当前位置： SCI文献检索 > LIFE SCIENCES期刊下所有文献 > Matrix metallopeptidase 9 as a host protein target of chloroquine and melatonin for immunoregulation in COVID-19: A network-based meta-analysis.

Matrix metallopeptidase 9 as a host protein target of chloroquine and melatonin for immunoregulation in COVID-19: A network-based meta-analysis.

Abstract：

AIMS:The molecular pathogenesis of COVID-19 is similar to other coronavirus (CoV) infections viz. severe acute respiratory syndrome (SARS) in human. Due to scarcity of the suitable treatment strategy, the present study was undertaken to explore host protein(s) targeted by potent repurposed drug(s) in COVID-19. MATERIALS AND METHODS:The differentially expressed genes (DEGs) were identified from microarray data repository of SARS-CoV patient blood. The repurposed drugs for COVID-19 were selected from available literature. Using DEGs and drugs, the protein-protein interaction (PPI) and chemo-protein interaction (CPI) networks were constructed and combined to develop an interactome model of PPI-CPI network. The top-ranked sub-network with its hub-bottleneck nodes were evaluated with their functional annotations. KEY FINDINGS:A total of 120 DEGs and 65 drugs were identified. The PPI-CPI network (118 nodes and 293 edges) exhibited a top-ranked sub-network (35 nodes and 174 connectivities) with 12 hub-bottleneck nodes having two drugs chloroquine and melatonin in association with 10 proteins corresponding to six upregulated and four downregulated genes. Two drugs interacted directly with the hub-bottleneck node i.e. matrix metallopeptidase 9 (MMP9), a host protein corresponding to its upregulated gene. MMP9 showed functional annotations associated with neutrophil mediated immunoinflammation. Moreover, literature survey revealed that angiotensin converting enzyme 2, a membrane receptor of SARS-CoV-2 virus, might have functional cooperativity with MMP9 and a possible interaction with both drugs. SIGNIFICANCE:The present study reveals that between chloroquine and melatonin, melatonin appears to be more promising repurposed drug against MMP9 for better immunocompromisation in COVID-19.

journal_name

Life Sci

journal_title

Life sciences

authors

Hazra S,Chaudhuri AG,Tiwary BK,Chakrabarti N

doi

10.1016/j.lfs.2020.118096

subject

Has Abstract

pub_date

2020-09-15 00:00:00

pages

118096

eissn

0024-3205

issn

1879-0631

pii

S0024-3205(20)30847-X

journal_volume

257

pub_type

杂志文章,meta分析

相关文献

LIFE SCIENCES文献大全
  • Cardiovascular effects of naloxone, naltrexone and morphine in the squirrel monkey.

    abstract：:Heart rate (HR) and mean arterial blood pressure (BP) were recorded from conscious, chair-restrained squirrel monkeys surgically prepared with chronically indwelling arterial and venous catheters to determine the effects of acute intravenous injections of two opiate antagonists and an agonist. Naloxone (0.3--10.0 mg/k...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(83)90085-1

    authors： Byrd LD

    更新日期：1983-01-24 00:00:00

  • Inflammatory cardiac fibroblast phenotype underlies chronic alcohol-induced cardiac atrophy and dysfunction.

    abstract：AIMS:The purpose of this study was to investigate mechanisms of chronic alcohol-induced cardiac remodeling and dysfunction. We also sought to determine the role of cardiac fibroblasts, which play a dynamic role in cardiac remodeling, in mediating these effects. MAIN METHODS:Adult male Wistar rats were exposed to ethan...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2020.117330

    authors： Mouton AJ,El Hajj EC,Ninh VK,Siggins RW,Gardner JD

    更新日期：2020-03-15 00:00:00

  • Polymorphisms and genetic linkage of histamine receptors.

    abstract：:Histamine is a biogenic amine that plays an essential role in controlling many physiological functions, both in the central nervous system (CNS) and the peripheral nervous system (PNS). Most of these physiological effects are mediated through interactions with four histamine receptor subtypes, all of which are members...

