 451, is responsible for the activation of pathways controlling cell survival, including the PI3K/Akt/mTOR cascade. Vanadium compounds were shown to have anti-neoplastic potenti...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2011.07.004

    authors： Gonçalves AP,Videira A,Soares P,Máximo V

    更新日期：2011-09-12 00:00:00

  • Periodic acceleration (pGz) prior to whole body ischemia reperfusion injury provides early cardioprotective preconditioning.

    abstract：AIMS:Periodic acceleration (pGz) is a method that applies repetitive sinusoidal head-to-foot motion to the horizontally positioned body. pGz adds pulses to the circulation as a function of frequency, thereby increasing shear stress to the endothelium. Pulsatile shear stress increases release of cardioprotective endothe...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2010.02.022

    authors： Adams JA,Wu H,Bassuk JA,Arias J,Uryash A,Jorapur V,Lamas GA,Kurlansky P

    更新日期：2010-05-08 00:00:00

  • 125I-beta-endorphin binding to neuroblastoma X glioma NG108-15 cells: distribution of delta opioid receptors.

    abstract：:The mouse neuroblastoma x rat glioma hybrid NG108-15 was previously shown to express delta opioid receptors. Because neuroblastoma cells display different phenotypes and cloned cell lines are heterogenous, we studied the characteristics and distribution of human 125I-beta-endorphin (125I-beta E) binding sites in cultu...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(92)90306-a

    authors： Cone RI,Rosenfeld S,Lameh J,Sadée W

    更新日期：1992-01-01 00:00:00

  • Azelnidipine treatment reduces the expression of Cav1.2 protein.

    abstract：AIMS:Azelnidipine, a third-generation dihydropyridine calcium channel blocker (DHP CCB), has a characteristic hypotensive effect that persists even after it has disappeared from the plasma, which is thought to be due to its high hydrophobicity. However, because azelnidipine is unique, it might have other unknown effect...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2021.119043

    authors： Nasu F,Obara Y,Okamoto Y,Yamaguchi H,Kurakami K,Norota I,Ishii K

    更新日期：2021-01-13 00:00:00

  • Carbon-11 labelled cholecystokininB antagonists: radiosynthesis and evaluation in rats.

    abstract：:Three cholecystokinin type B (CCKB) receptor antagonists were labelled with 11C and evaluated ex vivo in rat biodistribution studies. The CCKB antagonists were YF 476 and two other compounds of the basic 3-ureido-1,4-benzodiazepine class. Following tail-vein administration of [11C]-YF 476 exceedingly low levels of rad...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/s0024-3205(00)01021-3

    authors： Wilson AA,Jin L,Garcia A,DaSilva JN,Houle S

    更新日期：2001-02-02 00:00:00

  • Bilirubin in metabolic syndrome and associated inflammatory diseases: New perspectives.

    abstract：:Diabetes mellitus is one of the major global health issues, which is closely related to metabolic dysfunction and the chronic inflammatory diseases. Multiple studies have demonstrated that serum bilirubin is negatively correlated with metabolic syndrome and associated inflammatory diseases, including atherosclerosis, ...

    journal_title：Life sciences

    pub_type： 杂志文章,评审

    doi：10.1016/j.lfs.2020.118032

    authors： Novák P,Jackson AO,Zhao GJ,Yin K

    更新日期：2020-09-15 00:00:00

  • Homocysteine accelerates atherosclerosis via inhibiting LXRα-mediated ABCA1/ABCG1-dependent cholesterol efflux from macrophages.

    abstract：AIMS:Macrophage-derived foam-cell formation plays a crucial role in the development of atherosclerosis, and liver X receptor alpha (LXRα) is a key regulator of lipid metabolism in macrophages. Homocysteine (Hcy) is an independent risk factor of atherosclerosis; however, the regulation of lipid metabolism and role of LX...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2018.10.060

    authors： Jin P,Bian Y,Wang K,Cong G,Yan R,Sha Y,Ma X,Zhou J,Yuan Z,Jia S

    更新日期：2018-12-01 00:00:00

  • Effects of ethanol on locomotor and anxiety-like behaviors and the acquisition of ethanol intake in Lewis and spontaneously hypertensive rats.

