Abstract:
:Abdominal aortic coarctation above the renal arteries leads to severe hypertension above the stenotic site and provides a model for simultaneous testing of the effects of increased and decreased pressure and consequently shear stress in the same animal. The effects of increased pressure, per se, on oxidative stress and antioxidant enzyme expression is unknown. We studied the protein expressions of antioxidant enzymes and NADPH oxidase (gp91phox subunit) in the aortic segments above and below the stenosis site in sham-operated control and aortic-banded rats at four weeks postoperatively. Compared with the control group, the banded group showed significant up-regulation of NADPH oxidase, catalase (CAT), Cu/Zn superoxide dismutase (SOD) and Mn SOD protein content in the thoracic aorta. In contrast, Mn SOD, Cu/Zn SOD and NADPH oxidase protein abundance were unchanged in the abdominal aortic segment below the stricture where blood pressure is not elevated, whereas CAT protein abundance was also elevated in the abdominal aorta. No changes were noted for glutathione peroxidase (GPX) protein content either in the thoracic or abdominal aortic segments. Coarctation-induced hypertension is associated with increased aortic CAT, Cu/Zn SOD, Mn SOD and NADPH oxidase protein expression. The up-regulation of NADPH oxidase increases reactive oxygen species (ROS) generation noted in the present study and contributes to inactivation of nitric oxide (NO) as shown previously in this model. Upregulation of antioxidant enzymes may be a compensatory response in the face of elevated pressure and oxidative stress. The normality of protein abundance in the abdominal aorta wherein blood pressure is not elevated points to the role of baromechanical factors, as opposed to circulating humoral factors that were similar in both segments, as a mechanism responsible for increased antioxidant enzyme expression.
journal_name
Life Scijournal_title
Life sciencesauthors
Sindhu RK,Roberts CK,Ehdaie A,Zhan CD,Vaziri NDdoi
10.1016/j.lfs.2004.10.014subject
Has Abstractpub_date
2005-01-07 00:00:00pages
945-53issue
8eissn
0024-3205issn
1879-0631pii
S0024-3205(04)00908-7journal_volume
76pub_type
杂志文章相关文献
LIFE SCIENCES文献大全abstract::Atherosclerosis (AS) is a chronic inflammatory disease that results from Oxidized low-density lipoprotein (Ox-LDL) induced endothelial dysfunction. Cytoplasmic polyadenylation element binding protein 1 (CPEB1) is closely related to the development of epithelial cells, but the role of CPEB1 in AS remains unknown. The R...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2019.116874
更新日期:2019-12-15 00:00:00
abstract::The effect of exosomes on receptor cells participating in intercellular communication has been extensively studied, but the effect of exosomes on donor cells remains unclear. It has been reported that exosomes secreted by renal proximal tubular epithelial cells (PTECs) under different stimuli accelerate acute and chro...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2020.118347
更新日期:2020-11-15 00:00:00
abstract::Fenfluramine, a drug that induces increased synaptic serotonin, was used to train Fawn-Hooded rats in a drug discrimination paradigm. This strain of rats is thought to possess a genetic serotonin storage abnormality. The intent of the study was to see if the Fawn-Hooded rat was similar or dissimilar to the more freque...
journal_title:Life sciences
pub_type: 杂志文章
doi:
更新日期:1997-01-01 00:00:00
abstract::The in vivo dipyridamole treatment for 16 days produced a significant decrease in chick plasma cholesterol, mainly due to the esterified form. This effect was especially patent in the VLDL + LDL fraction. Similar results were observed in triglyceride content. To our knowledge, this is the first report on this hypolipi...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(91)90574-u
更新日期:1991-01-01 00:00:00
abstract::Human UDP-glucuronosyltransferases (UGTs) 1A6 and 1A9 were expressed using Semliki Forest virus (SFV) vectors. Infection of chinese hamster lung fibroblast V79 cells with recombinant SFV-UGT viruses resulted in efficient protein expression as detected by metabolic labeling, Western blot analyses and immunofluorescence...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(00)00831-6
更新日期:2000-10-06 00:00:00
abstract:AIMS:Glioblastoma is one of the most invasive tumors of the central nervous system, and has a high degree of malignancy and poor prognosis. Harmine, an active ingredient extracted from perennial herbs, has been reported to have obvious antitumor effects on various tumors. However, the effects of harmine on glioblastoma...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2021.119112
更新日期:2021-01-26 00:00:00
abstract::Insulin resistance (IR) impairs endothelium-mediated vasodilation in cerebral arteries as well as K+ channel function in vascular smooth muscle. Peripheral arteries also show an impaired endothelium-dependent vasodilation in IR and concomitantly show an enhanced contractile response to endothelin-1 (ET-1). However, th...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2005.01.028
