Production of growth related oncogene protein-alpha in human umbilical vein endothelial cells stimulated with soluble interleukin-6 receptor-alpha: role of signal transducers, janus kinase 2 and mitogen-activated kinase kinase.

abstract：:N(G)-Nitro-L-arginine methyl ester (L-NAME), inhibits the three isozymes of nitric oxide synthase (NOS) in vitro and in vivo. The mechanism of NOS inhibition by L-NAME is uncertain. L-NAME was a time-dependent inhibitor of neuronal NOS (nNOS). Concommitantly, L-NAME was hydrolyzed, non-enzymatically, to N(G)-Nitro-L-a...

journal_title：Life sciences

authors： Furfine ES,Carbine K,Bunker S,Tanoury G,Harmon M,Laubach V,Sherman P

更新日期：1997-01-01 00:00:00

abstract：:Circadian rhythms might be involved in addictive behaviors. The pineal secretory product melatonin decreases cocaine sensitization in rats; mice mutant for the critical melatonin-synthesizing enzyme, arylalkylamine N-acetyltransferase (AANAT), exhibit altered behaviors. We hypothesized that AANAT/melatonin system, whi...

journal_title：Life sciences

authors： Uz T,Javaid JI,Manev H

更新日期：2002-05-10 00:00:00

abstract：:Although exogenous cannabinoid ligands such as delta9-tetrahydrocannabinol (THC) have been implicated in reward-related learning and aversion, the hedonic effects of the endogenous cannabinoid agonist anandamide (arachidonylethanolamide) have never been assessed. Thus, the effects of anandamide were tested in a place ...

journal_title：Life sciences

authors： Mallet PE,Beninger RJ

更新日期：1998-01-01 00:00:00

abstract：UNLABELLED:The present study was conducted to examine whether melatonin impairs serotonin (5HT) release and uptake in rat platelets. Exposure of platelet-rich plasma samples (PRP) to melatonin induced a concentration-dependent inhibition of 5HT uptake and the value of IC50 was 1.3 x 10(-3) M. We have also investigated ...

journal_title：Life sciences

authors： Martín FJ,Atienza G,Aldegunde M,Míguez JM

更新日期：1993-01-01 00:00:00

abstract：:Maternal malnutrition is known to impair fetal growth and predispose to the development of hypertension and type 2 diabetes. Recently, studies have demonstrated that intrauterine malnutrition is followed later in male offspring by oxidative stress characterized by increased superoxide generation due to activation of N...

journal_title：Life sciences

authors： Franco MC,Akamine EH,Rebouças N,Carvalho MH,Tostes RC,Nigro D,Fortes ZB

更新日期：2007-01-30 00:00:00

abstract：:An in vitro preparation of rabbit thoracic aorta was tested in order to determine whether isometric contractile force induced by endothelin-1 (ET-1) in this preparation is changed when the tissue is exposed to ultraviolet (UV) light. After constriction of an aortic segment to a steady-state level of tension with ET-1,...

journal_title：Life sciences

authors： Nordberg LO,Raffa RB,Tallarida RJ

更新日期：1993-01-01 00:00:00

abstract：:DL-alpha-difluoromethylornithine (DFMO), 4-deoxypyridoxine (4-DOP), and methylglyoxal bis (guanylhydrazone) (MGBG) were tested as inhibitors of acute skin graft rejection. Proximal full thickness tail skins were exchanged between C57BL/6 and Balb/C mice. Distal autografts were placed to monitor healing. Inhibitors wer...

journal_title：Life sciences

authors： Campbell RA,Kurtz GL,Norton-Reel DJ

更新日期：1991-01-01 00:00:00

abstract：:Nitric oxide (NO) may play an important regulatory role in airway function. We have, thus, investigated in vitro whether epithelium derived NO may modulate cholinergic neurotransmission, via release of NO in guinea pig trachea, by using L-arginine (L-ARG), a precursor of NO synthesis, and L-N(G)-nitro-arginine-methyl-...

journal_title：Life sciences

authors： Matera MG,D'agostino B,Cardone M,Calderaro V,Rossi F

更新日期：1995-02-17 00:00:00

abstract：:A variety of chromatographic approaches are detailed for enhancement of signal and selectivity for determination of biogenic amines by HPLC with amperometric detection. Microbore HPLC columns offer significant signal enhancement due to the reduced elution volume. Selection of novel surfactants such as N-methyl oleoyl ...

journal_title：Life sciences

authors： Mefford IN

更新日期：1987-08-17 00:00:00

abstract：:Aim Doxorubicin (Dox) is one of the most cardiotoxic anti-cancerous drug that is widely used for broad-range of cancers. There is an urgent need for developing cardio-oncological therapeutic interventions. Natural products having both anti-cancerous potential as well as cardioprotective effects may hold a great potent...

