Abstract：
:To evaluate the relative contributions of the ovarian inhibin and estradiol-17 beta (E) on the regulation of FSH secretion, inhibin and E in ovarian venous plasma (OVP) and FSH and LH in peripheral plasma were simultaneously measured using superovulating rats with special reference to follicular maturation. By the transplantation of a pituitary gland from adult male rats under the kidney capsule between 1100 and 1200 hr on diestrus-1 in cyclic rats, superovulation was successfully induced on the morning of the next estrus without any additional treatment with human chorionic gonadotropin (hCG). The number of maturing follicles capable of ovulating in response to hCG significantly increased at 12 hours after the grafting as compared with sham-operated controls and further increases occurred until the afternoon of proestrus. In the superovulating rat, first and second surges of FSH were completely blocked and an LH surge was also partially suppressed during the periovulatory period when surges of FSH and LH were normally observed in controls. Contents of FSH as well as LH in the animal's own pituitary gland were suppressed significantly after the grafting as compared with controls. A marked increase in inhibin activity in OVP of rats with a pituitary transplant occurred concomitantly with an increase in the number of follicles capable of ovulating whereas E levels in OVP did not so. Inhibin activity in OVP at each point was much higher in the pituitary grafted rats than in controls but this was not true for E levels. These results suggest that ovarian inhibin derived from the maturing follicles rather than E may be a primary factor for regulation of FSH secretion, and high levels of endogenous inhibin can suppress synthesis of LH as well as FSH in the pituitary gland of the female rat.
journal_name
Life Scijournal_title
Life sciencesauthors
Tsukamoto I,Taya K,Watanabe G,Sasamoto Sdoi
10.1016/0024-3205(86)90445-5subject
Has Abstractpub_date
1986-07-14 00:00:00pages
119-25issue
2eissn
0024-3205issn
1879-0631pii
0024-3205(86)90445-5journal_volume
39pub_type
杂志文章相关文献
LIFE SCIENCES文献大全abstract：:Previous studies with N-terminal fragments of substance P (SP) have suggested the existence of two separate SP receptor populations. SP1 receptors are found in guinea pig ilea and rat colons. SP2 receptors are found in mouse spinal cords and rat salivary glands. We have now found that substitution of Gly9 in substance...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(85)90198-5
更新日期：1985-02-25 00:00:00
abstract：:Information concerning the cellular localization of dopamine receptor subtypes in the nucleus accumbens (NAcc) was obtained using receptor autoradiographic analysis. Unilateral, stereotaxic injection of the axon-sparing neurotoxin, quinolinic acid, into the NAcc resulted in a prominent loss of dopamine D1 receptors (a...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(91)90609-f
更新日期：1991-01-01 00:00:00
abstract：:The effect of the vasopressin neuropeptide des-glycinamide (Arg8)-vasopressin (DGAVP) on reducing the acquisition of intravenous heroin self-administration in rats was analyzed. When rats reduced in body weight were allowed to self-administer heroin for 1 h per day in the presence of a fixed time, non contingent food ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(88)90565-6
更新日期：1988-01-01 00:00:00
abstract：:To determine the mechanism of anoxic vasoconstriction, precontracted rat aortic rings were exposed to 95% N2, which caused additional contraction. Reoxygenation (95% O2) resulted in initial relaxation followed by contraction. Indomethacin did not affect anoxic contraction or reoxygenation-mediated events, but NG-monom...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(91)90316-4
更新日期：1991-01-01 00:00:00
abstract：:Although the understanding of migraine pathophysiology is still incomplete, there seems to be little doubt that dilatation of cranial blood vessels, including meningeal arteries, is involved in the headache phase of migraine. Since calcitonin gene-related peptide (CGRP) has been implicated in this vasodilatation, the ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2006.01.003
更新日期：2006-06-13 00:00:00
abstract：:Abdominal aortic coarctation above the renal arteries leads to severe hypertension above the stenotic site and provides a model for simultaneous testing of the effects of increased and decreased pressure and consequently shear stress in the same animal. The effects of increased pressure, per se, on oxidative stress an...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2004.10.014
更新日期：2005-01-07 00:00:00
abstract：AIMS:Extensive evidence supports a role for voltage-gated calcium channels (VGCC) and TRPV1 receptors in pain transmission and modulation. We investigated the profile of analgesic interaction between Phα1β toxin (a VGCC blocker) and SB366791 (selective TRPV1 antagonist) in a model of acute pain induced by capsaicin. Ch...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2017.06.018