    journal_title：Life sciences

    pub_type： 杂志文章,评审

    doi：10.1016/j.lfs.2013.08.012

    authors： Micallef S,Stark H,Sasse A

    更新日期：2013-10-10 00:00:00

  • A novel bacteristatic action of bovine and porcine serum that is reversed by norepinephrine.

    abstract：:A previously unreported anti-bacterial activity against Escherichia coli has been found in porcine and bovine sera, but not in human or chicken sera. The activity is not affected by heat inactivation of the complement system, and is bacteriostatic rather than bactericidal. Growth inhibition is reversible by addition o...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(95)00277-d

    authors： Lenard J,VanDeroef R

    更新日期：1995-01-01 00:00:00

  • AIM2 gene silencing attenuates diabetic cardiomyopathy in type 2 diabetic rat model.

    abstract：AIMS:Absent in melanoma 2 (AIM2) is a cytosolic DNA sensor which plays an important role in inflammasome formation and is involved in various cellular functions including pyroptosis, fibrosis, and tissue injury. Our study aimed to investigate whether AIM2 plays a role in diabetic cardiomyopathy (DCM) and to explore its...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2019.02.035

    authors： Wang X,Pan J,Liu H,Zhang M,Liu D,Lu L,Tian J,Liu M,Jin T,An F

    更新日期：2019-03-15 00:00:00

  • TNF-α and cancer cachexia: Molecular insights and clinical implications.

    abstract：:Cancer cachexia characterized by a chronic wasting syndrome, involves skeletal muscle loss and adipose tissue loss and resistance to conventional nutritional support. Cachexia is responsible for the reduction in quality and length of life of cancer patients. It also decreases the muscle strength of the patients. The p...

    journal_title：Life sciences

    pub_type： 杂志文章,评审

    doi：10.1016/j.lfs.2016.11.033

    authors： Patel HJ,Patel BM

    更新日期：2017-02-01 00:00:00

  • Tetrandrine, a calcium antagonist of Chinese herbal origin, interacts with vascular muscle alpha 1-adrenoceptor.

    abstract：:The effects of tetrandrine (TET) on the contractile responses of rat aortic rings and perfused rat mesenteric arteries to phenylephrine (PE) were investigated. TET inhibited the maximal contraction to PE in a concentration-dependent manner. TET significantly inhibited the transient contraction in Ca(2+)-free medium pr...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/s0024-3205(96)00552-8

    authors： Kwan CY,Chen YY,Ma MF,Daniel EE,Hui SC

    更新日期：1996-01-01 00:00:00

  • Dexamethasone programs lower fatty acid absorption and reduced PPAR-γ and fat/CD36 expression in the jejunum of the adult rat offspring.

    abstract：:The progeny of rats born and breastfed by mothers receiving dexamethasone (DEX) during pregnancy exhibits permanent reduction in body weight and adiposity but the precise mechanisms related to this programming are not fully understood. In order to clarify this issue, the present study investigated key aspects of lipop...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2020.118765

    authors： de Souza DN,Teixeira CJ,Veronesi VB,Murata GM,Santos-Silva JC,Hecht FB,Vicente JM,Bordin S,Anhê GF

    更新日期：2021-01-15 00:00:00

  • Genetic selection for ethanol withdrawal severity: differences in replicate mouse lines.

    abstract：:We report an ongoing within-family selective breeding project for the severity of handling-induced withdrawal seizures in mice made physically dependent on ethanol by inhalation. Two Withdrawal Seizure Prone (WSP) and two Withdrawal Seizure Resistant (WSR) lines have been subjected to five generations of selection, an...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(83)90751-8

    authors： Crabbe JC,Kosobud A,Young ER

    更新日期：1983-09-05 00:00:00

  • Induction of nitric oxide synthase expression by Withania somnifera in macrophages.

