Central administration of 8-OH-DPAT and mCPP stimulates prolactin secretion in ovariectomized, estrogen-treated rats: lack of an effect on tuberoinfundibular dopaminergic neuron activity.

abstract：:The aim of the present study was to assess the effects of peanut (Arachis hypogaea L.) shell extracts (PSE) on lipases and to evaluate its potential development for the treatment of obesity. The peanut shells were extracted in 95% ethanol, and the extracts were screened for inhibitory effects on pancreatic lipase (PL)...

journal_title：Life sciences

authors： Moreno DA,Ilic N,Poulev A,Raskin I

更新日期：2006-05-08 00:00:00

abstract：AIMS:The protein kinase C (PKC) family of enzymes has been implicated in cellular proliferation, differentiation, and apoptosis. However, the distribution of specific PKC isoforms with varying functions in normal and malignant human tissues remains to be determined. The objective of this study was to investigate the ex...

journal_title：Life sciences

authors： Ali S,Al-Sukhun S,El-Rayes BF,Sarkar FH,Heilbrun LK,Philip PA

更新日期：2009-05-22 00:00:00

abstract：:Previous studies showed that acute treatment with aminophylline (AMPY) significantly elevated maximum thermogenesis and improved cold tolerance in rats and man in severe cold. However, the exact mechanism by which AMPY enhances thermogenesis was unknown. Rats receiving enprofylline (ENPRO) (1.5 and 15 mg/kg, i.p.), a ...

journal_title：Life sciences

authors： Wang LC,Jourdan ML,Lee TF

更新日期：1989-01-01 00:00:00

abstract：:Nucleotides, e.g. ATP and ADP, are important signaling molecules, which elicit several biological responses. The degradation of nucleotides is catalyzed by a family of enzymes called NTPDases (nucleoside triphosphate diphosphohydrolases). The present study reports the enzymatic properties of a NTPDase (CD39, apyrase, ...

journal_title：Life sciences

authors： Rico EP,Senger MR,Fauth Mda G,Dias RD,Bogo MR,Bonan CD

更新日期：2003-09-05 00:00:00

abstract：:Unconjugated bilirubin (UCB), like trifluoperazine (TFP), dibucaine (DBC) and praziquantel (PZQ), induces erythrocyte morphological changes, lysis and lipid exfoliation. In the present study we determined whether TFP, DBC and PZQ toxicity to erythrocytes was potentiated or reverted by UCB. Human erythrocytes were eith...

journal_title：Life sciences

authors： Brito MA,Malheiros SV,Meirelles NC,Brites D

更新日期：2001-07-13 00:00:00

abstract：:The plasma membrane ATPase on the human umbilical vein endothelial cell line (ECV304) was demonstrated to be an ecto-enzyme. Hydrolysis of ATP was measured by monitoring the appearance of inorganic phosphorus. Hydrolysis of extracellular ATP was insensitive to oligomycin, vanadate, ouabain and N-ethylmaleimide, compou...

journal_title：Life sciences

authors： Meghji P,Burnstock G

更新日期：1995-01-01 00:00:00

abstract：OBJECTIVE:To explore the effect of urantide on atherosclerotic myocardial injury by antagonizing the urotensin II/urotensin II receptor (UII/UT) system and regulating the mitogen-activated protein kinase (MAPK) signalling pathway. METHODS:Atherosclerosis (AS) was established in rats by administering a high-fat diet an...

journal_title：Life sciences

authors： Zhao J,Miao G,Wang T,Li J,Xie L

更新日期：2020-12-01 00:00:00

abstract：:The ontogenetic development of [3H]-spiroperidol binding sites was measured in the optic tectum, cerebellum, forebrain base, and forebrain roof of 1-, 4-, and 16-day-old chicks. In the chick optic tectum and cerebellum both the density and the total number of [3H]-spiroperidol binding sites increased from 4- to 16-day...

journal_title：Life sciences

authors： McDougall SA,Neisewander JL,Bardo MT,Zolman JF

更新日期：1989-01-01 00:00:00

abstract：:Red wine, at a final dilution of 1/50, caused release of [14C]5-hydroxytryptamine (5-HT) from preloaded platelets, an effect which was not observed with any white wines or beers tested. Since 5-HT, is probably released from body stores during migraine attacks and red wine is known to provoke migraine episodes in susce...

journal_title：Life sciences

authors： Jarman J,Glover V,Sandler M

更新日期：1991-01-01 00:00:00

abstract：:Cognitive function of rats treated with saline (control), THA (8 mg/kg, i.p.), scopolamine (5 mg/kg, i.p.), or a combination of THA (8 mg/kg) and scopolamine (5 mg/kg) was tested in the Morris water maze. The latency to find the platform in the water maze was used to evaluate performance. THA did not significantly alt...

