Abstract：
:This study demonstrates the formation of gamma-glutamyl peptides from glutamine and plasma amino acids, as catalyzed by gamma-glutamyl transpeptidase. It also establishes the effect of various amino acids in modulating the rate of glutamine utilization as well as the hydrolytic or transfer product formed. The mechanism of the utilization of glutamine as catalyzed by gamma-glutamyl transpeptidase, involves the formation of a gamma-glutamyl enzyme bound intermediate as the initial step, with release of the amide nitrogen as ammonium, NH+4, Figure 1. The gamma-glutamyl enzyme bound intermediate either reacts with the acceptor amino acids or water; reaction with amino acids yields gamma-glutamylpeptides via the transfer pathway and reaction with water yields glutamate via the hydrolytic pathway.
journal_name
Life Scijournal_title
Life sciencesauthors
Dass PDdoi
10.1016/0024-3205(83)90682-3subject
Has Abstractpub_date
1983-10-31 00:00:00pages
1757-62issue
18eissn
0024-3205issn
1879-0631pii
0024-3205(83)90682-3journal_volume
33pub_type
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