Effect of phenobarbital on metabolism of polyphosphoinositides of rat brain synaptosomes.

abstract：:Angiotensin (AII) and atrial natriuretic peptide (ANP) exert opposite effects on phosphorylation of a 17.6 kDa nuclear protein from bovine adrenal glomerulosa cells. The protein was separated by sodium dodecyl sulfate electrophoresis and blotted onto polyvinylidene difluoride, and the N-terminal sequence was obtained....

journal_title：Life sciences

authors： Elliott ME

更新日期：1990-01-01 00:00:00

abstract：BACKGROUND:Most hepatocellular carcinoma cases are diagnosed at late stages of the disease, which makes it the second cause of cancer mortality worldwide. For advanced-stage patients, chemotherapeutic drugs are the best treatment option; however, their adverse effects and high cost are still major obstacles for effecti...

journal_title：Life sciences

authors： Mahmoud YI,Shehata AMM,Fares NH,Mahmoud AA

更新日期：2021-01-15 00:00:00

abstract：:Glycation-modified hemoglobin in diabetes mellitus has been suggested to be a source of enhanced catalytic iron and free radicals causing pathological complications. The present study aims to verify this idea in experimental diabetes. Pelargonidin, an anthocyanidin, has been tested for its antidiabetic potential with ...

journal_title：Life sciences

authors： Roy M,Sen S,Chakraborti AS

更新日期：2008-05-23 00:00:00

abstract：AIMS:Alzheimer's disease (AD) is characterized by vascular dysfunction, in addition to memory impairment. Previously we found that β-sheet breaker peptides (βSBPs) improved memory impairment induced by amyloid β-peptide Aβ40. In this study we investigated βSBP effects on vascular responses in a rat model of AD. MAIN M...

journal_title：Life sciences

authors： Bölükbaşı Hatip FF,Hatip-Al-Khatib I

更新日期：2013-02-27 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is the most prevalent neuromuscular disease worldwide. It is a lethal and progressive neurodegenerative disease, principally affecting motor neurons; patient clinical characteristics are muscle weakness, dysphagia and respiratory failure. The mean age is related to family history (4...

journal_title：Life sciences

authors： Recabarren-Leiva D,Alarcón M

更新日期：2018-01-15 00:00:00

abstract：:Pretreatment with a low dose of 3-nitropropionic acid (3-NPA) has been shown to induce ischemic tolerance in the gerbil hippocampus. It is well known that sublethal (2-min) ischemia also induces ischemic tolerance. To investigate the acquisition of ischemic tolerance with 3-NPA, we examined the protein expression afte...

journal_title：Life sciences

authors： Kato K,Shimazaki K,Kamiya T,Amemiya S,Inaba T,Oguro K,Katayama Y

更新日期：2005-10-21 00:00:00

abstract：:The energy balance equation applicable to all living organisms was used as a framework on which to construct a critical review of some of the more controversial aspects of the obesity problem. The equation matches energy intake against all the known forms of work that the body does in utilizing that energy, including ...

journal_title：Life sciences

authors： Rampone AJ,Reynolds PJ

更新日期：1988-01-01 00:00:00

abstract：:The interactions of aminoglycoside, 3',4'-dideoxykanamycin B(DKB) with ATP and its related compounds were investigated. ATP, ADP, cyclic AMP and FAD bound to the DKB-conjugated Sepharose 4B column. The binding of DKB to ATP was also confirmed by equilibrium gel filtration. In the acidic pH region, the fluorescence of ...

journal_title：Life sciences

authors： Inaba A,Aramaki Y,Takahashi M,Tsuchiya S

更新日期：1986-10-13 00:00:00

abstract：:Diazepam binding inhibitor (DBI) is a 9-kD polypeptide that was first isolated in 1983 from rat brain by monitoring its ability to displace diazepam from the benzodiazepine (BZD) recognition site located on the extracellular domain of the type A receptor for gamma-aminobutyric acid (GABAA receptor) and from the mitoch...

journal_title：Life sciences

authors： Costa E,Guidotti A

更新日期：1991-01-01 00:00:00

abstract：:Chlordimeform (CDM) and demethylchloridimeform (DCDM) mimic the action of octopamine in elevating adenylate cyclase activity in intact nerve cords of the American cockroach, Periplaneta americana. At a concentration of 1 x 10(-5)M, DCDM (13.5x increase within 20 minutes) is a more potent effector of the response than ...

journal_title：Life sciences

authors： Gole JW,Orr GL,Downer RG

更新日期：1983-06-27 00:00:00

abstract：:While attempting to delineate the reason for the reported extreme variability of beta-endorphin-like immunoreactivity (beta-ir) in human plasma (eg., nondetectable to 1 ng/ml) by standard radioimmunoassay, we noted that a substantial portion of circulating beta-ir was associated with erythrocytes. That erythrocyte ass...