更新日期:2005-09-16 00:00:00
abstract::Toll-like receptors (TLRs) play important roles in the pathogenesis of atherosclerosis. On the other hand, serum high sensitivity C-reactive protein (hsCRP) is known as an independent coronary risk factor, but cardiovascular events do occur even in low hsCRP levels. We investigated whether the TLR4 expression levels o...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2006.08.027
更新日期:2006-12-03 00:00:00
abstract:AIMS:Smokers have lower plasma concentrations of high-density lipoprotein (HDL) cholesterol and apolipoprotein A-I (apo A-I) compared with nonsmokers. To determine the molecular basis of this observation, the effect of activation of the aryl hydrocarbon receptor (AhR) on apo A-I gene expression was examined. MAIN METH...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2012.06.002
更新日期:2012-07-26 00:00:00
abstract::A synthetic peptide corresponding to a sequence of 26 amino acids contained in endogenous rat atrial natriuretic factor (ANF), was infused into one renal artery of anesthetized dogs for a comprehensive in vivo evaluation of the renal and systemic effects of pure ANF. The results proved conclusively that ANF acted dire...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(85)90283-8
更新日期:1985-01-07 00:00:00
abstract:AIMS:Gastrointestinal cancers are a kind of deadly malignancy afflicting close to a million peoples worldwide. 5-Fluorouracil (5-Fu) is a main chemotherapeutic agent for cancer treatment. However, prolonged exposure of 5-Fu to cancer cells may cause chemoresistance and decrease the therapeutic potential of 5-Fu. MAIN ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2018.03.054
更新日期:2018-05-15 00:00:00
abstract::Electroshock induced seizures in the rat enhanced high affinity specific Na+ independent binding of 3H-gamma aminobutyric acid (GABA) to frozen, Triton X-100 treated cerebral synaptic membranes 30 minutes after exposures to electroshock, although no change in 3H GABA binding was observed in similarly treated preparati...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(82)90756-1
更新日期:1982-11-29 00:00:00
abstract::Acute post-ischemic cardiac failure was studied in isolated rat hearts. Xylitol, glutamine, aspartic acid and glycine were added during reperfusion, resulting in no inotropic effect. Concanavalin A had a moderate inotropic effect. When concanavalin A added with xylitol, glutamine, aspartic acid and glycine, a rapid re...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(93)90705-8
更新日期:1993-01-01 00:00:00
abstract::The concentration of epinephrine, norepinephrine, dopamine, met-enkephalin-, ACTH-, calcitonin- and somatostatin-like immunoreactivity (IR) were determined in the extracts of 9 adrenal pheochromocytomas from 7 patients. Six of these patients had Sipple's syndrome. There was a close correlation between the amounts of m...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(84)90652-0
更新日期:1984-07-23 00:00:00
abstract::Effects of sophoricoside and its analogs on proinflammatory cytokines have been investigated. Sophoricoside, genistein and orobol exhibited inhibitory effects on IL-5, IL-3, GM-CSF and IL-6 bioactivities. Genistin showed inhibitory effects on IL-5 and IL-3 bioactivities, but did not inhibit GM-CSF and IL-6 bioactiviti...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(00)00873-0
更新日期:2000-10-27 00:00:00
abstract::The effects of central administration of two serotonin receptor agonists, 8-OH-DPAT and mCPP, on tuberoinfundibular dopaminergic (TIDA) neuron activity and serum prolactin (PRL) levels in ovariectomized, estrogen-treated rats were determined. 8-OH-DPAT dose-dependently (0.1-10 microgram/rat, icv) stimulated serum PRL ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(96)00077-x
更新日期:1996-01-01 00:00:00
abstract:AIMS:Diabetic nephropathy is a growing health concern, which is reported to be associated with inflammation. Luteolin has been explored for the treatment of some diabetic complications. Although several studies have verified the effect of luteolin on diabetic nephropathy, the mechanism by which the therapeutic effects ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2019.03.073
更新日期:2019-05-15 00:00:00
abstract:AIMS:Active immunization with human vascular endothelial growth factor (hVEGF) vaccines provides a therapeutic option instead of bevacizumab therapy. However, the immunity to self-molecule is difficult to elicit due to immune tolerance. A bioactive peptide of two tandem repeats of mHSP70407-426 (M2) has exhibited poten...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2018.03.039
更新日期:2018-05-15 00:00:00