journal_title：Life sciences

authors： Jackson JJ,Soliman MR

更新日期：1996-01-01 00:00:00

abstract：:We examined, in young adult women, the association between current low dose oral contraceptive (OC) use and plasma levels of C-reactive protein (CRP), an acute phase reactant predictive of cardiovascular disease risk. We conducted a cross-sectional analysis of 30 healthy, non-smoking, non-obese women (18 OC users and ...

journal_title：Life sciences

authors： Dreon DM,Slavin JL,Phinney SD

更新日期：2003-07-25 00:00:00

abstract：:Advanced chronic kidney disease is associated with high rates of cardiovascular disease. Considering the crucial role of capillaries in renal function, our study aimed to evaluate microparticles related to vascular physiology examining the link between stages of chronic kidney disease with circulating endothelial (EMP...

journal_title：Life sciences

authors： Fonseca F,Ballerini AP,Izar MC,Kato J,Ferreira CE,Fonzar W,do Amaral J,Rezende P,Machado-Santelli G,França C

更新日期：2020-11-01 00:00:00

abstract：AIMS:Doxorubicin is a widely used anthracycline derivative anticancer drug. Unfortunately, the clinical use of doxorubicin has the serious drawback of cardiotoxicity. In this study, we investigated whether baicalein, a bioflavonoid, can prevent doxorubicin-induced cardiotoxicity in vivo and we delineated the possible u...

journal_title：Life sciences

authors： Sahu BD,Kumar JM,Kuncha M,Borkar RM,Srinivas R,Sistla R

更新日期：2016-01-01 00:00:00

abstract：:Neurological diseases are becoming increasingly prominent worldwide due to rapidly aging populations, which greatly contributes to increasing healthcare costs. The development of neuroprotective drugs has so far proven exceptionally difficult due to the blood-brain barrier. One novel approach to address this challenge...

journal_title：Life sciences

authors： Crowe TP,Greenlee MHW,Kanthasamy AG,Hsu WH

更新日期：2018-02-15 00:00:00

abstract：:A natural product betulinic acid (BA) has gained a huge significance in the recent years for its strong cytotoxicity. Surprisingly, in spite of being an interesting cancer protecting agent on a variety of tumor cells, the normal cells and tissues are rarely affected by BA. Betulinic acid and analogues (BAs) generally ...

journal_title：Life sciences

authors： Kumar P,Bhadauria AS,Singh AK,Saha S

更新日期：2018-09-15 00:00:00

abstract：:The number of GABAergic neurons as determined by GAD immunocytochemistry and total neurons as determined from Nissl preparations were counted and classified at the light microscopic level in the inferior colliculus (IC) of the genetically epilepsy prone rat (GEPR) and the non-epileptic Sprague-Dawley (SD) strain of ra...

journal_title：Life sciences

authors： Roberts RC,Ribak CE

更新日期：1986-09-01 00:00:00

abstract：AIMS:We tested the hypothesis that respiratory quotient (RQ) determines sympathovagal balance associated with metabolism of stored and dietary energy substrates. MAIN METHODS:Six 18-20 year-old African-American males were studied after two control pretreatments of fasting and post-treatments of metabolizing high-fat a...

journal_title：Life sciences

authors： Millis RM,Austin RE,Bond V,Faruque M,Goring KL,Hickey BM,Blakely R,Demeersman RE

更新日期：2009-07-17 00:00:00

abstract：:Several antihistamines were evaluated for their ability to interact with sigma, muscarinic and histaminic H1 binding sites in rat brain preparations. All of the antihistamines were able to interact with the sigma site, as well as the other two sites. In addition, tripelennamine was found to elicit sigma-like behaviors...

journal_title：Life sciences

authors： Gray NM,Contreras PC,Allen SE,Taylor DP

更新日期：1990-01-01 00:00:00

abstract：:We examined the effects of estrogen, 12-O-tetradecanoylphorbol 13 acetate (TPA), and lipopolysaccharide (LPS) on the gene expression of platelet-derived growth factor (PDGF) by the monocyte/macrophage cell line, THP-1. THP-1 cells were exposed to TPA for 48 or 96 hours to induce differentiation. Some were treated with...

journal_title：Life sciences

authors： Shanker G,Sorci-Thomas M,Adams MR

更新日期：1995-01-01 00:00:00

abstract：AIMS:We previously found that paeoniflorin, a major constituent of Paeonia lactiflora Pall, could induce heat shock proteins (HSPs) in cultured mammalian cells without apparent toxicity (Yan et al. 2004). We here investigated the induction of HSPs by paeoniflorin in mouse stomach and the effect of paeoniflorin on the H...

