Abstract:
:Effects of scratching behavior on dermatitis, transepidermal water loss (TEWL) and serum IgE concentrations were examined in NC/Nga (NC) mice with toenails (WIT) and without toenails (WOT). The first study was a preventive treatment done to cut off hind toenails before dermatitis induction and the second study was a therapeutic treatment by cutting off hind toenails of NC mice with severe dermatitis. In the preventive study, scratching behavior significantly increased in both WIT and WOT after dermatitis induction. Skin severity score, TEWL, number of mast cells and serum IgE concentration statistically increased in WIT but not in WOT after dermatitis induction. Histological changes coincided with the skin severity score in WIT, while no changes were observed in WOT. In the therapeutic study, skin severity score in WOT but not in WIT statistically decreased after cutting off the hind toenails. TEWL and numbers of mast cells in WOT were statistically lower compared with findings in WIT. Thus scratching up the skin with toenails seemed to be the most important factor leading to dermatitis in NC mice.
journal_name
Life Scijournal_title
Life sciencesauthors
Hashimoto Y,Arai I,Nakanishi Y,Sakurai T,Nakamura A,Nakaike Sdoi
10.1016/j.lfs.2004.07.022subject
Has Abstractpub_date
2004-12-31 00:00:00pages
783-94issue
7eissn
0024-3205issn
1879-0631pii
S0024-3205(04)00869-0journal_volume
76pub_type
杂志文章相关文献
LIFE SCIENCES文献大全abstract:AIMS:Fenofibrate is a peroxisome proliferator-associated receptor alpha agonist (PPARα) used clinically for the management of dyslipidemia and is a myocardial fatty acid oxidation stimulator. It has also been shown to have cardiac anti-hypertrophic properties but the effects of fenofibrate on the development of eccentr...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2012.10.022
更新日期:2013-01-17 00:00:00
abstract::Previous studies have shown that cytochrome P450-Arachidonic Acid (P450-AA) metabolites modify the vascular tone of several vessels and that vasopressin (AVP) stimulates P450-AA metabolism. Thus, in the present study, we decided to investigate if the vasoconstrictor effect of AVP is related to activation of P450-AA me...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(95)00108-i
更新日期:1995-01-01 00:00:00
abstract::The conversion of lyso-platelet activating factor (lyso-PAF) to PAF in cultured paranasal sinus mucosa obtained from normal human subjects was studied. The PAF concentration in the medium was determined after addition of lyso-PAF. PAF became detectable at 10 minutes after the addition of 10(-8)M lyso-PAF, and reached ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(93)90483-j
更新日期:1993-01-01 00:00:00
abstract::Autophagy is an essential cellular mechanism which plays "housekeeping" role in normal physiological processes including removing of long lived, aggregated and misfolded proteins, clearing damaged organelles, growth regulation and aging. Autophagy is also involved in a variety of biological functions like development,...
journal_title:Life sciences
pub_type: 杂志文章,评审
doi:10.1016/j.lfs.2017.08.029
更新日期:2017-11-01 00:00:00
abstract::Persistent neurochemical changes consistent with parkinsonism have been reported in brains of mice treated with repeated high doses of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). We now report that ethanol or acetaldehyde potentiate MPTP-induced damage to mouse striatum. One hour after the combined treatments...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(87)90030-0
更新日期:1987-03-02 00:00:00
abstract::Uncoupling proteins (UCPs) are supposed to be involved in diet-induced thermogenesis. Their activities are usually elevated by feeding and reduced by fasting in normal animals. To investigate whether fasting affects the expression of UCPs mRNA in brown adipose tissue (BAT) of bilateral ventromedial hypothalamus (VMH)-...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(03)00225-x
更新日期:2003-05-16 00:00:00
abstract::Corticotropin releasing factor (CRF), one of the major effectors of stress, plays a major role in the natural course of drug addiction by accelerating the acquisition of psychostimulant self-administration and increasing incentive motivation for the drug itself and for drug-associated stimuli. Stress-induced CRF is al...
