Abstract:
:A natural product betulinic acid (BA) has gained a huge significance in the recent years for its strong cytotoxicity. Surprisingly, in spite of being an interesting cancer protecting agent on a variety of tumor cells, the normal cells and tissues are rarely affected by BA. Betulinic acid and analogues (BAs) generally exert through the mechanisms that provokes an event of direct cell death and bypass the resistance to normal chemotherapeutics. Although the major mechanism associated with its ability to induce direct cell death is mitochondrial apoptosis, there are several other mechanisms explored recently. Importantly, mathematical modeling of apoptosis has been an important tool to explore the precise mechanism involved in mitochondrial apoptosis. Thus, this review is an endeavor to sum up the molecular mechanisms underlying the action of BA and future directions to apply mathematical modeling technique to better understand the precise mechanism of BA-induced apoptosis. The last section of the review encompasses the plausible structural modifications and formulations to enhance the therapeutic efficacy of BA.
journal_name
Life Scijournal_title
Life sciencesauthors
Kumar P,Bhadauria AS,Singh AK,Saha Sdoi
10.1016/j.lfs.2018.07.056subject
Has Abstractpub_date
2018-09-15 00:00:00pages
24-33eissn
0024-3205issn
1879-0631pii
S0024-3205(18)30442-9journal_volume
209pub_type
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