更新日期：2017-08-01 00:00:00
abstract：:Swim therapy in the form of moderate physical activity has general health benefits. Regular exercise prevents the progression of chronic diseases affecting the different bodily systems. The metabolic alterations associated with following such lifestyle remain not fully understood. The aim of the present study was to e...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2020.118516
更新日期：2020-12-01 00:00:00
abstract：BACKGROUND:Cisplatin resistance has been found to contribute to the failure of ovarian carcinoma treatment. Oridonin is a natural en-kaurane tetracyclic diterpenoid compound discovered in Rabdosia rubescene (Henmsl.) Hara. Herein, we tested whether oridonin could exert chemo-sensitization activity on cisplatin-resistan...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2019.116709
更新日期：2019-09-15 00:00:00
abstract：AIMS:The type 2 muscarinic receptor (M2R) differs from the other G-protein-coupled muscarinic receptor (type 4, or M4R) in tissue distribution and physiologic effects. We studied the impact of these receptors on sleep and arousal by using M2R and M4R knock-out (KO) mice. MAIN METHODS:M2R and M4R KO and genetically int...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2009.11.019
更新日期：2010-01-30 00:00:00
abstract：:Tramadol is a clinically-effective, centrally-acting analgesic. This drug is a racemic mixture of two enantiomers, each one displaying different mechanisms: (+)tramadol displays opioid agonist properties and inhibits serotonin reuptake while (-)tramadol inhibit preferentially noradrenaline reuptake. The action of tram...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(98)00369-5
更新日期：1998-01-01 00:00:00
abstract：:Responses of atrial mRNA, atrial peptide and plasma peptide of atrial natriuretic factor (ANF) to treatments to alter fluid volume were studied in rats using RNA dot hybridization assay and radioimmunoassay. Specific changes in the level of ANF mRNA relative to total atrial RNA were observed in atria from sodium restr...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(85)90157-2
更新日期：1985-05-13 00:00:00
abstract：:A simple and sensitive method for the determination of isoprenaline (ISO) in plasma by high performance liquid chromatography (HPLC) with electrochemical detection is presented. Blood pressure and heart rate responses to i.v. infusion of ISO (15, 38 and 76 ng/kg/min) were studied in 15 subjects. Blood samples for ISO ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(86)90044-5
更新日期：1986-08-18 00:00:00
abstract：:We examined the direct effect of magnesium ion on aldosterone production by adrenal cells using collagenase-dispersed zona-glomerulosa cells in rats. The effects of magnesium on aldosterone production stimulated by angiotensin II or ACTH were also investigated. Both magnesium sulphate (MgSO4) and magnesium chloride (M...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(89)90327-5
更新日期：1989-01-01 00:00:00
abstract：:The effects of sucrose feeding on parameters associated with (Na+,K+)-ATPase in brown adipose tissue were compared in rats treated with parenteral 6-hydroxydopamine and vehicle. Sucrose feeding significantly increased K+-p-nitrophenylphosphatase and ouabain binding in brown adipose tissue from rats treated with vehicl...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(84)90623-4
更新日期：1984-01-23 00:00:00
abstract：AIMS:Diabetes increases oxidant stress and impairs endothelium-dependent relaxation. We investigated whether the antioxidant 3',4'-dihydroxyflavonol (DiOHF) reduces the release of superoxide (O(2)(-)) and preserves endothelial function in aortae from diabetic rats. MAIN METHODS:Type-1 diabetes was induced in Sprague-D...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2009.04.012
更新日期：2009-07-03 00:00:00
abstract：:Cyclic octapeptide analogues of somatostatin (SS) like SMS 201-995 [H-(D) Phe-Cys-Phe-(D) Trp-Lys-Thr-Cys-Thr(ol)] or its Tyr3-derivative 204-090, displaced [125I-Tyr11]-SS 100% from pancreatic membranes but only 62-75% from brain membranes; the remaining sites were displaced by SS. These data indicate that some mini-...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(85)90155-9
更新日期：1985-05-13 00:00:00
abstract：:The biosynthesis of digitalis-like compounds (DLC) was determined in bovine and rat adrenal homogenates, as well as in primary rat adrenal cells, by following changes in the concentration of DLC using three independent sensitive bioassays: inhibition of [3H]-ouabain binding to red blood cells and competitive ouabain a...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(98)00186-6
更新日期：1998-01-01 00:00:00