journal_title：Life sciences

authors： Asai M,Kawashima D,Katagiri K,Takeuchi R,Tohnai G,Ohtsuka K

更新日期：2011-02-14 00:00:00

abstract：:Rats were submitted to 110 dB white noise exposure for 1, and 6 hours and brain alpha 1, beta 1 and benzodiazepine receptor binding was evaluated with selective ligands. An increase in cerebral benzodiazepine receptor (CBR) concentration, without any significant change in affinity constant, occurred after the 6 h trea...

journal_title：Life sciences

authors： Breschi MC,Martini C,Scatizzi R,Cristofani R,Giannaccini G,Martinotti E,Lucacchini A

更新日期：1995-01-01 00:00:00

abstract：:Active Hexose Correlated Compound (AHCC), an extract derived from fungi of Basidiomycetes family has been shown to act as a biological response modifier in various disorders. In our present study, ferric nitrilotriacetate (Fe-NTA), which generates hydroxyl radicals in vivo, was given intraperitoneally to rats and AHCC...

journal_title：Life sciences

authors： Ye SF,Ichimura K,Wakame K,Ohe M

更新日期：2003-12-19 00:00:00

abstract：:Upregulation of vascular NAD(P)H oxidase has been considered an important source for elevated levels of reactive oxygen species that contribute to several cardiovascular disease states, including the vascular complications of diabetes mellitus. Previous studies have shown that treatment with antioxidants corrects impa...

journal_title：Life sciences

authors： Cotter MA,Cameron NE

更新日期：2003-08-22 00:00:00

abstract：:The platelet activating factor (PAF) receptor of the guinea pig peritoneal eosinophil was characterized by radioligand ([3H]WEB 2086) binding and measurement of PAF-stimulated membrane GTPase activity. Specific binding of [3H]WEB 2086 was rapid, reversible and saturable, with an equilibrium KD of 20.4 nM at 0 degrees ...

journal_title：Life sciences

authors： Dent G,Barnes PJ

更新日期：1993-01-01 00:00:00

abstract：:The biochemical changes of the elements of cholinergic neurotransmission (choline acetyltransferase, ChAT; acetylcholinesterase, AChE; butyrylcholinesterase, BuChE; and muscarinic cholinergic receptors, mAChR) as well as the electrolyte content were studied in ischemic lumbar spinal cord segments of newborn pigs. Isch...

journal_title：Life sciences

authors： Tekulics P,Rakonczay Z,Szerdahelyi P,Kása P,Gulya K

更新日期：1990-01-01 00:00:00

abstract：OBJECTIVE:The present study aimed to investigate the ability of hesperidin to suppress the migration and invasion of A549 cells, and to investigate the role of the SDF-1/CXCR-4 cascade in this suppression. METHODS:We performed a Transwell migration assay to measure the migratory capability of A549 cells treated with 0...

journal_title：Life sciences

authors： Xia R,Xu G,Huang Y,Sheng X,Xu X,Lu H

更新日期：2018-05-15 00:00:00

abstract：:This study was designed to evaluate the synergistic cytotoxicity of herb prescription, Palgin, in adriamycin-treated cancer cells. The combination of Palgin and adriamycin synergistically augmented the cytotoxicity of Chang and HL-60 cells, but not in Hep3B and Alexander cells. The cytotoxicity of two drugs was reveal...

journal_title：Life sciences

authors： Lim YS,So HS,Kim MS,Moon G,Won JH,Baek SW,Moon SR,Yang SH,Kim BJ,Ko CB,Park R

更新日期：2002-10-04 00:00:00

abstract：AIMS:Epidemiological studies report that individuals who exercise are less likely to abuse drugs. Preclinical studies report that exercise, in the form of treadmill or wheel running, reliably decreases the self-administration of psychomotor stimulants and opioids. To date, preclinical studies have only examined the eff...

journal_title：Life sciences

authors： Lacy RT,Strickland JC,Brophy MK,Witte MA,Smith MA

更新日期：2014-10-02 00:00:00

abstract：:Cultured adult skin fibroblasts were studied for binding and functional evidence of muscarinic receptors in order to assess their utility as a model of cholinergic function in affective illness. Saturable, specific, high affinity binding could be demonstrated in intact cells from some cell lines with [3H]-NMS, but not...

journal_title：Life sciences

authors： Kelsoe JR Jr,Gillin JC,Janowsky DS,Brown JH,Risch SC,Lumkin B

更新日期：1986-04-14 00:00:00

abstract：:Green tea and its major constituent epigallocatechin gallate (EGCG) have been extensively studied as a potential treatment for a variety of diseases, including cancer. Epidemiological data have suggested that EGCG may provide protective effects against hormone related cancers, namely breast or prostate cancer. Extensi...

journal_title：Life sciences

authors： Stuart EC,Scandlyn MJ,Rosengren RJ

更新日期：2006-11-17 00:00:00