Protective effect of cepharanthin on cisplatin-induced renal toxicity through metallothionein expression.

abstract：:Ribonucleotide reductase is the rate limiting enzyme of de novo DNA synthesis; its activity is significantly increased in tumor cells related to the proliferation rate. Therefore the enzyme is considered to be an excellent target for cancer chemotherapy. In the present study we tested the in vitro and in vivo antitumo...

journal_title：Life sciences

authors： Fritzer-Szekeres M,Novotny L,Romanova D,Göbl R,Sedlak J,Vachalkova A,Rauko P,Elford HL,Szekeres T

更新日期：1998-01-01 00:00:00

abstract：:Despite the lack of knowledge of the effects of electronic cigarettes (e-cigarettes, e-cigs) on public health, they have been proposed as a part of smoking cessation efforts. Recently, several basic scientific studies have pointed out how e-cigs can generate carcinogens, such as e-cig liquid thermal degradation by-pro...

journal_title：Life sciences

authors： Vivarelli F,Canistro D,Cirillo S,Cardenia V,Rodriguez-Estrada MT,Paolini M

更新日期：2019-07-01 00:00:00

abstract：AIMS:Tetramethylpyrazine (TMP), one of the active ingredients isolated from a Chinese herbal prescription, possesses protective effects against oxidative stress caused by high glucose in endothelial cells. In this study, the role of TMP in preventing muscle cells from palmitate-induced oxidative damage was investigated...

journal_title：Life sciences

authors： Gao X,Zhao XL,Zhu YH,Li XM,Xu Q,Lin HD,Wang MW

更新日期：2011-04-25 00:00:00

abstract：:In recent years, serum S100B has been used as a secondary endpoint in some clinical trials, in which serum S100B has successfully indicated the benefits or harm done by the tested agents. Compared to clinical stroke studies, few experimental stroke studies report using serum S100B as a surrogate marker for estimating ...

journal_title：Life sciences

authors： Tanaka Y,Koizumi C,Marumo T,Omura T,Yoshida S

更新日期：2007-08-02 00:00:00

abstract：:Substrate stiffness is essential for cell functions, but the mechanisms by which cell sense mechanical cues are still unclear. Here we show that the frequency and the amplitude of spontaneous Ca2+ oscillations were greater in chick cardiomyocytes cultured on the stiff substrates than that on the soft substrates. The s...

journal_title：Life sciences

authors： Liu S,Gao X,Wu X,Yu Y,Yu Z,Zhao S,Zhao H

更新日期：2019-10-15 00:00:00

abstract：AIM:The study is aimed at evaluating the chemosensitization and apoptotic effect of aglycone rich extracts of dietary phytoestrogens (derived from soybean and flaxseed) on estrogen receptor positive, MCF-7 and estrogen receptor negative, MDA-MB-231 cells. The extracts show potent activity on both the cell lines, hence,...

journal_title：Life sciences

authors： Dutta S,Kharkar PS,Sahu NU,Khanna A

更新日期：2017-09-15 00:00:00

abstract：AIMS:This study investigates the effect of a new combination of glucosamine hydrochloride, chondroitin sulfate, methylsulfonylmethane, Harpagophytum procumbens root extract (standardized to 3% harpagoside) and bromelain extract (GCMHB) on formalin-induced damage to cartilage tissue in the rat knee joint and evaluates t...

journal_title：Life sciences

authors： Ucuncu Y,Celik N,Ozturk C,Turkoglu M,Cetin N,Kockara N,Sener E,Dundar C,Arslan A,Dogan H,Kurt N,Suleyman H

更新日期：2015-06-01 00:00:00

abstract：:The vascular endothelium is recognized as a barrier between blood and blood vessel wall. The abnormality of vascular endothelium is critical for atherosclerosis, hypertension and diabetes. Oxidative stress, inflammation, obesity, hyperlipidemia and insulin resistance are major contributors to endothelial dysfunction i...

journal_title：Life sciences

authors： Sun HJ,Hou B,Wang X,Zhu XX,Li KX,Qiu LY

更新日期：2016-12-15 00:00:00

abstract：AIMS:GnRH-DFF40 (gonadotropin releasing hormone-DNA fragmentation factor 40) humanized recombinant immunotoxin serves as a prospective candidate for targeted therapy of malignancies with over-expressed gonadotropin releasing hormone receptor (GnRHR). In this study, we attempted to generate a GnRH-based chimeric protein...

journal_title：Life sciences

authors： Barazesh M,Mohammadi S,Jalili S,Kavousipour S,Faraji SN,Mokarram P,Pirhadi S

更新日期：2021-01-15 00:00:00

abstract：:Abdominal aortic coarctation above the renal arteries leads to severe hypertension above the stenotic site and provides a model for simultaneous testing of the effects of increased and decreased pressure and consequently shear stress in the same animal. The effects of increased pressure, per se, on oxidative stress an...