journal_title:Life sciences
pub_type: 杂志文章,评审
doi:10.1016/j.lfs.2009.11.005
更新日期:2010-01-02 00:00:00
abstract:AIMS:Previous investigations by our group have shown that prenatal treatment with lipopolysaccharide (LPS; 100 μg/kg, intraperitoneally) on gestation day (GD) 9.5 in rats, which mimics infections by Gram-negative bacteria, induces short- and long-term behavioral and neuroimmune changes in the offspring. Because LPS ind...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2014.10.019
更新日期:2015-01-01 00:00:00
abstract::Clinical data indicate that hydroalcoholic extracts of Hypericum perforatum might be as valuable as conventional antidepressants in mild-to-moderate depression, with fewer side effects. One clinical trial using two extracts with different hyperforin contents indicated it as the main active principle responsible for th...
journal_title:Life sciences
pub_type: 杂志文章,评审
doi:10.1016/j.lfs.2004.04.005
更新日期:2004-07-16 00:00:00
abstract:AIMS:Head and neck squamous cell carcinoma (HNSCC) is an highly aggressive tumor with heterogeneous prognosis. We here report that immune-related genes (IRGs) could effectively distinguish prognostically different HNSCC patients. MATERIALS AND METHODS:MRNA levels of 1333 IRGs that from ImmPort database in HNSCC sample...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2020.117906
更新日期:2020-09-01 00:00:00
abstract:AIMS:The prognoses of patients with gastric cancer(GC) vary in different stages, which is mainly due to the great differences in tumor and tumor microenvironment. This study is aimed to explore the specific differences. MAIN METHODS:Based on RNAseq-based expression data from The Cancer Genome Atlas database and GSE154...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2020.118402
更新日期:2020-11-15 00:00:00
abstract:AIMS:The purpose of our investigative work has been to determine whether there can be therapeutic roles in the administration of sildenafil citrate, heparin and several neuropeptides on an animal model where gastric ulcers were induced with acetic acid, and to compare their efficacy. MATERIALS AND METHODS:The animals ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2017.08.013
更新日期:2017-10-01 00:00:00
abstract::The discovery and development of new drugs targeting voltage-gated ion channels are important for treating a variety of medical conditions and diseases. Ion channels are molecular nanostructures expressed ubiquitously throughout the whole body, and are involved in many basic physiological processes. Over the years, na...
journal_title:Life sciences
pub_type: 杂志文章,评审
doi:10.1016/j.lfs.2011.04.020
更新日期:2011-10-10 00:00:00
abstract::Voltage-dependent Ca2+ channels of fura-2-loaded ganglionic cells from the myenteric plexus of newborn rats were pharmacologically characterised. In contrast to completely dissociated myenteric cells, intact ganglia showed a stronger loading with the Ca2+-sensitive dye and a reproducible stimulation of the fura-2 sign...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2004.12.053
更新日期:2005-09-30 00:00:00
abstract::Diabetes Mellitus (DM) can produce an increase in the cardiac action potential duration and QT interval that can be associated with sudden death. These cardiac effects are due to a region-specific decrease in repolarizing outward K(+) currents. Some authors have suggested that the proarrhythmic effects of diabetes can...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2006.03.014
更新日期:2006-07-24 00:00:00
abstract::We administered a series of alpha-blocking drugs to the nucleus reticularis lateralis (NRL) of the medulla oblongata, the main site for the hypotensive action of clonidine. These experiments were performed on pentobarbital anaesthetized cats. Drugs were injected through a needle which was stereotaxically inserted. Pra...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(87)90566-2
更新日期:1987-03-16 00:00:00
abstract::The analgesic buprenorphine hydrochloride (Bph) induced apoptosis-like cell death in the caspase-3-deficient human breast cancer cell line, MCF-7. This apoptosis-like cell death activated key molecules in the mitochondrial apoptotic pathway: cytochrome c, caspase-9, caspase-7, and caspase-6. Bph caused the release of ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2003.11.032
更新日期:2004-06-04 00:00:00
abstract:AIMS:Cerebral atrophy resulting from neurodegeneration is highly prevalent in individuals with diabetes; however, the underlying mechanisms for diabetic neurodegeneration are not fully understood. Here we hypothesized that hyperglycemia induces molecular signaling that favors induction of proliferation in post mitotic,...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2018.05.019
更新日期:2018-07-15 00:00:00