    abstract：:Withania somnifera (ashwagandha, Indian ginseng) is an immunostimulant herbal medicine used to improve overall health and prevent diseases, particularly in the elderly. However, the mechanisms underlying its immunostimulant effect is poorly understood. To elucidate the mechanism of Withania somnifera, we investigated ...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/s0024-3205(02)02472-4

    authors： Iuvone T,Esposito G,Capasso F,Izzo AA

    更新日期：2003-02-21 00:00:00

  • Tumor control by hypoxia-specific chemotargeting of iron-oxide nanoparticle - Berberine complexes in a mouse model.

    abstract：AIM:To evaluate the therapeutic efficacy of hypoxic cell-sensitizer Sanazole (SAN) -directed targeting of cytotoxic drug Berberine (BBN) and Iron-oxide nanoparticle (NP) complexes, to solid tumor in Swiss albino mice. MAIN METHODS:NP-BBN-SAN complexes were characterized by FTIR, XRD, TEM and Nano-size analyzer. This c...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2017.12.036

    authors： Sreeja S,Krishnan Nair CK

    更新日期：2018-02-15 00:00:00

  • Antioxidant, a pro-oxidant and cytotoxic effects of Achyrocline satureioides extracts.

    abstract：:In this study we compared the antioxidant properties of five different extracts of different composition obtained from Achyrocline satureioides' inflorescences (Compositae), a widely used Brazilian folk medicinal herb. All of the extracts presented significant antioxidant potential identified by TRAP assay, which incr...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2003.09.073

    authors： Polydoro M,de Souza KC,Andrades ME,Da Silva EG,Bonatto F,Heydrich J,Dal-Pizzol F,Schapoval EE,Bassani VL,Moreira JC

    更新日期：2004-04-23 00:00:00

  • Morphine tolerance in arthritic rats and serotonergic system.

    abstract：:To understand whether chronic inflammation alters the development of morphine tolerance, the tail-flick test was used to evaluate the analgesic effect of morphine (75 mg tablet, s.c.) in the arthritic rats at the day 9-12 after the inoculation with Freund's adjuvant. Spinal cord monoamines and amino acid neurotransmit...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/s0024-3205(99)00008-9

    authors： Li JY,Wong CH,Huang KS,Liang KW,Lin MY,Tan PP,Chen JC

    更新日期：1999-01-01 00:00:00

  • Evidence for the presence of a new plasma factor which acts synergistically to ADP induced platelet aggregation.

    abstract：:The existence of a new factor (AF) in mice acting synergistically with known proaggregatory stimuli has been suggested by the present study in the plasma of mice challenged with intravenous collagen and adrenaline. Indomethacin, nordihydroguaretic acid (NDGA), BW 755C, phentolamine, cimetidine and ketanserin could not...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(90)90224-f

    authors： Dikshit M,Srimal RC

    更新日期：1990-01-01 00:00:00

  • Oleic acid protects against cadmium induced cardiac and hepatic tissue injury in male Wistar rats: A mechanistic study.

    abstract：AIMS:The aim of the present study was to evaluate the possible antioxidant role of oleic acid (OA) against Cd-induced injuries in the heart and liver tissues of male Wistar rats. MAIN METHODS:Rats were treated with either vehicle (control), or OA (10 mg/kg b.w., fed orally), or Cd (0.44 mg/kg b.w., s.c.), or both (OA ...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2020.117324

    authors： Bhattacharjee B,Pal PK,Chattopadhyay A,Bandyopadhyay D

    更新日期：2020-03-01 00:00:00

  • High-fat diet affects gut nutrients transporters in hypo and hyperthyroid mice by PPAR-a independent mechanism.

    abstract：AIMS:High fat diet consumes and thyroid hormones (THs) disorders may affect nutrients metabolism, but their impact on the absorptive epithelium, the first place of nutrients access, remains unknown. Our aim was to evaluate the intestinal morphology and nutrients transporters content in mice fed standard (LFD) or high f...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2018.03.053

    authors： Losacco MC,de Almeida CFT,Hijo AHT,Bargi-Souza P,Gama P,Nunes MT,Goulart-Silva F

