Preconditioning modulates pulmonary endothelial dysfunction following ischemia-reperfusion injury in the rat lung: role of potassium channels.

abstract：:Effects of scratching behavior on dermatitis, transepidermal water loss (TEWL) and serum IgE concentrations were examined in NC/Nga (NC) mice with toenails (WIT) and without toenails (WOT). The first study was a preventive treatment done to cut off hind toenails before dermatitis induction and the second study was a t...

journal_title：Life sciences

authors： Hashimoto Y,Arai I,Nakanishi Y,Sakurai T,Nakamura A,Nakaike S

更新日期：2004-12-31 00:00:00

abstract：:While attempting to delineate the reason for the reported extreme variability of beta-endorphin-like immunoreactivity (beta-ir) in human plasma (eg., nondetectable to 1 ng/ml) by standard radioimmunoassay, we noted that a substantial portion of circulating beta-ir was associated with erythrocytes. That erythrocyte ass...

journal_title：Life sciences

authors： Fisher A,Comly M,Do R,Tamarkin L,Ghazanfari AF,Mukherjee AB

更新日期：1984-05-07 00:00:00

abstract：:The effects of t-butylhydroperoxide (TBH) and cigarette smoke on lung mechanics (CDYN and RL) and glutathione status (GSH) were studied using an isolated perfused and ventilated rat lung preparation. TBH (200, 400, 1000 microM) infused via the pulmonary circulation caused a dose-related bronchoconstriction. The lung G...

journal_title：Life sciences

authors： Ryrfeldt A,Kröll F,Berggren M,Moldéus P

更新日期：1988-01-01 00:00:00

abstract：:In saturation binding experiments, (+)pentazocine, (+)3-(3-hydroxyphenyl)-N-propylpiperidine (3-PPP), haloperidol and rimcazole did not inhibit the binding of [3H]DTG in a purely competitive fashion. Although Scatchard analysis indicated that [3H]DTG bound to a single site, the inhibition curves of some, but not all, ...

journal_title：Life sciences

authors： DeHaven-Hudkins DL,Fleissner LC

更新日期：1992-01-01 00:00:00

abstract：:The antiarrhythmic and cardioprotective drug stobadine, possessing antioxidant and neuroprotective properties, was studied as to its in vitro effect on aggregation of human blood platelets. Pretreatment of platelets with stobadine for 30 s inhibited stimulated platelet aggregation in a dose-dependent way. Depending on...

journal_title：Life sciences

authors： Jancinová V,Nosál R,Danihelová E

更新日期：1999-01-01 00:00:00

abstract：:The temporal relationship of changes in cAMP and cGMP to oocyte maturation was examined in proestrous hamsters (day 4). The first series of experiments showed, in normal cycling hamsters, an increase in cAMP and a decrease in cGMP at 1400 h shortly after the rise in LH with oocyte maturation beginning at 1800 h. When ...

journal_title：Life sciences

authors： Hubbard CJ

更新日期：1983-10-24 00:00:00

abstract：:This report documents studies on the spontaneous reactivation of human erythrocyte acetylcholinesterase and human serum butyrylcholinesterase following inhibition by organophosphinate esters. The spontaneous reactivation reactions were carried out at 26.0 degrees C in 0.10 M phosphate buffer of pH 7.6. Based upon resu...

journal_title：Life sciences

authors： Lawson MA,Lieske CN,Fox-Talbot MK,Meyer HG

更新日期：1985-05-06 00:00:00

abstract：AIMS:The aim of this study is to investigate the expression and cytoprotective function of a 72-kDa heat shock protein (HSP72) using a reflux esophagitis model in rats. MAIN METHODS:Expression of HSP60, HSP72, and HSP90 in rat esophageal mucosa was evaluated by Western blot analysis before and after hyperthermia (42.5...

journal_title：Life sciences

authors： Izumi Y,Otaka M,Takahashi T,Takada M,Shimada Y,Asaoka D,Nagahara A,Itoh H,Watanabe S

更新日期：2009-04-10 00:00:00

abstract：:This study examines the influence of ovariectomy and administration of a pharmacologic dose of estradiol on amylase release from isolated-dispersed rat pancreatic acini and cholecystokinin receptors on rat acinar cell membranes. Rats were sham ovariectomized (intact) or ovariectomized (Ovx) and 21 day timed release pe...

journal_title：Life sciences

authors： Blevins GT Jr,Huang HS,Tangoku A,Mckay DW,Rayford PL

更新日期：1991-01-01 00:00:00

abstract：AIMS:Ganoderma lucidum, a traditional Chinese medicine, is well known as a modulator of functions of the immune system as well as an anti-tumour agent. However, its active compounds and their molecular mechanisms of action are not well established. GLIS, a proteoglycan isolated from the fruiting body of G. lucidum, sti...