journal_title：Life sciences

authors： Jain A,Rani V

更新日期：2018-07-15 00:00:00

abstract：:Chymase is an important enzyme for the generation of angiotensin (Ang) II and in the activation of transforming growth factor (TGF)-beta1. Therefore, chymase may be involved in the hemodialysis access dysfunction, which is caused by intimal hyperplasia that occurs after polytetrafluoroethylene (PTFE) graft implantatio...

journal_title：Life sciences

authors： Jin D,Ueda H,Takai S,Muramatsu M,Furubayashi K,Ibaraki T,Kishi K,Katsuoka Y,Miyazaki M

更新日期：2007-09-29 00:00:00

abstract：:To assess the possible role of altered central serotonin function in psychiatric disorders, investigators have utilized pharmacological challenge testing with an amino acid mixture to decrease blood tryptophan concentration and, indirectly, brain serotonin levels. The aim of this pilot study was to assess the effectiv...

journal_title：Life sciences

authors： Wolfe BE,Metzger ED,Jimerson DC

更新日期：1995-03-17 00:00:00

abstract：:Trimidox (3,4,5-trihydroxybenzohydroxamidoxime), a recently synthesized inhibitor of ribonucleotide reductase (RR), was shown to exert anti-proliferative activities in HL-60 and K562 human leukemia cell lines and to prolong the life span of mice inoculated with L1210 mouse leukemia cells. Here we test whether trimidox...

journal_title：Life sciences

authors： Rosenberger G,Fuhrmann G,Grusch M,Fassl S,Elford HL,Smid K,Peters GJ,Szekeres T,Krupitza G

更新日期：2000-11-17 00:00:00

abstract：AIMS:Fructose administration induces hepatic oxidative stress, insulin resistance, inflammatory and metabolic changes. We tested their potential pathogenic relationship and whether these alterations can be prevented by R/S-α-lipoic acid. MAIN METHODS:Wistar rats received during 21days a commercial diet or the same die...

journal_title：Life sciences

authors： Castro MC,Massa ML,Arbeláez LG,Schinella G,Gagliardino JJ,Francini F

更新日期：2015-09-15 00:00:00

abstract：:In order to determine whether CCl4, CBrCl3, CBr4 or CHCl3 undergo oxidative metabolism to electrophilic halogens by liver microsomes, they were incubated with liver microsomes from phenobarbital pretreated rats in the presence of NADPH and 2,6-dimethylphenol. The analysis of the reaction mixtures by capillary gas chro...

journal_title：Life sciences

authors： Mico BA,Branchflower RV,Pohl LR,Pudzianowski AT,Loew GH

更新日期：1982-01-11 00:00:00

abstract：:We have investigated the antidiabetic activity of luteolin 5-rutinoside in streptozotocin(STZ)-induced diabetic rats. Treatment for 20 days with 2 mg/kg increased both pancreatic insulin and DNA content. When both luteolin 5-rutinoside (2 mg/kg) and glibenclamide (1 mg/kg) were administered concurrently to STZ-diabeti...

journal_title：Life sciences

authors： Zarzuelo A,Jiménez I,Gámez MJ,Utrilla P,Fernadez I,Torres MI,Osuna I

更新日期：1996-01-01 00:00:00

abstract：AIMS:Several lines of evidence support the hypothesis that the oxidation of low density lipoprotein (LDL) may play a crucial role in the initiation and progression of atherosclerosis. Various studies have shown a positive effect of antioxidant compounds on oxidative modification of LDL and atherogenesis. In view of thi...

journal_title：Life sciences

authors： de Lima Portella R,Barcelos RP,de Bem AF,Carratu VS,Bresolin L,da Rocha JB,Soares FA

更新日期：2008-12-19 00:00:00

abstract：:The cardio- and neuroprotective effect of the pyridoindole stobadine (S) is conditioned mainly by its good radical scavenging properties. It has been showed by EPR experiment, that the ultimate product of the reaction of stobadine with hydroxyl radical is the nitroxyl radical. However, for the unsaturated dehydrostoba...

journal_title：Life sciences

authors： Májeková M,Májek P,Mach P

更新日期：1999-01-01 00:00:00

abstract：:We studied Na,K-ATPase mRNA expression in cardiomyopathic (Bio 14.6) and normal (F1b) Syrian hamster ventricles. In Northern blot analysis, Na,K-ATPase alpha 1, alpha 2, alpha 3 and beta 1 isoform mRNAs were detected in 3-week-old Bio 14.6 and F1b hamster ventricles. We then investigated the expression of alpha 1 subu...

journal_title：Life sciences

authors： Tsuruya Y,Ikeda U,Yamamoto K,Seino Y,Kanbe T,Shimada K

更新日期：1994-01-01 00:00:00

abstract：AIMS:The purpose of this study was to compare the changes of antihyperalgesic effectiveness of zonisamide (25 and 50 mg/kg), an antiepileptic drug, on the early and late phases of neuropathy and to investigate the role of serotonergic descending inhibitory pain pathways in antihyperalgesic effectiveness of zonisamide i...