    更新日期：2018-06-01 00:00:00

  • A role for calcium/calmodulin kinase in insulin stimulated glucose transport.

    abstract：:Previous research has shown that the CAMK (calcium/calmodulin dependent protein kinase) inhibitor, KN62, can lead to reductions in insulin stimulated glucose transport. Although controversial, an L-type calcium channel mechanism has also been hypothesized to be involved in insulin stimulated glucose transport. The pur...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2003.06.041

    authors： Wright DC,Fick CA,Olesen JB,Lim K,Barnes BR,Craig BW

    更新日期：2004-01-02 00:00:00

  • Development of a radioiodinated ligand for characterising alpha 1-adrenoceptors.

    abstract：:Two alpha-adrenoceptor antagonists, phentolamine and 2-(beta-(4-hydroxyphenyl)-ethylaminomethyl)-tetralone (BE 2254) which are phenolic derivatives were radioiodinated after chloramine-T oxidation of Na125I and the labelled material isolated by chromatography. 125I-phentolamine does not bind selectively to alpha-adren...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(82)90623-3

    authors： Adams A,Jarrott B

    更新日期：1982-03-15 00:00:00

  • Transcriptional up-regulation of nNOS in the dorsal vagal complex during low endotoxemia.

    abstract：:The present study analyses the expression and distribution of neuronal nitric oxide synthase (nNOS) in the brainstem of animals pre-treated with Escherichia coli or Helicobacter pylori LPS, at doses that modulate gastric motor function. Systemic administration of H. pylori LPS prevented in a dose-dependent manner (5, ...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2005.03.007

    authors： Quintana E,Hernández C,Moran AP,Esplugues JV,Barrachina MD

    更新日期：2005-07-15 00:00:00

  • A comparative study of the affinities of some tricyclic antidepressants for the muscarinic cholinergic receptor in human and guinea-pig bladder, ileum and brain in relation to differential drug potency.

    abstract：:Following a report that nortriptyline was found useful in the control of enuresis in adults, presumably as an anticholinergic, its likely mechanism of action and apparent bladder specificity have now been investigated in vitro. The ratios of anticholinergic potencies (reciprocal of dissociation contents, Ki) for four ...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(87)90093-2

    authors： Rehavi M,Weiss H,Nissenkorn I,Rubinstein R,Cohen S

    更新日期：1987-05-04 00:00:00

  • Impairment of testicular function in electronic cigarette (e-cig, e-cigs) exposed rats under low-voltage and nicotine-free conditions.

    abstract：:Despite the lack of knowledge of the effects of electronic cigarettes (e-cigarettes, e-cigs) on public health, they have been proposed as a part of smoking cessation efforts. Recently, several basic scientific studies have pointed out how e-cigs can generate carcinogens, such as e-cig liquid thermal degradation by-pro...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2019.04.059

    authors： Vivarelli F,Canistro D,Cirillo S,Cardenia V,Rodriguez-Estrada MT,Paolini M

    更新日期：2019-07-01 00:00:00

  • Functional analysis of muscarinic acetylcholine receptors using knockout mice.

    abstract：:Because of the low selectivity of available ligands, pharmacological approaches to elucidate the functional difference among muscarinic acetylcholine receptor (mAChR) subtypes have been problematic. As an alternative approach, we have established a series of mutant mouse lines deficient in each mAChR subtype (mAChR KO...

    journal_title：Life sciences

    pub_type： 杂志文章,评审

    doi：10.1016/j.lfs.2004.05.034

    authors： Matsui M,Yamada S,Oki T,Manabe T,Taketo MM,Ehlert FJ

    更新日期：2004-11-05 00:00:00

  • Physiological stress response to video-game playing: the contribution of built-in music.

    abstract：:Recent studies on video game playing have uncovered a wide range of measurable physiological effects on the organism, such as increases in cardiovascular activity and breathing responses. However, the exact source of these effects remains unclear. Given the well-known effects of sound on physiological activity, especi...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2004.11.011

    authors： Hébert S,Béland R,Dionne-Fournelle O,Crête M,Lupien SJ

    更新日期：2005-04-01 00:00:00

  • Effects of bicyclol on dimethylnitrosamine-induced liver fibrosis in mice and its mechanism of action.