    abstract：:The purpose of the present study was to investigate whether Lewis (LEW) and spontaneously hypertensive rats (SHR), characterized in numerous behavioral tests as strains with high-anxiety and low-anxiety, respectively, could differ in their sensitivity to the effects of ethanol in the elevated plus maze (EPM) and the o...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2005.01.013

    authors： Da Silva GE,Vendruscolo LF,Takahashi RN

    更新日期：2005-06-24 00:00:00

  • Endothelins and endothelin receptor antagonists: binding to plasma proteins.

    abstract：:Endothelins (ET) are 21-amino acid peptides that bind to membrane receptors to initiate a wide range of pathophysiological effects. PD-156707, L-749329, Ro-470203, and A-127722 are potent non-peptide ET receptor antagonists developed recently. When tested in human and rat plasma, both ET-1 and -3 and the four aforemen...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(96)00168-3

    authors： Wu-Wong JR,Chiou WJ,Hoffman DJ,Winn M,von Geldern TW,Opgenorth TJ

    更新日期：1996-01-01 00:00:00

  • 2-O-methyl PAF as a Ca2+ mobilizer in Madin Darby canine kidney cells.

    abstract：:In Madin-Darby canine kidney (MDCK) cells, the effect of 2-O-methyl PAF, an inactive analogue of platelet activating factor (PAF), on intracellular Ca2+ concentration ([Ca2+]i) was measured by using the Ca2+-sensitive fluorescent dye fura-2. 2-O-methyl PAF (> or = 15 microM) caused a rapid rise of [Ca2+]i in a concent...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2004.10.064

    authors： Yeh JH,Huang CJ,Lee JH,Hsu SS,Chen JS,Cheng HH,Chang HT,Huang JK,Chung HM,Mei-Yin Y,Jan CR

    更新日期：2005-06-03 00:00:00

  • Effects of endurance physical training on hydroxyl radical generation in rat tissues.

    abstract：:Physical exercise is known to increase oxygen consumption to compensate for enhanced ATP consumption and thus to induce oxidative stress in tissues. Our previous data indicate that training significantly increased the hydroxyl radical level in rat tissues after physical exercise, but reduced the basal level in aged ra...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/s0024-3205(98)00468-8

    authors： Itoh H,Ohkuwa T,Yamamoto T,Sato Y,Miyamura M,Naoi M

    更新日期：1998-01-01 00:00:00

  • Effect of luteotrophic hormone (LH) and thymosin on mitogen-induced blast transformation of Balb/c mouse lymphoid cells.

    abstract：:The present study investigates the effect of a pituitary hormone (LH) and a thymic factor (Thymosin Fraction 5 = TF5) on in vitro and in vivo spleen cell proliferative response of 2, 6 and 8-month-old Balb/c mice. In vitro experiments showed that the addition of LH at various concentrations (0.5, 5, 50 or 500 ng/ml) t...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(90)90031-l

    authors： Rouabhia M,Ghanmi Z,Chakir J,Othmane O,Deschaux P

    更新日期：1990-01-01 00:00:00

  • In vivo binding of [11C]tetrabenazine to vesicular monoamine transporters in mouse brain.

    abstract：:The time course of regional mouse brain distribution of radioactivity after i.v. injection of a tracer dose of [11C]tetrabenazine ([11C]TBZ) has been determined. Radiotracer uptake into brain is rapid, with 3.2% injected dose in the brain at 2 min. Egress from the brain is also very rapid, with only 0.21% of the injec...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(92)90228-h

    authors： DaSilva JN,Kilbourn MR

    更新日期：1992-01-01 00:00:00

  • Insulin analogs: Glimpse on contemporary facts and future prospective.

    abstract：:Insulin remains a predominant life-saving medication for type 1 and type 2 Diabetes Mellites. Natural insulin secretion limits the fluctuation of the narrow and high surge of blood glucose levels. However, imitating the same by external insulin remains a challenge as a variety of insulin analogs (rapid acting, short a...