journal_title：Life sciences

authors： Sindhu RK,Roberts CK,Ehdaie A,Zhan CD,Vaziri ND

更新日期：2005-01-07 00:00:00

abstract：:Although peripheral actions have been shown for the brain-gut peptide, motilin, its localization in the CNS of mammals suggests some physiological role at this site. In the present experiments intracerebroventricular or intrathecal, but not peripheral, administrations of motilin produced a dose-related and naloxone re...

journal_title：Life sciences

authors： Porreca F,Dray A

更新日期：1984-06-25 00:00:00

abstract：AIMS:Circular RNAs (circRNAs) have been emerged as novel regulators in multiple tumorigenesis, including melanoma. CircRNA_0084043 was recently demonstrated to be deregulated in human melanoma cells. Nevertheless, its role and mechanism are largely unrevealed in melanoma. MATERIALS AND METHODS:Expression of circ_00840...

journal_title：Life sciences

authors： Chen Z,Chen J,Wa Q,He M,Wang X,Zhou J,Cen Y

更新日期：2020-02-15 00:00:00

abstract：:Growth-related oncogene protein-alpha (GRO-alpha) is a member of the C-X-C chemokine family with a wide variety of biological activities. We studied the production of GRO-alpha by human umbilical vein endothelial cells (HUVEC) in response to the stimulation with soluble form of interleukin-6 receptor alpha (sIL-6R). s...

journal_title：Life sciences

authors： Matsumiya T,Imaizumi T,Itaya H,Shibata T,Yoshida H,Sakaki H,Kimura H,Satoh K

更新日期：2002-05-17 00:00:00

abstract：:The ability of metformin (MF) to acutely relax phenylephrine (PE)-induced contraction in the isolated rat tail artery is reported to be accompanied by repolarization of the arterial smooth muscle cell (SMC) membranes. These membranes contain potassium (K) channels which if opened could mediate such repolarization and ...

journal_title：Life sciences

authors： Peuler JD,Lee JM,Smith JM

更新日期：1999-10-29 00:00:00

abstract：:The content of lactic acid in red blood cells, plasma, and Ehrlich ascites tumor cells were measured by a gas-liquid chromatography using a column with a terephtalic acid support coated with polyethylene glycol-6000. The lactic acid contents were directly determined in aqueous samples, because they were converted to a...

journal_title：Life sciences

authors： Kageyama K,Onoyama Y,Nakajima T,Tumura M,Nishida T,Kogawa H,Tanabe K

更新日期：1992-01-01 00:00:00

abstract：:Endogenous opioid peptides have been implicated in the pathophysiology of shock (1-5). In anaesthetised mongrel dogs, administration of E coli endotoxin caused a rise in plasma met-enkephalin-like immunoreactivity (MLI). Biochemical characterisation of MLI by gel filtration chromatography revealed various molecular fo...

journal_title：Life sciences

authors： Evans SF,Medbak S,Hinds CJ,Tomlin SJ,Varley JG,Rees LH

更新日期：1984-04-09 00:00:00

abstract：:Although exposure to broad band (0.2-20 MHz) electromagnetic fields (EMF) is part of the treatment of several diseases, little is known as to their effects on myocardial protein expression and resistance to ischemia-reperfusion (I/R). We exposed Sprague-Dawley rats to either high (H, 10 min/day at 200 V/m, 36.1 microT...

journal_title：Life sciences

authors： Ronchi R,Marano L,Braidotti P,Bianciardi P,Calamia M,Fiorentini C,Samaja M

更新日期：2004-09-03 00:00:00

abstract：:A time course study on the effects of an interferon inducing agent, polyriboinosinic polyribocytidylic acid (poly rIrC) on the hepatic cytochrome P-450 dependent progesterone metabolism was performed. Administration of a single dose of poly rIrC (10 mg/kg i.p.) to adult male Wistar rats caused a time dependent effect ...

journal_title：Life sciences

authors： Wong JY,Lee EJ,Moochhala SM

更新日期：1993-01-01 00:00:00

abstract：AIMS:Brain injuries based on their causes are divided into two categories, TBI and NTBI. TBI is caused by damages such as head injury, but non-physical injury causes NTBI. Prolactin is one of the blood factors that increase during brain injury. It has been assumed to play a regenerative role in post-injury recovery. M...

journal_title：Life sciences

authors： Yousefvand S,Hadjzadeh MA,Vafaee F,Dolatshad H

更新日期：2020-12-15 00:00:00

abstract：:Previous studies demonstrated a direct action of interleukin-1 (IL-1) on release of hormones from rat anterior pituitary cells in monolayer culture. To rule out any possibility of a paracrine effect from the elevated hormones in the static monolayer system, and to examine further the dynamics of hormone release elicit...