journal_title：Life sciences

authors： Fisher A,Comly M,Do R,Tamarkin L,Ghazanfari AF,Mukherjee AB

更新日期：1984-05-07 00:00:00

abstract：:We have previously shown that transforming growth factor-beta1 (TGF-beta1) is involved in the fibroblast-induced organization and differentiation of transformed phenotypically crypt-like T84 intestinal epithelial cells into absorptive enterocyte-like cells, when cultured within a three-dimensional collagen gel. We hav...

journal_title：Life sciences

authors： Lindfors K,Halttunen T,Kainulainen H,Mäki M

更新日期：2001-08-10 00:00:00

abstract：AIM:Cadmium is a persistent ubiquitous environmental toxicant that elicits several biological defects on delicate body organs. Growing evidence suggests that cadmium (Cd) may perturb signaling pathways to induce oxidative pancreatitis. Thus, we explored whether hesperidin, a flavonone, could mitigate Cd-induced oxidati...

journal_title：Life sciences

authors： Aja PM,Izekwe FI,Famurewa AC,Ekpono EU,Nwite FE,Igwenyi IO,Awoke JN,Ani OG,Aloke C,Obasi NA,Udeh KU,Ale BA

更新日期：2020-10-15 00:00:00

abstract：AIMS:The clinical efficiency of dendritic cell (DC) therapy needs to be improved. Exosomes, as membrane nano-vesicles, carry bio-macromolecules and play essential roles in intercellular crosstalk. Here, it is proposed that tumor cell-derived exosomes could function as vehicles to deliver exogenous miRNA-155 into DCs, f...

journal_title：Life sciences

authors： Asadirad A,Hashemi SM,Baghaei K,Ghanbarian H,Mortaz E,Zali MR,Amani D

更新日期：2019-02-15 00:00:00

abstract：:Bu-Zhong-Yi-Qi-Tang (BZYQT), a Chinese herbal medicine, inhibited the proliferation of human hepatoma cell lines (Hep3B, HepG2 and HA22T) dose-dependently. The IC50s of BZYQT on the proliferation of Hep3B, HepG2 and HA22T were 432.5+/-31.8 microg/ml, 455.4+/-24.2 microg/ml, and 2284.3+/-77.2 microg/ml respectively on ...

journal_title：Life sciences

authors： Kao ST,Yeh CC,Hsieh CC,Yang MD,Lee MR,Liu HS,Lin JG

更新日期：2001-08-17 00:00:00

abstract：AIMS:We previously reported that cysteinyl leukotriene receptor 2 (CysLT(2)) mediates ischemic astrocyte injury, and leukotriene D(4)-activated CysLT(2) receptor up-regulates the water channel aquaporin 4 (AQP4). Here we investigated the mechanism underlying CysLT(2) receptor-mediated ischemic astrocyte injury induced ...

journal_title：Life sciences

authors： Qi LL,Fang SH,Shi WZ,Huang XQ,Zhang XY,Lu YB,Zhang WP,Wei EQ

更新日期：2011-01-03 00:00:00

abstract：:Gastric mucosal lipid peroxide levels, based on the amounts of thiobarbituric acid reacting substances, increased soon after oral application of absolute ethanol. On the other hand, gastric mucosal nonprotein sulfhydryl levels slightly but significantly decreased. Administration of 20% ethanol, a mild irritant which c...

journal_title：Life sciences

authors： Mizui T,Doteuchi M

更新日期：1986-06-09 00:00:00

abstract：:Withania somnifera (ashwagandha, Indian ginseng) is an immunostimulant herbal medicine used to improve overall health and prevent diseases, particularly in the elderly. However, the mechanisms underlying its immunostimulant effect is poorly understood. To elucidate the mechanism of Withania somnifera, we investigated ...

journal_title：Life sciences

authors： Iuvone T,Esposito G,Capasso F,Izzo AA

更新日期：2003-02-21 00:00:00

abstract：:Certain things have not changed since my colleague and I last reviewed the role of dietary salt in hypertension [Haddy, F.J., Pamnani, M.B., 1995. Role of dietary salt in hypertension. Journal of the American College of Nutrition 14, 428-438]. Over half of hypertensives are still salt sensitive, i.e., they respond to ...

journal_title：Life sciences

authors： Haddy FJ

更新日期：2006-09-20 00:00:00

abstract：:Plasma levels of prolactin, growth hormone, glucagon insulin and glucose were measured in non-treated control rats, bromocriptine-treated control rats and GH3-cell-tumor-bearing rats with and without bromocriptine treatment. Bromocriptine treatment increased plasma levels of glucagon, insulin and glucose in control ra...