    journal_title：Life sciences

    pub_type： 杂志文章,评审

    doi：10.1016/j.lfs.2019.01.011

    authors： Sharma AK,Taneja G,Kumar A,Sahu M,Sharma G,Kumar A,Sardana S,Deep A

    更新日期：2019-02-15 00:00:00

  • Tissue uptake of ketamine and norketamine enantiomers in the rat: indirect evidence for extrahepatic metabolic inversion.

    abstract：:Ketamine, used clinically as an intravenous analgetic and dissociative anaesthetic agent, is a racemate with both pharmacokinetic and pharmacodynamic enantioselectivity. S-ketamine has been found have a higher clearance and greater potency than R-ketamine as well as a greater therapeutic index. We performed a study in...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/s0024-3205(01)01287-5

    authors： Edwards SR,Mather LE

    更新日期：2001-09-14 00:00:00

  • ODC-polyamine system is involved in morphine analgesia.

    abstract：:alpha-Difluoromethylornithine (DFMO) directly infused into a brain-lateral ventricle (12.5, 25 and 50 micrograms/rat) dose- and time-dependently inhibited brain ODC activity. While having no influence per se on pain threshold, DFMO significantly inhibited the analgesic activity of morphine (15 mg/kg i.p.), this effect...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(89)90614-0

    authors： Genedani S,Bernardi M,Tagliavini S,Bertolini A

    更新日期：1989-01-01 00:00:00

  • Protease inhibitors protect macrophages from lipopolysaccharide-induced cytotoxicity: possible role for NF-kappaB.

    abstract：:Recent studies suggest lipopolysaccharide (LPS) mediated cell death as underlying mechanism of hyporesponsiveness and dysfunction of macrophages in the late phase of septic shock. In the present study LPS (0.001 - 30 microg/ml) caused a concentration-dependent toxicity in the macrophage cell line (J774.1A) within 24 h...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/s0024-3205(98)00031-9

    authors： Abate A,Schröder H

    更新日期：1998-01-01 00:00:00

  • The important role played by chemokines influence the clinical outcome of Helicobacter pylori infection.

    abstract：:The extended infection with Helicobacter pylori (H. pylori), one of the most frequent infectious agents in humans, may cause gastritis, peptic ulcers, gastric mucosa-associated lymphoid tissue (MALT) lymphoma, and gastric cancer. During H. pylori infection, different kinds of inflammatory cells such as dendritic cells...

    journal_title：Life sciences

    pub_type： 杂志文章,评审

    doi：10.1016/j.lfs.2019.116688

    authors： Jafarzadeh A,Nemati M,Jafarzadeh S

    更新日期：2019-08-15 00:00:00

  • Hispidulin exhibits neuroprotective activities against cerebral ischemia reperfusion injury through suppressing NLRP3-mediated pyroptosis.

    abstract：AIM:Ischemia/reperfusion (I/R) injury is the major cause of neurological deficit following stroke. Our previous study showed neuroprotective effects of hispidulin against cerebral ischemia reperfusion injury (IRI). In this study, we further examined the involvement of pyroptosis in this neuroprotective function. MATER...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2019.116599

    authors： An P,Xie J,Qiu S,Liu Y,Wang J,Xiu X,Li L,Tang M

    更新日期：2019-09-01 00:00:00

  • Stability of epidermal growth factor in the gastrointestinal lumen of suckling and weaned pigs.

    abstract：:The stability of epidermal growth factor (EGF) in the gastrointestinal humen of 3-day-old suckling and 45-day-old weaned pigs was examined by incubating iodine labeled recombinant human EGF (hEGF) in the gastrointestinal fluids at 37 degrees C and monitoring the generation of acid soluble radioactivity. Chromatographi...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(96)00285-8

    authors： Shen WH,Xu RJ

    更新日期：1996-01-01 00:00:00

  • Vitamin E, membrane fluidity, and blood pressure in hypertensive and normotensive rats.

    abstract：:Vitamin E treatment was found to lower blood pressure, and increase membrane fluidity in rats. The objectives of this study were to investigate the effects of the antioxidant, vitamin E, on the blood pressure and erythrocyte membrane fluidity in spontaneously hypertensive (SHR) and normotensive (WKY) rats. Membrane fl...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/s0024-3205(00)00775-x

    authors： Pezeshk A,Derick Dalhouse A

    更新日期：2000-09-01 00:00:00

  • Using mRNAsi to identify prognostic-related genes in endometrial carcinoma based on WGCNA.