abstract::The effect of anti beta adrenoceptor IgG from chagasic sera upon Ca2+-ATPase and Na++K+-ATPase of myocardial membrane was studied. Chagasic IgG stimulated Ca2+-ATPase and inhibited Na++K+-ATPase activities. Both enzymatic effects of the IgG could be prevented after beta adrenoceptor blockade or after the absorption of...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(87)90131-7
更新日期:1987-01-26 00:00:00
abstract:AIMS:Chloropropanol is a contaminant produced during food processing, and 1,3-dichloro-2-propanol (1,3-DCP) is one of the most-studied and most common chloropropanol-related food contaminants. Epigallocatechin-3-gallate (EGCG) is the most abundant ester catechin in tea polyphenols. We studied the potential therapeutic ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2018.08.007
更新日期:2018-09-15 00:00:00
abstract::This study demonstrates the formation of gamma-glutamyl peptides from glutamine and plasma amino acids, as catalyzed by gamma-glutamyl transpeptidase. It also establishes the effect of various amino acids in modulating the rate of glutamine utilization as well as the hydrolytic or transfer product formed. The mechanis...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(83)90682-3
更新日期:1983-10-31 00:00:00
abstract::This study examined the protective effect of phenobarbital on kainic acid-induced deficits in acquisition learning. A single kainic acid injection (9 mg/kg i.p.) was administered five days prior to testing using the Morris water maze test. Kainic acid produced deficits in the acquisition of spatial information observe...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(00)00658-5
更新日期:2000-06-30 00:00:00
abstract:AIMS:We investigated whether cAMP-mediated protein kinase A(PKA) and Epac1/Rap1 pathways differentially affect brain tumor cell death using 4-(3-cyclopentyloxy-4-methoxyphenyl)-2-pyrrolidone(rolipram), specific phosphodiesterase type IV(PDE IV) inhibitor. MAIN METHODS:A172 and U87MG human glioblastoma cells were used....
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2011.12.010
更新日期:2012-02-27 00:00:00
abstract::Effects of amphetamine on concentrations of dopamine, norepinephrine and serotonin in several monoamine-containing cell body and terminal regions were examined left and right separately in rats. Results suggest that amphetamine reduced the L-R asymmetry of most of these measures, and this effect is more significant in...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(87)90334-1
更新日期:1987-04-06 00:00:00
abstract::The vascular endothelium is recognized as a barrier between blood and blood vessel wall. The abnormality of vascular endothelium is critical for atherosclerosis, hypertension and diabetes. Oxidative stress, inflammation, obesity, hyperlipidemia and insulin resistance are major contributors to endothelial dysfunction i...
journal_title:Life sciences
pub_type: 杂志文章,评审
doi:10.1016/j.lfs.2016.11.005
更新日期:2016-12-15 00:00:00
abstract::We determined by PCR the number of (A-C)n repeats in the 2. 1 kb upstream of the aldose reductase (AR2) gene in healthy control subjects and in patients with NIDDM in Japanese. Sixty-one patients were recruited based on the severity of retinopathy and subdivided into two groups with proliferative retinopathy and witho...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(99)00329-x
更新日期:1999-01-01 00:00:00
abstract:AIMS:Thrombin is a serine proteinase that is not only involved in coagulation cascade, but also mediates a number of biological responses relevant to tissues repair, and induces bronchoconstriction. TGF-β plays a pivotal role in airway remodeling due to its effects on airway smooth muscle proliferation and extracellula...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2018.02.012
更新日期:2018-03-15 00:00:00
abstract::Uptake of serotonin and 3H-imipramine binding in platelets of depressed patients were investigated simultaneously with changes in clinical state. Both Vmax for serotonin uptake and Bmax for 3H-imipramine binding were significantly lower in unmedicated depressed patients with respect to normal subjects. Successful trea...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(85)90201-2
更新日期:1985-02-25 00:00:00
abstract::Studies have reported that taraxasterol (TAR) is effective in the treatment of immune liver injury and alcoholic liver injury. The mechanism of action is mainly related to the inhibition of inflammation. To determine the key molecular mechanisms for the effect of TAR on alleviating ethanol and high-fat diet-induced li...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2020.118546
更新日期:2020-12-01 00:00:00
abstract:INTRODUCTION AND AIM:Polycystic ovary syndrome is one of the most common causes of female infertility, affecting 5-10% of the population. Women with PCOS manifest hyperandrogenism, hyperinsulinemia, low-grade systemic inflammation, and polycystic ovaries. Unfortunately, current available medications are only symptomati...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2019.116640
更新日期:2019-09-01 00:00:00