    abstract：:The aim was to investigate the suppressive effect of bicyclol on hepatic fibrosis induced by dimethylnitrosamine (DMN) in mice and the mechanism of its action. Hepatic fibrosis was established by intraperitoneal injection of 8 mg kg(-1) day(-1) on three consecutive days of each week for 4 or 5 weeks. In the prophylact...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2006.02.025

    authors： Hu QW,Liu GT

    更新日期：2006-07-04 00:00:00

  • Evidence for a model of activation of central sigma systems.

    abstract：:Evidence for a drug-induced activation of central sigma systems is presented. The model is the locomotor activation initiated by a subcutaneous (SC) challenge of 1.6 mg/kg of (+)-butaclamol, (+)-BUT, given 30 min before 10 mg/kg SC of (-)-N-allylnormetazocine, (-)-NAN, in Sprague-Dawley male rats which have been pretr...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(89)90448-7

    authors： Iwamoto ET

    更新日期：1989-01-01 00:00:00

  • Enhanced function of inhibitory presynaptic cannabinoid CB1 receptors on sympathetic nerves of DOCA-salt hypertensive rats.

    abstract：AIMS:This study was performed to examine whether hypertension affects the sympathetic transmission to resistance vessels of pithed rats via inhibitory presynaptic cannabinoid CB1 receptors and whether endocannabinoids are involved in this response. MATERIALS AND METHODS:We compared uninephrectomised rats rendered hype...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2015.03.022

    authors： Toczek M,Schlicker E,Grzęda E,Malinowska B

    更新日期：2015-10-01 00:00:00

  • Time-course of the murine lymphoid tissue involution during and following stressor exposure.

    abstract：:Groups of 35-day-old male C57BL/6 mice were stressed 1 hour per day by immobilization for 1, 2, 3, 5, 8, 11 or 14 consecutive days. Control groups were left undisturbed. The animals were then killed and body weight and the weights of the thymus, spleen and axillary lymph nodes determined. Chronic immobilization stress...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/s0024-3205(97)00606-1

    authors： Domínguez-Gerpe L,Rey-Méndez M

    更新日期：1997-01-01 00:00:00

  • Regulation of fatty acid synthesis and Delta9-desaturation in senescence of human fibroblasts.

    abstract：AIMS:Normal human cells in culture progressively lose their capacity for replication, ending in an irreversible arrested state known as replicative senescence. Senescence has been functionally associated to the process of organismal ageing and is also considered a major tumor-suppressing mechanism. Although a great dea...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2008.11.009

    authors： Maeda M,Scaglia N,Igal RA

    更新日期：2009-01-16 00:00:00

  • Zonisamide: Antihyperalgesic efficacy, the role of serotonergic receptors on efficacy in a rat model for painful diabetic neuropathy.

    abstract：AIMS:The purpose of this study was to compare the changes of antihyperalgesic effectiveness of zonisamide (25 and 50 mg/kg), an antiepileptic drug, on the early and late phases of neuropathy and to investigate the role of serotonergic descending inhibitory pain pathways in antihyperalgesic effectiveness of zonisamide i...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2013.12.012

    authors： Bektas N,Arslan R,Ozturk Y

    更新日期：2014-01-24 00:00:00

  • Lifelong treadmill training improves muscle function detected by a modified grip strength test during aging in BALB/c mice.

    abstract：AIMS:The objective of this study was to establish a more accurate analytical model and method for grip strength test of mice and to investigate the beneficial effects of lifelong exercise training to prevent functional decline of muscle during aging. MAIN METHODS:Fifty randomly selected adult male BALB/c mice (24-56 w...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2020.117603

    authors： Zhao Y,Shen F,Gong M,Jin L,Ren X,Liu K,Lu J

    更新日期：2020-06-15 00:00:00