    abstract：AIMS:Cancer Stem Cells (CSCs) refers to heterogeneous tumor cells retaining the abilities of self-renewal and differentiation. This study used mRNAsi, which is an index to describe the similarity between tumor cells and CSCs, to define genes involved in endometrial carcinoma. MATERIALS AND METHODS:The mRNA expression ...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2020.118231

    authors： Liu J,Wu Z,Sun R,Nie S,Meng H,Zhong Y,Nie X,Cheng W

    更新日期：2020-10-01 00:00:00

  • Inhibition of immune cell proliferation with haloperidol and relationship of tyrosine hydroxylase expression to immune cell growth.

    abstract：:Previous studies indicated that exogenous dopamine and its agonists directly regulated mitogen-induced immune cell proliferation. In this study, we further investigated role of endogenous dopamine in immune cell growth. Haloperidol, a general antagonist for dopamine receptors, could reduce the cell growth rate of T ce...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/s0024-3205(98)00170-2

    authors： Tsao CW,Lin YS,Cheng JT

    更新日期：1998-01-01 00:00:00

  • Vitamin D receptor gene expression in human pituitary gland.

    abstract：:1,25-dihydroxyvitamin D3 has important physiological effects such as calcium transport and cell growth and differentiation. These biological effects are mediated by their binding to specific intracellular receptor termed vitamin D receptor (VDR). VDR mRNA expression has been demonstrated in several tissues, but to dat...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/s0024-3205(96)00586-3

    authors： Pérez-Fernandez R,Alonso M,Segura C,Muñoz I,García-Caballero T,Diguez C

    更新日期：1997-01-01 00:00:00

  • Passive immunization with an anti-substance P antibody prevents substance P- and neurokinin A-induced bronchospasm in anesthetized guinea-pigs.

    abstract：:In a guinea-pig model of asthma, active immunization against substance P (SP) prevented the development of airways' hyperresponsiveness and reduced bronchospastic responses to SP (i.v.). The rat-mouse heterohybridoma NC1/34 secretes a specific, rat IgG1, anti-substance P antibody (alpha-SP Ab) which was isolated and p...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(95)00255-5

    authors： Jafarian A,Suresh MR,Kreutz FT,Biggs DF

    更新日期：1995-01-01 00:00:00

  • Chronic intermittent hypobaric hypoxia protects vascular endothelium by ameliorating autophagy in metabolic syndrome rats.

    abstract：AIMS:The study aimed to investigate the protective effect of chronic intermittent hypobaric hypoxia (CIHH) on endothelium function and relaxation of mesenteric artery in metabolism syndrome (MS) rats. MAIN METHODS:Male adult Sprague-Dawley rats were randomly divided into control (CON), CIHH (treated with 28-days hypob...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2018.05.008

    authors： Cui F,Guan Y,Guo J,Tian YM,Hu HF,Zhang XJ,Zhang Y

    更新日期：2018-07-15 00:00:00

  • Calcium handling by platelets from normal and malignant hyperthermia-susceptible pigs.

    abstract：:Platelets from normal and malignant hyperthermia (MH)-susceptible pigs were evaluated for differences in 45calcium uptake in the absence or presence of caffeine (2-16 mM), halothane (0.05-0.5%), or halothane and caffeine together. There were no statistically significant differences in basal or halothane-inhibited calc...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(91)90184-d

    authors： Miller KE,Brooks RR,Bonk KR,Carpenter JF

    更新日期：1991-01-01 00:00:00

  • Prostacyclin (PGI2) induces rapid depletion of cyclic AMP levels in brain nuclei of rats.

    abstract：:Intravenous injection of prostacyclin (100 micrograms/kg) in rats resulted in a decrease of systolic blood pressure within 2 minutes. Concentrations of cAMP in 15 brain regions and nuclei were determined by radioimmunoassay. In lower brain stem nuclei, such as the nucleus of the solitary tract and the lateral reticula...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(87)90439-5

    authors： Schmid G,Bahner U,Palkovits M,Geiger H,Heidland A

    更新日期：1987-12-07 00:00:00