abstract：:LncRNA small nucleolar RNA host gene 3 (Snhg3) has been involved in cell proliferation and migration in malignant cells. However, its role in regulating functions of non-malignant cells has been hardly reported. Here, we found Snhg3 expression was sharply induced in primary brain microvascular endothelial cells (BMVEC...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2019.116929
更新日期：2019-11-15 00:00:00
abstract：:The characteristics and distribution of putative thyrotropin releasing hormone (TRH) receptors were studied in rat central nervous system using the TRH analogue 3H-(3MeHis2)TRH as a radiolabeled ligand. The analogue had a dissociation constant of 2.3 +/- 0.2 nM and a receptor density of 34 +/- 2 fm/mg protein in whole...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(82)90315-0
更新日期：1982-05-24 00:00:00
abstract：AIMS:Epigenetic and genetic alterations are crucial events in the onset and progression of human cancers including colorectal cancer (CRC). This work aims to probe the relevance of lysine demethylase 5B (KDM5B) to the progression of CRC and the possible molecules involved. MATERIALS AND METHODS:KDM5B expression in CRC...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2020.118726
更新日期：2021-01-01 00:00:00
abstract：:We found that platelet-activating factor (PAF) stimulated the production of prostaglandin (PG) E2 in MC3T3-E1 cells in a time- and dose-dependent manner. 1.0 microM PAF gave a maximal stimulation of PGE2 production by MC3T3-E1 cells after a 4 hr PAF-treatment. Furthermore, the PAF-induced PGE2 production was abolished...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(91)90598-6
更新日期：1991-01-01 00:00:00
abstract：:Glutathione homeostasis was investigated in unilaterally nephrectomized and sham-operated rats. Following twelve days of compensatory renal growth, it was found that the concentrations of glutathione and glutathione disulfide in representative samples of the entire remnant right kidney from the nephrectomized rats wer...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(88)90132-4
更新日期：1988-01-01 00:00:00
abstract：:The O2 affinity of "stripped" (cofactor-free) hemoglobin (Hb) of the elasmobranch, Squalus acanthias is decreased by ATP, the main erythrocytic phosphate cofactor but increased by urea at physiological concentration. When both compounds are present, as in life, urea decreases the ATP sensitivity, indicating that previ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(83)90105-4
更新日期：1983-05-02 00:00:00
abstract：:The effect of chronic cigarette smoke exposure on the activity of rat trachea and lung ornithine decarboxylase (ODC) and s-adenosyl-methionine decarboxylase (AdoMet-DC) was determined. Male rats were exposed once daily for 10 min to mainstream (MS) or different sidestream (SS) dilutions of fresh Kentucky 2R1 cigarette...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(85)90567-3
更新日期：1985-12-09 00:00:00
abstract：AIMS:Inducible nitric oxide synthase (iNOS) pathway has been in the limelight since its discovery as a key mediator in the process of liver fibrogenesis. Therefore, the objective of the current study was to elucidate the in vivo molecular mechanism underlying the hepatic preventive relevance of eugenol (EUG) and telmis...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2018.11.031
更新日期：2019-01-01 00:00:00
abstract：:NF-kappaB that plays an important role in iNOS expression is one of the targets of various potential anti-inflammatory agents including resveratrol. Resveratrol contains a structural similarity with estrogen, and there has been speculation about resveratrol as estrogen agonist. In this study, the mechanism and structu...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(02)01971-9
更新日期：2002-09-13 00:00:00
abstract：AIM:Ischemia/reperfusion (I/R) injury is the major cause of neurological deficit following stroke. Our previous study showed neuroprotective effects of hispidulin against cerebral ischemia reperfusion injury (IRI). In this study, we further examined the involvement of pyroptosis in this neuroprotective function. MATER...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2019.116599
更新日期：2019-09-01 00:00:00
abstract：:The effects of isolation and water scheduling on mitogen induced lymphocyte proliferation were investigated. Isolated rats were animals which had been raised in group-housed conditions and then transferred to individual cages with ad lib access to water for a 1 or 2 week period. Water scheduled rats were maintained in...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(88)90472-9
更新日期：1988-01-01 00:00:00
abstract：:The effect of Bacillus Calmette-Guérin (BCG) treatment in allergic pulmonary reaction was studied in mice genetically selected accordingly to a High (H-IVA) or Low (L-IVA) antibody responsiveness. Mice were immunized with ovalbumin (OVA) or OVA plus BCG. Two days after nasal antigenic challenge, seric IgE and IgG1 ant...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2005.04.003
更新日期：2005-08-12 00:00:00