journal_title：Life sciences

authors： Knudtzon J,Johansen PW,Haug E,Gautvik K

更新日期：1986-08-18 00:00:00

abstract：:Aim Determine changes in the expressions of the ion channel-TRPV1-and neuropeptides-NKA, NKB, calcitonin gene-related peptide (CGRP), and SP-in 14-, 21-, and 42-day-old rats after inhaling 1.5% and 2.6% sevoflurane. MAIN METHODS:A small in-house inhalation anesthesia chamber was designed to allow 14-, 21-, and 42-day...

journal_title：Life sciences

authors： Liu D,Yuan J,Fei X,Zhu Y,Zhou Y,Zhang C,Dong L,Zhu Z

更新日期：2020-05-15 00:00:00

abstract：:We have examined the role of membrane hyperpolarization in mediating vascular hyporeactivity induced by bacterial lipopolysaccharide (LPS) in endothelial-denuded strips of rat thoracic aorta ex vivo. The injection of rats with LPS caused a significant fall of blood pressure and a severe vascular hyporeactivity to nore...

journal_title：Life sciences

authors： Chen SJ,Wu CC,Yang SN,Lin CI,Yen MH

更新日期：2000-12-29 00:00:00

abstract：:Central administration of neurotensin (NT) results in a variety of neurobehavioral effects which, depending upon the administration site, resemble the effects of antipsychotic drugs (APDs) and psychostimulants. All clinically effective APDs exhibit significant affinities for dopamine D(2) receptors, supporting the hyp...

journal_title：Life sciences

authors： Dobner PR,Deutch AY,Fadel J

更新日期：2003-06-27 00:00:00

abstract：:In this study we analyzed the N-formyl-Met-Leu-Phe (fMLP)-induced calcium signal in alveolar macrophages (AM) isolated from ovalbumin-sensitized (OA-sensitized AM) and naive (naive AM) guinea-pigs. Guinea-pigs were sensitized by subcutaneous injection of OA and AM were isolated by bronchoalveolar lavage 6 weeks therea...

journal_title：Life sciences

authors： Failli P,Bindi D,Franceschelli F,Tanini A,Ciuffi M,Mazzetti L,Zilletti L

更新日期：2001-08-24 00:00:00

abstract：:The effect of various fractions of black tea [(Camellia Sinensis) (L) O. Kuntze (Theaceae)] on the function of mammalian skeletomotor apparatus was studied. The theaflavin fraction (Tfs) produced a concentration- dependent facilitation of indirect twitch responses of the rat phrenic nerve diaphragm preparation and the...

journal_title：Life sciences

authors： Basu S,Chaudhuri T,Chauhan SP,Das Gupta AK,Chaudhury L,Vedasiromoni JR

更新日期：2005-05-13 00:00:00

abstract：:The NLRP3 inflammasome regulates innate immune and inflammatory responses by promoting pro-inflammatory cytokines such as IL-18 and IL-1β. NLRP3 is one of the main factors restricting the activation of the inflammasome, which is closely related to the abundance and localization of NLRP3. A substantial number of studie...

journal_title：Life sciences

authors： Ge Q,Chen X,Zhao Y,Mu H,Zhang J

更新日期：2021-02-15 00:00:00

abstract：:Hypercalcemic strains of the rat Walker 256 (W256) tumor synthesize parathyroid hormone-related protein (PTHrP) and at least one of them produces an ill-defined transforming growth factor activity. We tested the production of transforming growth factor (TGF) beta by a hypercalcemic W256 tumor strain, and assessed its ...

journal_title：Life sciences

authors： Benítez-Verguizas J,Loarte D,de Miguel F,Esbrit P

更新日期：1999-01-01 00:00:00

abstract：AIMS:Amiodarone (AMIO) is currently used in medical practice to reverse ventricular tachycardia. Here we determine the effects of AMIO in the electromechanical properties of isolated left ventricle myocyte (LVM) from mice and guinea pig and in a cellular model of Long QT Syndrome Type 3 (LQTS-3) using anemone neurotoxi...

journal_title：Life sciences

authors： Beserra SS,Santos-Miranda A,Sarmento JO,Miranda VM,Roman-Campos D

更新日期：2020-08-15 00:00:00

abstract：:Neuroblastoma x glioma hybrid cells NG 108-15 were chronically treated with opioid agonists and tested for their development of "tolerance" as evaluated by the loss of inhibitory activity of opioids upon cAMP-accumulation. Desensitization was dose-dependent and non-competitive and highly selective, since the activity ...

journal_title：Life sciences

authors： Wüster M,Costa T,Gramsch C

更新日期：1983-01-01 00:00:00

abstract：:[3H]5-HT exhibited specific binding in membrane preparations of Hymenolepis diminuta. The specific binding was saturable, reversible and temperature dependent. A non-linear Scatchard plot was obtained in a concentration range of 11 nM - 1000 nM [3H]5-HT, which could be resolved into sites having apparent dissociation ...

journal_title：Life sciences

authors： Ribeiro P,Webb RA

更新日期：1987-02-23 00:00:00