journal_title：Life sciences

authors： Zhang J,Tang Q,Zhou C,Jia W,Da Silva L,Nguyen LD,Reutter W,Fan H

更新日期：2010-11-20 00:00:00

abstract：:Epinephrine (E) infusions raise blood pressure and there is an excess incidence of hypertension among males and blacks. However, reports of E levels by ethnicity, gender, and blood pressure status are inconsistent. Insensitive assays, variability in plasma E levels within individuals, and the small size of most studie...

journal_title：Life sciences

authors： González-Trápaga JL,Nelesen RA,Dimsdale JE,Mills PJ,Kennedy B,Parmer RJ,Ziegler MG

更新日期：2000-05-05 00:00:00

abstract：:The effects of eight catechin derivatives on vascular tone in rat thoracic aorta were examined. Catechin derivatives (10 microM) potentiated the contractile response to phenylephrine in endothelium-intact arteries. The potentiations produced by EGCg and EGC were almost absent in endothelium-denuded arteries and abolis...

journal_title：Life sciences

authors： Sanae F,Miyaichi Y,Kizu H,Hayashi H

更新日期：2002-10-11 00:00:00

abstract：AIMS:Tetramethylpyrazine (TMP), one of the active ingredients isolated from a Chinese herbal prescription, possesses protective effects against oxidative stress caused by high glucose in endothelial cells. In this study, the role of TMP in preventing muscle cells from palmitate-induced oxidative damage was investigated...

journal_title：Life sciences

authors： Gao X,Zhao XL,Zhu YH,Li XM,Xu Q,Lin HD,Wang MW

更新日期：2011-04-25 00:00:00

abstract：:Evidence is provided for the abilities of endogenous 6-(Arg or Lys)-opioid peptides to interact with kappa-receptors as agonists. Dynorphin-(1-17) and -(1-8), alpha- and beta-neo-endorphin, [Met5]-enkephalin-Arg6-Phe7 and des acetyl salmon endorphin I significantly inhibited the electrically-evoked contractions of rab...

journal_title：Life sciences

authors： Oka T,Negishi K

更新日期：1982-10-18 00:00:00

abstract：:The cardiovascular and respiratory effects of alfentanil in conscious freely moving rats, were evaluated after initial and subsequent injections. Doses of alfentanil (50, 130, 260, and 500 ug/kg) were given to naive rats (n = 4-5) and 1 hour later this dose was repeated. The resultant cardiovascular and respiratory ef...

journal_title：Life sciences

authors： Doorley BM,Knight VV,Spaulding TC

更新日期：1988-01-01 00:00:00

abstract：AIMS:Centella asiatica has been used to treat kidney diseases in Chinese traditional medicine. Asiaticoside (an extraction of C. asiatica) exerts a variety of pharmacological effects including immunomodulatory and anti-inflammatory functions. However, the mechanism of asiaticoside in the treatment of renal diseases rem...

journal_title：Life sciences

authors： Wang Z,Liu J,Sun W

更新日期：2013-09-03 00:00:00

abstract：:Chlorin e(6) and its derivatives are promising sensitizers for photodynamic therapy (PDT). In order to compare the photodynamic effects of 8 novel derivatives of chlorin e(6) and to explore some mechanisms of their effects at the cellular level, we studied PDT-induced changes in bioelectric activity of crayfish mechan...

journal_title：Life sciences

authors： Uzdensky AB,Dergacheva OY,Zhavoronkova AA,Reshetnikov AV,Ponomarev GV

更新日期：2004-03-12 00:00:00

abstract：:This paper describes the use of complex liposomes as real membrane models to evaluate the potential benefits of several antioxidants in relation to lipid peroxidation. The xanthine oxidase/Fe(3+)-ADP-EDTA and the Fe(2+)/H2O2 systems have been used to generate hydroxyl radicals and the water soluble azo-compound 2,2'-a...

journal_title：Life sciences

authors： Gutiérrez ME,García AF,Africa de Madariaga M,Sagrista ML,Casadó FJ,Mora M

更新日期：2003-04-11 00:00:00

abstract：:Tobacco smoke (TS) is a potent source of oxidants and oxidative stress is an important mechanism by which TS exerts its toxicity in the lung. We have shown that TS induces heat shock (HS)/stress protein (HSP) synthesis in human monocytes. Pulmonary surfactant (PS) whose major physiological function is to confer mechan...

journal_title：Life sciences

authors： Pinot F,Bachelet M,François D,Polla BS,Walti H

更新日期：1999-01-01 00:00:00

abstract：:In order to investigate the action of ethanol on the anterior pituitary gland, the effect of ethanol on prolactin secretion in vitro was studied. Ethanol significantly increased the in vitro incorporation of 3H-leucine into both prolactin contained within the pituitary gland and that released into the medium. The enha...