journal_title：Life sciences

authors： Bektas N,Arslan R,Ozturk Y

更新日期：2014-01-24 00:00:00

abstract：:Biphasic cutaneous reaction with peak response at 1 (early phase) and 24 to 48 hour (late phase) was elicited by epicutaneous challenge with antigen in actively and passively sensitized mice. Mice were actively immunized with dinitrophenylated (DNP) ascaris antigen and challenged with dinitrofluorobenzene (DNFB). Pass...

journal_title：Life sciences

authors： Sakurai T,Inagaki N,Nagai H

更新日期：1994-01-01 00:00:00

abstract：:Dihydroergosine (50 and 100 mg/kg) enhanced the incidence of bicuculline (3 mg/kg)-induced convulsions in female rats, while 100 mg/kg of dihydroergosine given to female mice made 45% convulsive dose of bicuculline (2.5 mg/kg) to be subconvulsive. The same dose of dihydroergosine enhanced in mice the latency of bicucu...

journal_title：Life sciences

authors： Pericić D,Tvrdeić A

更新日期：1990-01-01 00:00:00

abstract：:Microiontophoretic study was performed to elucidate dopaminergic mechanism in the nucleus accumbens (Acc) of rats anesthetized with chloral hydrate. Iontophoretically applied dopamine produced an inhibition of glutamate-induced firing in 28 (62%) out of 45 Acc neurons tested. The dopamine-induced inhibition of 14 Acc ...

journal_title：Life sciences

authors： Akaike A,Sasa M,Takaori S

更新日期：1983-06-06 00:00:00

abstract：:Thymol induced superoxide production (O2-) by blood leukocytes was examined in various primates including man. Leukocytes of chimpanzee and hamadryas baboon cells showed only 35% of the maximal O2- production rate obtained in human cells, and those of the Japanese monkey and orang-utan failed to respond. In contrast, ...

journal_title：Life sciences

authors： Suzuki Y,Nakamura S,Sugiyama K,Furuta H

更新日期：1987-09-28 00:00:00

abstract：:Oxytocin (OT) and arginine-8-vasopressin (AVP) were measured by radioimmunoassay in micropunched hypothalamic neurosecretory nuclei of estrous cycling female Sprague-Dawley rats. In the paraventricular nucleus (PVN): the concentration (pg/microgram protein) of OT was significantly higher in rats in diestrus than durin...

journal_title：Life sciences

authors： Greer ER,Caldwell JD,Johnson MF,Prange AJ Jr,Pedersen CA

更新日期：1986-06-23 00:00:00

abstract：:The aim of the present study was to determine the role of adrenals in gonadal activity in the male toad during the breeding season. Exogenous administration of corticosterone or metapyrone for 6 days inhibited adrenal delta5-3beta(delta 5-3 beta) hydroxysteroid (delta5-3beta-HSD) and testicular 17beta (17 beta) hydrox...

journal_title：Life sciences

authors： Biswas NM,Chaudhuri GR,Sarkar M,Sengupta R

更新日期：2000-02-18 00:00:00

abstract：:Basic fibroblast growth factor (bFGF) has a neurotrophic effect both in vitro and in vivo, and is considered to play an important role in the maintenance of neuronal functions in the normal brain. Neural damage in brain contusion progresses after the primary injury of trauma because of cerebral hemodynamic and metabol...

journal_title：Life sciences

authors： Iwamoto Y,Yamaki T,Murakami N,Sugawa N,Yoshino E,Ueda S,Nosaka K,Nishino H,Iwashima A

更新日期：1994-01-01 00:00:00

abstract：:It has been shown that the antagonism of glutamate receptors activity was able inhibit proliferation and induce apoptosis in several neuronal and non-neuronal cancer cell lines. In addition, it has been shown that glutamate might facilitate the spread and growth of leukemia T cells through interactions with AMPA recep...

journal_title：Life sciences

authors： Parenti S,Casagrande G,Montanari M,Espahbodinia M,Ettari R,Grande A,Corsi L

更新日期：2016-05-01 00:00:00

abstract：:A completely randomized controlled study based on a rabbit model was designed to study the effect of repetitive ischemic preconditioning (IPC) on a spinal cord ischemic reperfusion injury. Twenty four white adult Japanese rabbits were randomly assigned to one of the 3 groups (n = 8 per group): Group I: sham-operation ...

journal_title：Life sciences

authors： Yu QJ,Wang YL,Zhou QS,Huang HB,Tian SF,Duan DM

更新日期：2006-09-05 00:00:00

abstract：:Food allergies have become increasingly prevalent during the past few decades. Diarrhea is one of the most frequent intestinal symptoms caused by food allergens and is characterized by imbalanced ion exchange and water transfer; however, the underlying mechanism of allergic diarrhea remains unclear. Water transfer acr...

journal_title：Life sciences

authors： Yamamoto T,Kuramoto H,Kadowaki M

更新日期：2007-06-20 00:00:00