Abstract：
:Cachexia is a complex medical condition characterized by significant weight loss associated with decreased body fat and protein; the condition may present itself with or without anorexia. We have isolated and partially characterized a proteoglycan (azaftig) from the urine of cancer and AIDS patients experiencing weight loss. When given to mice, the purified azaftig resulted in a significant decrease in body weight and body fat without any effect on appetite. The results of these studies show that azaftig may be one of the many factors participating in the emergence of the cachectic state.
journal_name
Life Scijournal_title
Life sciencesauthors
Figueroa J,Vijayagopal P,Debata C,Prasad A,Prasad Cdoi
10.1016/s0024-3205(99)00069-7subject
Has Abstractpub_date
1999-01-01 00:00:00pages
1339-47issue
15eissn
0024-3205issn
1879-0631pii
S0024320599000697journal_volume
64pub_type
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