journal_title：Life sciences

authors： Seilicovich A,Duvilanski BH,Debeljuk L,Díaz MC,Muñoz Maines V,Rettori V

更新日期：1984-11-05 00:00:00

abstract：:Thirty-seven women, aged 31-78 years, on two separate mornings consumed a decaffeinated beverage to which 6 mg caffeine/kg lean body mass or no caffeine were added. Total urine output of water, calcium, magnesium, sodium, chloride, potassium and creatinine increased in the two hours following caffeine ingestion when c...

journal_title：Life sciences

authors： Bergman EA,Massey LK,Wise KJ,Sherrard DJ

更新日期：1990-01-01 00:00:00

abstract：:alpha-Difluoromethylornithine (DFMO) directly infused into a brain-lateral ventricle (12.5, 25 and 50 micrograms/rat) dose- and time-dependently inhibited brain ODC activity. While having no influence per se on pain threshold, DFMO significantly inhibited the analgesic activity of morphine (15 mg/kg i.p.), this effect...

journal_title：Life sciences

authors： Genedani S,Bernardi M,Tagliavini S,Bertolini A

更新日期：1989-01-01 00:00:00

abstract：:Plasma 7B2-immunoreactivity (7B2-IR) concentrations in umbilical artery (UA), umbilical vein (UV) and maternal vein (MV) were measured by RIA at the time of obstetrical delivery at term. Plasma 7B2-IR concentrations (Mean +/- SEM) in UA (N = 12), UV (N = 16) and MV (N = 16) were 725 +/- 69, 699 +/- 64 and 116 +/- 4.5 ...

journal_title：Life sciences

authors： Iguchi H,Natori S,Nawata H,Kato K,Ibayashi H,Chan JS,Seidah NG,Chretien M

更新日期：1987-10-19 00:00:00

abstract：:A number of experimental studies report that biological systems can be affected by in vivo exposure to low frequency and extremely low frequency electromagnetic fields. However, attempts to independently replicate some of these studies have shown the reported effects to be elusive. The difficulty in replicating result...

journal_title：Life sciences

authors： Ubeda A,Díaz-Enriquez M,Martínez-Pascual MA,Parreño A

更新日期：1997-01-01 00:00:00

abstract：:Microvascular changes in the brain are significant causes of cerebral edema and ischemia injury. A number of studies suggest that angiotensin (Ang) II may be involved in the initiation and regulation of processes occurring in brain ischemia. We recently reported that Ang II injures brain microvascular endothelial cell...

journal_title：Life sciences

authors： Liu HQ,Wei XB,Sun R,Cai YW,Lou HY,Wang JW,Chen AF,Zhang XM

更新日期：2006-02-16 00:00:00

abstract：:The association of [3H] [D-Ala2, D-Leu5] enkephalin ([3H]DADLE]) with mouse neuroblastoma cells (N4TG1) was investigated. Under identical conditions the time course, dose response curve and temperature dependence for ligand uptake were similar to those for ligand-induced receptor loss (down regulation). Uptake of [3H]...

journal_title：Life sciences

authors： Blanchard SG,Chang KJ,Cuatrecasas P

更新日期：1982-09-20 00:00:00

abstract：:The effects of capsaicin on cellular growth and intracellular calcium mobilization were examined in human cervical carcinoma derivation, HeLa cells. Capsaicin inhibited cellular growth and increased intracellular calcium level in HeLa cells. This capsaicin-induced intracellular calcium concentration rise was blocked b...

journal_title：Life sciences

authors： Takahata K,Chen X,Monobe K,Tada M

更新日期：1999-01-01 00:00:00

abstract：AIMS:This study aims to identify by a molecular genetic approach potential targets in mast cells at which 1,4-benzodiazepines may cause their inhibitory effect on mast cell activity. MAIN METHODS:Gene expression analyses with microarray gene chip and/or quantitative PCR were performed using 1,4-benzodiazepine-treated ...

journal_title：Life sciences

authors： Haenisch B,Huber M,Wilhelm T,Steffens M,Molderings GJ

更新日期：2013-03-14 00:00:00

abstract：:Synthesis and degradation of polyphosphoinositides in a rat brain synaptosome preparation were depressed by phenobarbital. Phosphatidylinositol-4-phosphate kinase (PIP-kinase), the enzyme which synthesizes phosphatidylinositol-4,5-bisphosphate (PIP2) was most strongly affected (50% inhibition at 3 mM phenobarbital); p...

journal_title：Life sciences

authors： Deshmukh DS,Kuizon S,Brockerhoff H

更新日期：1987-11-02 00:00:00

abstract：:Doxorubicin and daunorubicin, the anthracycline antitumor agents, were evaluated for their in vitro and in vivo effect on phosphodiesterase (PDE) activity in mouse tissues. Doxorubicin at a concentration of 10(-4)M inhibited cardiac c-AMP (adenosine 3',5', monophosphate) PDE activity 50% of the control whereas in lung...

journal_title：Life sciences

authors： Law J,Fumagalli A,Schein PS,Rahman A

更新日期：1985-02-11 00:00:00