journal_title：Life sciences

authors： Beach JE,Smallridge RC,Kinzer CA,Bernton EW,Holaday JW,Fein HG

更新日期：1989-01-01 00:00:00

abstract：:Adult female Sprague-Dawley rats were prepared with permanent cortical EEG and temporalis EMG electrodes and i.v. cannulae. They were made tolerant to and physically dependent on morphine by automatic, hourly injections. These physically dependent rats were then trained to lever press for 10 mg/kg injections of morphi...

journal_title：Life sciences

authors： Khazan N,Young GA,Calligaro D

更新日期：1983-01-01 00:00:00

abstract：:Vascular smooth muscle cell (VSMC) accumulation and endothelial cell dysfunction are associated with pathogenesis of atherosclerosis. Long noncoding RNA taurine up-regulated gene 1 (TUG1) has been reported to play an important role in cardiovascular diseases, including atherosclerosis. However, the regulatory mechanis...

journal_title：Life sciences

authors： Wu X,Zheng X,Cheng J,Zhang K,Ma C

更新日期：2020-02-15 00:00:00

abstract：:It has been shown that the main psychoactive component of marihuana, delta9-tetrahydrocannabinol (THC) has mainly inhibitory effects on the regulation of reproduction. Recently, the purification and availability of the endogenous ligand of the cannabinoid receptor, arachidonyl ethanolamide, anandamide, (ANA) and its s...

journal_title：Life sciences

authors： Wenger T,Tóth BE,Juanéda C,Leonardelli J,Tramu G

更新日期：1999-01-01 00:00:00

abstract：UNLABELLED:Based on preclinical findings, cellular therapy has become a promising therapeutic approach for neonatal hypoxia-ischemia (HI). However, before translation into the clinical setting, new and effective routes of cell delivery must be determined. Intra-arterial (IA) delivery is an attractive route of cellular ...

journal_title：Life sciences

authors： Greggio S,de Paula S,Azevedo PN,Venturin GT,Dacosta JC

更新日期：2014-02-06 00:00:00

abstract：:The object of this study was to develop an assay for platelet activating factor (PAF) in rat plasma, and to utilise this to determine the effects of dietary fish oil on PAF in normotensive and spontaneously hypertensive rats. Measurement of platelet activating factor in blood plasma has proved difficult because of its...

journal_title：Life sciences

authors： Croft KD,Sturm MJ,Codde JP,Vandongen R,Beilin LJ

更新日期：1986-05-19 00:00:00

abstract：AIM:The present study aimed to understand the relationship between pharmacological activation of mGlu4 receptors and regulation of its gene in the hippocampus. MAIN METHODS:The expression level of the GRM4 gene, encoding mGluR4 receptors, was studied in the hippocampus and frontal cortex of rats after pharmacological ...

journal_title：Life sciences

authors： Pershina EV,Arkhipov VI

更新日期：2016-05-15 00:00:00

abstract：:To evaluate the relative contributions of the ovarian inhibin and estradiol-17 beta (E) on the regulation of FSH secretion, inhibin and E in ovarian venous plasma (OVP) and FSH and LH in peripheral plasma were simultaneously measured using superovulating rats with special reference to follicular maturation. By the tra...

journal_title：Life sciences

authors： Tsukamoto I,Taya K,Watanabe G,Sasamoto S

更新日期：1986-07-14 00:00:00

abstract：:Reportedly, excitatory amino acids are involved in the control of gonadotropin secretion of rats and non-human primates. The aim of this study was to investigate the effect of chronic blockade of NMDA (N-methyl-D-aspartic acid) receptors by the non competitive receptor antagonist MK-801 on gonadotropin secretion and t...

journal_title：Life sciences

authors： Veneroni O,Cocilovo L,Müller EE,Cocchi D

更新日期：1990-01-01 00:00:00

abstract：:The present study was performed to determine if the attenuated pressor response to vasopressin in conscious non-estrous female rats is due in part to an enhanced V2-like receptor vasodilator action. In male rats, infusion of vasopressin at a rate of 1 ng.min(-1).kg body weight-1 (wt) resulted in an increase in mean ar...

journal_title：Life sciences

authors： Wang YX,Crofton JT,Liu H,Sato K,Share L

更新日期：1996-01-01 00:00:00

abstract：:In order to determine the effect of relaxin and estradiol on collagen and noncollagen synthesis by mammary gland fibroblasts, fibroblasts isolated from guinea pig mammary glands were grown on plastic or Cytodex-3 collagen coated microcarriers. On plastic, estradiol (600 pg/ml) increased the incorporation of tritiated ...

journal_title：Life sciences

authors： Sheffield LG,Anderson RR

更新日期：1984-11-26 00:00:00