abstract::Red wine, at a final dilution of 1/50, caused release of [14C]5-hydroxytryptamine (5-HT) from preloaded platelets, an effect which was not observed with any white wines or beers tested. Since 5-HT, is probably released from body stores during migraine attacks and red wine is known to provoke migraine episodes in susce...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(91)90265-d
更新日期:1991-01-01 00:00:00
abstract::The present study was conducted to characterize the binding of neurotransmitter receptors (dopamine D(2), serotonin 5-HT(2), histamine H(1), adrenaline alpha(1) and muscarine M(l) receptors) in the rat's brain after the oral administration of haloperidol, risperidone, and olanzapine. Haloperidol at 1 and 3 mg/kg displ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2007.01.038
更新日期:2007-04-03 00:00:00
abstract::Buddlejasaponin I and saikosaponin 1 and 2, biologically active compounds from Scrophularia scorodonia and Bupleurum rigidum respectively, exert potent in vivo antiinflammatory effects on mouse ear edema induced by phorbol myristate acetate (PMA). The effects of these compounds on swelling and other inflammatory param...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(98)00376-2
更新日期:1998-01-01 00:00:00
abstract::5-hydroxytryptamine (5-HT) caused concentration-dependent relaxation of isolated rings from porcine vena cava contracted with alpha-methyl 5-HT or prostaglandin F2 alpha. Relaxation was not blocked by propranolol (1 micron), atropine (1 micron), indomethacin (3 microns), mepyramine (1 micron), cimetidine (1 micron), o...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(84)90240-6
更新日期:1984-07-30 00:00:00
abstract:AIMS:Obesity represents a global health problem. Excessive caloric intake promotes the release of inflammatory mediators by hypertrophic adipocytes and obesity-induced inflammation is now recognized as a risk factor for the development of several diseases, such as cardiovascular diseases, insulin resistance, type-II di...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2020.118618
更新日期:2021-01-01 00:00:00
abstract::The metabolism and disposition of N-hydroxy-3,4-methylenedioxyamphetamine (N-OH MDA) was studied by utilizing rat liver slices as well as by intravenous pharmacokinetic studies in rats. In the liver slice experiments, N-OH MDA (16 micrograms/ml) was incubated with rat liver slices and the disappearance of N-OH MDA and...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(94)00726-8
更新日期:1994-01-01 00:00:00
abstract:AIM:This study was undertaken to examine the effect of cyclooxygenase (COX) 2 inhibition on the development of muscular insulin resistance in high-fat-induced obese rats. MAIN METHODS:The rats were on a regular chow diet (C) or high-fat enriched diet (HFD) energy-restrictedly (HFr), or ad libitum (HFa) for 12weeks. Th...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2011.05.006
更新日期:2011-07-18 00:00:00
abstract::Peripheral blood cells express the complete non-neuronal cholinergic system. For example synthesis of acetylcholine and nicotinic as well muscarinic receptors have been demonstrated in leucocytes isolated from human peripheral blood. In the present experiments mononuclear cells and granulocytes were isolated from the ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2007.01.010
更新日期:2007-05-30 00:00:00
abstract::In the CNS, dopamine (DA) is a recognized neurotransmitter as well as a precursor for norepinephrine (NE) and epinephrine (EPI). In contrast to the CNS, DA has been assumed to be only a precursor in peripheral tissues. There is now, however, considerable evidence to support the hypothesis that it may function as a neu...
journal_title:Life sciences
pub_type: 杂志文章,评审
doi:10.1016/0024-3205(83)90827-5
更新日期:1983-04-11 00:00:00
abstract::Lipopolysaccharide (LPS) has been known to induce endotoxin shock via production of inflammatory modulators such as tumor necrosis factor alpha (TNF-alpha), or nitric oxide (NO). In this study, we have examined the effect of naringin (NG), one of the flavonoids, on LPS-induced endotoxin shock in mice and NO production...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2005.04.051
更新日期:2006-01-11 00:00:00
abstract::Nicotine is the main constituent of tobacco smoke responsible for the elevated risk of the cardiovascular disease and sudden coronary death associated with smoking, presumably by provoking cardiac arrhythmias. The cellular mechanisms may be related to the ability of nicotine to prolong action potentials and to depolar...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(99)00370-7
更新日期:1999-01-01 00:00:00
abstract::The purpose of this study was to investigate the involvement of calcium in K+ currents and its effects on amino acid accumulation and on the membrane potential regulated by tri-iodo-L-thyronine (T3) in Sertoli cells. Immature rat testes were pre-incubated for 30 min in Krebs-Ringer bicarbonate buffer and incubated for...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2003.08.005
更新日期:2004-01-23 00:00:00